1-Bromo-4-Iodobenzene

Fengxi Chemical

Specifications

HS Code	858466
Name	1 - Bromo - 4 - Iodobenzene
Molecularformula	C6H4BrI
Molarmass	282.904 g/mol
Appearance	Pale yellow to light brown solid
Density	2.24 g/cm³ (estimated)
Meltingpoint	40 - 42 °C
Boilingpoint	257 - 258 °C
Solubilityinwater	Insoluble
Solubilityinorganicsolvents	Soluble in common organic solvents like ethanol, ether, and chloroform
Flashpoint	109.8 °C
Stability	Stable under normal conditions, but light - sensitive

As an accredited 1-Bromo-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 4 - iodobenzene packaged in 100 - gram vials for secure storage and handling.
Storage	1 - Bromo - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapors from escaping. Store it separately from oxidizing agents and reactive chemicals. Since it is potentially hazardous, proper labeling indicating its nature must be maintained for easy identification and safe handling.
Shipping	1 - Bromo - 4 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under regulated conditions, avoiding heat and direct sunlight, with proper hazard labels to ensure safe transit due to its chemical nature.

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General Information

Historical Development

1 - Bromo - 4 - Iodobenzene is a compound commonly used in organic synthesis. Back in the past, organic chemistry was first developed, and the exploration of halogenated aromatics was still shallow. However, chemists have gradually clarified its characteristics through unremitting research.
In the early days, the synthesis technology was limited, and it was quite difficult to obtain 1 - Bromo - 4 - Iodobenzene. Chemists have repeatedly tried various methods, from simple substitution reactions to complex catalytic processes.
With the passage of time and technological progress, new synthesis methods continue to emerge. The discovery of more efficient catalysts and the optimization of reaction conditions have made it easier to prepare 1-Bromo-4-Iodobenzene, and the yield has also increased significantly. The application of this compound in the fields of drug development and materials science has also become increasingly widespread due to the progress of synthesis technology. Its development history is a vivid portrayal of the continuous progress of chemical research.

Product Overview

1 - Bromo - 4 - Iodobenzene is also an important compound in organic chemistry. It is above the benzene ring, with one bromine and one iodine in a para-position structure. Looking at its properties, under normal temperature, it is mostly in a solid state, with a specific melting and boiling point, and can be dissolved in organic solvents.
This compound is widely used in the field of organic synthesis. It is often a key raw material for the construction of complex organic molecules. It can introduce other functional groups through various reactions such as nucleophilic substitution, and then derive many organic compounds.
There are also various methods for preparation. Or through the halogenation reaction of benzene, through precise regulation of the reaction conditions, bromine and iodine can be introduced into the benzene ring in an orderly manner; or through other organic synthesis strategies, the preparation of this compound can be achieved.
Because of its importance in organic synthesis, chemical researchers continue to study it in depth, hoping to expand its application range and contribute to the development of organic chemistry.

Physical & Chemical Properties

1 - Bromo - 4 - Iodobenzene is also an organic compound. Its physical and chemical properties can be investigated. Looking at its physical properties, at room temperature, it is solid, colored or nearly white, like a crystalline powder, with a certain melting point, about [specific melting point value]. This value is quite critical when identifying and purifying the substance. Its boiling point is also fixed, about [specific boiling point value], which is an important characterization of its gasification.
As for chemical properties, above the benzene ring, two atoms of bromine and iodine give the substance a unique reactivity. Bromine and iodine are both halogen atoms, which can participate in nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. And because of the benzene ring conjugate system, the electron cloud distribution of the substance is different, which affects the difficulty and check point of its reaction. These physicochemical properties have a wide range of uses in the field of organic synthesis and can be the key raw materials for the construction of complex organic molecules.

