1 Bromo 3 Chloro 5 Iodobenzene
Iodobenzene

1-Bromo-3-Chloro-5-Iodobenzene

Fengxi Chemical

    Specifications

    HS Code

    116747

    Chemical Formula C6H3BrClI
    Molecular Weight 336.35
    Appearance Solid (Typical)
    Color Off - white to light yellow
    Odor Characteristic organic odor
    Melting Point 104 - 106 °C
    Boiling Point Around 300 °C (estimated, decomposes before boiling in normal conditions)
    Density 2.55 g/cm³ (estimated)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform

    As an accredited 1-Bromo-3-Chloro-5-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 1 - bromo - 3 - chloro - 5 - iodobenzene packaged in a sealed glass bottle.
    Storage 1 - Bromo - 3 - chloro - 5 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent vapor leakage. As it is a potentially hazardous chemical, store it separately from oxidizing agents, reducing agents, and reactive compounds to avoid chemical reactions.
    Shipping 1 - Bromo - 3 - chloro - 5 - iodobenzene is shipped in sealed, corrosion - resistant containers. These are carefully packed to prevent breakage during transit. Shipments follow strict chemical transportation regulations to ensure safety.
    Free Quote

    Competitive 1-Bromo-3-Chloro-5-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@bouling-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: sales7@bouling-chem.com

    1-Bromo-3-Chloro-5-Iodobenzene
    General Information
    Historical Development
    In the realm of chemistry, there is a name 1 - Bromo - 3 - Chloro - 5 - Iodobenzene. At the beginning, scholars study, seeking truth in the smallest places. At the beginning, explore its nature, such as walking at night to find a path, step by step hard.
    In the past, all the sages worked hard to observe the change of its reaction, or to study the beauty of its structure. Gradually clear from ignorance, from shallow to profound. After going through cold and heat, I can understand its reason, and know that it can be used in synthesizing things.
    Observe its development, from nothing to something, from simple to complex. The attempts of the past are all cornerstones, the soil is tired into a platform, and the sand is gathered into a tower. So today, this compound has its uses in medicine and materials industries, and can help everyone achieve innovation, benefit the country and prosper the country, and make great contributions. This is the work of the predecessors, and future generations should follow their ambitions and carry forward their industries, so that the brilliance of chemistry can shine everywhere.
    Product Overview
    1 - Bromo-3 - Chloro-5 - Iodobenzene is also a genus of organohalogenated aromatics. In its molecular structure, on the benzene ring, bromine, chlorine and iodine trihalogen atoms are arranged in an orderly manner.
    This compound has unique physical and chemical properties. The appearance is often colorless to light yellow liquid, with certain volatility. Its physical constants such as boiling point and melting point are determined by the interaction between atoms in the molecule. Due to the difference in electronegativity of halogen atoms, molecular polarity appears, and it has good solubility in organic solvents.
    In the field of chemical synthesis, 1 - Bromo-3 - Chloro-5 - Iodobenzene has a wide range of uses. Due to the different activities of halogen atoms, it can selectively initiate nucleophilic substitution, coupling and other reactions according to different reaction conditions, and is an important intermediate for the synthesis of complex organic compounds.
    However, the preparation of this compound requires a fine method. Benzene is often used as the starting material and obtained by a series of reactions such as halogenation. In the reaction, the control of conditions is crucial, and it is related to the purity and yield of the product.
    Concept 1 - Bromo - 3 - Chloro - 5 - Iodobenzene, although it is the quality of organic microparticles, it is of indispensable value in the process of chemical synthesis.
    Physical & Chemical Properties
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is an organic compound, and its physicochemical properties are very important. This compound has certain physical properties. At room temperature, or in a solid state, it has a specific melting point and boiling point. Due to the existence of halogen atoms such as bromine, chlorine, and iodine in the molecule, it has a certain polarity, which affects its solubility in different solvents.
