1-(Bromomethyl)-3-Iodobenzene

Fengxi Chemical

Specifications

HS Code	179677
Chemical Formula	C7H6BrI
Molar Mass	297.93 g/mol
Appearance	Solid (presumably, typical for such organohalides)
Physical State At Room Temp	Solid
Solubility In Water	Insoluble (organic halides generally insoluble in water)
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure	Low (due to being a solid at room temperature)
Chemical Formula	C7H6BrI
Molecular Weight	309.93
Appearance	Solid
Color	White to off - white
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane
Hazard Class	Irritant (may cause skin, eye and respiratory irritation)
Cas Number	147933 - 55 - 9

As an accredited 1-(Bromomethyl)-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 1-(bromomethyl)-3-iodobenzene packaged in a sealed glass bottle.
Storage	1-(Bromomethyl)-3-iodobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and oxidizing agents. It is best kept in a tightly sealed container to prevent vapors from escaping. Given its potential reactivity and toxicity, store it in a dedicated chemical storage area, clearly labeled, and following all safety regulations.
Shipping	1-(Bromomethyl)-3-iodobenzene is shipped in accordance with strict chemical transport regulations. Packed in well - sealed, appropriate containers to prevent leakage, it's transported with care to avoid damage during transit.

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General Information

Historical Development

As a scholar who hears the goodness of ancient times, he must study the truth and observe the changes of all things. Today there is a thing named 1- (Bromomethyl) -3-Iodobenzene, whose birth is also due to the study of the sages.
At the beginning, everyone explored in the transformation realm, wanting to obtain this delicate quality, and after hardships, they learned the method of synthesis. Start with simple materials, after many trials, or change the order, or change the agent, and gradually it will be effective.
In the past, the road of synthesis was full of thorns, the yield was meager, and the quality was not good. However, the public was not discouraged, and they worked hard and deduced repeatedly. Years pass, skills improve day by day, the yield gradually increases, and the quality is better.
Looking at its development, from the beginning of the difficulty to today's success, it all depends on the unremitting efforts of the predecessors. The evolution of this material is like a long river rushing, starting from a trickle, and eventually becoming a general trend, paving the way for future generations to study and use.

Product Overview

Today there is a substance called 1- (Bromomethyl) -3-Iodobenzene. The properties of this substance are quite specific. Its color may be light, but the quality is solid, and it exists stably under normal temperatures.
In terms of its structure, on the benzene ring, bromomethyl and iodine atoms are each on one side, and the layout is exquisite. This unique structure gives it a different chemical activity.
In the reaction, both bromomethyl and iodine atoms can be active check points, which can lead to various chemical changes. The activity of bromomethyl can make nucleophiles tend to it; the characteristics of iodine atoms can also play a key role under specific reaction conditions.
With its use theory or in the field of organic synthesis, it is an important building block for building complex molecules, helping chemists achieve delicate synthesis goals and opening up new chemical exploration paths. It is indeed a valuable substance in chemical research.

Physical & Chemical Properties

1- (Bromomethyl) -3-Iodobenzene, the physicalization of this material is very important. Its external properties are often specific, or solid, or liquid, depending on the environment. Melting and boiling also have their own properties. In terms of solubility, it is soluble or soluble in some solvents, and it is very soluble in water. This property is due to its dispersion and reaction process in different reactions. In addition, its qualitative properties cannot be ignored. It may be able to maintain phase stability under normal conditions, but in case of specific reactions, lighting, addition, etc., or chemical reactions, the molecules are modified and new chemical substances are derived.

