What are the chemical properties of ethyl 1- (4-methoxyphenyl) -6- (4-iodophenyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate?

4-Methoxybenzyl-6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester, this compound has a variety of chemical properties.

From the structural point of view, it contains many different substituents. Among methoxybenzyl groups, methoxy is the electron cloud density of the benzene ring, which can affect the electron cloud density of the benzene ring and increase the electron cloud density of the benzene ring o-para-position, which is conducive to the occurrence of electrophilic substitution reactions, such as halogenation, nitrification, etc., and can affect the stability of the benzyl group connected to the pyridine ring due to electronic effects. 4-Chlorobenzyl, the chlorine atom has electron-sucking induction effect and electron conjugation effect. The overall electron-sucking induction effect is the main one, which makes the benzyl electron cloud biased towards the chlorine atom, which affects the connection with the pyridine ring and participates in the reactivity. For example, in the nucleophilic substitution reaction, the chlorine atom can be used as a leaving group to react with the nucleophilic reagent to form a new compound.

The pyridine ring is an important structure of the compound. The nitrogen atom on the ring has lone pair electrons, which makes the electron cloud of the pyridine ring unevenly distributed. The density of the adjacent electron cloud of the nitrogen atom is relatively low, and the interposition is relatively high. The nucleophilic substitution reaction can occur, and the nucleophilic reagent attacks the electron-defici At the same time, the pyridine ring nitrogen atom can coordinate with metal ions to form complexes, which can be expanded in the fields of catalysis and materials.

Ester group - COOCH < CH < CH > CH
is active in nature and can undergo hydrolysis reaction. It hydrolyzes to form carboxylic acids and ethanol under acidic conditions, and hydrolyzes more thoroughly under alkaline conditions to form carboxylic salts and ethanol. This hydrolysis reaction is used in organic synthesis to prepare carboxylic acids or perform functional group conversion. Carbonyl - C = O is a strong electron-absorbing group, which affects the distribution of electron clouds in surrounding chemical bonds, making α-hydrogen acidic to a certain extent. Under the action of bases, it can form carbon negative ions and participate in nucleophilic addition, condensation and other reactions, such as hydroxyaldehyde condensation reaction with aldehyde and ketone,

Due to these structures and properties, this compound has potential application value in the fields of organic synthesis and medicinal chemistry. It can be used as an intermediate to synthesize specific biologically active compounds, or to develop new drugs through structural modification.

What are the synthesis methods of 1- (4-methoxyphenyl) -6- (4-iodophenyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester

To prepare 3-carboxyacetamide, the method is as follows:
The first raw material, 1 - (4-methoxybenzyl) -6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-indazolo [3,4-c] indazole is the starting material. Among them, methoxybenzyl, chlorobenzyl and indazolo are related to each other, and the state of oxygen and tetrahydro also affects the reaction direction.

The method of synthesis can be obtained by chemical transformation. Or first act on the methoxybenzyl group with a specific reagent to make the methoxy group leave, and then introduce the desired group. This step may require mild conditions to prevent other check points from being disturbed. For example, catalyzed by acid or Lewis acid, the methoxy group is changed through a process such as nucleophilic substitution.

As for chlorobenzyl, it can be reacted with a nucleophilic substitution reaction to react with a reagent containing a carboxyl acetamide precursor. Or activate chlorobenzyl first, such as with metal reagents (such as magnesium, lithium, etc.) to obtain an organometallic reagent, and then react with a carbonyl compound related to carboxyacetamide to form a carbon-carbon bond to introduce a carboxyacetamide moiety.

Or start from the oxo-generation and tetrahydrogenation structure, through oxidation, reduction or rearrangement reaction, adjust the molecular skeleton and gradually guide 3-carboxyacetamide. For example, the oxygen is first reduced to the original hydroxyl group, and then the carboxyacetamide fragment is introduced through a series of reactions such as esterification and amidation. And in the reaction, it is necessary to pay attention to the selectivity of the reaction check point. The protection group strategy can be used to protect the specific group, and then deprotection is performed at an appropriate time to achieve the purpose of precise synthesis. In this way, after multiple steps of delicate reactions, 3-carboxyacetamide may be obtained.

