1-Chloro-2-Iodobenzene

Fengxi Chemical

Specifications

HS Code	613899
Chemical Formula	C6H4ClI
Molar Mass	239.45 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	219 - 221 °C
Melting Point	-10 °C
Density	1.876 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	97 °C
Odor	Characteristic aromatic odor
Stability	Stable under normal conditions, but light - sensitive

As an accredited 1-Chloro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - chloro - 2 - iodobenzene in 500 - gram glass bottles, well - sealed for protection.
Storage	1 - Chloro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent fire risks. Keep it in a tightly sealed container to avoid leakage and exposure to air or moisture, which could potentially lead to chemical reactions. Store it separately from oxidizing agents and incompatible substances to ensure safety.
Shipping	1 - chloro - 2 - iodobenzene is shipped in sealed, corrosion - resistant containers. It's classified as a hazardous chemical, so shipments follow strict regulations, ensuring proper labeling, secure packaging, and transport by approved carriers.

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General Information

Historical Development

1 - Chloro - 2 - Iodobenzene is an organic compound, and its historical development is very interesting. In the past, when organic chemistry was first developed, many chemists dedicated themselves to exploring the synthesis and properties of various compounds. At that time, the research methods were still simple, but the previous chemists started the journey of this compound research with tenacity and wisdom.
In the early days, limited to technology, the understanding of 1 - Chloro - 2 - Iodobenzene only stopped at preliminary structure speculation. Later, with the advancement of chemical analysis technology, spectroscopic analysis and other means helped chemists to accurately determine its structure.
Synthesis methods have also undergone changes. The initial synthesis process is complicated and the yield is low. After years of research, chemists have continuously improved, and new synthesis paths have emerged to improve yield and purity. This compound has become increasingly useful in the field of organic synthesis, becoming a key intermediate for the preparation of complex organic molecules, promoting the vigorous development of organic chemistry, and has also emerged in related fields such as materials science, with promising prospects.

Product Overview

1 - Chloro - 2 - Iodobenzene is an organic compound. It is a colorless to pale yellow liquid with a special odor. In this compound, the chlorine atom and the iodine atom occupy adjacent positions above the benzene ring.
The preparation method often involves the skills of organic synthesis. It can be obtained through steps such as the halogenation of benzene. The reaction process requires strict control of conditions, such as temperature, type and dosage of catalyst, etc., to ensure the purity and yield of the product.
1 - Chloro - 2 - Iodobenzene has a wide range of uses in the field of organic synthesis and can be used as an intermediate to prepare a variety of organic materials with special functions. Due to its unique structure, it is endowed with unique activity in chemical reactions, and can participate in various types of reactions, such as nucleophilic substitution reactions. It is valued by organic synthesis chemists and is of great value in the research and industrial production of organic chemistry.

Physical & Chemical Properties

1 - Chloro - 2 - Iodobenzene is an organic compound with unique physical and chemical properties. Looking at its properties, it is a colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is about 210-212 ° C. Due to the existence of a certain van der Waals force and hydrogen bonding between molecules, a specific energy is required to gasify it. The density is 1.88 g/cm ³, which is greater than that of water. Due to the large relative mass of chlorine and iodine atoms in the molecular structure, the molecules are tightly packed.
In terms of chemical properties, the activities of chlorine and iodine atoms in this compound are different. The chlorine atom has a certain nucleophilic substitution activity, and substitution reactions can occur under suitable nucleophilic reagents and reaction conditions. Iodine atoms are relatively more active, and they are easier to leave in some reactions. They participate in various organic synthesis and transformation, such as coupling reactions with unsaturated hydrocarbons under metal catalysis, providing the possibility for the construction of complex organic molecular structures.

