1 Bromo 2 Fluoro 4 Iodobenzene 98

1-Bromo-2-fluoro-4-iodobenzene, with a purity of 98% and 25%, its main uses are as follows.
In the field of organic synthesis, this compound is a key raw material. It often plays the role of the starting stone when building complex organic molecular structures. Because of the bromine, fluorine and iodine atoms it contains, each has unique reactivity and can participate in a variety of chemical reactions.
Bromine atoms can interact with many nucleophiles through nucleophilic substitution reactions. For example, when encountering nucleophiles containing hydroxyl and amino groups, new carbon-oxygen bonds or carbon-nitrogen bonds can be formed, thereby constructing more complex organic compound structures, which provides the possibility for the synthesis of new drug molecules in the field of medicinal chemistry. The introduction of
fluorine atoms has a profound impact on the properties of organic compounds. Its electronegativity is extremely high, which can change the electron cloud distribution of molecules, thereby improving the stability and biological activity of compounds. In pesticide synthesis, compounds with fluorine atoms often exhibit better insecticidal and bactericidal properties. 1-Bromo-2-fluoro-4-iodobenzene, as a fluorine-containing raw material, can be used to prepare such high-performance pesticides.
Iodine atoms also have unique reactivity. In metal-catalyzed coupling reactions, such as palladium-catalyzed coupling reactions, they can react with other organic halides or alkenyl groups, aryl boronic acids, etc., to realize the construction of carbon-carbon bonds, so as to synthesize organic materials with specific structures and functions. It also has important applications in the field of materials science.
Furthermore, in the process of drug development, 1-bromo-2-fluoro-4-iodobenzene can be used as the structural unit of lead compounds. Through subsequent chemical modification and derivatization, new drug molecules with better pharmacological activity and lower toxicity can be explored, which will contribute to the development of the pharmaceutical industry.

1-Bromo-2-fluoro-4-iodobenzene, this substance is used in the chemical industry, and its use is quite critical. It is often involved in various fields of organic synthesis, such as the creation of drugs, the synthesis of special materials, etc. Its 98% purity is priced in the market, which is difficult to hide. Due to many factors, its price is affected.
The first to bear the brunt is the cost of raw materials. To prepare 1-bromo-2-fluoro-4-iodobenzene, bromide, fluoride and iodide are required, and their prices fluctuate. If the supply of raw materials changes, or encounters natural and man-made disasters, policy regulation, and the price of raw materials rises, the cost of 1-bromo-2-fluoro-4-iodobenzene will also rise, and the market price will rise.
Furthermore, the difficulty of the production process is closely related to the cost. If the synthesis of this compound requires complicated steps, harsh reaction conditions, such as high temperature, high pressure, special catalysts, and the yield is not high, the energy consumption, equipment investment and time costs required for such production will increase greatly, and the market price will be high.
The market supply and demand situation is also a key factor in pricing. If many pharmaceutical companies or material manufacturers have strong demand for 1-bromo-2-fluoro-4-iodobenzene, but limited production and supply, according to the reason of supply and demand, the price will rise; on the contrary, if the demand is low and the supply is excessive, the price will fall.
In addition, regional differences also have an impact. In different places, the price will be different due to different transportation costs, tax policies, and market competition. In places with convenient transportation and chemical industry concentration, the price may be relatively easy due to low transportation costs and intense competition; while in remote places, the price may be higher due to high transportation costs and relatively closed markets.
Overall, the market price of 98% pure 1-bromo-2-fluoro-4-iodobenzene may range from tens to hundreds of yuan per gram, but this is only a rough estimate. The actual price needs to be determined according to the specific market conditions at that time.