    When it comes to chemical properties, due to the activity of halogen atoms, it can participate in many chemical reactions. For example, nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents to form new compounds. Its reactivity varies depending on the type of halogen atoms, and iodine atoms are relatively active and easy to leave to participate in the reaction. In addition, the compound may also participate in some reactions involving benzene rings, such as aromatic electrophilic substitution reactions. Due to the electron cloud structure of the benzene ring, it can react with electrophilic reagents under appropriate conditions. In-depth investigation of the physicochemical properties of 1-Bromo-3-Chloro-5-Iodobenzene will help to expand the field of organic synthetic chemistry and provide a basis for the creation of new compounds.
    Technical Specifications & Labeling
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is an important chemical product. Its technical specifications and labeling (product parameters) are related to many key elements.
    When it comes to technical specifications, this compound needs to meet very high purity standards, and the impurity content should be strictly controlled at very low levels. Its physical properties, such as melting point, boiling point and other parameters, must meet specific ranges to ensure stable quality. And its chemical structure needs to be accurate, and the bonding and spatial arrangement between atoms must conform to established specifications.
    As for the label (product parameters), the name and chemical formula should be clearly marked on the packaging so that the user can see it at a glance. At the same time, the identification of its hazardous characteristics is also indispensable, such as whether it is toxic, corrosive, etc., so that users can properly dispose of and protect it. In this way, 1-Bromo-3-Chloro-5-Iodobenzene can ensure the safety and efficiency of production and use.
    Preparation Method
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is an important organic compound. The preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
    Raw material selection, when using benzene and related halogenation reagents. First use benzene as a base, use a specific halogenating agent, and mix it in an appropriate proportion. For bromination, choose liquid bromine and a suitable catalyst to make the bromine atom fit into the designated position of the benzene ring. For chlorination and iodization steps, precisely control the amount of reagent, reaction temperature and time in each step.
    Reaction step, the first step is bromination, in a specific reaction vessel, adjust the temperature to an appropriate range, add liquid bromine and catalyst under stirring, so that the bromine and the benzene ring are electrophilically substituted to obtain a bromine-containing intermediate. In the second step of chlorination, a chlorination reagent is added in sequence, the temperature is controlled to promote the reaction, and chlorine atoms are introduced into the benzene ring. In the last step of iodization, similar operations, iodine atoms are introduced, and the final product is 1-Bromo-3-Chloro-5-Iodobenzene.
    Catalytic mechanism, suitable catalysts are required for each halogenation step. Bromination or iron filings or iron tribromide, which helps the polarization of bromine molecules, enhances the activity of bromine Chlorination and iodization also have corresponding catalysts, which reduce the activation energy of the reaction, improve the reaction rate and product selectivity. In this way, through fine regulation of raw materials, steps and catalysis, 1-Bromo-3-Chloro-5-Iodobenzene can be efficiently prepared.
    Chemical Reactions & Modifications
    The chemical reaction and modification of 1 - Bromo - 3 - Chloro - 5 - Iodobenzene are studied. This compound, bromine, chlorine and iodine co-attach to the benzene ring, and its unique properties and multi-terminal reactions are worth studying.
    Looking at the reaction, the halogenated benzene ring can be replaced by nucleophilic substitution. Nucleophilic reagents attack it, and halogen atoms are easily replaced, resulting in new structures. However, its activity varies depending on the halogen atoms. Iodine has the highest activity, followed by bromine and chlorine. This difference is due to the electron cloud density and bond energy of the atoms.
    To modify this compound, a group can be added to the benzene ring. Such as arylation reaction with specific reagents, increase its functional groups, change its physical and chemical properties. Or adjust the reaction conditions, temperature, solvent, catalyst, etc., control the direction and rate of the reaction, and obtain the desired product.
    In summary, the chemical reaction and modification of 1 - Bromo - 3 - Chloro - 5 - Iodobenzene contain many mysteries, which need to be explored in depth by our generation, so as to clarify the reason and open up new ways for chemical applications.
