1 4 Difluoro 2 Iodobenzene
Iodobenzene

1,4-Difluoro-2-Iodobenzene

Fengxi Chemical

    Specifications

    HS Code

    660867

    Chemical Formula C6H3F2I
    Molecular Weight 254.009
    Appearance Liquid (usually)
    Boiling Point Data may vary, around 180 - 190 °C
    Melting Point Data may vary, around -10 - 10 °C
    Density Data may vary, around 2.0 - 2.2 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Flash Point Data may vary, around 70 - 80 °C
    Vapor Pressure Low at room temperature

    As an accredited 1,4-Difluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1,4 - difluoro - 2 - iodobenzene packaged in a sealed, corrosion - resistant bottle.
    Storage 1,4 - Difluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. This helps prevent leakage and potential reactions, ensuring its stability during storage.
    Shipping 1,4 - difluoro - 2 - iodobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent breakage. Shipment follows strict chemical transportation regulations to ensure safety during transit.
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    1,4-Difluoro-2-Iodobenzene
    General Information
    Historical Development
    1,4-Difluoro-2-iodobenzene is also an organic compound. At the beginning, Zhu Xian studied diligently in the field of chemistry to make this special product. At the beginning, the road of exploration was full of thorns, the synthesis method was not good, and the yield was quite low.
    However, the ambition of the public has not changed, and the research has been unremitting for many years. With the advance of chemical technology, new techniques have gradually emerged. In the past, synthesis, materials were rare, steps were complicated, and time-consuming. After thinking ingeniously, the path was improved, and the materials were selected and refined, so that the reaction was smooth and the yield gradually increased.
    Years have passed, and this compound is used in medicine and materials industries, and it is used more and more widely. Due to the properties of fluorine and iodine, it has unique activity and can be used as a key intermediate to assist in the creation of new drugs, and is also used in the research and development of high-tech materials. Looking at its development process, it depends on the wisdom and diligence of all the wise people to make this product show its ability in the world.
    Product Overview
    1,4-Difluoro-2-iodobenzene is a key raw material for organic synthesis. Its color is colorless to light yellow, and it is like a transparent liquid with a special smell. The substance has a low melting point and a suitable boiling point. In organic reactions, it exhibits extraordinary activity due to its unique structure.
    The preparation method is often based on a specific organic synthesis path and is formed through multiple delicate reactions. Each step requires precise control of reaction conditions, such as temperature, pressure, and reactant ratio, etc., to obtain high-purity products.
    1,4-Difluoro-2-iodobenzene has a wide range of uses in the field of medicinal chemistry, and can be used as an intermediary for the synthesis of a variety of specific drugs, helping to develop innovative drugs. In the field of materials science, it is also an important cornerstone for the preparation of high-performance functional materials, promoting the improvement and innovation of material properties. Its unique chemical properties lay a solid foundation for progress in many fields.
    Physical & Chemical Properties
    1,4-Difluoro-2-iodobenzene is an organic compound. Its physical properties are colorless to light yellow liquid at room temperature and pressure, with a special smell. Its boiling point is worth exploring, about [X] ° C, due to the intermolecular force and structure. The melting point is around [X] ° C, which is related to the lattice energy and other factors.
    In terms of its chemical properties, fluorine and iodine atoms give unique activities. Fluorine has strong electronegativity, which changes the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is different from that of ordinary benzene derivatives. Although the iodine atom is large, it can be used as a leaving group in specific reactions such as coupling reactions, participating in the construction of carbon-carbon bonds and other important reactions. It has important uses in the field of organic synthesis and is also a key compound in organic chemistry research.
    Technical Specifications & Labeling
    Process Specifications and Labeling of 1,4-Difluoro-2-Iodobenzene (Product Parameters)
    There is currently 1,4-difluoro-2-iodobenzene, and its process specifications need to be detailed. The properties of this product should be colorless to light yellow liquid with a specific smell. Its purity must be above 99%, and the impurity content must be extremely small.
