1 Bromo 2 5 Difluoro 4 Iodobenzene
Iodobenzene

1 Bromo 2 5 Difluoro 4 Iodobenzene

Fengxi Chemical

Specifications

HS Code

327238

Name 1-bromo-2,5-difluoro-4-iodobenzene
Molecular Formula C6H2BrF2I
Molecular Weight 329.88
Appearance Typically a colorless to pale yellow liquid
Boiling Point Data may vary, around 210 - 230 °C
Solubility Sparingly soluble in water, soluble in organic solvents like dichloromethane
Vapor Pressure Low at room temperature
Name 1-bromo-2,5-difluoro-4-iodobenzene
Molecular Formula C6H2BrF2I
Molar Mass 327.885 g/mol
Appearance Typically a colorless to light - colored liquid or solid
Density Data depends on physical state and conditions
Solubility Soluble in organic solvents like dichloromethane, chloroform, etc., poorly soluble in water
Purity Can be of various purities depending on production method, e.g., 95%+, 98%+
Name 1-bromo-2,5-difluoro-4-iodobenzene
Molecular Formula C6H2BrF2I
Molecular Weight 327.88
Appearance Solid (Typical organic solid)
Solubility In Water Insoluble (organic halide, non - polar)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Hazard Irritant, harmful if swallowed, inhaled or in contact with skin due to halogen content
Chemical Formula C6H2BrF2I
Molar Mass 337.88 g/mol
Appearance Solid (presumably, based on similar haloarenes)
Solubility In Water Insoluble (non - polar due to hydrocarbon and halogen content)
Solubility In Organic Solvents Soluble in non - polar organic solvents like dichloromethane, chloroform
Vapor Pressure Low (due to its relatively high molar mass and solid nature)
Reactivity Reactive towards nucleophilic substitution reactions due to the presence of halogens
Packing & Storage
Packing 100g of 1 - bromo - 2,5 - difluoro - 4 - iodobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 2,5 - difluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and strong oxidizing agents. Store it in a tightly sealed container to prevent evaporation and exposure to moisture or air, which could potentially lead to degradation or chemical reactions. Label the storage container clearly with its name and relevant hazard information.
Shipping 1 - bromo - 2,5 - difluoro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and handling to prevent any risks during transit.
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1-bromo-2,5-difluoro-4-iodobenzene 1-bromo-2,5-difluoro-4-iodobenzene 1-bromo-2,5-difluoro-4-iodobenzene
General Information
Frequently Asked Questions
What is the main use of 1 - bromo - 2,5 - difluoro - 4 - iodobenzene
1-Bromo-2,5-difluoro-4-iodobenzene is also an organic compound. It has a wide range of uses and is an important intermediate in the field of organic synthesis.
First, it can be used as a key starting material when creating new drug molecules. The characteristics of halogen atoms in its structure enable chemists to skillfully transform it into various structural units with specific biological activities through various chemical reactions, such as nucleophilic substitution and coupling reactions. For example, nucleophilic substitution reactions with nucleophiles containing nitrogen, oxygen, or sulfur can form new carbon-heteroatom bonds, resulting in compounds with potential pharmacological activities, opening up new avenues for drug development.
Second, in the field of materials science, this compound also has wonderful uses. Through the polymerization or functionalization reactions it participates in, materials with special photoelectric properties can be prepared. For example, in the synthesis of organic semiconductor materials, the unique electronic and spatial effects of bromine, fluorine, and iodine atoms can be used to precisely regulate the molecular structure and electron cloud distribution of the materials, thereby optimizing the conductivity, fluorescence and other properties of the materials. It is expected to be applied to the manufacture of organic Light Emitting Diodes (OLEDs), organic solar cells and other devices.
Third, in the field of pesticide chemistry, 1-bromo-2,5-difluoro-4-iodobenzene can also be used as an important building block for the synthesis of new pesticides. Derivatives obtained after chemical modification may have an efficient control effect on specific pests and pathogens, and because of their unique structure, they may reduce their impact on the environment, meeting the needs of the development of green pesticides.
What are the physical properties of 1 - bromo - 2,5 - difluoro - 4 - iodobenzene
1-Bromo-2,5-difluoro-4-iodobenzene is a kind of organic compound. Its physical properties are very important, and it is related to its behavior in various chemical processes and applications.
First of all, its phase and appearance. Under normal temperature and pressure, 1-bromo-2,5-difluoro-4-iodobenzene is mostly in a liquid state, but it may vary depending on the surrounding environmental conditions. Its color is often nearly colorless to light yellow, and its appearance is clear and transparent. These characteristics can be known by direct observation with the naked eye and are the basis for preliminary identification.
times and melting point and boiling point. Melting point, the temperature at which a substance changes from solid to liquid state. The melting point of 1-bromo-2,5-difluoro-4-iodobenzene is within a certain range, although it varies slightly due to the precise determination method and the influence of impurities. The boiling point is the temperature at which the substance changes from liquid to gaseous state, and its boiling point also has a certain value. This property is of great significance in chemical operations such as distillation and separation. It helps to control the state transition of compounds for the purpose of purification or separation.
Furthermore, density. Density is the mass of a unit volume of a substance. The density of 1-bromo-2,5-difluoro-4-iodobenzene is greater than that of water, so if it coexists with water, it must sink underwater. This property is crucial in practical operations such as liquid-liquid separation, and suitable separation processes can be designed accordingly.
Solubility cannot be ignored either. In organic solvents, such as ethanol, ether, dichloromethane, etc., 1-bromo-2,5-difluoro-4-iodobenzene usually exhibits good solubility, due to the principle of "similar phase solubility", its organic structure is compatible with the intermolecular forces of organic solvents. In water, its solubility is very small, and this difference can be exploited in operations such as extraction to achieve extraction and purification of compounds.
In addition, 1-bromo-2,5-difluoro-4-iodobenzene is volatile and will slowly evaporate to the gas phase in an open environment. Although its vapor pressure is not high, under specific temperature and pressure conditions, it also affects its storage and use, and needs to be properly disposed of to prevent volatilization loss or cause safety problems.
