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1- (3-fluoro-2-iodophenyl) What are the main uses of ethanone?
1 - (3-fluoro-2-iodophenyl) ethanone, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the introduction of specific fluorine and iodine atoms, the physical and chemical properties of compounds can be significantly changed, such as lipophilicity and biological activity. In the process of many drug development, molecules with specific structures need to be constructed. With its unique structure, 1 - (3-fluoro-2-iodophenyl) ethanone can cleverly react with other reagents to build a complex and biologically active molecular structure, thereby enabling the creation of new drugs.
In the field of materials science, it also has important uses. When some functional materials are prepared, they can be used as starting materials to participate in the reaction to shape the special properties of the material. For example, in the synthesis of optoelectronic materials, by participating in the reaction, the material can be endowed with specific electron transport properties or optical properties to meet the diverse needs of material properties in different scenarios.
In the field of organic synthetic chemistry, it is an extremely important building block. Chemists can use its reaction with various nucleophiles and electrophiles to expand the carbon chain, introduce different functional groups, and achieve precise construction of complex organic molecules. With the activity of fluorine, iodine, and carbonyl in its structure, various organic reactions such as nucleophilic substitution and addition can be carried out, providing a rich path for the synthesis of various organic compounds.
1- (3-fluoro-2-iodophenyl) What are the physical properties of ethanone
1 - (3-fluoro-2-iodophenyl) ethyl ketone is one of the organic compounds. Its physical properties are quite critical and it is widely used in various fields of chemical industry.
Looking at its properties, it is mostly liquid under normal conditions, but it is not decisive, or it may change depending on the environment. Its color may be colorless to light yellow, and this color change is also affected by impurities and purity.
Talking about the boiling point, the boiling point of this compound is quite high, due to the strong intermolecular force. The exact value of the boiling point will vary slightly depending on the exact measurement conditions, but it is generally within a certain range. The high boiling point makes it require specific temperature conditions for separation and purification.
In terms of melting point, there is also a specific value. The melting point reflects the critical temperature at which it changes from solid to liquid. When the temperature reaches this value, the thermal motion of the molecule intensifies, the lattice structure gradually disintegrates, and then it is converted from solid to liquid.
Solubility is also an important physical property. 1 - (3-fluoro-2-iodophenyl) ethyl ketone has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is because the functional groups contained in the molecular structure can form specific interactions with organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc., thereby increasing their solubility. In water, its solubility is relatively limited, due to the difference between the polarity of the water molecule and the polarity of the compound molecule, and the weak interaction between the two.
Density is also a factor to consider. Its density may be different from that of water, which is of great significance in operations such as liquid-liquid separation. If the density is greater than that of water, it will be in the lower layer when delaminating; otherwise, it will be in the upper layer. This property provides an important basis for practical operation.
In addition, the volatility of this compound is relatively low, which restricts the ability of molecules to escape from the liquid phase due to intermolecular forces. Low volatility, during storage and use, can reduce losses and safety risks due to volatilization. However, in a specific reaction environment, if its gasification is required to participate in the reaction, conditions such as temperature and pressure need to be properly regulated.
1- (3-fluoro-2-iodophenyl) What are the synthesis methods of ethanone
To prepare 1 - (3-fluoro-2-iodophenyl) ethyl ketone, there are various methods. First, it can be obtained from 3-fluoro-2-iodobenzoic acid through a series of reactions. First, 3-fluoro-2-iodobenzoic acid and alcohols are formed into esters under acid catalysis. Sulfuric acid is often used as a catalyst, and heating prompts the reaction to proceed in the direction of esterification to obtain 3-fluoro-2-iodobenzoate. The ester is then treated with a strong reducing agent such as lithium aluminum hydride, and in a suitable solvent such as anhydrous ether, the reducing agent is carefully added dropwise to reduce the ester group to alcohol to obtain 3-fluoro-2-iodophenyl ethanol. Then, with a suitable oxidizing agent, such as PCC (pyridinium chlorochromate salt), in a solvent such as dichloromethane, the alcohol can be oxidized to an aldehyde, and further with a stronger oxidizing agent, such as Jones reagent (sulfuric acid solution of chromium trioxide), the aldehyde can be oxidized to 1 - (3-fluoro-2-iodophenyl) ethyl ketone.