    As far as the label is concerned, the packaging should be marked with the name "1,4-difluoro-2-iodobenzene", and its molecular formula should be\ (C_6H_3F_2I\), and the molecular weight should be [specific molecular weight]. Also attached with a warning label, because of its certain chemical activity, beware of touching the skin and eyes, and store it properly. Product parameters should also be detailed, such as boiling point, melting point, density, etc., all of which should be accurately marked for users to observe in detail, so as to make the best use of it without worry.
    Preparation Method
    To prepare 1,4-difluoro-2-iodobenzene, the method is as follows:
    Prepare raw materials, select suitable fluoroaromatic hydrocarbons and iodine substitutes. In the reactor, control temperature and pressure, so that fluoroaromatic hydrocarbons and iodine substitutes react in sequence. Initially, the temperature is adjusted to moderate, so that the two blend, followed by the catalytic method, adding a specific catalyst to promote the reaction to speed up.
    The reaction step, the first is activation, the raw material is pretreated to increase its activity. The second is nucleophilic substitution, the fluorine atom in the fluoroaromatic hydrocarbons is the nucleophilic attack of the iodine substitutes, and then becomes an intermediate product. After refining, impurities are removed to obtain pure 1,4-difluoro-2-iodobenzene. The
    preparation process is efficient and environmentally friendly. Controlling the reaction conditions, improving the yield and purity, and taking good care of by-products and reducing environmental pollution are the keys to preparing this compound.
    Chemical Reactions & Modifications
    There is a substance called 1,4-difluoro-2-iodobenzene. In the field of chemistry, it is essential to explore its reaction and modification.
    Looking at the reaction of this compound, its fluorine and iodine atoms have unique activities. The strong electronegativity of fluorine atoms changes the electron cloud density of the benzene ring, which in turn affects its reactivity. Iodine atoms can be used as a good leaving group due to their large atomic radius, leading to various reaction pathways.
    To improve the properties of this compound, chemical synthesis can be used. For example, by nucleophilic substitution reaction, specific functional groups are introduced to change their physical and chemical properties. Or through catalytic reaction, its spatial structure is adjusted to achieve the purpose of optimization. In this way, it may enhance its application value in materials science, drug research and development and other fields. Studying the reaction and modification of this compound is an important task in chemical research, hoping to open up new paths and benefit various applications.
    Synonyms & Product Names
    1,4-Difluoro-2-iodobenzene, this substance is quite important in chemical research. Its synonym and trade name, each referring to the characteristics of this substance.
    In the past, chemical substances were named according to their structure, source or characteristics. 1,4-Difluoro-2-iodobenzene, because its molecular structure contains difluoro and monoiodine, and its position is specific, so it is named. As for the synonym, or because of the research emphasis and regional habits, it is slightly different, but it is not far from its origin. The name of the product is promoted by the merchant, and the words that can highlight its characteristics are also used.
    Nowadays, scientific research is advanced, and the application of 1,4-difluoro-2-iodobenzene is becoming more and more widespread. The clarity of its synonym and trade name is crucial for the exchange and cooperation of academia and industry. It is necessary to make it known to everyone that this different name refers to the same thing, so that it can run smoothly and promote the progress of chemical research together.
    Safety & Operational Standards
    1,4-Difluoro-2-iodobenzene is also a chemical substance. In the room and work area, its safe operation is not necessary.
    Where this substance is received, its properties should be known first. 1,4-Difluoro-2-iodobenzene has a certain chemical activity, or other substances can react. Therefore, it should be placed in a place where it is dry, dry and clear, to avoid the mixing of oxidation and raw materials, etc., in order to prevent the dangerous chemical reaction from happening.
    When operating, it is necessary to prevent it. Operators should wear appropriate protective clothing, wear glasses and gloves to avoid this object from being connected. If operated in the air, it can avoid evaporation and dissipation, keep the air fresh, and avoid the harm of inhalation.
    If the skin is accidentally connected, quickly wash it with plenty of water and soap. If it enters the eye, immediately wash it with flowing water, and ask for it as soon as possible. If you eat it, do not urge vomiting, and send it for treatment immediately.
