What is the chemical structure of 1,3-benzenedicarboxamide, N~ 1~, n~ 3~ -bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (2-methoxyacetyl) amino] -n~ 1~ -methyl-
This is the chemical name of the 1,3-benzenephthalamide derivative. To clarify its chemical structure, let me explain it in detail.
The core of this compound is a benzene ring, which is connected with a benzenephthalamide group at the 1,3 position. Looking at its N ² and N ³ positions, there are 2,3-dihydroxypropyl groups, respectively. This is an alkyl group containing hydroxyl groups, which endows the molecule with specific hydrophilicity and reactivity.
Furthermore, the 2,4,6 positions of the benzene ring are all connected with iodine atoms. The introduction of iodine atoms greatly affects the physical and chemical properties of the molecule, or enhances its density and changes its electron cloud distribution.
At the 5th position, there is a complex group connected to the amino group, which is the (2-methoxyacetyl) amino group, and the methoxyacetyl group is connected to the amino group. This structure affects the polarity and steric resistance of the molecule.
And the N ² position is also connected with a methyl group. The presence of methyl groups also affects the overall properties of the molecule, or changes the stereochemistry and lipophilicity of the molecule.
Overall, the interaction of various functional groups in this chemical structure determines the unique physical, chemical and biological properties of the compound. Each group synergistically affects its solubility, stability and chemical reactivity.
What are the physical properties of 1,3-benzenedicarboxamide, N~ 1~, n~ 3~ -bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (2-methoxyacetyl) amino] -n~ 1~ -methyl-
1% 2C3-benzodiformamide, N ², n ³ -bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5 - [ (2-methoxyacetyl) amino] -N ² -methyl - The physical properties of this substance are as follows:
Its appearance is often in a specific form, or crystalline, crystal clear in appearance, with a regular geometric shape; or powdered, delicate and uniform, with a sense of quicksand to the touch. Its color may be as white as snow, pure and free; or slightly yellowish, like the shimmer of morning light, showing a natural color.
Under normal temperature, the texture of this substance is relatively stable, just like a stable person, and it is not moved by any changes in the outside world. When exposed to high temperature, it is like ice melting in water, gradually softening and deforming, showing unique thermal characteristics.
Its solubility is also an important physical property. In some specific solvents, it can dissolve into water like salt, quietly disappear, and blend with the solvent to form a uniform mixed system; in other solvents, it is like oil floating in water, difficult to blend, and each is independent and well-defined.
The density of this substance is just as good as the measure of its internal firmness. With a specific amount of equipment, it can be known that the mass of its unit volume is given, just like giving it a unique weight mark in space. In practical applications, this characteristic is related to the precise control of many processes and processes.
Its melting point and boiling point are also key properties. At the melting point, such as the critical point, the state of matter changes from solid to liquid, opening another form journey; at the boiling point, like the moment of sublimation, the substance turns into a gaseous state, breaks free from the shackles of the liquid state, and floats freely in the air. Both of these are important characteristics of its physical properties and are of great significance in many fields such as chemical industry and pharmaceuticals.
What is the main use of 1,3-benzenedicarboxamide, N~ 1~, n~ 3~ -bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (2-methoxyacetyl) amino] -n~ 1~ -methyl-
1% 2C3 - benzenedicarboxamide, N fond, n ³ - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodo - 5 - [ (2 - methoxyacetyl) amino] - n fond - methyl - This substance is in the medical tract and is mostly used for imaging. Looking at its pharmacology, it can block the passage of rays in the body because of its iodine content, making the imaging more clear.
In the field of medical imaging, its application is quite critical. In X-ray and CT imaging, the introduction of this substance can make the boundaries of specific organs and tissues clear, help the doctor to detect the location, size and shape of the lesion, and lay the foundation for accurate diagnosis. For example, in angiography, the drug containing this ingredient is injected, and the contours of the blood vessels are immediately clearly displayed, and diseases such as vascular stenosis and blockage cannot be hidden.