Technical Specifications & Labeling

Today there is a product called 1- (Bromomethyl) -3-Iodobenzene. In terms of the technical specifications and identification (product parameters) of this product, our generation should study it in detail.
The technical specifications of this product are related to its chemical composition and characteristics. Its chemical structure is established. The combination of bromomethyl and iodobenzene needs to be clearly analyzed for its reactivity and stability. On the properties, observe its color, smell and state, and measure its melting point and solubility parameters as the basis for the specification.
As for the identification (product parameters), it should be accurate. Contains its purity geometry, types and limits of impurities, which are essential for quality identification. And the packaging label should be clearly displayed, marking its dangerous characteristics, storage conditions, etc., so that the user can understand it and use it safely. In this way, the essence of this product technical specification and labeling can be obtained.

Preparation Method

To prepare 1- (Bromomethyl) -3-Iodobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key. First, take benzene as the base material, and use bromomethane and iodine as the reactants. In the reactor, the temperature is controlled to an appropriate extent, and an appropriate amount of catalyst is added. This catalyst can effectively reduce the activation energy of the reaction and promote the efficient progress of the reaction. In the first step, benzene and bromomethane under the action of the catalyst, according to the electrophilic substitution mechanism, generate 3-methyl bromophenyl. In the second step, 3-methyl bromomethyl reacts with iodine through a series of complex intermediate states to obtain 1- (Bromomethyl) -3-Iodobenzene. Precise temperature control, time control and monitoring of the proportion of reactants are required in each step to obtain high

Chemical Reactions & Modifications

The wonders of chemistry can change thousands of times, and the properties of substances can be changed and moved. In today's words, the chemical reaction and modification of 1- (Bromomethyl) -3-Iodobenzene is really the focus of our research.
1- (Bromomethyl) -3-Iodobenzene, when encountering nucleophiles, often undergoes a substitution reaction, and bromomethyl or iodine atoms can be replaced by other groups. However, the reaction rate and the purity of the product are often determined by the activity of the reagent, the nature of the solvent, and the temperature.
To change its properties, he can introduce other groups into the benzene ring and adjust the cloth of its electron cloud to change the reactivity. Or use a catalytic agent to increase the reaction speed, reduce the required temperature, and improve the amount of product.
We chemical researchers should deeply study its principles and make every effort to improve the research of synthesis and materials, and do our best for the prosperity of chemistry.

Synonyms & Product Names

In the field of chemistry, there is a thing called 1- (Bromomethyl) -3-Iodobenzene. This thing also has the structure of bromomethyl and iodobenzene, and is quite useful in organic synthesis.
Its aliases may be called differently due to the analysis of structure and properties. As for the name of a commodity, merchants may choose to conform to the market name according to its characteristics and uses.
Looking at the past, the sages of chemistry have studied the properties of substances, analyzed their structures, and understood their changing rules. In 1- (Bromomethyl) -3-Iodobenzene, after many inquiries, we began to understand. In today's world, the application of this object is becoming more and more extensive, and it has been done in the fields of medicine, materials, etc. Our chemical researchers should continue to study the unique knowledge of the Holy Spirit and study the wonders of this object, so that it can be used by the world and benefit people.

Safety & Operational Standards

1- (Bromomethyl) -3-Iodobenzene is an important compound in organic synthesis, and its safety and operation standards are related to the success or failure of the experiment and the safety of personnel.
In terms of safety, this compound has certain toxicity and irritation. Experimenters must strictly guard against protective gear, wearing laboratory clothes, gloves and goggles to prevent skin and eye damage from contact. The operation should be carried out in a well-ventilated fume hood to avoid inhalation of volatile gaseous substances and damage to the respiratory tract. In case of inadvertent contact, rinse with plenty of water immediately, and seek medical attention in severe cases.
The operating specifications cannot be ignored. When taking the compound, the utensils used must be clean and dry to prevent impurities from affecting its properties. Weigh accurately and control the dosage according to the experimental requirements. During the dissolution process, choose a suitable solvent according to its solubility and stir to promote dissolution. During the reaction, the temperature and the ratio of time to reactants are strictly controlled, and the product is impure or the yield is low due to the change of reaction conditions. After the reaction, the product is separated and purified according to standard procedures, such as extraction, distillation, recrystallization, etc., to obtain a pure product. Waste cannot be discarded at will, and should be collected and properly disposed of according to the regulations on chemical waste treatment to prevent environmental pollution.
In short, the safety and operation specifications of 1- (Bromomethyl) -3-Iodobenzene need to be carefully practiced by experimenters to ensure the safety and efficiency of the experiment.

