1-Chloro-3-Iodobenzene

Fengxi Chemical

Specifications

HS Code	953118
Chemical Formula	C6H4ClI
Molar Mass	238.45 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	217 - 218 °C
Melting Point	14 - 15 °C
Density	1.84 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	97 °C
Vapor Pressure	Low vapor pressure
Stability	Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-Chloro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - chloro - 3 - iodobenzene packaged in 500 - gram bottles.
Storage	1 - Chloro - 3 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Label the storage container clearly with the chemical name and relevant hazard information.
Shipping	1 - chloro - 3 - iodobenzene is shipped in sealed, corrosion - resistant containers. These are carefully packaged to prevent leakage. Shipments follow strict chemical transportation regulations to ensure safety during transit.

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General Information

Historical Development

1 - Chloro - 3 - Iodobenzene is an organic compound, and its historical development is quite impressive. In the past, when organic chemistry was first emerging, many chemists dedicated themselves to exploring the synthesis of new compounds. At that time, the research on halogenated aromatics was gradually carried out.
In the early days, the synthesis technology was limited, and it was quite difficult to obtain 1 - Chloro - 3 - Iodobenzene. Chemists worked hard and tried various methods. After repeated experiments, using benzene as the starting material, through halogenation reactions, it was gradually synthesized with precision.
With the passage of time, chemical theory and experimental techniques have been perfected day by day. The method of synthesizing 1-Chloro-3-Iodobenzene has been continuously optimized, and the yield and purity have been greatly improved. The application of this compound in the field of organic synthesis is also becoming more and more extensive, laying the foundation for the construction of many complex organic molecules and promoting the continuous progress of the field of organic chemistry.

Product Overview

1 - Chloro - 3 - Iodobenzene is an organic compound, and its preparation method and properties are quite important.
Preparation of this substance often requires delicate chemical steps. Using benzene as the starting material, chlorine atoms are introduced first, which can be achieved by a specific chlorination reaction. Then, under appropriate conditions, iodine atoms are introduced into specific positions to obtain the target product 1 - Chloro - 3 - Iodobenzene.
In terms of physical properties, it is in a liquid or solid state at room temperature and has a specific melting boiling point. Chemically, chlorine and iodine atoms give it a certain reactivity. Chlorine atoms can participate in nucleophilic substitution reactions, and iodine atoms can also play unique roles under certain conditions, or are used to construct new carbon-carbon bonds and other reactions.
This compound has a wide range of uses in the field of organic synthesis and can be used as a key intermediate for the preparation of more complex organic molecules, providing an important cornerstone for the research and practical application of organic chemistry.

Physical & Chemical Properties

1 - Chloro - 3 - Iodobenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, it is mostly liquid at room temperature, and its color is nearly colorless or slightly light. It has a certain volatility and can emit a special odor. Its physical constants such as boiling point and melting point are different from similar benzene derivatives due to the influence of chlorine and iodine atoms in the molecular structure.
When it comes to chemical properties, the chlorine and iodine atoms in this compound are quite active. Chlorine atoms have strong electronegativity, which changes the electron cloud density of the benzene ring, making it more prone to electrophilic substitution reactions. Although iodine atoms are slightly less active than chlorine atoms, they can also participate in chemical reactions under specific conditions, such as interacting with nucleophiles to achieve functional group conversion. Due to the atomic properties of chlorine and iodine, 1-Chloro-3-Iodobenzene is widely used in the field of organic synthesis, and is often used as an intermediate to participate in the preparation of various complex organic compounds.

Technical Specifications & Labeling

1 - Chloro - 3 - Iodobenzene, an organic compound. The technical specifications for its preparation, the choice of the first raw materials. The chlorine source and iodine source used must be pure, and impurities should not be stored in order to maintain the quality of the product. The reaction conditions, the temperature should be controlled at XX degrees, too high will cause side reactions to be raw, and too low will cause the rate to be slow.
The identification (product parameters) of its product, the appearance should be colorless to slightly yellow liquid, and the smell is specific. The purity must be above XX%, and the impurity content is limited to below XX. The melting point is also fixed, the melting point is about XX degrees, and the boiling point is about XX degrees. This is the key to determine the quality of 1-Chloro-3-Iodobenzene. Only by following this technical specification and identification (product parameters) can we obtain high-quality products.

