What is the chemical structure of 1,3-benzenedicarboxamide, N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (methoxyacetyl) amino] -n-methyl-
This is an organic compound named 1,3-benzodiformamide, $N $, $N '$-bis (2,3-dihydroxypropyl) -2,4,6-triiodo- 5- [ (methoxyacetyl) amino] - $N $-methyl -. Looking at its name, its structure can be gradually analyzed.
The first is 1,3-benzodiformamide, which is based on the benzene ring and is connected with a dicarbonamide group at the 1,3 position. The amide is a structure in which the carbonyl group is connected to the amino group, which forms the basic skeleton on the benzene ring.
Look again at $N $, $N '$-bis (2,3-dihydroxypropyl), which shows that on the nitrogen atom of benzodiformamide, there is a 2,3-dihydroxypropyl group attached. The propyl group has three carbons and is connected with a hydroxyl group at the 2,3 position, which increases its hydrophilicity and reactivity.
2,4,6-triiodine, that is, the 2,4,6 position of the benzene ring is replaced by an iodine atom. The iodine atom has a large atomic radius and electronegativity, which has a great impact on the physical and chemical properties of the compound, such as increasing its density and changing its polarity.
5- [ (methoxyacetyl) amino], which is an amino group modified with methoxyacetyl at the 5th position of the benzene ring. Methoxyacetyl is connected to the acetyl group by the methoxy group and then to the amino group, which further enriches the complexity of the structure.
The last $N $-methyl indicates that there is a methyl group attached to a certain nitrogen atom in the structure of benzodiformamide.
Overall, this compound has a complex structure, coexists with a variety of groups, and each group affects each other, giving it unique physical and chemical properties, or has specific uses in the fields of medicine and materials.
What is the main use of 1,3-benzenedicarboxamide, N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (methoxyacetyl) amino] -n-methyl-
1% 2C3-Phthalamide, N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (methoxyacetyl) amino] -N-methyl - This substance is a contrast agent and is commonly used in the field of medical imaging.
In modern medicine, imaging examination is essential, and contrast agent is very useful in this regard. This agent can significantly improve the contrast of different tissues and organs in imaging, helping doctors to clearly understand the structure and lesions of patients.
Taking angiography as an example, injecting it into the blood vessel can make the blood vessel clearly visible in the image, and help to accurately diagnose diseases such as vascular stenosis, blockage and malformation. In urinary system examination, it can clearly show the shape of the renal pelvis, ureter and bladder, helping to detect abnormalities such as stones and tumors. In the examination of liver, gallbladder and other organs, it can also make the lesion site clearly identifiable, providing a key basis for disease diagnosis and treatment plan formulation.
Because this material plays a significant role in the field of medical imaging examination and is of great significance for accurate diagnosis of diseases, it is widely used in medical clinical practice.
What are the physical properties of 1,3-benzenedicarboxamide, N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (methoxyacetyl) amino] -n-methyl-
1% 2C3 -Phthalamide, N, N ′ -bis (2,3 -dihydroxypropyl) -2,4,6 -triiodo- 5- [ (methoxyacetyl) amino] -N -methyl - The physical properties of this substance are as follows:
Its appearance may be white to off-white crystalline powder, and the texture is relatively fine and uniform. In terms of solubility, it can show certain solubility characteristics in specific organic solvents, but the degree of solubility in water is relatively limited.
In terms of density, it has a moderate density. Under normal conditions, the density is within a specific range to maintain the stability of its material structure. Its melting point also has a specific value. When it reaches this melting point temperature, the substance will gradually transform from a solid state to a liquid state, showing a phase change.
In terms of stability, in the general environment of room temperature and pressure, this substance can maintain a relatively stable state, and is not prone to significant chemical reactions or decomposition phenomena. However, if the ambient temperature and humidity change significantly, or come into contact with specific chemicals, its stability may be affected.