Technical Specifications & Labeling

1 - Chloro - 2 - Iodobenzene is also a chemical product. Its technology is not good enough (commodity quality) to be shipped. Those who are skilled, explain the method of its synthesis, the raw materials used must be refined, and the anti-parts must be controlled, such as the degree, force, and anti-resistance. And the synthesis step is appropriate, and it can be determined.
To be the first to state its name, 1 - Chloro - 2 - Iodobenzene is also. Show its molecular formula and molecular weight, so that it can be known. More understanding properties, such as external temperature, melting temperature, solubility, etc. And the degree of clarity, to show the product. In this way, the 1 - Chloro - 2 - Iodobenzene technique is the key to the price (commodity price).

Preparation Method

1 - Chloro - 2 - Iodobenzene is an organic compound. The preparation method is related to the raw materials, production process, reaction steps and catalytic mechanism.
The selection of raw materials is very critical, such as benzene and related halogenates. With benzene as the starting material, chlorine and iodine atoms need to be introduced through a halogenation reaction. First, chlorine gas reacts with benzene under specific conditions to generate chlorobenzene. This reaction often requires a catalyst, such as ferric chloride. The catalytic mechanism lies in the polarization of chlorine molecules, which is more likely to be electrophilic substituted with benzene rings.
Later, chlorobenzene and iodine react from suitable reaction steps. Iodine sources such as potassium iodide can be used to catalyze a halogen exchange reaction under the catalysis of copper salts. The reaction conditions such as temperature and solvent selection are all affected. Generally, polar solvents are selected to facilitate ionic reaction. The reaction mechanism of this step is nucleophilic substitution. Iodine ions attack the carbon site attached to the chlorine atom of chlorobenzene, and the chloride ions leave to obtain 1-Chloro-2-Iodobenzene. The whole preparation process requires fine control of each reaction condition to achieve good yield and purity.

Chemical Reactions & Modifications

Today there is a substance called 1-Chloro-2-Iodobenzene. In the field of chemistry, its reaction and modification are particularly important.
Looking at its reaction, it can encounter various reagents and undergo various changes. Such as the reaction of nucleophilic substitution, halogen atoms can be easily formed into new compounds. For this reaction, it is crucial to choose the appropriate conditions, such as temperature and solvent. If the temperature is high, the reaction speed will be increased; if the solvent is different, it will also affect the path and rate.
As for modification, other groups can be introduced to change its properties. Or increase its stability, or change its solubility. By chemical means, adjust its structure to suit different needs. Or used in drug synthesis, or used in material preparation.
In the course of chemical research, it is of great significance to explore the reaction and modification of 1-Chloro-2-Iodobenzene, such as digging treasure, paving the way for progress in many fields.

Synonyms & Product Names

1 - Chloro - 2 - Iodobenzene, which is also the raw material of chemistry. The same name and the city name are related to the cognition and transmission of the industry.
In the course of my chemical research, it is common to see more than one thing. 1 - Chloro - 2 - Iodobenzene, also known as o-chloroiodobenzene. The two, one is the system name, according to the rules of chemical structure; the other is the popular name, which is convenient for industry communication. Its market name, or varies from business to business or use, but they all refer to the same substance.
The name of o-chloroiodobenzene is given by the relative position of chlorine and iodine, which is commonly used in the industry. The name of the city often takes into account the application, market, etc. Or because it is used for a specific synthesis, it is named after its use; or because of the target customer, it is named after meeting the needs. Although the names are different, they are actually one.
When we study, we must clarify the relationship between the same name and the city name in order to use it accurately and be correct in experimentation and production. This is crucial in the chemical industry.