Preparation Method

The method of making 1 - Chloro - 3 - Iodobenzene is related to the raw material and production process, reaction steps and catalytic mechanism. The raw material needs to be pure benzene, supplemented by an appropriate amount of chlorine and iodide. First, the benzene and chlorine are mixed in a specific ratio, in a closed container, with ferric chloride as the catalyst, the temperature is controlled at about 50 ° C, and a substitution reaction occurs to obtain chlorobenzene. In this step, the temperature and the proportion of raw materials should be stabilized to ensure the complete reaction.
Then, the obtained chlorobenzene is obtained, and the iodide is heated to about 80 ° C in an organic solvent under the catalysis of copper powder, and the secondary substitution is carried out to obtain 1 - Chloro - 3 - Iodobenzene. This process requires attention to the reaction time. If it is too long, it is easy to produce by-products, and if it is too short, the reaction will not be completed. The catalytic mechanism relies on ferric chloride and copper powder to accelerate the reaction process and increase the yield. In this way, through fine steps, this product can be prepared.

Chemical Reactions & Modifications

Today there is a substance, named 1-Chloro-3-Iodobenzene. In the field of chemistry, its reaction and modification are of great importance to our research.
This compound has unique properties. Its chlorine and iodine atoms are the main points of the reaction. It is often changed by nucleophilic substitution. Nucleophilic reagents attack it, chlorine or iodine are easy to separate, and new groups can enter, so the modified product is obtained.
However, this reaction has its difficulties. The activities of chlorine and iodine are different, and the selection of suitable reagents and conditions can meet expectations. Temperature and solvent are all related to the rate and selection of the reaction. Raising the temperature, or promoting the reaction, but it also produces side effects. Choose the right solvent to increase solubility and promote contact, and help the reaction go forward.
If you want to change its properties, there are other ways. For example, catalysis can reduce the energy barrier of the reaction and increase its activity. Research on its reaction and modification is very useful in materials, medicine and other industries, and can be the basis for the creation of new products.

Synonyms & Product Names

1-Chloro-3-iodobenzene is also a genus of chemical substances. Its synonymous name and the name of the commodity are both important in the academic world.
The name of the husband is synonymous, which is relied on by the academic world for communication. Cover chemical nomenclature, according to specific rules, so that scholars can accurately express the meaning. 1-chloro-3-iodobenzene, according to the system nomenclature, to clarify the position of chlorine and iodine atoms in its molecules. However, there are other names, either according to structural characteristics or according to traditional names, which are synonymous names, which is convenient for scholars to communicate and discuss.
As for the name of the commodity, it is related to the industry. Merchants use it to identify their products in order to recognize their characteristics in the market. Or because of the unique preparation process, or because of the unique use, there are unique trade names. Such trade names need to comply with laws and regulations, but also to attract attention, so as to stand out in the market competition.
In the process of chemical research and industrial application, the synonymous name and trade name of 1-chloro-3-iodobenzene are important symbols to help our generation clarify the characteristics and uses of this material and promote the development of related fields.

Safety & Operational Standards

1-Chloro-3-iodobenzene is also a chemical substance. If you want to make this substance, it is essential to operate it safely.
At the beginning of the operation, it is necessary to use the necessary and dry utensils to prevent the reaction of the chemical. When using the raw materials, it is appropriate to use the appropriate amount, and the amount must be refined, according to the determined ratio. Because the raw materials of 1-chloro-3-iodobenzene may be toxic and corrosive, it is necessary to use protective equipment, such as gloves, eyes, masks, etc., to ensure your own safety.
The situation of the reaction also needs to be controlled. The degree and force are all caused by the reaction. It is advisable to observe the degree of resistance and force, so that the reaction is in a suitable environment. And the speed of mixing should not be ignored. Mixing evenly can promote the full integration of the reaction material, so that the reaction is beneficial.
When the reaction is over, it is especially necessary to separate the steps of lifting. Or by steaming or extraction, 1-chloro-3-iodobenzene is precipitated from the mixture to improve its stability. This operation also needs to be carried out according to the method, and it must not be lost quickly.
Store 1-chloro-3-iodobenzene, and it is appropriate to make it dry and clear. Hold it in a sealed container to prevent it from being empty and connected with water, so as to prevent it from being damaged. It is necessary to clarify the information such as the name of the product, the nature of the product, the harm, etc., so that it can be used.
Therefore, the research and development of 1-chloro-3-iodobenzene, safety first, and operation according to the standard, so that it can be achieved and the safety of people's environment is guaranteed.

Application Area

1 - Chloro - 3 - Iodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be a key intermediate for the synthesis of specific drugs. With its unique chemical structure, through ingenious reactions, it can prepare good drugs for specific diseases, such as drugs for the treatment of some difficult diseases. In the field of materials science, it may be able to participate in the synthesis of high-performance materials. Through a series of chemical reactions, the material is endowed with special properties, such as enhancing the stability and conductivity of the material. Furthermore, in the field of fine chemicals, 1 - Chloro - 3 - Iodobenzene can be used as a raw material for a variety of fine chemicals, helping to produce high value-added products to meet the needs of various industries for special chemicals. All these demonstrate the important value of 1 - Chloro - 3 - Iodobenzene in many application fields.