1-Bromo-2-fluoro-4-iodobenzene is an important intermediate in organic synthesis and is widely used in many fields. The preparation of this compound usually requires careful planning of the synthesis route, and with suitable reaction and process conditions, high yield and purity can be achieved.
The first step is to introduce halogen atoms on the benzene ring by halogenation reaction. If benzene is used as the starting material and brominated, bromobenzene can be prepared. In this process, liquid bromine is often used as the brominating agent and iron tribromide as the catalyst. The chemical reaction formula is: $C_6H_6 + Br_2\ xrightarrow [] {FeBr_3} C_6H_5Br + HBr $. < Br >
In the second step, bromobenzene is fluorinated and fluorine atoms are introduced. This reaction may require specific fluorination reagents and reaction conditions. If a suitable nucleophilic fluorination reagent is selected and reacted in a suitable solvent and temperature, fluorine-containing benzene derivatives can be obtained.
In the last step, the iodization reaction is carried out for the benzene ring containing bromine and fluorine. The commonly used iodization reagents and reaction conditions need to be carefully selected to ensure the precise introduction of iodine atoms into the target position.
To achieve a high purity of more than 98%, the separation and purification operation after the reaction is crucial. Methods such as distillation, recrystallization, and column chromatography can be used to remove impurities and improve the purity of the product. The
distillation method is based on the difference in the boiling point of each substance to achieve the separation of the mixture. For compounds with significant differences in boiling points, distillation can effectively separate the target product. The
recrystallization method achieves the purpose of purification by selecting a suitable solvent, dissolving the product in a hot solvent, recrystallizing and precipitating after cooling, while the impurities are left in the mother liquor.
Column chromatography takes advantage of the different adsorption capacities of adsorbents for different compounds to achieve separation. The reaction mixture is loaded onto a chromatographic column filled with an adsorbent, eluted with a suitable eluent, and fractions containing the target product can be collected separately.
Through this series of synthesis and purification steps, 1-bromo-2-fluoro-4-iodobenzene with a purity of more than 98% can be obtained. In actual production, this process needs to consider many factors such as the control of reaction conditions, the cost and availability of raw materials, and the requirements of equipment, in order to achieve efficient and economical production.

1-Bromo-2-fluoro-4-iodobenzene, with a content of 98%, its storage conditions are very critical. This compound has special properties and needs to be properly stored to maintain its quality and stability.
It should be placed in a cool and well-ventilated place. Because a cool environment can slow down its chemical reaction rate. If it is in a high temperature environment, the molecular activity is enhanced, which is easy to cause adverse reactions such as decomposition and polymerization, resulting in lower purity. Well-ventilated can quickly disperse harmful gases that may be volatilized by compounds and ensure the safety of storage space.
Keep the storage place dry. 1-Bromo-2-fluoro-4-iodobenzene is prone to reactions such as hydrolysis when exposed to water. The presence of water will destroy its molecular structure and affect its chemical properties. Therefore, the storage environment should be avoided to be humid, and a desiccant can be used to assist in maintaining a dry state.
Furthermore, keep away from fire sources and oxidants. This compound may be flammable and prone to fire in case of fire sources; and oxidants can react violently with it, resulting in dangerous accidents. When storing, it should be isolated from fire sources, oxidants, etc., and a separate storage area should be set up.
Packaging should not be ignored, and a well-sealed container must be used. Sealed packaging can prevent the intrusion of external factors such as air and moisture, and maintain the purity and stability of the compound. Be sure to reseal after use to prevent external factors from affecting the remaining compound.
Store 1-bromo-2-fluoro-4-iodobenzene in a cool, ventilated, dry place, away from sources of ignition and oxidants, and in well-sealed packaging to ensure the quality and safety of the compound during storage.

1-Bromo-2-fluoro-4-iodobenzene, its 98% purity Quality Standard, has the following items:
Appearance, usually should be off-white to light yellow crystalline powder, pure in appearance, no visible impurities, this is the preliminary visual discrimination points. Because of the purity of the appearance, it is related to the purity of the product at the beginning.
Melting point, the melting point of this substance is roughly within a specific range. Accurate determination of the melting point can effectively identify its purity. If the melting point deviates from the normal range, or the melting range is too wide, it suggests that the product may be mixed with impurities, resulting in changes in its physical properties.
Content determination, using high performance liquid chromatography (HPLC) as a common method. A specific chromatographic column, such as a C18 column, is required to be suitable for mobile phase detection at a specific wavelength. The obtained peak area integral value is calculated to obtain the content of 1-bromo-2-fluoro-4-iodobenzene, which should reach more than 98%. This is a key quality index, which directly reflects the amount of main components of the product.
Impurity inspection, including the inspection of related substances. By HPLC method, in addition to detecting the main component peaks, it is necessary to pay attention to the number and area of other impurity peaks. The area of a single impurity peak shall not exceed a certain limit, and the area of the total impurity peak shall also be controlled within the specified range, in order to ensure that the impurity content in the product is extremely low and does not affect its subsequent use performance.
Moisture content, often determined by Karl Fischer method. Excessive moisture can cause chemical reactions in the product during storage and use, affecting stability and purity. Therefore, the moisture content should be controlled at a very low level, such as no more than a certain percentage.
Incinerating residue, take an appropriate amount of sample, after high temperature incineration, the quality of the residual residue should be below the specified limit. This indicator reflects the content of inorganic impurities in the product. If there is too much residue, it indicates that more inorganic impurities are mixed in the product, which affects the quality.
The above Quality Standards are interrelated to ensure that the quality requirements of 1-bromo-2-fluoro-4-iodobenzene with 98% purity can be used normally in scientific research, production and many other fields.