In urography, it can help doctors understand the condition of the kidneys, ureter, bladder, and detect stones, tumors and other diseases. Because it can effectively enhance the contrast of the image, it has made great contributions to the early diagnosis and early treatment of diseases, which is an indispensable tool for doctors to diagnose diseases.
What is the synthesis method of 1,3-benzenedicarboxamide, N~ 1~, n~ 3~ -bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (2-methoxyacetyl) amino] -n~ 1~ -methyl-
To prepare 1% 2C3-phthalamide, N% 7E1% 7E, n% 7E3% 7E-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (2-methoxyacetyl) amino] -n% 7E1% 7E-methyl, the method is as follows:
Take an appropriate amount of 2,3-dihydroxypropylamine first, place it in a clean reactor, and cool it in an ice-water bath to stabilize the temperature in the kettle between 0-5 ° C. Slowly add an organic solvent dissolved in 1,3-benzodiformyl chloride dropwise. When adding dropwise, continue to stir to ensure that the two are fully mixed. This reaction is an acylation process. After the dropwise addition is completed, keep stirring at low temperature for 1-2 hours to complete the reaction.
Then, take another container, mix an appropriate amount of 2-methoxyacetic acid with sulfuryl chloride, heat it to 40-50 ° C, and react for about 1-2 hours to obtain 2-methoxyacetyl chloride. The obtained 2-methoxyacetyl chloride is slowly added to the above reaction system at room temperature, and an appropriate amount of acid binding agent is added to promote the reaction, and the reaction is continuously stirred for 3-4 hours.
Then add an appropriate amount of iodizing reagent to the reaction system, such as the mixture of potassium iodide and hydrogen peroxide, control the reaction temperature at 50-60 ° C, and the reaction is 4-5 hours to achieve iodine substitution reaction. After the reaction is completed, the product is extracted with an appropriate organic solvent, washed and dried for many times, and purified by column chromatography to obtain pure 1% 2C3-benzodiformamide, N% 7E1% 7E, n% 7E3% 7E-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (2-methoxyacetyl) amino] -n% 7E1% 7E-methyl. During the whole process, attention should be paid to the precise control of the reaction conditions, and caution must be taken in each step to obtain the ideal yield and purity.
1, 3-benzenedicarboxamide, N~ 1~, n~ 3~ -bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (2-methoxyacetyl) amino] -n~ 1~ -methyl - What are the safety precautions
1% 2C3 - benzenedicarboxamide (1,3 - phthalamide), N ¬, n ³ - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodo - 5 - [ (2 - methoxyacetyl) amino] - n ¬ - methyl - This drug is related to many safety precautions and should not be ignored.
This drug is a complex chemical synthesis with unique ingredients and many iodine elements. It is not available for people who are allergic to iodine. Before taking medication, it is necessary to carefully review the patient's past allergy history, especially those who are allergic to iodine and iodine-containing preparations. If you use it rashly, you may cause serious allergies, such as rash, itching, shortness of breath, and even shock, which endangers your life.
Furthermore, if this drug enters the body, it may be metabolized or affect the function of the liver and kidney. Therefore, if the function of the liver and kidney is not good, you need to be careful with the medication. During the medication period, when the liver and kidney function indicators are regularly checked. If the indicators are abnormal, you need to adjust the dosage or stop the medication according to the situation to prevent the liver and kidney damage from worsening.
When taking medication, medical practitioners should also pay close attention to the patient's reaction If the patient suddenly feels unwell, headache, dizziness, nausea, vomiting and other symptoms after taking the medicine, the cause should be immediately verified and properly disposed of. If this medicine is used in combination with other medicines, it may interact with each other. Therefore, when the patient visits the doctor, he must tell the truth about the other medicines used, so that the doctor can weigh the pros and cons to ensure the safety of the medicine.
The route of medication also needs to be strictly in accordance with the doctor's instructions, or intravenous injection, or other methods, and must not be changed by himself, so as not to affect the efficacy of the medicine and lead to safe diseases. Only by paying attention to all the details can we ensure the safety of the medication.