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What are the main uses of 1,1 '-biphenyl, 4-bromo-4' -iodine?
1,1 '-Binaphthalene, 4-sulfonic acid-4' -carboxylic acid, this substance has a wide range of uses. In the field of medicinal chemistry, it can be used as a key chiral ligand. Chiral ligands play an extraordinary role in asymmetric synthesis, which can efficiently guide reactions and promote the formation of chiral compounds of specific configurations. The preparation of many drug components relies heavily on chiral synthesis, which can significantly improve the activity and efficacy of drugs, while reducing adverse reactions. Therefore, 1,1 '-binaphthalene, 4-sulfonic acid-4' -carboxylic acid is of great significance in the development and production of chiral drugs.
In the field of materials science, it also shows unique value. With its own structural properties, it can participate in the construction of functional materials with special optical and electrical properties. For example, in the creation of organic Light Emitting Diode (OLED) materials, it can be used as a key structural unit to optimize the material's luminous efficiency, stability and other properties, and contribute to the development of new display technologies.
In addition, in the field of catalytic chemistry, this substance is often used as an important part of catalysts or catalysts. Its unique molecular structure can provide a suitable space environment and electronic effect for catalytic reactions, thus effectively improving the rate and selectivity of catalytic reactions, enabling many chemical reactions to proceed more efficiently and accurately, and is widely used in various organic synthesis reactions.
What are the physical properties of 1,1 '-biphenyl, 4-bromo-4' -iodine
The physical properties of 1,1 '-binaphthalene, 4-sulfonic acid-4' -carboxylic acid are as follows:
Its outer surface is often in the shape of a crystalline solid. This is due to the interaction of molecules such as, van der forces, etc., which promote the orderly arrangement of molecules, thus forming a crystal. In terms of solubility, it has the best solubility in soluble molecules such as methanol, ethanol, water, etc. Due to the fact that the sulfonic acid groups (-SOH) and carboxylic acid groups (-COOH) in its molecules are all soluble groups, soluble molecules can be formed, which increases their dispersion in solution, but has little solubility in non-soluble molecules such as n-hexane and benzene.
Melting boiling is also an important physical property. Due to the force of the molecule, it has high melting boiling. In the molecule, the sulfonic acid carboxylic acid group can form a molecule, which increases the attractive force of the molecule. To make the material from solid or liquid or from liquid, more energy needs to be provided to overcome these forces, so the melting boiling is high.
The compound has a certain acidity. The sulfonic acid group can be formed from the sulfonic acid group, and it can be acidic in aqueous solution. The acidic phase of the sulfonic acid group, because the sulfonic acid has a high degree of resonance and qualitative, can effectively disperse the charge and make the acid more susceptible.
In addition, the 1,1 '-naphthalene part has a certain photoactivity. If there is a chiral center in the molecule, and the whole molecule does not have a plane or a center, it may be optically active, which may have special uses in the field of optical materials. In some optical reflections, it may be used as a chiral reflector, causing the reflector to travel in a specific direction, resulting in a specific shape.
Is the chemical properties of 1,1 '-biphenyl, 4-bromo-4' -iodine-stable?
The physical properties of 1,1 '-binaphthalene, 4-aldehyde-4' -nitrile are quite stable. This is because of its unique molecular structure. The naphthalene rings are connected by a single bond to form a large conjugated system, giving it a certain rigidity and stability.
From the perspective of spatial structure, the two naphthalene rings of the binaphthalene part are twisted at a certain angle to avoid coplanarity and form a unique chiral environment. This special spatial arrangement makes the intermolecular forces relatively stable, and it is difficult for external factors to easily change its structure.
The introduction of 4-aldehyde and 4 '-nitrile groups, although they are active groups, also enhances the overall stability when they are connected to the binaphthalene skeleton. The carbonyl group of the aldehyde group is conjugated with the naphthalene ring, and the triple bond of the nitrile group also participates in electron delocalization, stabilizing the distribution of molecular electron clouds.
In addition, carbon-carbon single bonds, carbon-hydrogen single bonds and other chemical bonds have high bond energies and require a large amount of energy to break. Even if there is a slight disturbance in the outside world, the molecular structure can still maintain stability. It is 1,1 '-binaphthalene, 4-aldehyde-4' -nitrile that exhibits good stability under normal conditions, and can maintain its inherent properties and play an important role in many fields such as organic synthesis and materials science.
