What is the chemical structure of 1- (5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl) pyrimidine-2,4 (1h, 3h) -dione?
1-%283%2C5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl%29pyrimidine-2%2C4%281h%2C3h%29-dione is an organic compound. Its chemical structure is quite complex and consists of several parts.
The first is the parent nuclear structure of pyrimidine-2,4 (1H, 3H) -dione, which is a nitrogen-containing heterocycle with a conjugated system and has an important impact on the stability and reactivity of the compound.
Secondly, the No. 1 position is connected to (3,5-di-O-acetyl-2-deoxy-5-C-iodopentafuran glycosyl). The pentafuran glycosyl is a carbohydrate structural unit with a five-membered ring. 2-Position deoxygenation, that is, the hydroxyl group in this position is replaced by hydrogen; 3,5-Position is di-O-acetyl, which means that these two hydroxyl groups form esters with acetyl groups, changing the steric hindrance and electron cloud distribution of sugar groups. 5-C-iodine is connected to the iodine atom at the 5-position carbon atom of the sugar group. The iodine atom is large in size and has special electronegativity, which significantly affects the physical and chemical properties of the compound.
Overall, this compound fuses heterocyclic and sugar-based structures, and its parts interact to give unique chemical and physical properties, which may have potential applications in organic synthesis, medicinal chemistry and other fields. The arrangement of various functional groups and special atoms in its structure provides many possibilities for chemical modification and reaction, or can be used to develop new compounds with specific biological activities.
What are the main physical properties of 1- (3, 5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl) pyrimidine-2,4 (1h, 3h) -dione?
1 - (3,5-di-O-acetyl-2-deoxy-5-C-iodopentafuran) pyrimidine-2,4 (1H, 3H) -dione, which is an organic compound. Its main physical properties are as follows:
Looking at its morphology, under normal temperature and pressure, or white to off-white solids, the texture is fine, and most of them are powder-like, which is determined by intermolecular interactions and crystal structure.
The melting point, as determined by experiments, is about a certain temperature range. This temperature is the critical temperature for the transition of the compound from solid to liquid state, reflecting the strength of intermolecular forces. When the temperature rises to the melting point, the thermal motion of the molecule intensifies, which is sufficient to overcome the lattice energy, and then the phase state transition occurs.
In terms of solubility, it shows specific solubility characteristics in common organic solvents. In halogenated hydrocarbon solvents such as dichloromethane and chloroform, it has a certain solubility. The intermolecular interaction between halogenated hydrocarbons and the compound can be achieved through van der Waals forces. However, the solubility in water is very small, because the molecular polarity of this compound is quite different from that of water molecules, and the intramolecular hydrogen bond also affects its dissolution in water.
Its density, compared with water, has a specific value. Density is the mass per unit volume of a substance and is closely related to the molecular structure. The relative mass of the compound and the way of molecular accumulation determine its density characteristics, which are of great significance in the study of separation, purification and related reaction systems.
In addition, the compound is also an important physical property for light and thermal stability. Under light or heat conditions, the molecular structure may change. Moderate light exposure may cause intra-molecular electron transitions, resulting in changes in chemical properties; when heated, excessive temperature may cause chemical bonds to break and decompose, which in turn affects its chemical activity and application efficiency.
What are the applications of 1- (5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl) pyrimidine-2,4 (1h, 3h) -dione?
1-%283%2C5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl%29pyrimidine-2%2C4%281h%2C3h%29-dione, it is an organic compound. This compound has potential uses in medicine, chemical industry and other fields.
In the field of medicine, it may be involved in the research and development of antiviral drugs. Due to its unique structure, it may act on specific targets of viruses and interfere with their replication, transcription and other life processes. And in anti-tumor research, there is also a certain possibility. Tumor cells grow rapidly and have a high demand for nucleotide metabolism. This compound may use its structural properties to intervene in the nucleotide metabolism pathway of tumor cells and inhibit the proliferation of tumor cells.
In chemical industry, due to its complex chemical structure, it can be used as an intermediate in organic synthesis. Using it as a starting material, through various chemical reactions, many novel compounds can be derived for the preparation of materials with special properties, such as polymer materials with unique optical and electrical properties, which may have applications in electronic and optical device manufacturing.
However, although it has potential application prospects in the above fields, its practical application still needs to be tested and verified by a large number of experiments to ensure its safety, effectiveness and other key properties, in order to realize the transformation from theory to practical application.
What is the preparation method of 1- (5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl) pyrimidine-2,4 (1h, 3h) -dione?
The preparation of 1- (3,5-di-O-acetyl-2-deoxy-5-C-iodopentanofuran glycosyl) pyrimidine-2,4 (1H, 3H) -dione is quite complicated, and it needs to be based on the delicate skills of organic synthesis.
First, suitable starting materials, such as sugar compounds and pyrimidine derivatives with specific structures, need to be prepared. Suitable protecting groups need to be modified to ensure the selectivity of the reaction check point. Select suitable acetylation reagents, such as acetic anhydride and suitable catalysts, to smoothly acetylate the hydroxy groups at 3,5 positions of the sugar compound to form 3,5-di-O-acetyl sugar intermediates.
Subsequently, for the step of 2-deoxygenation and 5-C-iodine substitution, the deoxygenation reagent and the iodine substitution reagent should be carefully selected. The deoxygenation process often removes the hydroxyl group at the 2 position of sugars and forms the corresponding deoxygenation structure by means of a specific chemical reaction. In the 5-C-iodine substitution step, suitable iodine sources and reaction conditions can be selected to precisely introduce iodine atoms into the 5-C position. These reactions require strict control of the reaction temperature, time and reagent dosage to obtain the ideal reaction yield and selectivity.
As for the pyrimidine-2,4 (1H, 3H) -diketone part, it can be obtained through the specific functional group conversion reaction of pyrimidine compounds. Afterwards, the modified sugar fragment is connected to the pyrimidine-2,4 (1H, 3H) -dione part by a delicate glycosylation reaction to construct the core structure of the target product. This glycosylation reaction also requires careful regulation of the reaction conditions to ensure the correctness and efficiency of glycosidic bond formation.
End, or the product needs to be purified by steps such as column chromatography, recrystallization, etc. to remove the by-products generated during the reaction and the unreacted raw materials to obtain high-purity 1- (3,5-di-O-acetyl-2-deoxy-5-C-iodopentafuran) pyrimidine-2,4 (1H, 3H) -dione. The whole preparation process requires the experimenter to be familiar with the skills of organic synthesis and to precisely control each step of the reaction in order to obtain the desired results.
What are the potential side effects or risks of 1- (5-di-o-acetyl-2-deoxy-5-c-iodopentofuranosyl) pyrimidine-2,4 (1h, 3h) -dione?
1-% (3,5-di-O-acetyl-2-deoxy-5-C-iodopentafuran) pyrimidine-2,4 (1H, 3H) -dione, although this substance has medicinal potential, it also has latent risk. It may have allergic worries, some people touch it, the body rash, itching is intolerable, even shortness of breath, swollen throat, endangering life. In addition, it may damage the liver, interfere with the metabolism and detoxification of the liver, causing abnormal liver function indicators. Long-term use, or cause liver fiber hyperplasia, liver cirrhosis disease. It also irritates the stomach and intestines, causing nausea, vomiting, abdominal pain, diarrhea, and disrupting the order of digestion. And because it has certain cytotoxicity, or affects normal cell division and function, interferes with immunity, and causes the body's disease resistance to decline. For clinical use, it is necessary to carefully observe the patient's response and weigh the pros and cons to policy safety.