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What is the synthesis method of 1,3-diiodo2-bromo-5- (tert-butyl) benzene?
The synthesis of 1% 2C3-dibromo-2-pentanol-5- (tert-butyl) benzene is an important topic in organic synthetic chemistry. To obtain this compound, the following steps can be followed:
The selection of starting materials is crucial. Benzene derivatives with appropriate substituents are often used as starting materials. This benzene derivative needs to reserve a reaction check point at a specific position for subsequent introduction of bromine atoms, pentanol and tert-butyl groups.
Introducing tert-butyl groups on the benzene ring, the common method is Fu-gram alkylation. Using tert-butyl halide as alkylation reagent, tert-butyl can be smoothly attached to the benzene ring under the catalysis of Lewis acid catalysts such as anhydrous aluminum trichloride. This reaction condition needs to be precisely controlled, and the temperature and the proportion of reactants all affect the yield and selectivity of the reaction.
Subsequently, bromine atoms are introduced at specific positions in the benzene ring. Bromine atoms can selectively replace hydrogen atoms on the benzene ring under the action of catalysts such as iron powder or iron tribromide. This step requires attention to the selectivity of the reaction check point. According to the positioning effect of the existing substituents on the benzene ring, the bromine atoms are guided to the desired position. The introduction of the
pentanol group is more complicated. Or pentanol derivatives containing appropriate functional groups can be prepared first, such as halide or enol ether derivatives of pentanol. Subsequently, the pentanol groups are attached to the brominated and tert-butylated benzene ring structures by nucleophilic substitution or other suitable reaction mechanisms. This process requires attention to the mildness of the reaction conditions to avoid adverse effects on the existing substituents.
Finally, the product is purified and identified. Purification is often carried out by classical methods such as column chromatography and recrystallization to obtain high-purity 1% 2C3-dibromo-2-pentanol-5- (tert-butyl) benzene. The structure and purity of the product are determined by means of modern analytical techniques such as nuclear magnetic resonance, mass spectrometry, and infrared spectroscopy.
In this way, according to the above synthesis path and method, through multi-step reaction and careful operation, the target compound 1% 2C3-dibromo-2-pentanol-5- (tert-butyl) benzene can be obtained.
What are the physical properties of 1,3-diiodo2-bromo-5- (tert-butyl) benzene?
1% 2C3 -dibromo-2-pentanol-5 - (tert-butyl) benzene foreign matter, its physical properties are as follows:
This substance is mostly liquid at room temperature, because there are various functional groups and specific atoms in the molecular structure, resulting in a specific range of intermolecular forces, which in turn determines its aggregation state.
Regarding its boiling point, due to the presence of bromine atoms, hydroxyl groups and phenyl rings in the molecule, the interaction of these structures enhances the intermolecular forces, and the boiling point is relatively high. However, the specific value will be affected by factors such as subtle interactions between molecules and external pressures.
In terms of solubility, the substance has a certain polarity, which is due to the presence of hydroxyl groups, so it should have a certain solubility in polar solvents such as alcohols and ketones. However, its molecules contain large non-polar parts such as benzene rings and tert-butyl groups, so it may also have some solubility in non-polar solvents such as alkanes, but its solubility in water is limited. Due to the difference between the hydrogen bond network formed between water molecules and the intermolecular force of the substance, it is not conducive to its dispersion and dissolution in water.
In appearance, it may be a colorless transparent or slightly colored liquid in its pure state, which is related to the absorption and scattering characteristics of light by the molecular structure. The vibration frequency of the chemical bond in the structure interacts with visible light to show a specific appearance. In terms of density, due to the relatively large atomic weight of bromine atoms, the molecular weight increases, and the overall density may be higher than that of common organic solvents.
In summary, 1% 2C3-dibromo-2-pentanol-5 - (tert-butyl) benzene foreign matter has unique physical properties, which are determined by its molecular structure and vary under different conditions.
In what fields is 1,3-diiodo2-bromo-5- (tert-butyl) benzene used?
1,3-Dichloro-2-bromo-5- (tert-butyl) benzene is used in many fields.
