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What is the chemical structure of 1- [ (3) -2-deoxy-beta-D-glycero-pentofuranosyl] -5-iodopyrimidine-2,4 (1H, 3H) -dione?
The chemical structure of 1 - [ (3-deoxy-β-D-glycerol-pentanosyl) ] - 5-iodopyrimidine-2,4 (1H, 3H) -dione is a complex and delicate structure in the field of organic chemistry. The core of this compound is a pyrimidine ring, which has many specific substituents and exhibits unique chemical properties.
The pyrimidine ring is the backbone of this molecule, consisting of two nitrogen atoms and four carbon atoms to form a six-membered heterocycle. At the 2nd and 4th positions of the pyrimidine ring, each is connected with a carbonyl group (C = O), which forms a 2,4 (1H, 3H) -diketone structure. This diketone structure endows the molecule with certain reactivity and chemical properties, and may play a key role in many chemical reactions and biological processes.
At the 5th position of the pyrimidine ring, an iodine atom is connected. The iodine atom has a large atomic radius and electronegativity. Its existence significantly affects the electron cloud distribution and spatial structure of the molecule, and then affects the physical and chemical properties of the compound, such as polarity, boiling point, solubility, etc. In organic synthesis reactions, the iodine atom is often an important reaction check point and can participate in various coupling reactions.
In the first position of the pyrimidine ring, a glycosyl group is connected, that is, [ (3-deoxy-β-D-glycerol-pentafuran glycosyl group) ]. This glycosyl group consists of five carbon atoms and constitutes a furan sugar ring with a five-membered ring structure. Among them, the third position is deoxygenated, which means that compared with the conventional sugar structure, this position lacks hydroxyl (-OH). The β-configuration indicates that the glycosidic bond configuration of the sugar ring and the pyrimidine ring is β-type, which determines the stereochemical structure of the molecule. The glycosyl part endows compounds with more biological activities. In nucleoside compounds, the interaction between glycosyl groups and bases is crucial to their biological functions.
To sum up, the chemical structure of 1- [ (3-deoxy-β-D-glycerol-pentafuran glycosyl) ] -5-iodopyrimidine-2,4 (1H, 3H) -dione is composed of a clever combination of pyrimidine ring, iodine atom and specific glycosyl groups. Each part affects each other, endowing the compound with unique chemical and biological characteristics, which may have important research value and application potential in the fields of organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 1- [ (3) -2-deoxy-beta-D-glycero-pentofuranosyl] -5-iodopyrimidine-2,4 (1H, 3H) -dione?
1 - [ (3 - deoxy - β - D - glycerol - pentafuran glycosyl) - 5 - iodopyrimidine - 2,4 (1H, 3H) - dione, this material has multiple physical properties. In its morphology, it is mostly white to off-white crystalline powder under normal conditions, with fine texture. Viewed under a microscope, it can be seen that its crystal structure is arranged regularly.
When it comes to solubility, this substance exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO), can quickly disperse and form a uniform solution, but its solubility in water is limited and only slightly soluble. This characteristic is derived from the ratio and interaction of hydrophobic groups and hydrophilic groups in its molecular structure.
In terms of melting point, the melting point is accurately determined to be in a specific temperature range, about [specific melting point value] ℃. This melting point characteristic can be used as an important physical index to identify this compound, and is also crucial in purity analysis. The presence of impurities often causes melting point fluctuations. In terms of stability, in dry, cool and dark environments, it can remain relatively stable. However, when exposed to strong light or high temperature environments, the molecular structure will gradually change, triggering decomposition reactions and causing changes in its chemical properties. In solutions with different pH values, the stability is also different, and it is more stable in neutral environments. Excessive acidity or alkalinity will accelerate its decomposition process. The above physical properties are all indispensable factors to consider when researching, producing and applying this compound, and are of great significance for accurately controlling its reaction conditions, preparation process and storage methods.
What is the main use of 1- [ (3) -2-deoxy-beta-D-glycero-pentofuranosyl] -5-iodopyrimidine-2,4 (1H, 3H) -dione?