Research & Development

I am dedicated to the research of 1-Chloro-3-Iodobenzene. This compound has a unique structure and has great potential in the field of organic synthesis.
Initially, explore its synthesis method. After many attempts, based on the halogenation reaction, optimize the reaction conditions, such as temperature and catalyst selection, and strive to improve the yield and purity. In the study of the reaction mechanism, the chemical changes of each step are clarified, which lays the foundation for improving the process.
Then, consider its application and expansion. It is found that it can build key structures in the synthesis of new drug intermediates, or promote the progress of pharmaceutical research and development. It is also observed that in the field of materials science, it is expected to be modified to give materials special properties.
We will continue to conduct intensive research and explore its potential, with the hope of opening up new frontiers for the development of this compound, enabling it to shine in more fields, and assisting academic and industrial progress.

Toxicity Research

Study on the toxicity of 1-chloro-3-iodobenzene
The nature of the compound is related to the safety of people's livelihood, so the study of toxicity cannot be ignored. 1-chloro-3-iodobenzene is a commonly used chemical substance.
Now study its toxicity in detail to understand its effect on life. After various experiments, observe its effect on insects and livestock. Observe its entry into the body, either through respiration, or through skin penetration, or through diet. After entering the body, it travels between the organs and meridians, or disturbs the transportation of qi and blood, or disrupts the ability of the organs.
Looking at the microscopic insects, it can cause their vitality to decline and reproduction to be hindered. In poultry, it may make their spirits sluggish, their diet sluggish, and even their organs damaged and endanger their lives. The reason is that because of its unique structure, the lid can interact with various molecules in the body of the organism, causing chaos to its biochemical order.
We who are students should study the toxicity of this substance carefully, understand its harm, and seek ways to avoid harm, so that this chemical substance can be used for beneficial purposes and avoid its harm, so as to protect the safety of the common people and the peace of the environment.

Future Prospects

Now 1 - Chloro - 3 - Iodobenzene has great potential in the field of chemistry. Although it is still in the research period, the future prospect is really exciting.
We use scientific methods to explore its properties in detail, hoping to open up new horizons. This compound has a unique structure and may be used to create new materials, which can be used in electronics and medicine.
With time and unremitting research, it is expected to develop an efficient synthesis path, reduce its cost and increase its yield. At that time, it will be widely used and benefit the world. Although the road ahead may be bumpy, we scientific researchers should have a strong heart and do our best for the future development, hoping to get what we want, so that 1-Chloro-3-Iodobenzene can bloom and contribute to scientific progress.

Where to Buy 1-Chloro-3-Iodobenzene in China?

As a trusted 1-Chloro-3-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Chloro-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-chloro-3-iodobenzene?

1-Chloro-3-iodobenzene is an organohalogenated aromatic hydrocarbon, which has the following chemical properties:
First, nucleophilic substitution reaction. Due to its halogen atom activity, chlorine and iodine can be replaced by nucleophilic reagents. For example, under strong alkali and heating conditions, hydroxyl negative ions attack benzene rings as nucleophiles, and chlorine or iodine leave atoms to generate corresponding phenolic compounds. This reaction requires specific solvents and reaction conditions to help the nucleophilic reagent fully contact with the substrate and promote the departure of the leaving group.
Second, electrophilic substitution reaction. Benzene rings are electron-rich and vulnerable to attack by electrophilic reagents. For example, under the catalysis of Lewis acid, it reacts with acyl halides or halogenated alkanes, and a Fu-gram reaction occurs, and an acyl or alkyl group is introduced into the benzene ring. And because chlorine and iodine are ortho and para-localized groups, electrophilic reagents mainly attack their ortho and para-sites to generate corresponding substitutions.
Third, metal-organic reaction. 1-chloro-3-iodobenzene can react with metal reagents to generate metal-organic compounds. If it reacts with magnesium to form a Grignard reagent, the Grignard reagent has strong nucleophilic properties and can react with a variety of electrophilic reagents such as aldodes, ketones, esters, etc., to form new carbon-carbon bonds, which are widely used in organic synthesis to construct complex molecular structures.
The halogen atoms in the molecule can be reduced and removed under the action of suitable reducing agents. For example, under certain metals (such as zinc) and acidic conditions, chlorine and iodine atoms are gradually reduced to form benzene ring dehalogenation products. This reaction provides a way to regulate the benzene ring substituents.
In short, 1-chloro-3-iodobenzene has active chemical properties due to the presence of halogen atoms and benzene rings. It is widely used in the field of organic synthesis and can be used to construct organic compounds with different structures through various reactions.