Second, 3-fluoro-2-iodobromobenzene is used as the starting material. In anhydrous tetrahydrofuran and other solvents, the Grignard reagent 3-fluoro-2-iodophenyl magnesium bromide is prepared by reacting with magnesium chips. Then acetyl chloride is introduced into the Grignard reagent to control the reaction temperature and time, and a nucleophilic substitution reaction occurs. The phenyl negative ion in the Grignard reagent attacks the carbonyl carbon of acetyl chloride, and the chlorine leaves. After hydrolysis, 1 - (3-fluoro-2-iodophenyl) ethyl ketone is obtained.
Or, starting from 3-fluoro-2-iodoaniline, it can be reacted with sodium nitrite at low temperature in hydrochloric acid medium to form diazonium salts. 3-Fluoro-2-iodobenzene can be obtained by replacing the diazo group with iodine ion. After that, under the catalysis of Lewis acid such as anhydrous aluminum trichloride, the reaction of Fu-gram acylation with acetyl chloride occurs, and the acetyl group is introduced into the benzene ring to prepare 1- (3-fluoro-2-iodophenyl) ethyl ketone.
All these methods have advantages and disadvantages, and they need to be selected carefully according to the actual situation, such as the availability of raw materials, the ease of control of reaction conditions, and the high or low yield.
1- (3-fluoro-2-iodophenyl) What to pay attention to when storing ethanone
1 - (3-fluoro-2-iodophenyl) ethyl ketone is an organic compound. When storing, many aspects need to be paid attention to.
Bear the brunt, temperature and humidity are crucial. This compound is quite sensitive to environmental conditions, and high temperature and high humidity can easily cause it to deteriorate. Therefore, it should be stored in a cool and dry place. Generally speaking, the temperature should be controlled between 15 ° C and 25 ° C, and the humidity should be maintained at 40% to 60%. If the temperature is too high, it may cause changes in its molecular structure and cause changes in its chemical properties; if the humidity is too high, it may cause the compound to absorb moisture, which will affect the purity and stability.
Secondly, light can also affect it. 1 - (3-fluoro-2-iodophenyl) ethyl ketone may be photosensitive, and long-term light exposure may cause it to undergo photochemical reactions, resulting in quality damage. Therefore, when storing, it should be placed in a dark place, such as using brown bottles, or stored in cabinets that are difficult to light.
Furthermore, the compound needs to be properly isolated from other substances. Because of its chemical activity, or react with oxidants, reducing agents, acids, bases, etc. When storing, it must be placed separately from such substances to prevent interactions from causing hazards such as fire, explosion, etc.
In addition, the choice of storage containers should not be ignored. Containers with suitable materials and good sealing should be selected. Common glass containers should be ensured to be free of cracks to prevent air and moisture from entering. If using plastic containers, consider their compatibility with the compound to prevent swelling, dissolution and other conditions from affecting the quality of the compound.
In short, when storing 1- (3-fluoro-2-iodophenyl) ethyl ketones, factors such as temperature, humidity, light, isolation and containers should be carefully considered to ensure their quality and stability.
1- (3-fluoro-2-iodophenyl) Whether ethanone is toxic
1 - (3-fluoro-2-iodophenyl) ethyl ketone is also a substance. To know whether it is toxic, we should study it in many ways. Guanfu's "Tiangong Kaiwu", although it does not directly state the toxicity of this substance, there are wonderful theories about its properties in various substances, or it can be explained.
The toxicity of husband substances is related to its chemical properties and the state of human action. 1 - (3-fluoro-2-iodophenyl) ethyl ketone contains fluorine and iodine. Fluorine is very active and often changes its properties in compounds. Iodine also has its unique properties, or reacts differently with other substances.
In chemical theory, compounds containing halogenated aryl groups have many activities. Such activities may cause them to interact with molecules in human cells, such as proteins, nucleic acids, etc. If the effect is improper, it may disturb the normal physiology of cells and cause toxicity.
The judgment of toxicity is not determined by chemical theory alone. Experimental evidence is also essential. If you test various experiments on animals, observe their reactions after ingestion or exposure to this substance, such as changes in behavior and physiological indicators, to determine the presence and strength of toxicity. Without detailed experimental data, it is difficult to determine its toxicity based on the chemical structure alone.
And the human body is different, and the reaction to the substance is also different. Or some people are sensitive to this substance, although the trace amount is also uncomfortable; or some people have strong tolerance and contact a little more, which is not a big problem. Therefore, in order to determine the toxicity of 1 - (3-fluoro-2-iodophenyl) ethanone, it is necessary to combine chemical analysis and biological experiments, and comprehensive consideration can be obtained.
