As a leading 1-(2-Deoxy-2-Fluoro-B-D-Arabinofuranosyl)-5-Iodo-2,4(1H,3H)-Pyrimidinedione supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodo-2,4 (1H, 3H) -pyrimidinedione?
1 - (2 - deoxy - 2 - fluoro - β - D - arabinofuranosyl) -5 - iodine - 2,4 (1H, 3H) - pyrimidinedione is a complex organic compound. In its chemical structure, pyrimidinedione is the core mother ring, and there is a carbonyl group at the 2nd and 4th positions, forming a dione state. There are iodine atoms at the 5th position, which endow the compound with specific chemical activity.
Furthermore, the first position is connected to a glycosyl group through glycosidic bonds, and this glycosyl group is 2-deoxy-2-fluoro - β - D-arabinofuran. Among them, "2-deoxy" indicates that the hydroxyl group at the second position of the glycosyl group lacks oxygen atoms and is replaced by hydrogen atoms; "2-fluoro" indicates that the fluorine atom is connected to the fluorine atom at the second position. The electronegativity of the fluorine atom is high, which has a great impact on the properties of the compound; "β-D-arabinofuran glycosyl" indicates that the configuration of the glycosyl ring is furan sugar type, and the configuration of the terminal carbon is β type, and the configuration of the sugar is The interaction of various parts of the chemical structure of this compound determines its unique physical, chemical and biological activities. It is of great significance in the fields of medicinal chemistry and organic synthesis. It is often a key intermediate for the development of antiviral and antitumor drugs. Due to its unique structure, it can interact with specific targets in organisms and exert pharmacological effects.
What are the main uses of 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodo-2,4 (1H, 3H) -pyrimidinedione?
1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodine-2,4 (1H, 3H) -pyrimidinedione, this drug is called fludarabine, and its main use is quite critical.
Fludarabine is commonly used in the treatment of chronic lymphocytic leukemia. In patients with chronic lymphocytic leukemia, abnormal lymphocyte proliferation in the blood and bone marrow is also a disease. Fludarabine can inhibit the proliferation and growth of cancer cells, help patients relieve the disease and prolong survival. Gai because it can interfere with the DNA synthesis of cancer cells, making it difficult for cancer cells to divide and multiply.
In addition, fludarabine also has therapeutic power for some indolent lymphomas, such as follicular lymphoma. Inert lymphoma grows relatively slowly, but fludarabine can act on it, either shrinking the tumor or controlling its development, improving the patient's symptoms and improving the quality of life.
Furthermore, fludarabine also plays a role in some hematopoietic stem cell transplantation pretreatment protocols. It can help remove abnormal cells from the patient's body before transplantation, create a suitable environment for subsequent stem cell implantation, and improve the success rate of transplantation.
What is the synthesis method of 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodo-2,4 (1H, 3H) -pyrimidinedione?
To prepare 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodine-2,4 (1H, 3H) -pyrimidinedione, the synthesis method is quite complicated.
First take the appropriate starting material, usually the compound containing the pyrimidine structure and the glycosylation reagent with a specific configuration. For the starting pyrimidine compound, the carbonyl group of the 2,4 position needs to be properly protected to prevent improper changes in the reaction. And the glycosylation reagent needs to contain 2-deoxy-2-fluoro-β-D-arabinofuranosyl. The configuration and substituent of this glycosyl group are crucial to the activity and structure of the final product.
When performing glycosylation reaction, it is often necessary to choose suitable reaction conditions. Choose suitable solvents, such as dichloromethane, acetonitrile, etc., to ensure the solubility and uniformity of the reaction of the reactants. At the same time, the choice of catalyst is also important. For example, some Lewis acid catalysts can promote the bonding reaction between glycosyl groups and pyrimidine, so that the two can be connected in a correct stereochemical manner.
After glycosylation, the purification of the product is particularly important. Impurities are often separated by column chromatography, and pure glycosylation products are obtained according to the different distribution coefficients of the product and the impurity in the stationary phase and the mobile phase.
