1-Bromo-3-Fluoro-2-Iodobenzene

Fengxi Chemical

Specifications

HS Code	995464
Chemical Formula	C6H3BrFI
Molecular Weight	303.897 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Around 230 - 235 °C
Density	Approx. 2.2 - 2.3 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure	Low at room temperature

As an accredited 1-Bromo-3-Fluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - bromo - 3 - fluoro - 2 - iodobenzene packaged in a sealed glass bottle.
Storage	1 - bromo - 3 - fluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of glass or a compatible plastic, to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions.
Shipping	1 - bromo - 3 - fluoro - 2 - iodobenzene is a chemical. Shipping should be in accordance with hazardous material regulations. It must be properly packaged in leak - proof containers, labeled clearly, and transported by approved carriers to ensure safety during transit.

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General Information

Historical Development

1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is also an organic compound. The process of its research and development is related to the evolution of chemical technology. In the past, chemists worked diligently on the way of organic synthesis. At first, only the properties and combinations of common compounds were known. However, the heart of seeking knowledge was not gone, so I explored the system of complex substances.
and a deeper solution to halogenated aromatics, involving such compounds containing polyhalides. Early attempts, often encountered many difficulties, the reaction conditions were difficult to control, and the yield was low. However, chemists were unyielding, and after repeated trial and error, the method was improved. Over time, the technology gradually refined, and the understanding of the reaction mechanism deepened. The development of 1-Bromo-3-Fluoro-2-Iodobenzene is a good example of the pursuit of truth and continuous breakthroughs in the history of chemistry.

Product Overview

There is a substance named 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. Its shape is also an organohalogenated aromatic hydrocarbon. Looking at its structure, on the benzene ring, the three atoms of bromine, fluorine and iodine are arranged in an orderly manner.
This compound is quite useful in the field of organic synthesis. Bromine atoms are quite active, and can introduce various functional groups due to nucleophilic substitution reactions, paving the way for the creation of new substances. Although fluorine atoms are small, they can significantly modify the physical and chemical properties of molecules, such as improving fat solubility and enhancing stability. Iodine atoms, due to their large size and polarizability, are often key players in coupling reactions, contributing to the construction of carbon-carbon bonds.
Synthesis of this product requires careful study of the reaction conditions, temperature control, and agent selection must be accurate. Improper operation can easily lead to side reactions due to the different activities of each halogen atom. During preparation, safety should also be paid attention to. Many halides are toxic and corrosive, and protection measures should not be ignored. In short, 1-Bromo-3-Fluoro-2-Iodobenzene is an indispensable raw material for the research and production of organic chemistry.

Physical & Chemical Properties

1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state, with a specific color, taste and phase state. Its boiling point and melting point are related to its morphological transformation at different temperatures, which is of great significance for separation and purification.
Regarding chemical properties, it has the typical reactivity of halogenated aromatics because it contains halogen atoms of bromine, fluorine and iodine. Nucleophilic substitution reactions can occur, and halogen atoms can be replaced by other nucleophilic groups, which are widely used in organic synthesis. The conjugate structure of benzene ring endows it with certain stability and electron cloud distribution characteristics, which affect its chemical reactivity and selectivity. The physicochemical properties of this compound lay the foundation for its application in organic synthesis, materials science and other fields.

Technical Specifications & Labeling

1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is an important compound. Its technical specifications and labeling (product parameters) are very important. The purity of this compound needs to reach a very high standard, and the impurity content must be strictly controlled. The appearance should be in a specific form, and the color must also comply with the regulations.
For labeling, key information such as name, chemical formula, molecular weight should be clearly marked on the packaging. Storage conditions are also clearly required. It should be placed in a dry, cool place, away from fire sources and oxidants. During transportation, specific rules must also be followed to prevent accidents. Only in this way can we ensure that 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene can be used safely and effectively in all aspects and play its due role.