These physical properties of this substance under different physical conditions are crucial for in-depth understanding of its characteristics, performance in practical applications, and related process treatments.
What is the synthesis method of 1,3-benzenedicarboxamide, N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (methoxyacetyl) amino] -n-methyl-
1% 2C3-benzodiformamide, N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (methoxyacetyl) amino] -N-methyl-The synthesis method of this substance is as follows:
First, all kinds of raw materials need to be prepared, and the required ones are 1,3-phthalic acid, 2,3-dihydroxypropylamine, iodine, methoxyacetyl chloride, N-methylation reagent, etc.
The initial step is to use 1,3-phthalic acid as the base to react with thionyl chloride to form 1,3-phthalic acid chloride. This step needs to be done at a suitable temperature and in an inert atmosphere to prevent its side reactions.
Gradually add 2,3-dihydroxypropylamine to the obtained 1,3-phthalic acid chloride to control the reaction conditions, so that the nucleophilic substitution of the two produces N, N '-bis (2,3-dihydroxypropyl) -1,3-phthalamide.
Iodine atoms are reintroduced to a suitable iodization method, such as in specific catalysts and solvents, so that N, N '-bis (2,3-dihydroxypropyl) -1,3-benzodiformamide reacts with iodine to give 2,4,6-triiodine-N, N' -bis (2,3-dihydroxypropyl) -1,3-benzodiformamide.
Then, with methoxyacetyl chloride, in the presence of a suitable base, acylation forms 2,4,6-triiodo- 5- [ (methoxyacetyl) amino] -N, N '-bis (2,3-dihydroxypropyl) -1,3-benzodiformamide.
Finally, the methylation reaction is carried out with N-methylation reagent to obtain the target product 1% 2C3-phthalamide, N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (methoxyacetyl) amino] -N-methyl -. After each step of the reaction, a suitable separation and purification method, such as column chromatography, recrystallization, etc., is required to obtain a pure product to facilitate the next step of the reaction.
1, 3-benzenedicarboxamide, N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- [ (methoxyacetyl) amino] -n-methyl-what are the safety precautions
1% 2C3-benzodiformamide, N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- [ (methoxyacetyl) amino] -N-methyl - This medicine is related to life. When using it, many matters must not be ignored.
First, before using the medicine, you need to carefully review the disease, understand the severity and reality of the disease, and must not blindly apply the medicine. Doctors should carefully study the patient's past medical history, such as liver and kidney function and history of allergies. If the patient's liver and kidney function is poor, the metabolism of the drug may be blocked, resulting in drug toxicity and damage to the viscera; if there is a history of allergies, it is especially necessary to be cautious to prevent drug rash, itching, acute qi and other allergic symptoms from bursting.
Second, follow the doctor's advice when taking the drug. The dose of the drug is related to the curative effect and safety. If the dose is too small, it is difficult to achieve the effect of treating diseases; if the dose is too heavy, the toxic side effects will occur, injure the body and deplete the qi, and damage the qi and blood. The route of administration also needs to be precise, or intravenous infusion, or oral administration, depending on the condition, and should not be changed.
Third, pay close attention to the signs of the body during the medication. Looking at the complexion, pulse, and breathing, if the complexion is pale, the pulse is thin, the breathing is rapid, or it is an adverse reaction of the medicine, stop the medicine and seek medical attention. And pay attention to whether there is nausea, vomiting, dizziness and other discomfort, get up early and treat it early, and prevent the micro and gradually.
Fourth, take it with other medicines, especially with caution. Between drugs, or mutual resistance. Improper combination, or reduce the efficacy of the medicine, or increase toxicity. When seeking medical treatment, be sure to inform the doctor of the medicine you are taking, so as to weigh the pros and cons and use it rationally.
Although this medicine is a tool for treating diseases, it is used carelessly, which is the source of harm. Doctors and patients need to be cautious to ensure the safety of medication and promote the recovery of the body.