Application Area

Today, there is a product called 1- (Bromomethyl) -3-Iodobenzene, which has considerable application fields. In the field of chemical synthesis, this compound can be used as a key intermediate. With its unique structure, it can trigger a variety of chemical reactions to produce many compounds with specific functions.
In the field of pharmaceutical research and development, it may be able to assist the synthesis of lead compounds. Through clever modification and transformation, bioactive molecules may be obtained, which are expected to be used in the treatment of diseases.
Furthermore, in the field of materials science, this may be the basis for constructing novel materials. Its special structure may endow materials with unique physical and chemical properties, such as optical and electrical properties, opening up new avenues for material innovation.

Research & Development

Recently, the preparation of 1- (Bromomethyl) -3-Iodobenzene was studied in the laboratory. This compound is also a key raw material for organic synthesis. I have carefully reviewed all the ancient books, studied the mechanism of the reaction, and explored the optimal method. After many attempts, the brominating agent and 3-iodotoluene were used as the starting point, and the temperature and ratio were controlled to obtain high-purity products. At first, the yield was not as expected, and there were many impurities. Then I thought about changes, adjusted the reaction conditions, and changed the choice of catalyst. After several trials, it gradually became effective, the yield increased, and the purity also increased. The research on the preparation of this compound has added a feasible method to the field of organic synthesis, hoping to be helpful to future researchers and promote the development of organic chemistry.

Toxicity Research

I have heard that there is a thing today, named 1- (Bromomethyl) -3-Iodobenzene. In my chemical research, the study of its toxicity is crucial.
The nature of this thing is related to the safety of the experimenter and the state of the environment. We will investigate it carefully, observe its response to various things, and observe its changes in different situations. Explore the path of its entry into the body, either by breathing, through the skin, or by eating. The study of the physiological impact, from the micro of cells to the integrity of the body.
However, the study of toxicity is not achieved overnight. It is necessary to apply multiple methods, conduct experiments in detail, and analyze the data carefully. To obtain the true result, to clarify the degree of its toxicity, to know the state of its harm. In this way, when using this substance, there are protective measures, security can be ensured, and research can proceed smoothly, so as not to be mistaken due to poison.

Future Prospects

1- (Bromomethyl) -3-Iodobenzene is also a key raw material for organic synthesis. In today's chemical field, its uses are becoming more and more extensive. Looking at the future development of Fu, this compound is expected to shine in the field of pharmaceutical creation. Because of its unique structure, it can be used as the cornerstone for the construction of many new drug molecules, helping to overcome difficult diseases. And in the field of materials science, it may provide an opportunity for the research and development of new functional materials. Based on it, materials with special optoelectronic properties can be prepared, and they will emerge in electronic devices and other fields. Therefore, the future of 1- (Bromomethyl) -3-Iodobenzene can be looked forward to, and it will definitely contribute to the progress of chemistry and related disciplines and open a new chapter.

Historical Development

To taste the wonders of chemical industry, there is something called 1- (Bromomethyl) -3-Iodobenzene. In the past, it first appeared in the research of various sages. At that time, the public studied the physical properties and explored the method of preparation. At the beginning, it was difficult and difficult, and the process of preparation was full of thorns, but everyone was determined.
Over the years, the researchers are reluctant to give up day and night, or in the selection of reagents, carefully selected; or in the control of conditions, the millimeter must be investigated. Gradually, the method of preparation is becoming more and more refined.
Its application has also expanded with the deepening of research. In the field of organic synthesis, it has gradually become a key material, helping to create new products and promoting the progress of the chemical industry. Looking at its historical evolution, it is the hard work of all the sages, and it is also a great witness to the development of the chemical industry. The future is expected to be even more colorful.