Preparation Method

Now I want to make 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. The choice of raw materials needs to be carefully selected. The compound containing benzene ring can be taken first, supplemented by reagents containing bromine, fluorine and iodine. The production process first reacts the benzene ring with the bromine-containing reagent according to a specific method, controls its temperature and time, and makes the bromine atom just fit into the designated position of the benzene ring.
Then, fluorine atoms and iodine atoms are introduced in sequence. The reaction steps should be rigorous, and the product of each step must be carefully separated and purified to maintain purity. Its catalytic mechanism, when finding a suitable catalyst, promotes the reaction to proceed efficiently, reducing energy consumption and yield. So, according to this method of preparing 1-Bromo-3-Fluoro-2-Iodobenzene, a pure product may be obtained, which lays the foundation for subsequent research and application.

Chemical Reactions & Modifications

Recently, the chemical changes of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene were studied in the room. This compound has a unique structure and a variety of reactions.
At first, the reaction was promoted according to the conventional method, but the results did not meet expectations. Its chemical activity is different from that of normal substances, and many reaction pathways are blocked.
So we thought about changes and explored its characteristics. Detailed observation of its structure shows that the dislocation of halogen atoms and electronic effects have a great influence.
After adjusting the reaction conditions, changing the temperature and changing the solvent, in order to improve. In higher temperature and polar solvents, the reaction activity gradually becomes apparent.
Finally, the revelation is that chemical things cannot be bound by ordinary laws. If you want to change it, you must study its nature carefully and take advantage of the situation to obtain the ideal results. The same is true for the research on 1-Bromo-3-Fluoro-2-Iodobenzene.

Synonyms & Product Names

Today there is a thing called 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. In the field of our chemical research, this thing has various synonymous names and commodity names.
The names of synonyms are all based on the rules of chemical naming, from different perspectives and according to different criteria. Or according to atomic positions, or according to the order of functional groups, although the names are different, they actually refer to the same thing.
As for the name of the commodity, it is ordered by the merchant when it is in circulation. Because of the needs of the market and the convenience of marketing, various easy-to-remember and unique names are taken to recognize its characteristics or clarify its use.
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, its synonymous names and commodity names, although diverse, are all signs of our chemical research, research and development, and application, helping us to accurately identify objects and communicate efficiently. It is indispensable in the process of chemical inquiry.

Safety & Operational Standards

1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is an important chemical substance. During its experimental operation and safe production, it is essential to strictly adhere to safety and operating practices.
This substance has certain chemical activity and should be stored in a dry, cool and well-ventilated place. Be sure to keep away from fire, heat and strong oxidants to prevent accidental chemical reactions. Packaging should be tight to avoid leakage.
When operating, the experimenter must wear appropriate protective equipment, such as protective gloves, goggles and lab clothes, to prevent the substance from contacting the skin and eyes. Operate in a fume hood to ensure air circulation and reduce the accumulation of harmful gases.
If you accidentally come into contact with this substance, if it comes into contact with the skin, you should immediately rinse with a large amount of water, and then seek medical attention according to the specific situation; if it splashes into the eyes, you need to immediately rinse the eyes with flowing water, and quickly go to the hospital for treatment.
When using this substance for reaction, you should accurately control the reaction conditions, such as temperature, pressure, and the proportion of reactants. Strictly follow the established reaction process and operating procedures, and do not change it without authorization. After the reaction is completed, the waste should be properly disposed of, classified, collected and disposed of in accordance with relevant environmental protection regulations, and must not be discarded at will to avoid pollution to the environment.
In conclusion, the safe and standard operation of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is not only related to the safety of the experimental personnel, but also important for environmental protection and the accuracy of the experimental results. It is necessary to exercise caution at all times and strictly abide by all safety and operating practices.

Application Area

1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is a unique chemical substance with a wide range of application fields. In the field of organic synthesis, this compound can be called a key intermediate. Due to its unique structure, bromine, fluorine and iodine atoms endow it with special reactivity and can participate in various chemical reactions.
In the field of drug research and development, with its special activity, it can be chemically transformed to construct molecular structures with specific pharmacological activities, helping to create new drugs. In material science, it can be integrated into polymer materials through chemical reactions, thereby endowing materials with unique electrical and optical properties and expanding the application range of materials. Furthermore, in the field of fine chemicals, it can carry out a series of derivatization reactions to prepare high-value-added fine chemicals to meet different industrial needs, which is actually a compound of great value in many application fields.