Safety & Operational Standards

1 - Chloro - 2 - Iodobenzene is an organic compound, which is crucial for its safety and operating practices.
This compound has certain chemical activity. During operation, the first priority is to ventilate the environment. The space where the operation is located must be well ventilated to prevent the accumulation of harmful gases and damage to the health of the operator.
Furthermore, the operator must be equipped with protective equipment. Such as protective gloves, which should be chemically resistant to protect the hands; protective glasses are also indispensable, which can effectively resist the damage of liquid splashes or volatiles to the eyes; wearing protective clothing can reduce the risk of direct contact between the compound and the body.
For storage, 1-Chloro-2-Iodobenzene should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent fire or dangerous reactions of compounds. It should be kept separate from other chemicals such as oxidants and reducing agents to avoid chemical reactions caused by improper mixing.
During access and operation, the movement should be stable and precise. Use suitable instruments, such as pipettes, droppers, etc., and measure accurately according to the experimental requirements. If you accidentally come into contact with the skin, you should immediately rinse with plenty of water and then seek medical attention as appropriate. If it splashes into the eye, you need to rinse the eye with flowing water immediately and seek medical attention quickly.
In conclusion, the operation of 1 - Chloro - 2 - Iodobenzene requires strict adherence to safety and operating standards, and careful care is taken to ensure the safety of personnel and the smooth conduct of the experiment.

Application Area

1 - Chloro - 2 - Iodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of many special drugs. Because of its unique chemical structure, it can be cleverly spliced with other molecules through specific chemical reactions to form substances with unique pharmacological activities.
In material science, this compound also has extraordinary performance. It can help to prepare high-performance functional materials, such as some materials with special optoelectronic properties. Through its participation in the synthesis, it may exhibit excellent conductivity, luminescence and other properties, opening up new avenues for the research and development of new materials.
Furthermore, in the fine chemical industry, 1-Chloro-2-Iodobenzene can be used to create high-value-added fine chemicals, improve product quality and performance, and contribute to the development of the industry. It is actually a compound with broad application prospects.

Research & Development

In recent years, I have focused on the research of 1-Chloro-2-Iodobenzene. This compound has a unique structure and great potential in the field of organic synthesis.
At the beginning, there were many difficulties in the preparation method. The raw materials are rare and expensive, the reaction conditions are harsh, and the yield is often low. However, I did not give up, and devoted myself to studying ancient books and modern treatises, and learned from the strengths of various families.
After months of tests, the reaction process was improved. The control of temperature and pressure was optimized, and high-efficiency catalysts were selected to gradually increase the yield. At the same time, the reaction mechanism was deeply explored, and the chemical changes of each step were clarified, laying the foundation for subsequent refinement.
Looking to the future, we want to expand its application range. Or for the creation of new drugs, or to help the research and development of high-performance materials. We firmly believe that with unremitting efforts, 1 - Chloro - 2 - Iodobenzene will be able to shine in the fields of scientific research and industry, and contribute to the development of academia and industry.

Toxicity Research

1-Chloro-2-iodobenzene is also a chemical product. It is a top priority for our generation to study its toxicity.
To observe this substance, its molecular structure is unique, and chlorine and iodine are combined in the benzene ring. Past studies have mostly concerned its chemical properties, but the study of toxicity is still lacking.
The study of toxicity must involve living things. Take mice as an experiment and feed them with 1-chloro-2-iodobenzene to observe their physiological changes. Not long ago, the mice showed signs of slow movement and poor diet.
Analyze its effect on cells, and add this substance to cultured cells to observe cell growth and metabolism. It was found that cell proliferation was inhibited and metabolism was chaotic.
In summary, 1-chloro-2-iodobenzene is toxic, and it has an impact on biophysiology and cells. However, in order to clarify its details, extensive research is needed to fully understand its harm and serve as the basis for protection and treatment.

Future Prospects

Today there is a thing called 1-Chloro-2-Iodobenzene. This is an organic compound with unique structure and properties. Looking at today's chemical research, its application prospects are quite promising.
In the future development, it may emerge in the field of drug synthesis. Because of its special functional groups, it can be used as a key intermediate to help create new drugs for human health and well-being. In materials science, it is also expected to become the cornerstone of building high-performance materials and improving the properties of materials.
We chemical researchers should devote ourselves to studying and exploring its potential. With unremitting efforts, we hope to uncover a new chapter in its future development, so that it can benefit the society and leave brilliant results for future generations. This is our vision for the future.