1 - [ (3-deoxygenated - β - D-glycerol-pentafuran glycosyl) - 5-iodopyrimidine-2,4 (1H, 3H) -dione], this compound is an important compound in the field of medicinal chemistry. Its main use is particularly critical, and it involves the development of antiviral drugs.
Watching the raging state of the virus, human beings have suffered from it repeatedly. To control the rampant virus, an effective way must be found. And this compound is like a light in the dark night in the field of antiviral research, leading researchers forward. Due to its unique chemical structure, it can affect the replication process of the virus. Viruses multiply in the host, just like cunning thieves, trying to steal the host's resources to strengthen themselves. And this compound can block the critical node of virus replication like a warrior, making it impossible to succeed.
In the path of medical research, researchers have worked hard to explore more mysteries of this compound. Or fine-tune its structure, hoping to enhance its anti-viral efficacy; or study its interaction with viral targets, in order to precisely attack the virus. And in drug development, it can be used as a lead compound, like the key to open the door to treasure, paving the way for the development of specific antiviral drugs, helping humans in the battle against viruses, seize the opportunity and protect the well-being of life.
What are the synthesis methods of 1- [ (3) -2-deoxy-beta-D-glycero-pentofuranosyl] -5-iodopyrimidine-2,4 (1H, 3H) -dione?
First, a sugar derivative with a suitable protective group and a modified pyrimidine compound can be used for nucleophilic substitution under specific catalyst and reaction conditions. The glycosyl group is connected to the pyrimidine ring, and then the target product is obtained through the deprotection step. This path requires fine control of the introduction and removal of the protective group to ensure the selectivity and yield of the reaction.
Second, pyrimidine-2,4-dione is used as the starting material, and the iodine atom is first introduced at the 5th position, and then the glycosylation reaction is carried out to introduce the 2-deoxy-beta-D-glycero-pentofuranosyl part. The glycosylation step may require the assistance of catalysts such as Lewis acid to promote the reaction between the glycosyl donor and the receptor.
Third, biosynthetic methods may be used. Through the catalysis of specific enzyme systems, the biosynthetic environment can be simulated in vivo or in vitro to achieve the synthesis of the target compound. This approach may have higher stereoselectivity and environmental friendliness, but it requires strict screening of enzymes and optimization of reaction conditions.
All synthesis methods have their own advantages and disadvantages. In actual operation, the choice should be made carefully according to factors such as raw material availability, cost, reaction difficulty and purity of the target product.
What are the safety and toxicity of 1- [ (3) -2-deoxy-beta-D-glycero-pentofuranosyl] -5-iodopyrimidine-2,4 (1H, 3H) -dione?
1 - [ (3 - deoxygenated - β - D - glycerol - pentafuran glycosyl) - 5 - iodopyrimidine - 2,4 (1H, 3H) - dione This substance is related to safety and toxicity, and it is an urgent matter. We should investigate its properties in detail to understand its behavior in various environments and biological systems.
Looking at past books, there is no record of its exact safety and toxicity. However, looking at the structure of its molecules, it contains iodine atoms and specific sugar groups and pyrimidine dione structures. The iodine atom is active, or causes chemical reactions in the body, causing changes in biological molecules such as proteins and nucleic acids. The structure of pyrimidinedione is commonly found in nucleic acid-related substances, or in processes involving cellular metabolism and genetic information.
With common sense, such compounds with complex structures may be cytotoxic. They may enter the cell, interfere with nucleic acid synthesis, transcription or translation, and disrupt the normal physiology of the cell. Or due to the characteristics of iodine, produce oxidative stress and damage cellular components, such as lipids, proteins and DNA.
As for the safety, it needs to be investigated by many experiments. It is advisable to test it in vitro cell models first to observe its effects on the growth, proliferation and apoptosis of different cell lines. Then animal experiments are used to investigate its absorption, distribution, metabolism and excretion, and its effects on the functions of various organs of the body.
However, it is only speculated based on the existing structure that this substance may have certain potential toxicity. When used and studied, strict safety procedures should be followed to prevent harm to the experimenter and the environment. Only through rigorous experiments can the exact safety and toxicity of it be obtained.