Research & Development

Yu Taste is dedicated to the research of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. This material property is unique and has great potential in the field of organic synthesis.
At the beginning, the preparation method was explored. After many attempts, the influence of different reaction conditions was observed. With a specific halogenated reagent, adjust the ratio, temperature and time to get a high-purity product. In the process, many obstacles were encountered, such as the disturbance of side reactions and the difficulty of product separation. However, perseverance, after repeated optimization, gradually obtained the best method.
Then study its reactivity. In various organic reactions, observe its performance. It was found that it exhibits unique activity in nucleophilic substitution reactions, and can introduce a variety of functional groups to open up new ways for the construction of organic molecules.
Looking to the future, we hope to expand its applications. Or used to create new drugs, or to help the research and development of high-performance materials. Adhering to the heart of research, we hope to use this substance as a basis to promote progress in the field of chemistry, and move forward step by step in the process of research and development, contributing to the academic community.

Toxicity Research

In modern times, chemistry has flourished, and the nature of various things has been explored more and more deeply. Today, there is a thing named 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, and the investigation of its toxicity is crucial.
Yu devoted himself to studying this thing, observing its structure, analyzing its components, and hoping to clarify its toxicity. After many experiments, he tested it with various organisms and observed its reaction. If this thing enters the body of a living being, it may disturb its physiological habits and damage its visceral functions.
The harm of toxicity must be prevented. Although this thing may have its uses in the chemical industry and other fields, its potential danger should also be taken seriously. It is necessary to carefully observe the rules of its system and use, so as to prevent its poison from flowing into the world and causing harm to living beings. To ensure that its benefits can be realized, and the harm can be eliminated, is the right path of chemical inquiry, and it is also the important task of our generation of researchers.

Future Prospects

Husband 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, it is also a matter of transforming things. We study it, hoping that it will not have a big impact before. This compound is special, it is exquisite, or it can be used in new research, which can break the limitations of the law and save the disease. Or it can be used in the field of new materials, so that the performance of the sub-device is greater, the calculation is faster, and the energy consumption is lower. Furthermore, in the field of synthesis, its possible results are important, helping to create strange things in the world and exploring the unknown. There may be a problem today, but we believe that in the future, we will be able to use its power and use it in the world, and it will be used in the future.

Where to Buy 1-Bromo-3-Fluoro-2-Iodobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-3-Fluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1 - bromo - 3 - fluoro - 2 - iodobenzene

1 + -Bromo-3-fluoro-2-iodobenzene is also an organic compound. Such halogenated aromatics are widely used in the field of organic synthesis.
One of them can be used to construct carbon-carbon bonds. Through palladium-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc., halogen atoms in 1 + -bromo-3-fluoro-2-iodobenzene can react with organoboron reagents, organotin reagents, etc., to form new aromatic hydrocarbon derivatives. This is a key step in medicinal chemistry and materials science, which can create organic molecules with specific structures and functions.
Second, it is also useful in the synthesis of complex cyclic compounds. Through the cyclization reaction in molecules, 1 + -bromo-3-fluoro-2-iodobenzene can close the ring under suitable conditions to form a special cyclic structure containing fluorine, bromine and iodine. Such structures are commonly found in the total synthesis of natural products and the preparation of new functional materials, giving the products unique physical and chemical properties.
Third, in drug research and development, because halogen atoms can affect the electron cloud distribution and lipophilicity of molecules, 1 + -bromo-3-fluoro-2-iodobenzene can be used as a key intermediate to synthesize compounds with potential biological activities. After structural modification and optimization, new drugs with good efficacy and small side effects may be found.
Fourth, in the field of materials science, halogen-containing aromatic hydrocarbon polymers synthesized from this raw material may have special optical and electrical properties, and can be applied to the manufacture of organic Light Emitting Diodes (OLEDs), field-effect transistors (FETs) and other devices to promote the development of electronic materials.