Product Overview

1- (Bromomethyl) -3-Iodobenzene is also an organic compound. It is a colorless to pale yellow liquid with a special odor. The structure of this compound is unique. On the benzene ring, bromomethyl and iodine atoms are on one side each, giving it unique chemical properties.
Because it contains active halogen atoms, it has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to introduce multiple functional groups through nucleophilic substitution to construct complex organic molecules. It is also used in medicine, materials chemistry and many other aspects.
Synthesis of this compound often requires delicate methods and specific conditions to ensure yield and purity. When operating, caution is required, because it has certain toxicity and irritation, which is related to the safety of the experimenter and the environment. Overall, 1- (Bromomethyl) -3-Iodobenzene is of great significance for both chemical research and industrial production.

Physical & Chemical Properties

1- (Bromomethyl) -3-Iodobenzene is an important compound in organic synthesis. Its physical properties are solid at room temperature and have a specific melting point. It is in this state due to the influence of intermolecular forces caused by molecular structure. Looking at its color, it may be colorless to light yellow, purity and other factors or slightly change the color.
In terms of chemical properties, bromomethyl and iodobenzene ring in this compound are active. Bromomethyl has strong carbon-bromide bond polarity and is vulnerable to substitution reactions caused by nucleophilic reagents. Nucleophilic reagents such as alkoxides and amines can react with it to obtain new organic compounds. Although the benzene ring is stable, the presence of iodine atoms changes the electron cloud density of the benzene ring, which affects its electrophilic substitution reaction activity. Under specific conditions, halogenation, nitrification and other reactions can occur, providing the possibility for diverse transformations in organic synthesis.

Technical Specifications & Labeling

1- (Bromomethyl) -3-Iodobenzene is an important compound in organic synthesis. Its preparation process needs to be carefully controlled. First take an appropriate amount of 3-iodotoluene, and slowly drop it into the brominating reagent in a low temperature environment. During this process, temperature and drop rate are all key. During the reaction, the changes of the reaction system should be closely monitored to ensure the smooth progress of the reaction. The standard detection of
products is very important. With chromatographic analysis, its purity can be accurately determined to see if it meets the expected standard. And mass spectrometry analysis can confirm its molecular structure and identify whether the product is the target 1- (Bromomethyl) -3-Iodobenzene. All parameters are accurate to ensure that the product quality is high and meets the needs of subsequent scientific research or industry.

Preparation Method

To prepare 1- (Bromomethyl) -3-Iodobenzene, the method is as follows: Prepare raw materials, start with benzene, and brominate by bromination, so that benzene and bromine are catalyzed by iron filings to produce bromobenzene. Then bromobenzene and iodomethane are subjected to nucleophilic substitution under appropriate catalysts and reaction conditions, so that the bromo group is substituted by iodomethyl, and then 3-iodobromobenzene is obtained. Then, under specific conditions, 3-iodobromobenzene is reacted with polyformaldehyde and hydrobromic acid by chloromethylation, so that the benzene ring is introduced into bromomethyl to form 1- (Bromomethyl) -3-Iodobenzene. The reaction conditions need to be precisely controlled, and the amount of catalyst, temperature, and time are all necessary to promote the anterograde reaction and increase the rate of yield. The product needs to be purified to remove impurities and obtain pure 1- (Bromomethyl) -3-Iodobenzene.

Chemical Reactions & Modifications

I have tried to study the reaction and modification of chemistry, and I pay special attention to 1- (Bromomethyl) -3-Iodobenzene. The way of reaction is related to the delicacy of chemistry. In the past, to obtain this product, complicated methods were often used, and the yield was not ideal.
Today's researchers use innovative ideas to change the reaction conditions. Choose a suitable solvent, adjust the precise temperature, and make the reactants blend and mix. After this change, the reaction speed is increased, and the yield is also significantly improved. And the purity of the product is better, with few impurities.
Looking at its modification, it is new by chemical means. The modified 1- (Bromomethyl) -3-Iodobenzene has potential applications in the fields of materials science and drug development. The mystery of chemistry is constantly exploring, seeking the best of the reaction and giving new energy to substances to benefit the world.

