What is the chemical structure of 1- ((2r, 3s, 4r, 5s) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1h, 3h) -dione?

This is the name of the organic compound, according to which it can be gradually resolved to obtain the chemical structure.

"1 - ((2R, 3S, 4R, 5S) - 3 - fluoro - 4 - hydroxy - 5 - (iodomethyl) tetrahydrofuran - 2 - yl) pyrimidine - 2,4 (1H, 3H) - dione", "pyrimidine - 2,4 (1H, 3H) - dione" is the parent nucleus structure of pyrimidine - 2,4 (1H, 3H) - dione, which contains a pyrimidine ring and is connected with a carbonyl group at the 2nd and 4th positions.

"1 - ((2R, 3S, 4R, 5S) - 3 - fluoro - 4 - hydroxy - 5 - (iodomethyl) tetrahydrofuran - 2 - yl) " indicates that at position 1 of pyrimidine - 2,4 (1H, 3H) - dione, a tetrahydrofuran group is connected. This tetrahydrofuran group has a specific stereoconfiguration, and (2R, 3S, 4R, 5S) is the configuration of its chiral center. There are fluorine atoms at position 3 of the tetrahydrofuran group, hydroxyl groups at position 4, and methyl iodine at position 5.

In summary, the chemical structure of this compound is to use pyrimidine-2,4 (1H, 3H) -dione as the parent nucleus, and to connect the tetrahydrofuran group of a specific stereo configuration at 1 position. The tetrahydrofuran group has fluorine at 3 positions, hydroxyl at 4 positions, and iodomethyl at 5 positions.

What are the main uses of 1- ((2r, 3s, 4r, 5s) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1h, 3h) -dione?

(1 - ((2R, 3S, 4R, 5S) - 3 - fluoro - 4 - hydroxy - 5 - (iodomethyl) tetrahydrofuran - 2 - yl) pyrimidine - 2, 4 (1H, 3H) -dione) This substance has a wide range of uses. In the field of medicine, it is often the key raw material for the creation of new antiviral drugs. Due to its unique structure, it can interfere with the replication mechanism of specific viruses, especially in the development of anti-RNA virus drugs, and may become a powerful "weapon" to overcome related viral infections.

In the field of organic synthetic chemistry, it is an important building block for building complex organic molecular structures. Due to its multiple activity checking points, organic chemists can derive and modify it through subtle chemical reactions to obtain organic compounds with different functions and characteristics, laying the foundation for the creation of new materials and fine chemicals.

In the in-depth research process of pharmaceutical chemistry, this compound, as a lead compound, provides an excellent sample for researchers to explore the relationship between structure and activity. Through ingenious modification and optimization of its structure, it is expected to discover drug candidates with better activity and better safety, promote the research and development process of innovative drugs, and contribute to the cause of human health.

What is the synthesis of 1- ((2r, 3s, 4r, 5s) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1h, 3h) -dione?

To prepare (1- ((2R, 3S, 4R, 5S) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1H, 3H) -dione, the method is as follows:
First take a suitable starting material, which may have the basic structure of pyrimidine-2,4 (1H, 3H) -dione, and reserve a group in an appropriate position for subsequent reaction.
One method, or first start with a compound containing a furan ring, introduce a fluorine atom at a specific position of the furan ring through a halogenation reaction, such as using a suitable fluorination reagent, under suitable reaction conditions, the fluorine atom is substituted for a specific hydrogen atom. This reaction requires precise control of reaction temperature, time and reagent dosage to achieve the expected regioselectivity.
Then, modify the furan ring and introduce hydroxyl groups. Or use hydrolysis reaction, nucleophilic substitution reaction and other means, according to the structure and reactivity of the raw material, choose the appropriate reaction path. If the raw material contains a group that can be attacked by nucleophilic reagents, react with a nucleophilic reagent with hydroxyl groups, so that the hydroxyl groups are connected to the designated position of the furan ring.
Reintroducing iodine methyl groups can react with intermediates containing active check points through halogenated hydrocarbons. In the presence of alkali or other catalysts, the modified furan ring intermediates are reacted with iodomethane or reagents that can produce iodomethyl groups, so that the iodomethyl groups are connected to the specific positions of the furan ring. This step also needs to pay attention to the reaction conditions to avoid side reactions.
The furan ring structure can be gradually constructed from pyrimidine-2,4 (1H, 3H) -dione. The pyrimidine ring is functionalized first, so that the pyrimidine ring has an active checking point that can be linked to the furan ring fragment. With suitable linking reagents and reaction conditions, the modified furan ring fragment is connected to the pyrimidine ring, and then the synthesis of the target compound is completed.
During the synthesis process, each step of the reaction requires the separation and purification of the product. Column chromatography, recrystallization, etc. can be used to ensure that the reaction proceeds in the expected direction, and finally high-purity (1- (2R, 3S, 4R, 5S) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1H, 3H) -dione is obtained.