What is the use of 1- (4-methoxyphenyl) -6- (4-iodophenyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester

The following inquiry is about the use of 1- (4-methoxybenzyl) -6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-indazolo [3,4-c] indazole-3-carboxylate ethyl ester. This compound has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to synthesize pharmaceutical molecules with specific biological activities. Due to its unique chemical structure, it can interact with specific targets in organisms, or it can be developed as a drug for the treatment of specific diseases, such as certain inflammation-related diseases, or by combining its structure with the check point of inflammatory factors to regulate the inflammatory response and achieve therapeutic effect.

In organic synthesis research, it is also an important building block. Chemists can use a variety of chemical reactions to modify its structure, expand structural diversity, and construct more complex and novel organic molecules, providing more possibilities for new drug development, materials science and other fields. And its special structure may have potential applications in the field of materials science, or it can participate in the construction of materials with special photoelectric properties for the preparation of organic Light Emitting Diodes, solar cells and other optoelectronic devices. By virtue of its own structure, the material is endowed with unique properties such as charge transfer and light emission.

1- (4-methoxyphenyl) -6- (4-iodophenyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate What is the market outlook for ethyl ester

"Tianwen Kaiwu" said: "The market prospect of 1- (4-methoxybenzyl) -6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-indazolo [3,4-c] indazolo-3-carboxylate is actually related to many factors. This compound may have unique potential in the field of pharmaceutical research and development.

In terms of its structure, the substitution of methoxybenzyl and chlorobenzyl gives the molecule a specific spatial configuration and electronic properties. In drug design, such structural modifications often affect the interaction between molecules and targets. Its oxygenation and tetrahydroindazolidoindazole structure may also determine the biological activity and selectivity of compounds.

At the market demand level, if the compound can be used as a new drug lead compound and has significant pharmacological activity for specific diseases, such as certain cancers and neurological diseases, the market prospect may be extremely broad. Today, the patient population of such diseases is huge, and there is a strong demand for specific drugs.

However, the market prospect is also constrained by factors such as research and development costs and regulatory approval. During the research and development process, a lot of resources need to be invested in activity screening, toxicity testing, etc. The strict regulatory approval also requires products to meet high standards of safety and efficacy.

Overall, if the research and development goes well, this 1- (4-methoxybenzyl) -6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro- 1H-indazolo [3,4-c] indazolo-3-carboxylate ethyl ester is expected to emerge in the pharmaceutical market, but in case of R & D obstacles or regulatory problems, the prospect may remain uncertain. "

What are the storage conditions for ethyl 1- (4-methoxyphenyl) -6- (4-iodophenyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate?

Storage conditions of 4-acetoxybenzyl-6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester
4-acetoxybenzyl-6- (4-chlorobenzyl) -7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester, this compound has special properties and is stored in It is necessary to treat it with caution and follow the following conditions to ensure its quality.

First, temperature conditions
This compound is quite sensitive to temperature and should be stored in a cool place, preferably 2-8 ° C. If the temperature is too high, the molecular activity will be enhanced, which may cause adverse reactions such as decomposition or polymerization, causing its chemical structure to be damaged, and its efficacy or other properties will also be damaged. If the temperature is too low, although the molecular activity can be reduced, some solvents or ingredients may freeze, which also affects their stability. Therefore, precise control of temperature is the key to storage.

Second, humidity conditions
The ambient humidity should not be underestimated. It should be placed in a dry place with a relative humidity of 40% - 60%. If the humidity is too high, the compound may absorb moisture, causing deliquescence, and some active groups react with water, resulting in deterioration; if the humidity is too low, although there is no worry about water vapor, it may be too dry environment or cause some compounds containing crystal water to lose crystal water, changing its physical and chemical properties.

III. Lighting Conditions
Light can accelerate many chemical reactions, and this compound is no exception. It should be stored in a dark place, preferably in a brown bottle or opaque container. Under light, the compound molecules absorb light energy and transition to an excited state, which is more prone to photochemical reactions, resulting in structural changes and quality degradation.

IV. Packaging and Isolation Conditions
Select suitable packaging materials to ensure good sealing. Glass bottles can be lined with plastic film, or high-quality plastic bottles can be sealed and packaged. It is essential to isolate the air, because oxygen or other gas components in the air, or reactions with compounds such as oxidation, affect its stability. During storage, minimize the number of times the package is opened and reduce the chance of contact with the external environment.