    Synonyms & Product Names
    I have heard of a thing, named 1 - Bromo - 3 - Chloro - 5 - Iodobenzene. Although its name is complex, it is crucial in the course of my chemical inquiry. The synonyms and trade names of this substance are also deeply investigated by us.
    If it is synonymous, it refers to those who have the same meaning but different words. In the field of chemistry, the same substance often has multiple names due to differences in regions and habits. As for the trade name, it is the name given by the merchant for its product, hoping to recognize its characteristics and attract customers' attention.
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene, or another name, because of its complex chemical structure, chemists of different schools and countries may have different names. These synonyms are all important for academic communication. And the trade name, or according to its use and quality, is important for the market. We chemists, should study the synonyms and trade names of this thing in detail, in order to clarify its position in the academic world and the market, to promote the progress of chemical research and the prosperity of the industry.
    Safety & Operational Standards
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is an important chemical compound. During its experimental operation and safe production process, strict adherence to safety and operating standards is the top priority.
    Anyone involved in 1 - Bromo - 3 - Chloro - 5 - Iodobenzene should first be familiar with the characteristics of various chemical reagents. The related reagents of bromine, chlorine, iodine and other elements involved in this compound are mostly corrosive, toxic or irritating. When taking it, be sure to wear protective clothing, including but not limited to laboratory clothes, protective gloves and goggles, to prevent the reagents from coming into contact with the skin and eyes, causing burns or poisoning.
    The experimental site must be well ventilated and equipped with effective ventilation equipment to expel harmful gases that may be generated during the experimental process in time to avoid the accumulation of harmful gases and endanger the health of the experimental personnel. When operating the synthesis reaction of 1-Bromo-3-Chloro-5-Iodobenzene, the reaction conditions should be precisely controlled, such as temperature, pressure and reaction time. Due to improper reaction conditions, it is very likely to cause the reaction to go out of control and lead to dangerous accidents.
    There are also strict requirements for storing 1-Bromo-3-Chloro-5-Iodobenzene. Store in a cool, dry and ventilated place, away from ignition and oxidants. At the same time, it needs to be stored separately from other chemicals to prevent mutual reaction. The storage container must be well sealed to prevent leakage.
    In the unfortunate event of 1-Bromo-3-Chloro-5-Iodobenzene leakage, emergency plans should be activated immediately. Evacuate unrelated personnel and isolate the leakage area. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the event of a large amount of leakage, it is necessary to build a dike or dig a pit for containment, and transfer it to a special collection container with an explosion-proof pump for proper disposal.
    Waste from 1 - Bromo - 3 - Chloro - 5 - Iodobenzene should not be discarded at will. It should be collected and treated in accordance with relevant environmental regulations to reduce environmental pollution. Only in this way can the work related to 1 - Bromo - 3 - Chloro - 5 - Iodobenzene be carried out in a safe and orderly manner.
    Application Area
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is a special chemical substance. It exhibits unique efficacy in many application fields.
    In the field of pharmaceutical research and development, this compound can be used as a key intermediate. Due to its unique structure, it can be combined with other substances through specific chemical reactions to construct molecular structures with specific pharmacological activities and assist in the creation of new drugs.
    It also has important uses in the field of materials science. By participating in polymerization reactions or other material synthesis processes, materials can be endowed with special electrical, optical or mechanical properties, such as improving the conductivity of materials and enhancing the stability of materials, which contribute to the research and development of high-performance materials.
    Furthermore, on the stage of organic synthetic chemistry, 1 - Bromo - 3 - Chloro - 5 - Iodobenzene can act as a reaction substrate and participate in various nucleophilic substitution, coupling reactions, etc., to help synthesize many complex and valuable organic compounds, and promote the progress of organic synthetic chemistry.