The above are all important physical properties of 1-bromo-2,5-difluoro-4-iodobenzene, which are indispensable factors in chemical research, chemical production and related application fields.
What are the synthesis methods of 1 - bromo - 2,5 - difluoro - 4 - iodobenzene
The common methods for synthesizing 1-bromo-2,5-difluoro-4-iodobenzene are as follows.
One is the halogenation reaction path. A suitable benzene derivative can be taken first, and this derivative needs to contain a group that can be replaced by a halogen atom. Substitution reactions are carried out in sequence with specific halogenating reagents, such as reagents containing bromine, fluorine, and iodine. If the benzene derivative is reacted with a brominating reagent under appropriate conditions, this condition needs to consider the reaction temperature, solvent and other factors. The temperature may be controlled within a certain range, such as 0-50 degrees Celsius, and a suitable solvent, such as dichloromethane, is selected to replace the hydrogen atom at a specific position on the benzene ring with the bromine atom. Then, fluorine atoms and iodine atoms are introduced in sequence. Each step requires precise control of the reaction conditions to achieve the synthesis of the target product.
The second can be achieved by coupling reaction. First prepare benzene derivative fragments containing different halogen atoms, such as bromine-containing benzene derivatives and fluorine-containing and iodine-containing fragments. With the help of metal-catalyzed coupling reactions, such as palladium-catalyzed coupling reactions. Palladium catalysts, ligands, bases and other substances are added to the reaction system to couple different fragments. Among them, the choice of ligands is very critical, and different ligands have a significant impact on the reaction activity and selectivity. The type and dosage of bases also need to be considered. Common bases such as potassium carbonate, etc. By adjusting these reaction parameters, each fragment is coupled to form 1-bromo-2,5-difluoro-4-iodobenzene.
Third, a protective group strategy can also be considered for synthesis. First protect the specific position on the benzene ring to avoid unnecessary reactions. After that, bromine, fluorine, and iodine atoms are introduced in sequence. After the introduction of each halogen atom is completed, the protective group is removed to obtain the target product. In this process, the selection of the protective group and the control of the removal conditions are extremely important. It is necessary to ensure that the protective group is stable during the halogenation reaction and can be removed smoothly under suitable conditions.
1 - bromo - 2,5 - difluoro - 4 - iodobenzene in storage and transport what precautions
1-Bromo-2,5-difluoro-4-iodobenzene is a chemical commonly used in organic synthesis. When storing and transporting, be sure to pay attention to many things to avoid accidents that endanger safety and quality.
The first word for storage is that because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. This chemical is quite sensitive to temperature and humidity, and it is easy to deteriorate in a high temperature and humid environment. If the temperature is too high, it may cause chemical reactions that damage the structure of the substance; if the humidity is too high, it may make the substance absorb moisture and affect the purity. Therefore, the temperature of the warehouse should be controlled within a specific range, such as between 15 ° C and 25 ° C, and the relative humidity should also be maintained at 40% to 60%.
Furthermore, this chemical should be stored in isolation from oxidizing agents, reducing agents and active metals. Because of the halogen atoms in its structure, it is easy to react violently when encountering the above substances, and even cause fire or explosion. If it coexists with strong oxidizing agents, or triggers oxidation reactions, it is dangerous to cause combustion and explosion. Different chemicals should be stored in zones and clearly marked for identification and management.
The choice of storage container is also crucial. Use corrosion-resistant materials such as glass, certain plastic or metal containers, and ensure that the containers are well sealed. Although glass containers are transparent and easy to observe the internal conditions, they are fragile. Plastic containers are lightweight and impact-resistant, so chemical resistance must be considered. Metal containers are sturdy and durable, but attention should be paid to whether they will react with chemicals. The selected container must be able to withstand a certain pressure to prevent leakage due to changes in internal pressure.
As for transportation, it is necessary to follow relevant regulations and standards. Transportation vehicles should be equipped with necessary emergency equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools and personal protective equipment. During transportation, vibration, collision and friction should be avoided to prevent damage and leakage of the container. If transported by road, drivers and escorts must be professionally trained and familiar with the characteristics of the chemical and emergency response methods.
1-bromo-2,5-difluoro-4-iodobenzene has strict requirements on the environment, containers, and operating practices when it is stored and transported. Only by carefully following all points can we ensure the safety of its storage and transportation and avoid harm to people and the environment.
What is the market price range for 1 - bromo - 2,5 - difluoro - 4 - iodobenzene?
I think what you are asking is the market price range of 1-bromo-2,5-difluoro-4-iodobenzene. However, the price of this product is difficult to hide in one word.
The price of the cover often changes due to many factors. First, different manufacturers have different prices. Large factories may have lower costs due to economies of scale and sophisticated technology, and their prices may be relatively affordable; small factories may have higher prices due to less production and limited technology.
Second, the market supply and demand situation is also the key. If there are many applicants, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Third, the fluctuation of the price of raw materials also affects the price of this product. If the raw material is expensive and the cost increases, its price in the market will also increase; if the price of raw materials falls, its price may be reduced.
Fourth, transportation and storage conditions also affect the price. This product may require special conditions for transportation and storage. If so, the cost increases and the price is also affected by it.
As for the exact price range, it is difficult to give. To know the details, or to consult the chemical product trading platform, supplier, and carefully observe the market conditions, you can get a more accurate price range.