1 4 Iodo Phenyl Piperidin 2 One

The chemical structure of 1 - (4-iodophenyl) piperidine-2-one is quite elegant. This compound is composed of a piperidine ring connected to a carbonyl group. The piperidine ring is a nitrogen-containing hexahedral ring, and its nitrogen atom occupies one corner of the ring, which gives the ring a unique electron cloud distribution and chemical activity.
In the second position of the piperidine ring, the carbonyl group (C = O) is connected to it. The carbon-oxygen double bond in the carbonyl group, and the electron cloud is biased towards the oxygen atom, so that the carbonyl carbon has a certain positive electricity and is vulnerable to attack by nucleophilic reagents. In many chemical reactions, this carbonyl group is often the active check point of the reaction, and can undergo reactions such as nucleophilic addition and condensation.
Furthermore, in the first position of the piperidine ring, a phenyl group is connected. This phenyl group is an aromatic hydrocarbon group with a conjugated large π bond, which endows the molecule with certain stability and special electronic effects. And the fourth position of the phenyl group has iodine atom substitution. Iodine atoms have a large atomic radius and have a strong electron-absorbing induction effect, which can affect the electron cloud distribution of molecules, and then affect the physical and chemical properties of molecules.
The existence of iodine atoms changes the polarity of molecules. In some reactions, it can participate in the reaction as a leaving group, providing many possible reaction paths for organic synthesis. Overall, the chemical structure of 1 - (4-iodophenyl) piperidine-2-one presents complex and unique chemical properties and reactivity due to the interaction of each group.

1 - (4-iodophenyl) piperidine-2-one is one of the organic compounds, which has important uses in medicinal chemistry, materials science and other fields.
In medicinal chemistry, it is often the key intermediate for the synthesis of many drugs. The structure of Geyne containing iodophenyl and piperidone endows the molecule with unique physical and chemical properties. It can be synthesized by organic means to connect other specific functional groups or structural fragments, and then construct compounds with specific pharmacological activities. For example, in the research and development process of some anti-cancer drugs, 1- (4-iodophenyl) piperidine-2-one can be used as a starting material to introduce active groups that interact with cancer cells through multi-step reactions, so as to obtain drug molecules with targeted anti-cancer efficacy.
In the field of materials science, it also shows unique application value. Due to its structural characteristics, it can participate in the synthesis of polymer materials. After polymerization and other reactions, its structural units are introduced into the polymer chain, which can change the optical, electrical and mechanical properties of the material. For example, in the preparation of organic optoelectronic materials, the introduction of this compound may adjust the fluorescence emission characteristics and charge transport ability of the material, making the material more suitable for the manufacture of organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices.
Furthermore, in the field of organic synthetic chemistry, 1 - (4-iodophenyl) piperidine-2-one is an important synthetic block, providing an effective way for the synthesis of complex organic molecules. Based on its structure, chemists can use various organic reactions, such as coupling reactions, nucleophilic substitution reactions, etc., to construct carbon-carbon bonds and carbon-heteroatom bonds, expand the complexity and diversity of molecules, and lay the foundation for the creation of new organic compounds.