Subsequent, iodine atoms are introduced at position 5. Appropriate iodizing reagents, such as N-iodosuccinimide (NIS), can be selected. During the reaction, the reaction temperature and time are controlled to prevent excessive iodization or other side reactions. After introducing iodine atoms, the target product 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodine-2,4 (1H, 3H) -pyrimidinedione is obtained through purification steps.
In this synthesis method, each step of the reaction needs to be carefully regulated, from the selection of raw materials, the control of reaction conditions, to the purification of the product, all of which are related to the purity and yield of the final product.
How safe is 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodo-2,4 (1H, 3H) -pyrimidinedione?
1 - (2 - deoxy - 2 - fluoro - β - D - arabinofuranosyl) - 5 - iodine - 2,4 (1H, 3H) - pyrimidinedione, the safety of this drug is of great concern to many people. However, it is difficult to find the details in ancient books, and now it is discussed in the text of "Tiangong Kaiwu".
The husband of this drug, although it is a new artificially created product, it is related to human life and cannot be ignored. Its safety is like a boat in the vast sea. If you are not careful, you will cause a disaster. To understand its safety, you need to explore it in many ways, such as the processing of medicinal materials, which needs to be carefully studied. In the synthesis of this medicine, the selection of raw materials should be cautious, just like the selection of good materials to build a vast building. There is no difference at all, and it is a thousand miles away.
Furthermore, the method of testing is also crucial. Those who need to imitate ancient medicine should conduct the method of testing drugs on animals and observe their reactions in detail. Observe their diet, daily life, and mental state. Slight abnormalities cannot be ignored. Just like the ancients looked at celestial phenomena to measure good luck and bad luck, the subtleties can reveal safety and danger.
However, animal testing is not enough. If it is used on humans, it is even more cautious. When applying the medicine as in ancient times, try it in small doses before a few patients, step by step, and observe its efficacy and adverse reactions. Don't be too hasty and play with human life.
During the course of medication, the changes should also be recorded in detail, just like the history of a historian, true and detailed. Only in this way can we have a more accurate understanding of the safety of 1- (2-deoxy-2-fluoro - β - D-arabinofuran) -5-iodine-2,4 (1H, 3H) -pyrimidinedione, and then we can rest assured that the medicine can be administered to everyone and ensure the well-being of the people.
What is the market outlook for 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodo-2,4 (1H, 3H) -pyrimidinedione?
1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodine-2,4 (1H, 3H) -pyrimidinedione, which is used in the field of medicine, the prospect is quite promising.
Looking at its application in antivirus, it shows a strong inhibitory power against specific viruses. For example, for some DNA viruses, it can interfere with the synthesis of viral nucleic acid with its unique chemical structure. Due to the characteristics of 2-deoxy-2-fluoro-β-D-arabinofuranosyl, it can effectively embed in the viral DNA chain, causing its synthesis to be blocked, just like the way of virus reproduction has set many obstacles, so it has attracted many attention in the market of antiviral drug research and development. Many pharmaceutical companies and scientific research teams have invested in it, hoping to develop it into a new type of antiviral drug to solve the suffering of patients.
In the field of anti-tumor research, it has also made a name for itself. Studies have shown that it is cytotoxic to some tumor cells and can inhibit the proliferation of tumor cells. Its mechanism of action may be related to interfering with the nucleic acid metabolism of tumor cells. To successfully convert it into anti-tumor clinical drugs, many rigorous tests are required. From basic cell experiments, to animal experiments, to human clinical trials, every step needs to be taken with care.
Although the 1- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -5-iodine-2,4 (1H, 3H) -pyrimidinedione market has a bright future, it also faces challenges. Optimization of the synthesis process is one of the keys. It is necessary to find an efficient and low-cost synthesis path to reduce production costs and improve production efficiency, so as to stand out in the market competition. And the comprehensive evaluation of safety and effectiveness requires a long and rigorous process. Only through many tests can it truly benefit patients and occupy a place in the pharmaceutical market.