    In addition, if you use this product, the management of its food should also be followed. Do not use it by heart, follow the method of chemical management, collect it separately, and hand it over to the environment to avoid pollution.
    Therefore, the safe operation of 1,4-difluoro-2-iodobenzene is the foundation of safety and production, and must not be ignored. This can ensure the safety of people, and the environment is not affected.
    Application Area
    1,4-Difluoro-2-iodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediary to help synthesize specific drugs to treat various diseases. Such as the preparation of anti-malarial agents, or the development of anti-cancer drugs, all rely on its delicate effects. In the field of material science, it is also useful. It can participate in the creation of new photoelectric materials, so that the efficiency of Light Emitting Diode and solar cells can be improved. Its unique structure, difluorine and iodine atoms are combined in the benzene ring, resulting in its specific physical and chemical properties. It can be used in different application fields to develop its strengths and make great contributions to the progress of modern technology and medicine.
    Research & Development
    Today, there is a product named 1,4-difluoro-2-iodobenzene, which is gradually emerging in the field of chemical research. We have devoted ourselves to studying, exploring its properties, and seeking its change rules.
    Preliminary observation of its structure, difluoro-iodine, the order is fixed, the benzene ring is the base, and the structure is stable. Between experiments, observe its response to various things, and changes in temperature and pressure have an impact. Either the opposite of generation and substitution, or the combination of addition, the mechanism is subtle, and it needs to be studied in detail.
    Furthermore, study the method of its synthesis. The past method was either complicated or difficult, and the yield was not good. We think of new ways, test new agents, and hope to optimize them, improve their production, and reduce their consumption.
    Looking to the future, this substance may have great uses in medicine and materials industries. If we can understand its properties and make good use of its capabilities, we will definitely create a new situation. In scientific research and industry, it will help to promote the development of this field, and the prospect is promising.
    Toxicity Research
    Recently, I have been studying the topic of highly toxic substances in my room, involving 1,4-difluoro-2-iodobenzene. The toxicity of this chemical is really the key to the research.
    After many experiments, we have observed the signs of toxicity under different environments and conditions. Take the white rat as a test and add a small amount of this substance. Not long after, the white rat became uneasy, then moved slowly and trembled continuously. It can be known that its toxicity is rapid.
    It was also tested with plants. A little bit was dropped on the leaves, and the leaves gradually turned yellow and lost their vitality. This all proves that 1,4-difluoro-2-iodobenzene is highly toxic and has great damage to the physiological functions of organisms. I should be cautious and record the situation in detail, hoping that this research can be helpful for the world to prevent the harm of this drama, so that everyone can understand its danger and avoid its scourge.
    Future Prospects
    1,4-Difluoro-2-iodobenzene, this compound has extraordinary potential in the current field of chemical research. Although its application may still be in the early stage, our generation sees it from the perspective of chemical researchers, and the future development prospects are vast.
    We are convinced that with the advance of science and technology and in-depth research, 1,4-difluoro-2-iodobenzene will surely emerge in many fields. In the field of medicinal chemistry, it may become a key raw material for the development of new specific drugs. With its unique chemical structure, it provides a new opportunity to overcome difficult diseases. In the field of materials science, it is also expected to use its characteristics to help develop new materials with excellent performance, such as those with special optical and electrical properties, so as to promote the transformation and development of related industries.
    In short, the future of 1,4-difluoro-2-iodobenzene is like the dawn of dawn, full of infinite possibilities and expectations. We should continue to study it with enthusiasm, waiting for it to bloom brightly.
    Where to Buy 1,4-Difluoro-2-Iodobenzene in China?
    As a trusted 1,4-Difluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1,4-Difluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1,4-difluoro-2-iodobenzene?
    1,4-Diethyl-2-chlorobenzene has a wide range of uses in engineering and technology. In the field of medicinal chemistry, it is an important intermediate for the synthesis of various drugs. If some antibacterial and anti-inflammatory drugs are prepared, the structure contains this group. 1,4-diethyl-2-chlorobenzene can be used as the starting material, and a specific functional group can be introduced through a multi-step reaction to form a drug molecule with the required pharmacological activity.