To prepare 1 - (4-iodophenyl) piperidine-2-one, the ancient method is often used to follow the principle of organic synthesis.
First, 4-iodobenzoyl chloride can be reacted with piperidine-2-one. First take an appropriate amount of 4-iodobenzoyl chloride, put it in a clean reactor, and dilute it with an organic solvent such as dichloromethane. Piperidine-2-one is also dissolved in the same solvent. Under low temperature and stirring, slowly drop the piperidine-2-one solution into the 4-iodobenzoyl chloride solution. In this case, the temperature needs to be controlled, and the reaction should not be overheated. After dripping, it is gradually warmed to room temperature and continuously stirred for a few times. After that, the product is purified by conventional separation methods, such as extraction, column chromatography, etc.
Second, 4-iodoaniline is used as the starting material. First, 4-iodoaniline is acylated with an appropriate acylating agent, such as acetic anhydride, in the presence of an acid or base of the catalyst amount to obtain 4-iodoaniline intermediates. Next, this intermediate reacts with a suitable halogenated alkane in an alkaline environment and introduces an alkyl chain. Then through the cyclization step, such as under the action of a specific dehydrating agent or Lewis acid, the molecule is cyclized to form 1- (4-iodophenyl) piperidine-2-one. After the reaction is completed, the impurities are removed by the method of separation and purification, and the purified product is obtained.
Third, it can be started from 4-iodobenzoic acid. 4-iodobenzoic acid is first converted into the corresponding acid anhydride or acid chloride, and then reacted with piperidine derivatives. The reaction conditions need to be carefully regulated, according to the activity of the reagents used, the temperature, time and other parameters. After the reaction, the product reaches the required purity after multiple washes, drying, distillation or recrystallization.
All ancient methods have their own advantages and disadvantages. When actually synthesizing, the choice should be made carefully according to the availability of raw materials, cost, and product purity requirements.

The physical properties of 1 - (4-iodophenyl) piperidine-2-one are related to its shape, state, color, taste, melting point, solubility, and other characteristics.
Its shape or crystalline state is often solid, and the quality is stronger. Looking at its color, or white to light yellow crystals, when pure, the color is uniform and bright. As for the smell, it is mostly light, or nearly odorless.
The matter of the boiling point is actually the key physical property. Its melting point is about a certain temperature range. When heated to this temperature, the substance gradually melts from the solid state to the liquid state. This change is due to the change of the intermolecular force. The boiling point is also a specific value. Under a specific pressure, the substance changes from the liquid state to the gaseous state. This process requires the absorption of sufficient energy to overcome the attractive force between molecules.
In terms of solubility, in organic solvents, such as common ethanol and acetone, it may have a certain solubility. However, in water, its solubility may not be good. Due to the molecular structure of the substance, it interacts weakly with water molecules. The density of this substance may be different compared with common solvents, and its density value reflects its mass per unit volume.
In addition, its optical properties such as refractive index also have unique characteristics. When light passes through the substance, the direction and speed of propagation change, and the value of refractive index indicates the degree of this change. These physical properties are of crucial significance in the identification, isolation and application of the substance, providing many key information for the study and use of this compound.

What you are asking is the price range of 1- (4-iodophenyl) piperidine-2-one in the market. However, the price of this compound is difficult to generalize, and it varies due to many factors.
First, purity is the key. If the purity is extremely high, it is almost pure, and the price is high. Because the purification process is complicated and requires exquisite skills and expensive equipment, the price is high. If the purity is slightly lower, although it can be used, the price must be lower.
Second, the difference between suppliers also affects the price. A reputable, reputable supplier with a long history of operation, whose quality control is strict, the quality of the goods supplied is high, and the price may be high. And emerging or unknown suppliers, in order to compete for market share, or reduce their prices to attract.
Third, the state of market supply and demand also affects the price. If the demand for this compound increases sharply and the supply is limited, if an industry urgently needs it to make a specific product, the price will rise. Conversely, if there is little demand and more supply, the price will fall.
Furthermore, the amount purchased is also related to the price. If you buy in bulk, the supplier may offer it at a preferential price to promote transactions. If you buy only a small amount, or at the usual higher unit price.
Overall, in the current market, the price of 1- (4-iodine-phenyl) piperidine-2-one, purchased in small quantities and with ordinary purity, may range from tens to hundreds of yuan per gram. If purchased in bulk and the purity requirements are not harsh, the unit price may be reduced to tens of yuan per gram. However, if high purity is desired, especially for precision scientific research and other fields, the price per gram may exceed 100 yuan, or even higher, reaching hundreds of yuan per gram. This is a rough guess, and the actual price still needs to be consulted with each supplier and determined according to real-time market conditions.