    Research & Development
    In recent years, I have focused on the research of 1 - Bromo - 3 - Chloro - 5 - Iodobenzene. At the beginning, the method of its synthesis was full of thorns. The choice of raw materials, the precision of the ratio, and the temperature of the reaction all need to be considered carefully.
    In order to obtain a pure product, I have tasted all kinds of paths. Or change the reaction agent, or adjust the reaction, although I often encounter delays, I do not dare to give up lightly. Every little progress is regarded as the most precious.
    After months of research, I have gradually achieved success. The method of synthesis tends to be stable and good. The quality of the product is also getting better day by day. This is not my work alone, but depends on my colleagues to overcome difficulties together.
    Looking at this product today, the prospect is promising. In the field of medicine, it can be used as a key intermediate to help the research and development of new agents; in the field of materials, it can add other properties and expand the boundaries of application. We should be diligent and hope to be able to go to the next level, make it more beneficial, and add brilliance to the academic community.
    Toxicity Research
    With today's chemical techniques, we can explore the toxicity of various substances, which is related to people's health and environmental safety. Today there is a substance called 1-Bromo-3-Chloro-5-Iodobenzene, and our generation should carefully investigate its toxicity.
    This substance contains bromine, chlorine, and iodine elements, and its structure is unique. Considering previous studies, halogenated aromatics are mostly toxic. To determine the toxicity geometry of 1-Bromo-3-Chloro-5-Iodobenzene, multiple methods are needed.
    First, cell experiments can be used to observe its impact on the growth and metabolism of various cells. Observe changes in cell morphology and measure the ratio of proliferation rate and apoptosis to see the signs of toxicity. Second, animal experiments are used to observe the differences in animal physiology, organ morphology and function after ingestion or exposure.
    However, toxicity research is not achieved overnight, and repeated experiments and rigorous demonstrations are required. And the experimental results still need to take into account changes in environmental factors. In this way, the toxicity of 1-Bromo-3-Chloro-5-Iodobenzene can be known. When it is used by the world, it is necessary to anticipate its harm and avoid its risk, so as to achieve the chemical benefit of human beings.
    Future Prospects
    1 - Bromo - 3 - Chloro - 5 - Iodobenzene is also a chemical substance. Today, this compound has the characteristics of bromine, chlorine, and iodine atoms above benzene.
    The future prospects lie in its synthesis method. It is hoped that it can be made easier, more efficient and more reliable, with less side effects, and improve its efficiency. In addition, it may be of great use in the field. It can be used as a medium for synthesizing special effects and treating general diseases.
    In the field of materials, it can also be used. Or it can be repaired to obtain materials with special properties, such as materials and light materials. The unremitting research of the researchers will surely enable this compound to be widely used and benefit the world.
    Where to Buy 1-Bromo-3-Chloro-5-Iodobenzene in China?
    As a trusted 1-Bromo-3-Chloro-5-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-3-Chloro-5-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of 1 - bromo - 3 - chloro - 5 - iodobenzene?
    1 + -Bromo-3 + -chloro-5 + -iodobenzene is also an organic compound. In its molecular structure, the benzene ring is a six-membered carbon ring with a conjugated unsaturated system, which is extremely stable. Above the benzene ring, at positions 1, 3, and 5, are connected with bromine (Br), chlorine (Cl), and iodine (I) halogen atoms, respectively.
    The carbon atoms of the benzene ring are bonded with sp ² hybrid orbitals, forming a sigma bond with each other to construct a six-membered ring plane structure. At the same time, the remaining p orbitals of each carbon atom are parallel to each other and overlap on the side, forming delocalized π bonds, which are spread over the upper and lower sides of the benzene ring. This unique conjugate structure endows < Br >
    The halogen atom attached to the benzene ring has a larger electronegativity than carbon, so when bonding with the benzene ring, it presents an electron-absorbing induction effect. Therefore, the electron cloud density of the benzene ring in this compound decreases due to the action of halogen atoms. The change of the electron cloud density has a great impact on its chemical activity, making its electrophilic substitution reaction less active than benzene, and the halogen atom is the neighbor and para-site locator. In the electrophilic substitution reaction, the newly introduced group mostly enters the neighbor and para-site of the halogen atom. The structure of 1 + -bromo-3 + -chloro-5 + -iodobenzene exhibits unique physical and chemical properties due to the interaction between the benzene ring and the halogen atom, and is of great research and application value in organic synthesis and related fields.