What are the synthesis methods of 1,1 '-biphenyl, 4-bromo-4' -iodine-
The synthesis method of 1% 2C1% 27-binaphthalene, 4-aldehyde-4% 27-carboxyl group, has various paths to follow.
First, it can be started by a derivative of naphthalene. First, the naphthalene is introduced into the functional group at the appropriate position through a specific substitution reaction, or a halogenating reagent is used to halogenate a specific carbon site on the naphthalene ring to obtain a halogenated naphthalene derivative. Then, it is treated with a metal-organic reagent, such as a Grignard reagent or a lithium reagent, and then reacted with the corresponding aldehyde group or carboxyl group into the reagent to gradually construct the target structure. If halogenated naphthalene is made into a Grignard reagent and reacted with a suitable aldehyde compound, an aldehyde group can be introduced; if it is reacted with carbon dioxide and subsequent aci
Second, it is achieved by coupling reaction. Naphthalene monomers containing aldehyde groups or carboxyl groups are selected under the action of transition metal catalysts, such as palladium-catalyzed Suzuki coupling and Stille coupling reactions. Taking Suzuki coupling as an example, naphthalene derivatives containing boron ester groups and naphthalene derivatives containing halogen atoms with aldehyde groups or carboxyl groups are coupled in the presence of base and palladium catalysts, resulting in the formation of 1% 2C1% 27-binaphthalene, 4-aldehyde-4% 27-carboxyl groups. This method has good selectivity and relatively mild conditions, which can effectively construct the binaphthalene structure and retain the required functional groups.
Third, the redox strategy is adopted. If the starting material contains functional groups that can be oxidized or reduced, it can be converted by oxidation or reduction reaction. For example, using binaphthyl derivatives containing alcoholic hydroxyl groups as raw materials, the alcoholic hydroxyl group can be oxidized to an aldehyde group by a suitable oxidant, such as a Dyss-Martin oxidant; if the starting material is a binaphthyl derivative containing an aldehyde group, the carboxyl group can be obtained by mild oxidation, such as oxidation with silver ammonia solution or Feilin reagent, etc. The carboxyl group part of the target product can be obtained.
All synthesis methods have their own advantages and disadvantages, and it is necessary to weigh factors such as the availability of raw materials, the difficulty of reaction conditions, yield and selectivity to determine the best synthesis method.
In which fields is 1,1 '-biphenyl, 4-bromo-4' -iodine used?
Compounds such as 1% 2C1% 27-binaphthalene, 4-aldehyde-4% 27-carboxylic are useful in many fields.
In the field of medicinal chemistry, it is often the key raw material for the creation of new drugs. Because the compound has a unique chemical structure and activity, or can be closely bound to specific biological targets, it exhibits various pharmacological activities such as antibacterial, antiviral, and anti-tumor. Therefore, drug developers often use this as a basis, modify and optimize, and strive to find new drugs with high efficiency and low toxicity.
In the field of materials science, it also has important applications. It can be used to prepare optoelectronic materials. With its special optical and electrical properties, it can be used in organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve the performance of such devices. For example, by adjusting the structure of the compound, its luminous color and efficiency can be changed, which will help the progress of display technology.
In the field of asymmetric catalysis, 1% 2C1% 27-binaphthalene, 4-aldehyde-4% 27-carboxylic derivatives often act as chiral ligands. Asymmetric catalysis is a key field of organic synthetic chemistry, aiming to selectively synthesize compounds of specific configurations. This kind of chiral ligand can be combined with metal catalysts to build an efficient asymmetric catalytic system, which plays an excellent catalytic role in a variety of organic reactions. It is of great significance in the synthesis of fine chemicals and the total synthesis of natural products. It can improve the selectivity and yield of the reaction and reduce the production cost.
It can also be seen in the field of analytical chemistry. Because of its structural characteristics, it can be used as an identification reagent for the detection and analysis of specific substances. By specifically interacting with the target analyte, detectable signal changes can be generated to achieve qualitative and quantitative analysis of the target substance, providing a powerful tool for environmental monitoring, food safety testing, etc.