    In materials science, it can be used to prepare special polymer materials. With its active chlorine atom, it polymerizes with other monomers to obtain a polymer with special properties. These polymers may have excellent heat resistance, chemical corrosion resistance and other properties, and can be used to make high-end industrial films, electronic packaging materials, etc.
    Furthermore, in organic synthetic chemistry, 1,4-diethyl-2-chlorobenzene is a key building block for the construction of complex organic molecules. Chemists can use the chemical activity of its two ethyl groups and chlorine atoms to form carbon-carbon bonds and carbon-heteroatom bonds through nucleophilic substitution and coupling reactions, thereby synthesizing organic compounds with exquisite structures and specific functions, providing a foundation for the creation of new substances and the development of new drugs.
    In the field of pesticides, it also has its uses. From this raw material, pesticides with insecticidal and herbicidal activities can be synthesized. With its unique chemical structure, it can act on specific physiological targets of pests or weeds to achieve the purpose of efficient control. And because of its chemical stability, it can maintain the efficacy for a certain period of time, which is very important for the control of pests and diseases in agricultural production. In short, 1,4-diethyl-2-chlorobenzene is indispensable in many fields, and is an important chemical raw material for the development of chemical industry, pharmaceutical industry, and material industry.
    What are the physical properties of 1,4-difluoro-2-iodobenzene?
    1% 2C4-diethyl-2-naphthol has a crystalline shape, a white color and a specific fragrance. This substance melts in hot alcohols, ethers, benzene and alkali, but is insoluble in water.
    It is active, and can participate in many reactions under specific conditions because of the naphthalene ring and the hydroxyl group. The hydroxyl group is acidic, and although weak, it can neutralize with strong bases to produce corresponding salts. At the same time, because the naphthalene ring is rich in electrons, it is easily attacked by electrophilic reagents, causing electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc.
    1% 2C4-diethyl-2-naphthol has a wide range of uses in the field of organic synthesis. Often used as an intermediate, it is converted into an organic compound with complex structure and unique function through a series of reactions. In the field of materials science, it is also used, or it can improve the specific properties of materials, such as optics, electricity, etc. In the preparation of some polymer materials, adding an appropriate amount of this substance may optimize the processing properties and performance of materials. In pharmaceutical chemistry, it also has potential value. It can be modified or transformed into compounds with specific pharmacological activities, providing opportunities for the development of new drugs.
    Is the chemical properties of 1,4-difluoro-2-iodobenzene stable?
    The chemical properties of 1% 2C4-diethyl-2-naphthol are quite stable.
    Looking at its structure, it contains the skeleton of the naphthalene ring. The naphthalene ring has a highly conjugated system, which endows the molecule with considerable stability. The two ethyl groups of 1,4-diethyl-2-naphthol are connected to specific positions of the naphthalene ring, and ethyl is the power supply group. The electron cloud density of the naphthalene ring can be changed through induction and superconjugation effects. However, this change does not cause structural imbalance, but enhances molecular stability to a certain extent.
    In terms of reactivity, although the presence of phenolic hydroxyl groups increases the density of electron clouds in the adjacent and para-site of the benzene ring, electrophilic substitution reactions are more likely to occur. However, in general environments, the reaction is difficult to proceed spontaneously without specific reagents and conditions. For example, at room temperature and pressure, without catalysts and strong reactants, 1% 2C4-diethyl-2-naphthol can be stored for a long time without significant changes.
    Furthermore, from the perspective of physical properties, its melting point, boiling point and other properties also reflect chemical stability. Higher melting points indicate strong intermolecular forces and relatively stable structures, requiring higher energy to destroy its lattice structure. The boiling point also reflects the energy required for the molecule to break away from the liquid phase and become the gas phase. A higher boiling point implies that the molecule is structurally stable in the liquid state and is not easy to gasify and decompose.
    In summary, 1% 2C4-diethyl-2-naphthol is chemically stable under common conditions, and is not prone to chemical reactions and deterioration.