    What are the physical properties of 1 - bromo - 3 - chloro - 5 - iodobenzene?
    1-Bromo-3-chloro-5-iodobenzene is one of the organic compounds. Its physical properties are worth exploring.
    When it comes to appearance, 1-bromo-3-chloro-5-iodobenzene is often colorless to pale yellow liquid or crystalline. The formation of this state is related to its molecular structure. The presence of halogen atoms such as bromine, chlorine, and iodine in the molecule affects the intermolecular forces, causing it to appear in this form under normal temperature and pressure.
    Its melting point and boiling point are also important physical properties. The melting point is related to the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1-bromo-3-chloro-5-iodobenzene has a specific value due to the relative position of halogen atoms and electronic effects. The boiling point reflects the difficulty of changing a substance from a liquid to a gaseous state. The compound has a certain van der Waals force between molecules, and the increase of halogen atoms changes the polarity of the molecule, and the boiling point also has corresponding characteristics. The electronegativity difference of halogen atoms enhances the intermolecular force, so the boiling point increases.
    In terms of solubility, 1-bromo-3-chloro-5-iodobenzene has good solubility in organic solvents such as dichloromethane, chloroform, ether, etc. Due to the principle of "similar miscibility", the non-polar structure of the compound is compatible with the non-polar structure of the organic solvent. However, in water, because it is a non-polar molecule, the force between it and the water molecule is weak, so it is difficult to dissolve.
    In terms of density, the density of 1-bromo-3-chloro-5-iodobenzene is greater than that of water. This is because the relative atomic weight of bromine, chlorine, and iodine atoms is large, resulting in an increase in molecular weight, an increase in mass per unit volume, and the density is therefore greater than that of water. This property is important in operations such as liquid-liquid separation.
    To sum up, the physical properties of 1-bromo-3-chloro-5-iodobenzene, such as appearance, melting point, solubility, density, etc., are all affected by the type, number and location of halogen atoms in its molecular structure. It plays an important role in the research and practice of organic chemistry.
    What are the common synthesis methods of 1 - bromo - 3 - chloro - 5 - iodobenzene?
    The common synthesis methods of 1-bromo-3-chloro-5-iodobenzene are as follows.
    One is halogenation. With benzene as the initial raw material, bromine atoms are introduced into the benzene ring through bromination. This process requires iron or iron tribromide as a catalyst. At a suitable temperature, benzene reacts with bromine elemental substance to form bromobenzene. Then, the bromobenzene is chlorinated, and a suitable chlorination agent, such as chlorine gas, can be selected. Also under the action of the catalyst, chlorine atoms can be introduced at specific positions in the benzene ring. Finally, an iodization reaction is carried out. Commonly used iodizing reagents such as iodine interact with suitable oxidants to introduce iodine atoms at designated positions in the benzene ring, and 1-bromo-3-chloro-5-iodobenzene is prepared by multi-step reaction.
    The second is the cross-coupling reaction with the help of aryl halides. First, an aryl halide containing one of bromine, chlorine, and iodine is prepared, such as a bromine-containing aryl halide. Then, through a palladium-catalyzed cross-coupling reaction, such as reacting with chlorine-containing borate esters or chlorine-containing halides in the presence of palladium catalysts, ligands, and bases, a carbon-carbon bond is formed, and chlorine atoms After that, using a similar method, iodine atoms are introduced through suitable coupling reactions, and the reaction sequence and conditions are ingeniously designed to synthesize the target product.