What are the physical properties of 1 - bromo - 3 - fluoro - 2 - iodobenzene

1 + -Bromo-3-fluoro-2-iodobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical and industrial applications.
This compound is mostly liquid at room temperature due to its intermolecular forces and structure. Its boiling point has attracted much attention, and it is estimated by experiments and theories that it is in a specific temperature range. Due to the characteristics of bromine, fluorine, and iodine atoms in the genus molecule, there is both van der Waals force and a certain degree of polarity between molecules, so the boiling point is unusual for hydrocarbon compounds.
The melting point also varies depending on the order of molecular structure and the interaction between atoms. In its solid-state structure, the atoms are arranged in an orderly manner, but the different atomic radii and electronegativity make the lattice energy complex, and the melting point has a unique value.
In terms of solubility, 1 + -bromo-3-fluoro-2-iodobenzene exhibits good solubility in organic solvents such as ethers and aromatics. Due to the principle of similar miscibility, its molecules have certain hydrophobicity and are compatible with the forces between organic solvent molecules. However, in water, the solubility is not good, and its molecular polarity is not enough to form a strong interaction with water molecules, making it difficult to break the hydrogen bond network between water molecules to accommodate the compound molecule.
Its density is also an important physical property. Due to the relatively large atomic masses of bromine, fluorine, and iodine atoms, the density of the compound is greater than that of common hydrocarbons. In the process of chemical operation and separation, the density properties are related to the basis for operations such as liquid-liquid stratification.
In addition, the color state of 1 + -bromo-3-fluoro-2-iodobenzene is usually colorless to pale yellow liquid. This color is derived from the absorption characteristics of molecules to specific wavelengths of light. Although it is not a widespread chromophore in conjugated systems, the presence of halogen atoms also has a slight impact on light absorption.
In summary, the physical properties of 1 + -bromo-3-fluoro-2-iodobenzene, such as boiling point, melting point, solubility, density, color state, etc., are determined by its molecular structure and atomic properties. It has important reference value in many fields such as organic synthesis and materials science, and is a key consideration for experimental operation and industrial production.

What are the synthesis methods of 1 - bromo - 3 - fluoro - 2 - iodobenzene

There are several methods for the synthesis of 1 + -bromo-3 + -fluoro-2 + -iodobenzene as follows.
One is the halogenation reaction method. First, benzene is taken as the starting material, and nitrobenzene is obtained by nitration reaction. Nitrobenzene uses iron powder and hydrochloric acid as the reducing agent to form aniline through reduction reaction. Aniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. Then, cuprous bromide and hydrobromic acid, potassium fluoride, potassium iodide, etc. are used as reagents to carry out halogenation substitution reactions, and bromine, fluorine, and iodine atoms are introduced in turn to obtain 1 + -bromo-3 + -fluoro-2 + -iodobenzene. However, there are many steps in this way, and the temperature of the diazotization reaction needs to be strictly
Second, palladium-catalyzed cross-coupling reaction can be used. 2,3-dihalobenzene is used as raw material, such as 2-bromo-3-fluorochlorobenzene. First, it is reacted with organolithium reagent or Grignard reagent to obtain the corresponding organometallic reagent. Then palladium complexes are used as catalysts to cross-couple with iodine reagents, thereby introducing iodine atoms to obtain the target product 1 + -bromo-3 + -fluoro-2 + -iodobenzene. This method has good selectivity and relatively mild reaction conditions, but the cost of palladium catalysts is high, and the reaction equipment and operation requirements are also high.
Third, nucleophilic substitution reaction can be used from halogenated aromatics. Using 2-bromo-3-fluorophenol as raw material, the phenolic hydroxyl group is first converted into a suitable leaving group, such as p-toluenesulfonate. After that, it undergoes nucleophilic substitution reaction with iodide salt under the action of appropriate solvent and base to form a carbon-iodine bond, resulting in 1 + -bromo-3 + -fluoro-2 + -iodobenzene. This method is relatively direct and the conditions are relatively easy to control, but it may be difficult to obtain the raw material 2-bromo-3-fluorophenol.
All synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, cost, reaction conditions and product purity to choose the most suitable method.