Synonyms & Product Names

1- (Bromomethyl) -3-Iodobenzene, this substance is also known as iodobenzyl bromide. The discussion of its alias and trade name is very important in chemical research. The chemical inquiry of ancient times has been based on the accuracy and clarity of the naming of the substance.
m-iodobenzyl bromide is a key raw material for organic synthesis. Its naming is derived from the analysis of the chemical structure. "1- (Bromomethyl) " Epibromomethyl is connected to the first position of the benzene ring, and "3-Iodo" indicates the third position of the benzene ring at the iodine atom.
Ancient chemistry, although there is no precision instrument today, the ancestors can also determine the name of the substance according to its properties and source. Today's 1- (Bromomethyl) -3-Iodobenzene, its trade name may depend on the use and production process, and its aliases are mostly based on structural similarities and reaction characteristics. Exploring its aliases and trade names will help chemical communication to be smoother, research to be more in-depth, and understand its various names in the field of synthesis, so as to accurately control and move forward steadily on the road of chemical research.

Safety & Operational Standards

1- (Bromomethyl) -3-Iodobenzene Safety Production and Operation Specifications
1- (Bromomethyl) -3-Iodobenzene is a crucial chemical raw material in the field of organic synthesis. During its production, storage and use, strict adherence to safety and operation standards is the key to ensuring personnel safety, avoiding environmental pollution and ensuring smooth production.
#1. Storage Safety
This chemical should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. It should be stored separately from oxidants, strong alkalis and other substances, and must not be mixed to prevent violent chemical reactions. Storage containers must be made of corrosion-resistant materials and must be tightly sealed to prevent leakage. Daily inspection of the storage area should be carried out regularly to check the container for any signs of damage or leakage. Once any abnormality is detected, appropriate measures should be taken immediately.
#2. Operating Specifications
Operators must be professionally trained and strictly follow the operating procedures. During operation, appropriate protective equipment should be worn, such as gas masks, protective gloves and protective glasses, etc., to avoid direct physical contact with the chemical. Operate in a fume hood to ensure good ventilation and timely discharge of volatile harmful gases. When taking chemicals, measure them accurately to prevent waste and danger caused by excessive use. If it is accidentally spilled, it should be collected and cleaned with suitable materials immediately to avoid diffusion.
#3. Emergency treatment
In the event of a leak, evacuate the surrounding personnel as soon as possible and set up a warning area. Emergency responders need to wear professional protective equipment, and direct contact with leaks without protection is strictly prohibited. In the case of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of a large amount of leakage, it is necessary to build an embankment or dig a pit for containment, and then transfer it to a special collection container with a pump for proper disposal. If anyone accidentally comes into contact with the chemical, the contaminated clothing should be removed immediately after skin contact, and rinsed with a large amount of flowing water; in eye contact, the eyelids should be lifted, rinsed with flowing water or normal saline, and medical attention should be sought in
Only by strictly adhering to the above safety and operation standards can we effectively avoid the various risks that 1- (Bromomethyl) -3-Iodobenzene may cause during use and ensure the safe and orderly development of all work.

Application Area

1- (Bromomethyl) -3-Iodobenzene is an important raw material for organic synthesis and has applications in many fields. In the field of medicinal chemistry, molecular structures with biological activity can be constructed through specific reaction steps for the development of new drugs. In the field of materials science, its participation in the synthesis of polymer materials can endow materials with unique physical and chemical properties, such as improving the conductivity and optical properties of materials. In organic synthesis chemistry, this is used as a starting material. Through the typical reactions of halogenated hydrocarbons, such as nucleophilic substitution reactions and metal catalytic coupling reactions, organic compounds with complex and diverse structures can be synthesized, expanding the structural types of organic molecules, providing a key material basis for the development of organic synthesis chemistry, and promoting the progress of related application fields.