Technical Specifications & Labeling

1 - Bromo - 4 - Iodobenzene is a chemical commonly used in organic synthesis. Its preparation process needs to be strictly controlled.
In the reaction process, the ratio of raw materials is extremely critical. It is necessary to precisely control the amount of each reactant, such as the relevant halogenated reagents, to ensure that the appropriate stoichiometric ratio participates in the reaction, which is related to the purity and yield of the product.
The reaction conditions cannot be ignored. The temperature needs to be maintained within a specific range or under moderate heating environment to promote the smooth progress of the reaction. And the reaction time needs to be strictly controlled. If it is too short, the reaction will not be complete, and if it is too long or side reactions will occur.
The quality inspection process should rely on advanced analytical methods. If chromatographic analysis is used, the purity of the product can be accurately determined to determine whether it meets the commercial parameters. With infrared spectroscopy, nuclear magnetic resonance, etc., the structure of the product can be accurately identified to ensure that it is the target product 1-Bromo-4-Iodobenzene. In this way, the technical specifications and commercial parameters of the product can be met.

Preparation Method

To prepare 1 - Bromo - 4 - Iodobenzene, the raw materials and production process, reaction steps and catalytic mechanism are very critical. Take benzene as the initial raw material, and first use iron filings as the catalyst to undergo bromination reaction with liquid bromine. In this step, bromine molecules are polarized under iron catalysis to generate bromine positive ions, and the benzene ring electron cloud attacks it electrophilically to obtain bromobenzene. The reaction conditions need to be controlled at room temperature, and the liquid bromine is added dropwise to prevent side reactions.
Then, bromobenzene is nitrified, mixed with concentrated sulfuric acid and concentrated nitric acid as reagents, and in a water bath at 50-60 ° C, to generate p-nitrobromobenzene. Using nitro electron absorption, the density of the benzene ring electron cloud is reduced, which is used for subsequent i
The p-nitrobromobenzene is then reduced, using iron and hydrochloric acid as reducing agents, the nitro group is changed to amino group to obtain p-aminobromobenzene. Finally, in an acidic medium, sodium nitrite reacts with p-aminobromobenzene to form a diazonium salt, and then reacts with potassium iodide. The diazonium group is replaced by iodine to obtain 1-Bromo-4-Iodobenzene. The whole process, the reaction conditions of each step are strictly controlled to achieve the ideal yield and purity.

Chemical Reactions & Modifications

To taste the wonders of chemical industry, it is related to the change of substances. For 1-Bromo-4-Iodobenzene, the chemical reaction and modification are the main points of our research.
Looking at the reaction, the properties of halogenated aromatics can be encountered with nucleophiles and replaced. However, the initial reaction may be due to slow survival rate and poor yield. If you try it with a nucleophilic reagent, the reaction conditions are severe, and the choice of temperature and solvent has a huge impact. It is often necessary to precisely control the temperature and find a suitable solvent to promote the smooth flow of the reaction.
As for the modification, the introduction of specific groups can be used to change its physicochemical properties. Or modify the benzene ring to increase its stability, or change its solubility, suitable for different applications. After repeated research and testing, the effect of different paths has been observed, and the best situation has been achieved, so that 1 - Bromo - 4 - Iodobenzene can be used in chemical fields to develop its growth, adding bricks and mortar to the prosperity of industry and the progress of science and technology, showing the charm and power of chemistry.

Synonyms & Product Names

1 - Bromo - 4 - Iodobenzene is a chemical commonly used in organic synthesis. It has many synonyms and is referred to as p-bromoiodobenzene in the industry literature. This name is based on its molecular structure. Bromo and iodine atoms are located in the benzene ring, hence the name.
As for the trade name, different manufacturers have different specifications. However, they all refer to this specific chemical substance. It is widely used in the chemical industry. In drug development, it is often used as a key intermediate to help build complex drug molecular structures. In the field of materials science, it is also an important raw material for the preparation of special functional materials.
Although the synonyms of this chemical and the trade name are different, they refer to the same entity, both serving scientific research and industrial production, and promoting the continuous progress of the chemical field.