Where to Buy 1-Chloro-2-Iodobenzene in China?

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Frequently Asked Questions

As a leading 1-Chloro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-chloro-2-iodobenzene?

1-Chloro-2-iodobenzene, or 1-chloro-2-iodobenzene, is widely used. In the field of organic synthesis, it is often an important raw material and intermediate.
First, when building complex organic molecular structures, both chlorine and iodine atoms have certain reactivity, which can participate in many nucleophilic substitution reactions. For example, under appropriate reaction conditions, chlorine atoms can be replaced by nucleophiles such as hydroxyl and amino groups, thereby introducing different functional groups, providing the possibility for the synthesis of various organic compounds containing special functional groups.
Second, this compound also has potential applications in medicinal chemistry. With its reactivity, it can be used to synthesize drug molecules with specific biological activities. In the process of many drug development, specific benzene ring structures need to be constructed and different substituents need to be introduced to adjust the activity, solubility and pharmacokinetic properties of drugs. 1-chloro-2-iodobenzene can be used as a starting material to prepare the required drug intermediates through multi-step reactions.
Third, in the field of materials science, it can participate in the synthesis of functional polymer materials. By polymerizing with other monomers, its structural units are introduced into the polymer chain to endow the material with special properties, such as changing the electrical and optical properties of the material, to meet the needs of different application scenarios.
In conclusion, 1-chloro-2-iodobenzene plays an important role in many fields such as organic synthesis, medicinal chemistry, and materials science, and plays an indispensable role in promoting the development of related fields.

What are the physical properties of 1-chloro-2-iodobenzene?

1-Chloro-2-iodobenzene, that is, 1-chloro-2-iodobenzene, is one of the organic halogenated aromatics. Looking at its physical properties, it is usually colorless to light yellow liquid with a special odor. Due to the presence of chlorine and iodine atoms in the molecule, its relative density is greater than that of water, and it is difficult to dissolve in water, but it is easily soluble in common organic solvents such as ethanol, ether, and benzene.
The boiling point of this compound is affected by the intermolecular force. The chlorine and iodine atoms increase the molecular mass and polarity, resulting in the increase of the intermolecular force, and the boiling point is higher, about 240-250 ° C. Its melting point depends on the regularity of molecular arrangement, and the melting point of this substance is about -3 ° C.
In addition, 1-chloro-2-iodobenzene has a low vapor pressure and a slower volatilization rate at room temperature. Its refractive index is related to the molecular structure and reflects the degree of refraction of light when passing through. Under specific conditions, the refractive index is about 1.635-1.640. These many physical properties have a great impact on its application in organic synthesis, medicinal chemistry and other fields.

Is 1-chloro-2-iodobenzene chemically stable?

1 - chloro - 2 - iodobenzene is a genus of organohalogenated aromatics. Its chemical properties are not stable, but have specific activity.
The chlorine atom and the iodine atom are both active check points. Due to the large electronegativity of the chlorine atom, the electron cloud density distribution of the benzene ring changes, and the electron cloud density of the adjacent and para-position increases slightly, so it is easy to be attacked by electrophilic reagents. In the electrophilic substitution reaction, although chlorine is an adjacent and para-position group, its electron-absorbing induction effect also exists, or affects the reaction rate and product distribution to a certain extent.
Although iodine atoms are slightly less electronegative than chlorine, their atomic radius is large, the C-I bond energy is relatively small, and they are more prone to heterocracking. This property allows 1-chloro-2-iodobenzene to participate in reactions such as nucleophilic substitution. Under appropriate nucleophilic reagents and reaction conditions, iodine atoms can be replaced by nucleophilic groups.
In addition, due to the presence of halogen atoms, 1-chloro-2-iodobenzene may participate in metal-catalyzed coupling reactions, such as palladium-catalyzed cross-coupling. Such reactions are widely used in the construction of carbon-carbon bonds and carbon-hetero bonds, and play an important role in the field of organic synthesis.
Furthermore, when 1-chloro-2-iodobenzene is heated, illuminated or exposed to specific chemical reagents, halogen atoms may undergo elimination reactions to form unsaturated phenyne intermediates. This intermediate has extremely high activity and can react with many reagents, resulting in a variety of reaction products.
In summary, the chemical properties of 1-chloro-2-iodobenzene are not stable, and they show rich reactivity in organic synthesis due to the characteristics of halogen atoms. It is used for organic chemistry research and synthesis.