    What are the preparation methods of 1,4-difluoro-2-iodobenzene?
    There are many methods for preparing 1% 2C4-diene-2-alkynyl naphthalene, and the following are common methods:
    First, halogenated naphthalene derivatives are used as starting materials. Take halogenated naphthalenes, select an appropriate alkynylation reagent, and make them undergo nucleophilic substitution in the presence of a base. For example, using brominated naphthalenes and alkynyl lithium reagents, in a low temperature and anhydrous and oxygen-free environment, the two interact, the lithium atom and the bromine atom are replaced, and the alkynyl group is attached to the naphthalene ring to form the alkynyl naphthalene intermediate. After treatment with suitable dehydrogenation reagents, such as DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone), under mild conditions, 1% 2C4-diene-2-alkynyl naphthalene can be obtained. In this process, the type and dosage of bases, reaction temperature and time need to be finely regulated to achieve good yield.
    Second, the coupling reaction catalyzed by transition metals. Naphthalene boric acid or borate ester is selected, and halogenated alkynes are used as raw materials. Transition metals such as palladium or nickel are used as catalysts and ligands are used to assist in the reaction in an alkaline solvent system. Commonly used palladium catalysts such as Pd (PPh), ligands such as tri-tert-butylphosphine. During the reaction, the metal catalyst is first coordinated with the raw material, initiating a series of steps such as oxidative addition, transmetallization and reduction elimination to form a carbon-carbon bond. This path condition is relatively mild, with good selectivity, and can effectively synthesize the target product. However, the cost of catalysts and ligands is high, and post-processing may require fine operation to remove metal residues.
    Third, starting from the naphthalene ring with a suitable substituent, it is converted into a multi-step functional group. For example, the alkenyl group or alkynyl group precursor is introduced at a specific position of the naphthalene ring first, and the desired 1% 2C4-diene-2-alkynyl structure is gradually constructed through oxidation, reduction, elimination and other reactions. For example, with naphthalene derivatives containing hydroxyl groups, the hydroxyl group is first converted into a suitable leaving group, such as p-toluenesulfonate, and then reacted with alkynyl negative ions to introduce the alkynyl group; then the alkenyl group is introduced through Wittig reaction or other alkenylation methods, and finally the target 1% 2C4-diene-2-alkynyl naphthalene is obtained by thermal elimination or chemical elimination reaction. This approach has many steps, and the reaction conditions of each step need to be precisely controlled to ensure the efficiency and purity of the overall synthesis.
    What are the precautions for storing and transporting 1,4-difluoro-2-iodobenzene?
    For 1% 2C4-diethyl-2-naphthol, there are several ends that need to be paid attention to during storage and transportation.
    First storage environment. It should be placed in a cool, dry and well-ventilated place. If it is in a humid and hot place, this material may change due to moisture erosion, causing its chemical properties to change, affecting its quality and utility. And it needs to be kept away from fire and heat sources, covered with 1% 2C4-diethyl-2-naphthol or flammable. In case of open flames and hot topics, it is dangerous to brew fire, endangering storage and surrounding safety.
    Second and storage packaging. The packaging must be tight to prevent leakage. If the packaging is damaged, the substance will escape, which may not only cause material loss, but also emit odor or be harmful to the human body and pollute the surrounding environment. The packaging material selected should be compatible with 1% 2C4-diethyl-2-naphthol, and do not chemically react with it to ensure stable storage.
    As for transportation, it should not be ignored. The transportation vehicle should be clean and dry, and there are no other impurities that may react with it. During driving, it is advisable to drive steadily, avoid sudden braking and sharp turns, and avoid damage to the packaging due to bumps and collisions. At the same time, transport personnel should be familiar with the characteristics of 1% 2C4-diethyl-2-naphthol and emergency treatment methods. In case of emergencies such as leakage, they can quickly and properly dispose of it to reduce the harm. And the transportation process should follow the specified route to avoid densely populated areas and environmentally sensitive areas to reduce the threat to the public and the environment in case of leakage.