Safety & Operational Standards

1 - Bromo - 4 - Iodobenzene is a compound commonly used in organic synthesis. Its experimental operation and safe production procedures are quite important.
The first word is safe. This compound is toxic and irritating, and can cause physical damage if it touches the skin, inhales or is ingested by mistake. Therefore, during operation, appropriate protective equipment must be worn, such as laboratory clothes, gloves and protective glasses, to avoid direct contact. And the operation should be carried out in a well-ventilated fume hood to prevent the accumulation of harmful gases and cause inhalation hazards.
As for the operation specifications. When weighing this compound, use a precise balance to ensure accurate dosage. When dissolving, choose a suitable solvent according to its solubility, and stir moderately to promote its full dissolution. During the reaction process, strictly control the temperature, reaction time and other conditions. Heating reactions need to pay attention to the heating rate to prevent overreaction.
After the reaction is completed, the separation and purification of the product is also critical. Pure products can be obtained by means of recrystallization, column chromatography, etc. The experimental waste, including unreacted raw materials, by-products and solvents, should be collected in accordance with regulations, properly disposed of, and cannot be dumped at will to avoid polluting the environment.
Only by strictly observing safety and operating standards can we ensure the smooth progress of 1-Bromo-4-Iodobenzene related experiments, and at the same time ensure the safety of experimental personnel and the environment is not damaged.

Application Area

1 - Bromo - 4 - Iodobenzene is an important organic compound. In the field of chemical industry, its application is quite extensive. In organic synthesis, it is often used as a key intermediate.
Looking at the past, many talented people have dedicated themselves to exploring its application field. It is used in pharmaceutical synthesis and can help create new drugs. Due to its special molecular structure, it can introduce key groups through a series of reactions to obtain compounds with specific pharmacological activities.
In the field of materials science, it also has good performance. It can participate in the preparation of materials with special functions, such as polymer materials with photoelectric properties. With its unique chemical properties, it endows materials with novel properties.
Furthermore, in the preparation of fine chemical products, 1-Bromo-4-Iodobenzene is also indispensable. It can provide important starting materials for the production of high-end paints, fragrances and other fine chemicals, and promote the development of related industries.

Research & Development

I have been studying chemical products for a long time, and recently I have focused on the product 1-Bromo-4-Iodobenzene. This product is also very crucial in the field of organic synthesis.
At the beginning, I studied its structure and knew that on the benzene ring, bromine and iodine are each in one place, with unique structures and unique properties. In order to clarify its properties, I tried it with various reagents and observed its reaction. After many tests, it was found that it is very active in the nucleophilic substitution reaction, and the iodine atom is easily attacked by nucleophilic reagents to produce new compounds.
Then find a method for its preparation. Consult the classics, refer to the methods of Fang family, and after repeated attempts and improvements, gradually obtain optimization strategies. When preparing, strictly control the temperature of the reaction, the ratio of time and reagents, and strive for high yield.
Today, this product has potential in the road of medicine and material synthesis. With time, in-depth research may open up a wider path for it, and it will be beneficial to scientific research and industry, but the future is promising.

Toxicity Research

1 - Bromo - 4 - Iodobenzene is also a chemical substance. Researchers of chemical substances often study the toxicity of chemical substances. Toxicity studies of this substance are of paramount importance.
The presence of bromo-iodine atoms in its contents may lead to specialization. Examining past studies, many aromatic compounds have a certain toxicity. 1 - Bromo - 4 - Iodobenzene also has the same reaction to biological substances due to molecular shape and molecular effect.
The activity of enzymes affects the physiological function of cells. And it may be lipid-soluble, easy to accumulate in biological membranes, and break the integrity of the membrane.
Therefore, we study its toxicity, observe the role of its biological macromolecules, and explore its toxicological system to understand the hazards of its health and human health, and provide evidence for prevention and control.

Future Prospects

Husband 1 - Bromo - 4 - Iodobenzene, the thing that transforms the body. I am researching it, and I hope that there will be no colorful exhibition.
In today's world, technology is changing day by day, and this compound may be of great use in the field of production. In the field of production, or it can be used to make new foundations, to help those who are sick and suffering. In the world of materials, or it can be used to make strange materials, to use it for general equipment, and to use it for work.
We must diligently research it, and explore its laws. Hope to use the fruit of intensive research to expand its path, so that it can be used in the future, and it will benefit the people. The unfinished development can be hoped for, and we have also exhausted our efforts to promote its success.

Where to Buy 1-Bromo-4-Iodobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-bromo-4-iodobenzene?

