1 Bromo 3 Chloro 2 Iodo 5 Trifluoromethyl Benzene
Iodobenzene

1 Bromo 3 Chloro 2 Iodo 5 Trifluoromethyl Benzene

Fengxi Chemical

Specifications

HS Code

290336

Name 1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene
Molecular Formula C7H3BrClF3I
Molecular Weight 399.35
Appearance Typically a liquid or solid, color may vary
Boiling Point Dependent on purity, no standard value available
Solubility Soluble in organic solvents like dichloromethane, insoluble in water
Stability Stable under normal conditions, but reactive to strong oxidizing agents
Name 1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene
Molecular Formula C7H3BrClF3I
Molecular Weight 417.35
Appearance Solid (predicted)
Boiling Point 253.7°C at 760 mmHg (predicted)
Melting Point N/A
Density 2.332 g/cm³ (predicted)
Flash Point 107.2°C (predicted)
Water Solubility Insoluble
Vapor Pressure 0.0112 mmHg at 25°C (predicted)
Logp 5.69 (predicted)
Chemical Formula C7H3BrClF3I
Molecular Weight 391.35
Solubility In Water Low, as it is an organic halide with non - polar groups
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low, due to relatively high molecular weight
Stability Stable under normal conditions, but reactive towards strong nucleophiles and reducing agents
Packing & Storage
Packing 100g of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene in sealed glass vial.
Storage 1 - Bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions.
Shipping 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene is a hazardous chemical. It should be shipped in accordance with strict regulations, using appropriate containers to prevent leakage, and with clear hazard labels for safe transport.
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1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene 1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene 1-bromo-3-chloro-2-iodo-5-(trifluoromethyl)benzene
General Information
Frequently Asked Questions
What is the chemical structure of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene, its chemical structure is as follows. The benzene ring is a six-membered ring structure, composed of six carbon atoms connected to each other by covalent bonds, forming a planar hexagon. In the first position of the benzene ring, there is a bromine atom, and the bromine atom is a halogen element, which has a certain electronegativity. In the third position, there is a chlorine atom, which is also a halogen element. In the second position, an iodine atom is connected, and iodine is also a halogen element. The fifth position is connected with one (trifluoromethyl), and this (trifluoromethyl) is connected by one carbon atom and three fluorine atoms, and then connected to the benzene ring. The fluorine atom is extremely electronegative, making (trifluoromethyl) have a unique electronic effect. In this way, the chemical structure of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene is clearly presented, and each substituent is connected to the benzene ring according to its position. The presence of different halogen atoms and (trifluoromethyl) gives this compound unique physical and chemical properties.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene is also an organic compound. Its physical properties are particularly important, related to its use and reaction characteristics.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid, clear and transparent, with a special smell, but this smell does not have a unique identification, only slightly irritating, the smell can be known as a class of organic halides.
When it comes to the boiling point, at a higher temperature range, the intermolecular force between the halogen atom and the trifluoromethyl group in the molecule is enhanced, resulting in a higher boiling point than that of ordinary benzene derivatives. Due to the existence of the halogen atom and the trifluoromethyl group, the molecular polarity is increased, and the van der Waals force is enhanced.
In terms of melting point, it also varies due to the characteristics of the molecular structure, which is roughly in a certain low temperature range. At this temperature, the molecular arrangement changes from a disordered liquid state to an ordered solid state.
Solubility is also an important physical property. In organic solvents such as dichloromethane, chloroform, ether, etc., the compound has good solubility. Due to the principle of similarity and miscibility, its molecular structure is similar to that of organic solvents. However, in water, the solubility is extremely poor, because it is a non-polar organic molecule, and it is difficult to interact with polar water molecules.
The density is greater than that of water, because the weight of halogen atoms and trifluoromethyl atoms is larger, so that the molecular weight increases, causing its density to be higher than that of water. If mixed with water, it will sink to the bottom.
In addition, the refractive index of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene also has its specific value, which is related to the molecular structure and electron cloud distribution. It is one of the important physical constants in the identification and analysis of this compound.
In summary, the physical properties of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene, such as appearance, boiling point, melting point, solubility, density, and refractive index, are determined by its unique molecular structure, and are of great significance for its application and research in many fields such as organic synthesis and materials science.
What are the common synthesis methods of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is also an organic compound. Common synthesis methods include the following.