What are the preparation methods of 1-chloro-2-iodobenzene?

1-Chloro-2-iodobenzene is also an organic compound. There are roughly several ways to prepare it.
First, benzene can be prepared by halogenation of benzene. Under appropriate conditions, benzene and chlorine are first chlorinated with iron or ferric chloride as a catalyst to obtain chlorobenzene. Then, chlorobenzene and iodine are reacted under specific reagents and conditions to achieve the purpose of introducing iodine atoms into the ortho-site. However, in this way, the iodine substitution reaction is difficult to control, and it is often necessary to find a suitable catalyst and reaction environment to increase the yield of the ortho-site product.
Second, o-chloroaniline can also be used as a starting material. First, the diazonium salt is prepared by diazotization of o-chloroaniline. Then, the diazonium salt interacts with iodine sources such as potassium iodide, and undergoes a transformation such as a Sandmeier reaction to obtain 1-chloro-2-iodobenzene. This method requires attention to the control of the conditions of the diazotization reaction. Temperature, pH and other factors have a great influence on the reaction. A little carelessness, or a cluster of side reactions can be caused, which affects the purity and yield of the product.
Third, the reaction involving organometallic reagents can also be used as a preparation method. For example, a suitable organolithium reagent or Grignard reagent reacts with a halogenated aromatic hydrocarbon precursor containing chlorine and iodine at low temperature and under the protection of inert gas. By rationally designing the reaction substrate and regulating the reaction conditions, chlorine and iodine atoms can be introduced into the specific position of the benzene ring as expected. This approach requires high reaction operation and needs to be carried out in an anhydrous and anaerobic environment to ensure the activity of the reagent and the smooth reaction.
The method of preparing 1-chloro-2-iodobenzene has its own advantages and disadvantages. It is necessary to choose the good one according to the actual demand, the availability of raw materials, the cost and the difficulty of the process.

1-chloro-2-iodobenzene need to pay attention to when storing and transporting

1-Chloro-2-iodobenzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
First word storage. This substance should be placed in a cool and ventilated warehouse. Because it is more sensitive to heat, high temperature may cause changes in chemical properties, or even cause danger, so a cool environment is essential. And the warehouse must be well ventilated to prevent the accumulation of volatile gases and reduce the risk of explosion and poisoning. In addition, it must be kept away from fire and heat sources. Open flames and hot topics can cause violent reactions and cause safety accidents. At the same time, it should be stored separately from oxidants, acids, bases, etc., and cannot be mixed. Cause 1-chloro-2-iodobenzene and the above substances are prone to chemical reactions, or cause serious consequences such as combustion and explosion.
The following transportation. When transporting, the packaging must be complete and firm. Make sure that it is not damaged and leaked due to bumps and collisions during transportation. The means of transportation must also be clean and dry, and no substances that can react with it shall remain. During transportation, it is necessary to prevent exposure to the sun and rain to avoid the impact of high temperature and humid environment on it. And the transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment for emergencies. If a leak occurs during transportation, drivers and passengers should immediately take emergency measures to evacuate the surrounding people, isolate the leakage pollution area, and strictly restrict access to prevent the expansion of the accident.
In conclusion, the storage and transportation of 1-chloro-2-iodobenzene requires careful attention and strict adherence to relevant norms and requirements to ensure the safety of personnel and the environment.