1-Bromo-4-iodobenzene is an organic compound, which has special chemical properties and is very important in the field of organic synthesis.
This compound contains two halogen atoms, bromine (Br) and iodine (I), and the activity of the halogen atom is one of its key chemical properties. In the nucleophilic substitution reaction, due to the strong electronegativity of the halogen atom, the electron cloud density of the benzene ring is affected, so that the halogen atom is easily replaced by the nucleophilic reagent. Take the reaction with sodium alcohol as an example. As a nucleophilic reagent, the anion of alcohol and oxygen can attack the carbon atom connected to the halogen atom. After a series of electron transfer, the halogen atom leaves to form an ether compound. This reaction condition is mild, and the assistance of suitable solvents and catalysts is often required to
The two halogen atoms of 1-bromo-4-iodobenzene can also participate in the metal catalytic coupling reaction. Like under palladium catalysis, Suzuki coupling reaction can occur with borate-containing esters or boric acid compounds. In the reaction, the palladium catalyst first undergoes oxidative addition with the halogen atom, then transmetallizes with the boric acid compound, and finally eliminates by reduction to form a new carbon-carbon bond to construct a complex aromatic compound. Such reactions are widely used in the fields of drug synthesis and materials science, and can effectively build molecular frameworks with specific structures and functions.
In addition, the chemical properties of 1-bromo-4-iodobenzene are also reflected in its effect on the electrophilic substitution of the benzene ring. The halogen atom is an ortho-para-localization group. Although the electron cloud density of the benzene ring is reduced, the electrophilic substitution reaction activity is slightly lower than that of benzene, but the reaction still mainly occurs in the ortho-site and para-site of the halogen atom. For example, when nitrification occurs, the nitro group is mainly introduced into the ortho-site or para-site of bromine and iodine to generate the corresponding nitro substitution product. This property can be used in the design of organic synthesis routes to precisely control the position of substituents and synthesize target products.

What are the common applications of 1-bromo-4-iodobenzene in organic synthesis?

1-Bromo-4-iodobenzene is a commonly used raw material in organic synthesis. It has a wide range of uses in organic synthesis, and its common applications are as follows.
First, it can be used to construct complex aromatic compounds. Through nucleophilic substitution reaction, its bromine or iodine atoms can be replaced by various nucleophilic reagents. For example, by reacting with carbon-containing nucleophiles, such as organometallic reagents (Grignard reagent or lithium reagent), alkyl, aryl and other carbon-based functional groups can be introduced into the benzene ring. This reaction is an important means for synthesizing polysubstituted aromatics, which can be used to prepare many organic materials with specific structures and functions, pharmaceutical intermediates, etc.
Second, 1-bromo-4-iodobenzene can participate in the coupling reaction catalyzed by palladium. Such as the Suzuki coupling reaction, in this reaction, it can form a new carbon-carbon bond with aryl boric acid under the action of palladium catalyst and base to construct biphenyl compounds. Biphenyl structures are commonly found in drug molecules, liquid crystal materials, etc. Another example is the Stille coupling reaction, which can also achieve the construction of carbon-carbon bonds when reacted with organotin reagents, providing an effective way to build a complex molecular skeleton in the field of organic synthesis chemistry.
Furthermore, taking advantage of the difference in activity between its two halogen atoms, selective reactions can be carried out. Due to the relatively higher activity of iodine atoms than bromine atoms, under appropriate conditions, iodine atoms can be selectively reacted, while bromine atoms are retained, and bromine atoms can be converted later. This strategy is conducive to the synthesis of organic compounds with specific substitution patterns. It is of great significance in fine organic synthesis and can accurately synthesize target products with specific functions and structures.

What are the methods of preparing 1-bromo-4-iodobenzene?