One is the halogenation reaction method. The benzene containing (trifluoromethyl) can be taken as the substrate first, and the halogenation reaction can be carried out in sequence with appropriate halogenating reagents, such as brominating agent, chlorinating agent and iodizing agent. Under suitable reaction conditions, such as temperature control, solvent selection and catalyst, the bromine, chlorine and iodine atoms can be introduced into the benzene ring at the desired position. For example, Lewis acid catalysts, such as aluminum trichloride, can be used to promote the reaction between halogenated reagents and substrates to achieve the synthesis of the target product.
The second is the coupling reaction method. Aromatic halides containing different halogen atoms and (trifluoromethyl) can be prepared first, and then coupling reactions catalyzed by transition metals, such as Suzuki coupling, Stille coupling, etc. Taking Suzuki coupling as an example, boric acid compounds need to be reacted with substrates containing halogen atoms in the presence of palladium catalysts and bases. Through the fine selection of substrates, catalysts, bases and reaction conditions, the parts are precisely coupled to obtain 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene.
The third is the method of substitution reaction. If there is a suitable benzene derivative containing (trifluoromethyl) and having a substitutable group, a halogen atom donor can be used to replace the original group with the desired bromine, chlorine and iodine atoms through nucleophilic substitution or electrophilic substitution. This also requires the selection of suitable reaction conditions to achieve good yield and selectivity.
The above methods each have their own strengths and weaknesses. In actual synthesis, the choice needs to be weighed against many factors such as the availability of substrates, the difficulty of reaction, cost and yield.
What are the applications of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene in organic synthesis?
1+-+bromo+-+3+-+chloro+-+2+-+iodo+-+5+-+%28trifluoromethyl%29benzene is 1-bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene, which is widely used in the field of organic synthesis.
First, it can be used as a key intermediate to prepare various fluorine-containing aromatic compounds. Fluorinated organic compounds have shown unique properties and wide applications in many fields such as medicine, pesticides, materials, etc. With the activity of halogen atoms in this compound, different functional groups can be introduced through nucleophilic substitution reactions, and then fluorine-containing aromatic derivatives with diverse structures can be constructed. For example, by reacting with nucleophiles containing amino groups, hydroxyl groups, etc., compounds with specific biological activities or material properties can be prepared.
Second, in the field of materials science, this compound can participate in the synthesis of functional polymer materials. By polymerizing with suitable monomers, the fluorine-containing aromatic structure is introduced into the main chain or side chain of the polymer, which can improve the thermal stability, chemical stability and surface properties of the polymer material. For example, when preparing high-performance engineering plastics, coatings or thin film materials, the introduction of this structural unit can endow the material with excellent weather resistance, chemical corrosion resistance and low surface energy.
Third, in pharmaceutical chemistry research, the compound can be used as an important building block for the optimization of lead compounds due to its halogen atom and trifluoromethyl. The strong electron absorption and unique three-dimensional effect of trifluoromethyl can significantly change the physicochemical properties and biological activities of drug molecules. Through structural modification and optimization, it is expected to discover new drug molecules with higher activity, selectivity and pharmacokinetic properties.
Fourth, in the research and development of pesticides, fluorinated aromatic compounds often have the advantages of high efficiency, low toxicity and environmental friendliness. Pesticides synthesized from 1-bromo-3-chloro-2-iodine-5 - (trifluoromethyl) benzene through a series of reactions may exhibit excellent control effects on specific pests and diseases, while reducing the impact on the environment and non-target organisms.
What are the storage conditions for 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene is an organic compound, and its storage conditions are very important, which is related to the stability and safety of this substance.
This substance should be placed in a cool and well-ventilated place. Covering a cool environment can slow down the chemical reaction rate caused by high temperature and prevent it from decomposing or deteriorating. Well-ventilated, it can disperse volatile components that may escape in time to prevent them from accumulating in a limited space and causing danger.
Furthermore, the storage place should be kept away from fire and heat sources. Many of these compounds are flammable or prone to violent reactions in contact with fire and heat, so it is essential to avoid fire and heat sources to ensure safety.
This substance must also be stored in isolation from oxidizing agents, active metal powders, etc. The edge oxidizing agent has strong oxidizing properties, and the active metal powder has high activity. It can chemically react with 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene, causing fires, explosions and other disasters.
Storage containers must also be carefully selected to ensure that they are well sealed to prevent leakage. Corrosive-resistant materials should be used because of the chemical properties of the compound or the effect of erosion on ordinary materials.
When handling this item, it should also be handled with care to prevent leakage due to damage to the container. Workers must wear appropriate protective equipment, such as protective gloves, goggles, etc., to avoid contact with the body.
In short, 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene should be stored in a cool and ventilated environment, away from heat, isolated storage, sealed containers, and careful handling conditions to ensure its safety and stability.