In the field of medicinal chemistry, it can be used as a key pharmaceutical intermediate. With the help of specific chemical reactions, its structure can be modified to synthesize compounds with specific pharmacological activities. For example, in the development and production of some drugs for the treatment of cardiovascular diseases, 1,3-dichloro-2-bromo-5- (tert-butyl) benzene can be used as a starting material to gradually build complex drug molecular structures through a series of substitution, addition and other reactions, providing effective drugs for the treatment of cardiovascular diseases.
In the field of materials science, this compound also has important value. For example, in the synthesis of polymer materials, it can be used to introduce special functional groups and change the physical and chemical properties of the material. For example, when preparing polymer materials with special optical properties, 1,3-dichloro-2-bromo-5-tert-butyl benzene participates in the reaction, which can make the synthesized polymer materials have unique light absorption and luminescence properties, and can be applied to optical displays, optoelectronic devices, etc.
In the field of organic synthesis chemistry, it is a commonly used basic raw material. Organic chemists can design and implement a variety of organic synthesis routes according to their structural characteristics. Through different reaction conditions and reagent combinations, the substituents on the benzene ring were further transformed, and many organic compounds with novel structures and unique functions were synthesized, which provided an important material basis for the development of organic chemistry and the creation of new substances.
What are the chemical properties of 1,3-diiodo2-bromo-5- (tert-butyl) benzene?
1% 2C3-dibromo-2-pentanol-5- (tert-butyl) benzene is one of the organic compounds. Its chemical properties are unique and related to the process and results of many chemical reactions.
In this compound, the bromine atom has high electronegativity, which makes the molecule polar. This polarity causes it to exhibit specific solubility in polar solvents, and in the nucleophilic substitution reaction, the bromine atom acts as a good leaving group, which is easily attacked by nucleophiles and leads to the formation of substitution products.
The hydroxyl group contained in the pentanol part can participate in the esterification reaction and react with acids to form ester compounds. The hydroxyl group can also dehydrate under suitable conditions to form olefins. Furthermore, tert-butyl is attached to the benzene ring, which has an effect on the electron cloud density of the benzene ring. Tert-butyl is an electron supply group, which will increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc., and the substitution positions tend to be ortho and para-sites of the benzene ring.
In addition, the stability of the compound is also affected by the interaction of each group. The steric hindrance effect cannot be ignored. The large volume of tert-butyl has a significant impact on the molecular spatial structure, which will interfere with the proximity of the reaction reagent to the reaction check point to a certain extent, thereby affecting the reaction rate and selectivity. This compound has important potential application value in the
What are the storage conditions for 1,3-diiodo2-bromo-5- (tert-butyl) benzene?
The storage conditions of 1% 2C3-dibromo-2-pentanone-5- (tert-butyl) ether are crucial to the quality and efficacy of this medicine. According to the principles of "Tiangong Kaiwu", all things need to be stored in a suitable place to preserve their properties.
This medicine should be placed in a cool place. If the cover is hot, the molecule is easy to move, or its structure is changed and its medicinal properties are damaged. In a cool place, the temperature is low and the molecule is quiet, which can preserve its quality for a long time. Such as the ancient ice, it is used in summer, and it also relies on low temperature to preserve its cold.
And it should be placed in a dry place. The moisture of water and moisture is easy to merge with the ingredients in the medicine, causing it to deliquesce and deteriorate. Just like ancient paper, it will rot when wet, and the same is true of medicine. Moisture enters, or biochemical reactions, and the drug-causing property is lost.
Furthermore, when protected from light. Light contains energy, or the ingredients that stimulate the medicine, promote its reaction, and make the quality of the medicine easy. The ancients hid treasures and played with them, and they often avoided light, for fear of its color and deterioration. The same is true of this medicine. It is hidden in the dark, which can reduce the harm of light.
And it needs to be sealed and stored. All kinds of gases in the air, such as oxygen, can cause oxidation of medicine; and there are microorganisms, or breed in medicine. Sealing can isolate air and microorganisms, and keep the medicine pure.
In summary, 1% 2C3-dibromo-2-pentanone-5- (tert-butyl) ether should be stored in a cool, dry, dark and sealed place, so it has all its medicinal properties and is ready for use.