1-Bromo-4-iodobenzene, that is, 1-bromo-4-iodobenzene, can be prepared by several methods.
First, benzene is used as the starting material. Bromobenzene can be obtained by electrophilic substitution of shilling benzene and bromine under the action of catalysts such as iron tribromide. Next, bromobenzene and iodine can be obtained by electrophilic substitution under appropriate conditions, such as copper powder or cuprous iodide catalysis, and under suitable solvents and temperatures. 1-bromo-4-iodobenzene can be obtained. The steps of this pathway are relatively straight, but the conditions of each step need to be carefully adjusted to increase the purity and yield of the product. < Br >
Second, starting from p-bromoaniline. P-bromoaniline is first reacted with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salt. After the diazonium salt is heated with potassium iodide solution, the diazonium group is replaced by iodine atom, and then 1-bromo-4-iodobenzene is obtained. Although this method is slightly complicated, the selectivity of the diazonation reaction and the substitution reaction is quite high, and the purity of the product is easy to control.
Third, the method of Grignard reagent is used. 1-bromo-4-iodobenzene can be formed by reacting magnesium p-bromide (prepared by reacting p-dibromobenzene with magnesium in anhydrous ether) with iodine. This process needs to be carried out under the harsh conditions of anhydrous and oxygen-free, because Grignard's reagent is extremely active and easy to decompose in contact with water and oxygen, so it is very effective for constructing carbon-halogen bonds.
All these preparation methods have their own advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, reaction conditions, product purity and yield.

What are the physical properties of 1-bromo-4-iodobenzene?

1-Bromo-4-iodobenzene, or 1-bromo-4-iodobenzene, is an organic compound. Its physical properties are crucial and are related to many chemical processes.
Looking at its appearance, it is often colorless to light yellow liquid, which makes it flexible to participate in reactions in many reaction systems. It has a certain volatility, and some molecules can escape to the gas phase at room temperature and pressure. This volatility not only affects its preservation, but also requires careful precautions during reaction operations to avoid loss or potential safety hazards.
Boiling point is a key physical constant. The boiling point of 1-bromo-4-iodobenzene is quite high, and a specific temperature is required to transform it into a gaseous state. This property is very important in the separation and purification process, and can be separated from other substances by distillation and other means according to the difference in boiling point. The melting point of
cannot be ignored, which determines its physical state at a specific temperature. When the temperature drops below the melting point, it changes from liquid to solid.
Density is also an important property. Compared with water, 1-bromo-4-iodobenzene has a higher density. If mixed with water, it will sink to the bottom. This property can be used in operations such as liquid-liquid separation.
In terms of solubility, 1-bromo-4-iodobenzene is insoluble in water, because water is a polar molecule, and the polarity of the compound is weak. However, it is soluble in organic solvents such as ethanol, ether, chloroform, etc. This solubility provides a basis for the selection of reaction solvents. In organic synthesis, suitable organic solvents can be selected to help it dissolve and participate in the reaction.
The physical properties of 1-bromo-4-iodobenzene are interrelated and play an important role in organic synthesis, analysis and testing. Chemists need to know in detail before making good use of this compound.

What do 1-bromo-4-iodobenzene need to pay attention to when storing and transporting?

1-Bromo-4-iodobenzene is an organic compound, and many things must be paid attention to when storing and transporting it.
Storage first. This compound is sensitive to heat and light, so it should be stored in a cool, dry and dark place. Heat can easily cause it to decompose and deteriorate, and light may also cause chemical reactions that damage its quality. Furthermore, the storage place must be well ventilated to prevent its volatilization and accumulation, which may cause danger. When storing, it should also be kept away from fire sources, heat sources and strong oxidants. Because it is an organic halide, it may burn and explode in case of hot topics, open flames or oxidants. And it needs to be stored separately from acids, alkalis and other substances, because the acid-base environment may promote chemical reactions. In addition, storage containers must also be carefully selected, and well-sealed containers should be used, preferably glass materials. Because of its stable chemical properties, it is not easy to react with 1-bromo-4-iodobenzene, which can effectively prevent leakage and volatilization.
As for transportation. During transportation, it is first necessary to ensure that the container is firm and intact to prevent collision and vibration from causing it to leak. When handling, the operation must be gentle to avoid brutal loading and unloading. Transportation vehicles should also be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. In the event of an accident, they can be responded to in time. Moreover, transportation route planning should not be ignored. It is necessary to stay away from densely populated areas and important facilities to reduce latent risks. At the same time, transportation personnel need to be professionally trained and familiar with the characteristics of 1-bromo-4-iodobenzene and emergency treatment methods to ensure the safety of the transportation process. In this way, the safety requirements for storage and transportation of 1-bromo-4-iodobenzene can be met.