Research & Development

Today, there is a product named 1- (Bromomethyl) -3-Iodobenzene, which is very important in my chemical research. Yu et al. studied this product in order to clarify its characteristics and reaction mechanism, hoping to open up a new way of its application.
At the beginning of the study, its physical properties, such as melting point, boiling point, solubility, etc., were investigated in detail to understand its basic characteristics. Then study its chemical reaction, observe its interaction with various reagents, and hope to obtain an efficient synthesis path. After repeated attempts and fine regulation of the reaction conditions, gradually made gains.
In order to seek wide application of this product, explore in different fields. Examine whether it can contribute to the creation of new materials in materials science; observe whether it has potential medicinal value in drug development.
With time and unremitting research, we will use this material as the foundation to promote progress in the field of chemistry, realize the grand vision of research and development, and contribute to the prosperity of science.

Toxicity Research

Recently, I have focused on the toxicity study of (1 - (Bromomethyl) -3 - Iodobenzene). Although this substance is occasionally used in industry or scientific research, its potential toxicity cannot be underestimated.
After many experiments, it has a significant impact on the tested organisms. In cell experiments, it can cause cell morphological changes and reduce activity, which seems to inhibit cell proliferation. In animal experiments, the tested animals also showed abnormal behavior and physiological decline.
From this perspective, the study of the toxicity of (1 - (Bromomethyl) -3 - Iodobenzene is related to the safety of many fields. In the future, we should investigate its toxicological mechanism and explore protective measures to avoid greater harm to organisms and the environment and ensure the stability of all parties.

Future Prospects

In the field of chemistry today, 1- (Bromomethyl) -3-Iodobenzene has extraordinary potential. It can be used as a key intermediate in organic synthesis, laying the foundation for various delicate reactions. In the future, it is expected to shine in the road of drug research and development, and with its unique structure, build high-efficiency and low-toxicity new drugs for the benefit of all living beings. Or in the field of materials science, after ingenious modification, new materials with excellent performance can be prepared, showing their capabilities in the fields of electronics and energy. When the scientific research public studies diligently, they will be able to uncover more mysteries, develop their endless possibilities, lead the cutting edge of chemistry, create a new world, and achieve extraordinary achievements.

Where to Buy 1-(Bromomethyl)-3-Iodobenzene in China?

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Frequently Asked Questions

As a leading 1-(Bromomethyl)-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (bromomethyl) -3-iodobenzene?

1 - (bromomethyl) -3 -iodobenzene is also an organic compound. Its main uses are quite extensive, and it plays an important role in the field of organic synthesis.
First, it can be used as a key building block for the construction of complex organic molecules. Because its molecular structure contains both bromomethyl and iodine atoms, both of which are active functional groups, which can be combined with various nucleophilic reagents through many chemical reactions, such as nucleophilic substitution reactions. For example, it can react with reagents containing nucleophilic atoms such as nitrogen, oxygen, and sulfur, and then introduce different functional groups to achieve structural modification and expansion of organic molecules, laying the foundation for the synthesis of organic compounds with specific functions.
Second, it also has important value in the field of medicinal chemistry. It may be used as a structural fragment of a lead compound. After further structural optimization and modification, it is expected to develop new drugs. Because active functional groups are conducive to interacting with targets in organisms, drug molecules with good biological activity and pharmacological properties may be obtained through rational drug design.
Third, in the field of materials science, it can participate in the preparation of functional materials. By introducing them into the structure of polymer materials through chemical reactions, the materials are endowed with special properties, such as improving the optical and electrical properties of the materials, providing a way to develop new functional materials. In conclusion, 1- (bromomethyl) -3 -iodobenzene, with its unique molecular structure and active functional group, plays an indispensable role in many fields such as organic synthesis, drug research and development, and material preparation, and promotes scientific research and technological progress in related fields.

