What is the chemical structure of this product 1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidine-2,4-dione

The compound is named (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl -5-iodopyrimidine-2,4-dione, and its structure can be disassembled and analyzed.

The pyrimidine ring is one of its core structures, and the pyrimidine-2,4-dione is substituted by carbonyl at the 2nd and 4th positions of the pyrimidine ring. The 5-position is connected with an iodine atom, which changes the electron cloud distribution and chemical activity of the pyrimidine ring. The sugar group part of

is a pentaoxopentane structure, that is, a furanose structure. The 2nd position is connected to the pyrimidine ring, and the 3rd position is substituted with a fluorine atom. The 4th position is a hydroxyl group, and the 5th position is connected with Among them, the stereoconfigurations of positions 2, 3, 4, and 5 are r, s, r, and r, respectively, indicating that the specific spatial arrangement may have a key impact on their biological activities and interactions. The introduction of fluorine atoms can often enhance the lipophilicity and metabolic stability of the compound. The hydroxyl and hydroxymethyl groups on the sugar group can participate in the formation of hydrogen bonds and affect the intermolecular interaction. This structural feature determines that the compound may have unique activity and application potential in pharmaceutical chemistry and other fields.

What is the main use of 1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidine-2,4-dione

1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxacyclopentyl - 2 - yl] - 5 - iodopyrimidine - 2,4 - diketone This substance is very useful in the field of medicine.

In the field of Guanfu medicine, it can be called a sharp weapon in the road of anti-virus. Due to its unique structure, it can enter the metabolic path of the virus and disturb its reproduction order. In the form of nucleoside analogs, imitating the shape of natural nucleosides, it is mistakenly accepted by viral polymerase and incorporated into the viral nucleic acid chain, causing the extension of the chain to be blocked, the ability of virus replication to be lost, and then the ravages of the virus to be curbed.

Also in the anti-cancer array, it has emerged. Tumor cells proliferate rapidly, and the need for nucleic acid synthesis is urgent. This compound can take advantage of its structure to intervene in the nucleic acid synthesis process of tumor cells, cut off the source of its proliferation, and control the growth of tumor cells, adding a sharp edge to the anti-cancer method.

Furthermore, in the context of scientific research, it provides precious samples for exploring the mysteries of life and studying the principles of nucleic acid metabolism. Therefore, 1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxacyclopentyl - 2 - yl] - 5 - iodopyrimidine - 2,4 - dione is of great value in the field of medical research.

1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidine-2,4-dione

To prepare 1 - [ (2R, 3S, 4R, 5R) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxacyclopentyl - 2 - yl] - 5 - iodopyrimidine - 2,4 - dione, the method is as follows:

Take appropriate starting materials, usually compounds containing pyrimidinedione structures and carbohydrate derivatives with specific chiral properties. If the active checking point on pyrimidinedione is protected with suitable protecting groups, the reaction can be more selective. On the side of the sugar-based derivative, fluorine atoms are introduced at position 3, hydroxyl groups at position 4, and hydroxymethyl groups at position 5 through specific reaction conditions, and its chiral configuration is (2R, 3S, 4R, 5R).

Nucleophilic substitution reaction can be used to introduce iodine atoms at position 5 of the pyrimidine ring with iodine-containing reagents. During the reaction process, the reaction temperature, time and ratio of reactants need to be precisely adjusted to make the reaction proceed in the direction of the target product. For example, in an organic solvent, in the presence of a specific catalyst, the reagent is slowly added dropwise to promote the smooth occurrence of the reaction and reduce side reactions.

After the reaction is completed, the separation and purification of the product need to be carried out. Unreacted raw materials and by-products can be removed by column chromatography, recrystallization and other means to obtain pure 1- [ (2R, 3S, 4R, 5R) -3 -fluoro-4-hydroxy-5- (hydroxymethyl) oxacyclopentyl-2-yl] -5 -iodopyrimidine-2,4-dione. In this way, the target product can be obtained.

1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidine-2,4-dione What is the price range in the market?

Today I have a question, what is the price range of 1 - [ (2r, 3s, 4r, 5r) -3 -fluoro-4-hydroxy-5 - (hydroxymethyl) oxacyclopentane-2-yl] -5 -iodopyrimidine-2,4 -dione in the market. This is a rather professional chemical, and its price is determined by many factors.

One, purity is the key. If the purity is extremely high, it is almost flawless, and can reach the level of scientific research, it will be expensive for precision experiments and research. However, if the purity is slightly lower, it is only suitable for general industrial use, and the price is slightly lower.

Second, the state of market supply and demand also has an impact. If the demand for this product is surging, but the supply seems to be a trickle, and the supply is in short supply, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline.

Third, the difficulty of preparation is also related to the price. If the preparation method is complicated, requires many steps, and requires strict equipment and technology, and consumes a lot of manpower, material resources, and financial resources, the price will not be low.

As far as I know, the price of such chemicals in the market ranges from tens to thousands of yuan per gram. If it is a common purity, used for general production, it may cost between tens of yuan and hundreds of yuan per gram; if it is a high purity, used for high-end scientific research, it may cost thousands of yuan per gram. However, this is only a rough estimate, and the actual price still needs to be consulted with the relevant chemical reagent supplier to obtain an accurate figure.

1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidine-2,4-dione

1-%5B%282r%2C3s%2C4r%2C5r%29-3-fluoro-4-hydroxy-5-%28hydroxymethyl%29oxolan-2-yl%5D-5-iodopyrimidine-2%2C4-dione is an organic compound, and its related Quality Standard is very critical, which is related to the quality and application of this compound.

First talk about the appearance, when it is a white to off-white crystalline powder with uniform color and no impurities visible to the naked eye. This is the initial standard for intuitively judging its quality.

Melting point is also important, it should be within a specific range, or [X] ℃ - [X] ℃. The precise melting point indicates that the purity of the compound is high. If the melting point deviates from this range, it may suggest that impurities are mixed in.

Purity is crucial. Determination by high performance liquid chromatography, the purity should not be less than 98.0%. The high purity guarantees the stability and reliability of the compound in scientific research, medicine and other applications. The impurity content needs to be strictly controlled, the single impurity should not exceed 0.5%, and the total impurity should not exceed 2.0%. These impurities may affect the activity, safety and stability of the compound.

The moisture content cannot be ignored, and should be controlled within a certain limit, such as not exceeding 0.5%. Excessive moisture or cause the compound to undergo reactions such as hydrolysis, which affects its quality.

Residual solvents depend on the solvents involved in the production process and must comply with relevant regulations. For example, the residual amount of common organic solvents such as ethanol and acetone should follow the requirements of pharmaceutical production quality management specifications to ensure their safety in use.

The relevant Quality Standards of this compound, from appearance to microscopic composition, are carefully specified to ensure that it is of high quality and suitable for various application scenarios.