1 - bromo - 3 - fluoro - 2 - iodobenzene What are the precautions in storage and transportation

1 + -Bromo-3 + -fluoro-2 + -iodobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound is sensitive to heat, light and air. Therefore, it should be stored in a cool, dry and well-ventilated place. Do not expose to direct sunlight or near heat sources. High temperature can cause it to decompose, or even cause dangerous reactions. If stored in a humid environment, water vapor may interact with the compound, causing it to deteriorate, damaging quality and purity.
Furthermore, this compound should be kept away from fire sources, oxidants, etc. It is flammable, in case of open flames, hot topics, or the risk of combustion and explosion. Oxidants can also react violently with it to form unpredictable products.
As for transportation. Packaging must be tight to prevent leakage. Use suitable packaging materials, such as chemical-resistant containers, to ensure safety during transportation. And transportation vehicles must have good ventilation equipment to prevent compound volatilization and accumulation.
Transportation personnel should also be professionally trained to be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage, effective measures should be taken immediately to evacuate personnel, isolate the scene, and properly handle it in accordance with relevant regulations.
Storage and transportation of 1 + -bromo-3 + -fluoro-2 + -iodobenzene must be handled with caution and in strict accordance with regulations to ensure safety and avoid accidents.

What are the environmental effects of 1 - bromo - 3 - fluoro - 2 - iodobenzene

1 + -Bromo-3-fluoro-2-iodobenzene is one of the organic halogenated aromatic hydrocarbons. Its impact on the environment is multi-faceted and complex.
First talk about the impact of its physical properties. 1 + -bromo-3-fluoro-2-iodobenzene has a certain vapor pressure and can evaporate into the atmosphere at room temperature. After entering the atmosphere, or participating in photochemical reactions, it can interact with active free radicals in the atmosphere because of its halogen atoms. For example, bromine, fluorine, and iodine atoms can be separated from the benzene ring under light conditions and react with hydroxyl radicals, which affects the balance of free radicals in the atmosphere, and then interferes with many oxidation processes in the atmosphere, which affects the chemical composition of the atmosphere and air quality.
Furthermore, its chemical stability is also related. This compound is relatively stable and degrades slowly in the natural environment. If released in soil, it is difficult to leach and migrate with water due to its hydrophobicity or adsorption on the surface of soil particles. However, long-term accumulation will change the soil physical and chemical properties and affect the structure and function of soil microbial communities. Microorganisms use soil organic matter as nutrients. The existence of 1 + -bromo-3-fluoro-2-iodobenzene may provide a new carbon source for microorganisms, but because of its halogen atom, or toxicity to microorganisms, it inhibits the growth and reproduction of some microorganisms and destroys the soil ecological balance.
As for the aquatic environment, if it enters the water body, it may be distributed in a specific area of the water phase due to differences in density and solubility. It is potentially toxic to aquatic organisms and can enter the aquatic organisms through the biofilm and accumulate in the adipose tissue. For example, after ingestion of fish, it may affect their nervous system and reproductive system functions. Long-term exposure may cause population decline and destroy the structure and function of the food chain of aquatic ecosystems.
And if 1 + -bromo-3-fluoro-2-iodobenzene is transmitted through the food chain, it can accumulate in high-trophic organisms and ultimately endanger human health. Humans can cause health problems through food intake or accumulation in the body, such as affecting the endocrine system, immune system, etc.
In summary, 1 + -bromo-3-fluoro-2-iodobenzene has a wide range of environmental impacts, from the atmosphere, soil to aquatic ecosystems. Its production, use and release need to be treated with caution to reduce potential harm to the environment and organisms.