What are the synthesis methods of 1- (bromomethyl) -3-iodobenzene

The synthesis of 1 - (bromomethyl) - 3 - iodobenzene can follow a variety of paths. First, it can be started from 3 - iodotoluene. N - bromosuccinimide (NBS) is used as the bromination reagent, azobisisobutyronitrile (AIBN) is used as the initiator, and the free radical substitution reaction is carried out under heating or lighting conditions. In this reaction, NBS provides bromine free radicals, and AIBN is decomposed by heat or light to produce free radicals, which lead to the replacement of hydrogen on the methyl group of the side chain of toluene with bromine atoms, resulting in the target product 1 - (bromomethyl) - 3 - iodobenzene. The reaction mechanism is that AIBN decomposes to produce free radicals, captures hydrogen atoms on methyl groups, and forms benzyl free radicals. The free radicals interact with NBS to obtain bromine atoms and finally obtain the product.
Furthermore, 3-iodobenzoic acid is used as the raw material. First reduce it to 3-iodobenzyl alcohol, and choose a reducing agent such as sodium borohydride (NaBH) to react in a suitable solvent such as methanol. The carboxyl group of 3-iodobenzoic acid is reduced to a hydroxyl group to obtain 3-iodobenzyl alcohol. Subsequently, with reagents such as hydrobromic acid (HBr) or phosphorus tribromide (PBr
), the hydroxyl group of 3-iodobenzyl alcohol is converted into a bromine atom to obtain 1- (bromomethyl) -3-iodobenzene. If HBr is used, it is a nucleophilic substitution reaction, bromine ions attack the carbon cation formed by the alcohol hydroxyl group, and the hydroxyl group leaves in the form of water; if PBr
is used, the phosphorus atom interacts with the hydroxyl group, and the bromine ion nucleophilic substitution forms a product.
In addition, 3-iodobenzaldehyde can be started from. After reacting with metal-organic reagents such as Grignard reagents, the carbon chain is first increased, and then a series of functional However, this process is a little complicated, and the reaction conditions and the purification of the intermediate need to be carefully controlled in order to obtain a better yield. In short, there are various methods for synthesizing 1- (bromomethyl) -3-iodobenzene, and the actual operation needs to be based on the availability of raw materials, the ease of control of the reaction conditions and the yield.

What are the physical properties of 1- (bromomethyl) -3-iodobenzene?

1 - (bromomethyl) - 3 - iodobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical processes and practical applications.
First of all, its appearance, under normal temperature and pressure, 1- (bromomethyl) - 3 - iodobenzene is often colorless to light yellow liquid. This color and shape are of great reference value in the preliminary identification and judgment of its purity. Its liquid state gives it a certain fluidity. In the reaction system, it can be dispersed more uniformly and participate in various chemical reactions.
Melting point and boiling point. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1- (bromomethyl) -3 -iodobenzene is about [X] ° C, which determines its physical state within a specific temperature range. The boiling point is about [X] ° C. When the temperature rises to the boiling point, the compound converts from liquid to gaseous state. The boiling point affects its behavior in separation and purification operations. It can be separated from other substances by distillation according to the difference in boiling points.
Furthermore, the density. The density of 1- (bromomethyl) -3 -iodobenzene is about [X] g/cm ³, which is heavier than water. This density characteristic is of great significance in operations involving liquid-liquid separation. For example, in the extraction process, the compound can be effectively separated from the aqueous phase according to different densities.
Solubility is also a key property. 1- (bromomethyl) -3 -iodobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic needs to be carefully considered when selecting the reaction solvent, separating and purifying the product. In organic solvents, specific interactions can be formed between molecules and solvent molecules, which is conducive to the progress of chemical reactions and the dissolution and separation of products.
In addition, 1- (bromomethyl) -3-iodobenzene has a certain degree of volatility. Although the volatility is not extremely strong, in the open system, some volatilization will also escape. Its volatility is affected by factors such as temperature and pressure. When the temperature increases and the pressure decreases, the volatilization rate will be accelerated accordingly. This property needs proper attention during storage and use, and should be sealed to prevent its volatilization loss and avoid its volatilization into the environment, causing potential harm. The physical properties of 1 - (bromomethyl) - 3 - iodobenzene play a fundamental role in determining its application in chemical synthesis, analytical testing, material preparation, and many other fields. Therefore, it is essential for chemists to deeply understand and accurately grasp these properties.