What are the physicochemical properties of 1- ((2r, 3s, 4r, 5s) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1h, 3h) -dione?

1 - ((2R, 3S, 4R, 5S) - 3 - fluoro - 4 - hydroxy - 5 - (iodomethyl) tetrahydrofuran - 2 - yl) pyrimidine - 2,4 (1H, 3H) -dione The physical and chemical properties of this substance are quite critical. In terms of physical properties, its appearance is often a solid state, but the specific color state varies depending on the purity and preparation method, or it is in a white crystalline state, or it is a white powder. The value of its melting point, after rigorous determination, is about a specific range. This value can be used as an important basis for identification and purification.

As for chemical properties, its molecules are rich in many reactive groups. The structure of pyrimidine-2,4 (1H, 3H) -dione gives it a certain acidity and alkalinity, and it may react with proton transfer in a specific acid-base environment. The existence of 3-fluorine and 4-hydroxyl groups makes the compound have unique nucleophilic and electrophilic reactivity. Fluorine atoms have strong electron absorption, which can change the electron cloud density of nearby chemical bonds, which in turn affects the activity and selectivity of the reaction. Hydroxyl groups, as common reactive groups, can participate in various organic reactions such as esterification and etherification. 5- (Iodomethyl) part, iodine atom activity is quite high, prone to substitution reaction, can interact with many nucleophiles to achieve molecular modification and derivatization. This compound has important application potential in the field of organic synthesis, or because of these unique physical and chemical properties.

What is the future of 1- ((2r, 3s, 4r, 5s) -3-fluoro-4-hydroxy-5- (iodomethyl) tetrahydrofuran-2-yl) pyrimidine-2,4 (1h, 3h) -dione in the market?

(1 - {[ (2R, 3S, 4R, 5S) -3 -fluoro-4-hydroxy-5 - (iodomethyl) tetrahydrofuran-2-yl] pyrimidine-2,4 (1H, 3H) -dione} has considerable application prospects in the market. This compound may be used as a key intermediate in the field of pharmaceutical research and development to help create new antimalarial drugs. Malaria has been raging for a long time, and the problem of resistance to traditional drugs is gradually emerging. The unique structure of this compound may be able to precisely bind to specific targets of malaria parasites, blocking their growth and reproduction pathways, and paving the way for the development of new antimalarial drugs.

In the field of antiviral drug research, it also has potential value. The viral structure and replication mechanism are complex, and this compound may be able to inhibit the proliferation of viruses by interfering with the synthesis of viral nucleic acid. For example, in the study of some RNA viruses, it is expected to intervene in the process of viral RNA transcription and translation by virtue of its structural properties, so as to develop new antiviral agents.

In addition, in the field of organic synthesis, this compound can be used as a multifunctional building block. Its complex and unique structure can provide a foundation for the construction of more complex organic molecules, and through ingenious chemical reactions, a series of organic compounds with special properties and uses can be derived. It has emerged in many fields such as materials science and fine chemicals, and has promoted the innovation and development of related industries. It has broad prospects and is worthy of in-depth exploration and development.)