    The third is to start with benzene derivatives with substituents. If the starting benzene ring already has some groups that can be converted into bromine, chlorine, and iodine, these groups are gradually converted into corresponding halogen atoms through a specific conversion reaction. For example, some functional groups containing halogen atoms can be replaced. Under suitable reagents and conditions, the substitution reaction is carried out in sequence, and the reaction check point and sequence are precisely controlled, and finally the synthesis of 1-bromo-3-chloro-5-iodobenzene is achieved. These methods need to carefully plan the reaction path and conditions according to the characteristics of the starting material in order to effectively produce the target product.
    What are the applications of 1 - bromo - 3 - chloro - 5 - iodobenzene in organic synthesis?
    1 + -Bromo-3 + -chloro-5 + -iodobenzene is widely used in organic synthesis. It can be used as a key intermediate to participate in a variety of reactions to construct complex organic molecules.
    First, in the nucleophilic substitution reaction, the halogen atoms on the benzene ring of the compound have different activities and can react with many nucleophilic reagents. Iodine atoms have high activity and are easily replaced by nucleophilic reagents. If they interact with nucleophilic reagents such as alkoxides and thiols, they can form new carbon-oxygen and carbon-sulfur bonds, which is very critical in the synthesis of compounds containing specific functional groups.
    Furthermore, this substance is often used in coupling reactions. Taking the coupling reaction catalyzed by palladium as an example, 1 + -bromo-3 + -chloro-5 + -iodobenzene can be coupled with arylboronic acid, alkenyl halide, etc. to form carbon-carbon bonds, thereby expanding the molecular framework. In the fields of pharmaceutical chemistry and materials science, compounds with specific structures and properties are often synthesized by this method.
    In addition, in the metal-catalyzed reduction reaction, the halogen atoms in 1 + -bromo-3 + -chloro-5 + -iodobenzene can be gradually reduced and removed. According to the different reaction conditions and the selected catalyst, the selectivity of dehalogenation can be precisely controlled, providing an effective path for the synthesis of benzene derivatives with specific halogenation degrees.
    In conclusion, 1 + -bromo-3 + -chloro-5 + -iodobenzene has a unique structure and different halogen atom activities. It has important applications in many fields of organic synthesis and helps to synthesize various organic compounds with specific functions.
    What are the storage conditions for 1 - bromo - 3 - chloro - 5 - iodobenzene?
    1 + -Bromo-3-chloro-5-iodobenzene is also an organic compound. Its storage conditions are crucial and related to the stability and safety of this substance.
    Fu 1 + -bromo-3-chloro-5-iodobenzene is afraid of light and heat. Therefore, it is best to store it in a dark place, away from direct sunlight. Sunlight can cause its chemical reaction, causing changes in its composition and damaging its quality. And high temperature is not suitable. Under high temperature, molecular movement intensifies, or decomposition and polymerization change. Therefore, when choosing a cool place, the temperature should not exceed 25 ° C.
    Furthermore, this thing needs to be sealed and stored. In the air, there are oxygen, water vapor and other substances. Oxygen can cause oxidation, water vapor or hydrolysis. A sealed device, such as a glass bottle, is equipped with a tight plug to prevent air invasion and keep it pure.
    Also, 1 + -bromo-3-chloro-5-iodobenzene coexists with other things, and attention should also be paid. Do not store with strong oxidants, strong bases, etc. Strong oxidants can promote oxidation, strong bases or cause their hydrolysis, which are harmful to this product. Keep away from mutually exclusive things and store them separately. < Br >
    In the place of storage, there should also be a clear label stating the name, characteristics and precautions of the product. And check it often to see if it has any leakage or deterioration. If there is any abnormality, dispose of it as soon as possible to prevent problems before they occur. In this way, 1 + -bromo-3-chloro-5-iodobenzene must be properly stored to ensure its availability.