What are the chemical properties of 1- (bromomethyl) -3-iodobenzene

1 - (bromomethyl) -3 -iodobenzene is one of the organic compounds. Its chemical properties are unique and have a number of characteristics.
First of all, its halogenated hydrocarbon properties. This molecule contains bromine and iodine dihalogen atoms, so it is quite active in the nucleophilic substitution reaction. The carbon at bromomethyl is partially positive due to the electron-absorbing action of the bromine atom, which is easy to be attacked by nucleophiles. In case of alcohol nucleophiles, such as ethanol under basic conditions, the bromine atom can be replaced by ethoxy to form the corresponding ether compound.
And its aromatic ring properties. The benzene ring has a conjugated system, which makes the molecule have a certain stability. However, the presence of iodine atoms and bromomethyl affects the electron cloud distribution of the benzene ring. Bromomethyl is an ortho-para-site locator, and iodine atoms also have a localization effect. The two work together to cause the electrophilic substitution reaction on the benzene ring to have a specific orientation. For example, when nitrification is carried out, the nitro group is polyintroduced into the ortho or para-site of bromomethyl.
In addition, the bromomethyl of 1- (bromomethyl) -3-iodobenzene can undergo many reactions. It can react with sodium cyanide, and bromine is replaced by a cyanyl group to obtain a product containing a cyanide group, which can be further hydrolyzed to a carboxyl group or reduced to an amino group, providing
Furthermore, although the iodine atom is larger than the bromine atom and has a slightly weaker tendency to leave, under certain conditions, in the case of strong nucleophiles or in appropriate catalytic systems, substitution reactions can also occur, providing the possibility for the construction of new carbon-heteroatom bonds. In the field of organic synthesis, this compound can be used as a raw material to prepare a variety of organic molecules with biological activity or special functions through a series of reactions.

What to pay attention to when storing and transporting 1- (bromomethyl) -3-iodobenzene

For 1 - (bromomethyl) - 3 - iodobenzene, many matters need to be paid attention to during storage and transportation. This is an organic compound with certain chemical activity and latent risk.
First storage environment. It should be stored in a cool, dry and well-ventilated place. Because it is sensitive to humidity and temperature, high temperature and humidity are easy to cause deterioration. If it is in a high temperature environment, it may cause chemical reactions, cause decomposition or polymerization, and damage quality and stability. Therefore, the warehouse temperature should be controlled in a suitable range, such as 15-25 degrees Celsius, and the humidity should be maintained between 40% and 60%.
Furthermore, it is necessary to pay attention to its packaging. Be sure to ensure that the packaging is tight to prevent leakage. It is advisable to use corrosion-resistant packaging materials, such as glass, specific plastic materials, etc. Because it contains halogen atoms such as bromine and iodine, or reacts with some metals, it is avoided to use metal packaging. Warning signs should be clearly marked on the outside of the package to indicate its danger.
When transporting, caution is also required. It should be transported separately from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances may cause severe chemical reactions or even explosions. The transportation process should be shock-proof and collision-proof to avoid leakage caused by damage to the packaging. The transportation vehicle should also be equipped with corresponding emergency treatment equipment and protective equipment to prepare for the unexpected.
In short, when storing and transporting 1- (bromomethyl) -3-iodobenzene, there are strict requirements for the environment, packaging and transportation conditions. Operating according to regulations can ensure safety and avoid accidents.