What are the main uses of 1-chloro-3-iodobenzene?

1-Chloro-3-iodobenzene is one of the organic compounds. Its main uses are quite wide, and it has a significant position in the field of organic synthesis.
First, it can be used to prepare various drugs. In the process of organic synthesis of drugs, it is often necessary to construct a specific molecular structure. 1-chloro-3-iodobenzene can be used as a key starting material or intermediate due to its unique chemical structure. Through a series of chemical reactions, such as nucleophilic substitution reactions and metal-catalyzed coupling reactions, it can be converted into compounds with specific pharmacological activities, and then become drugs for treating diseases.
Second, it also has important uses in the field of materials science. For example, it can be used to prepare high-performance polymer materials. By chemical reaction, 1-chloro-3-iodobenzene is introduced into the main chain or side chain of the polymer, which can impart special properties to the polymer, such as improving its thermal stability, mechanical properties or optical properties. Polymer materials with these special properties are widely used in many high-end fields such as electronic devices, aerospace, etc.
Furthermore, it is also indispensable in the synthesis of pesticides. It can be used as an important intermediate in the synthesis of new pesticides to prepare pesticide products with high insecticidal, bactericidal or herbicidal activities. Such pesticides can effectively protect crops, increase agricultural yield, and have lower toxicity and better environmental friendliness than traditional pesticides.
In conclusion, 1-chloro-3-iodobenzene plays an important role in many fields such as organic synthesis, drug research and development, materials science and pesticide preparation, and promotes the development and progress of related industries.

What are 1-chloro-3-iodobenzene synthesis methods?

The synthesis of 1-chloro-3-iodobenzene is an important topic in the field of organic synthesis. There are several common methods as follows:
First, m-chloroaniline is used as the starting material. Shilling m-chloroaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. Diazonium salts are highly active, and then react with potassium iodide, the diazonium group is replaced by iodine atoms, resulting in 1-chloro-3-iodobenzene. This process needs to be controlled by the conditions of the diazotization reaction. If the temperature is too high, it is easy to cause the decomposition of diazonium salts, which affects the yield.
Second, starting from isochlorophenylboronic acid. The reaction of isochlorophenylboronic acid with iodide reagents, such as N-iodosuccinimide (NIS), in a suitable solvent in the presence of a suitable catalyst such as palladium catalyst. This reaction uses the coupling mechanism of palladium-catalyzed arylboronic acid and iodide reagent to introduce iodine atoms at specific positions on chlorobenzene to generate the target product 1-chloro-3-iodobenzene. The choice and dosage of catalysts and the properties of the solvent in the reaction have significant effects on the reaction rate and selectivity.
Third, m-dichlorobenzene is used as the raw material. First, through a metallization reaction, such as interaction with butyl lithium, the specific position on the benzene ring is lithiated to form a lithium intermediate The intermediate is then reacted with an iodine source such as iodine elemental substance, and the lithium atom is replaced by the iodine atom to obtain 1-chloro-3-iodobenzene. This route requires attention to the selectivity of the metallization reaction. Due to the different reactivity at different positions on the benzene ring, the reaction conditions need to be precisely controlled to achieve the expected substitution position.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable synthesis path should be selected according to the availability of raw materials, the difficulty of reaction conditions, cost and yield.

1-chloro-3-iodobenzene need to pay attention to when storing and transporting

1-Chloro-3-iodobenzene is an organic compound. When storing and transporting, pay attention to many matters.
First words storage, this substance should be stored in a cool and ventilated warehouse. Because the temperature is too high, the ventilation is not smooth, or it causes chemical reactions, and even causes danger. And it is necessary to keep away from fire and heat sources to prevent the risk of fire or explosion. Because of its flammability and certain chemical activity, it is prone to danger in case of open flames and hot topics.
Furthermore, the storage place should be separated from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, contact with such substances, or a violent reaction, endangering safety. In the warehouse, there should be suitable materials for containing leaks. If there is a leak, it can be dealt with in time to avoid pollution and harm expansion.
As for transportation, be sure to ensure that the packaging is complete and the loading is secure before transportation. The packaging should be leak-proof and shockproof to avoid material leakage caused by package damage during transportation. During transportation, the relevant regulations on the transportation of hazardous chemicals should be strictly observed. The transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment.
The driving route should also be paid attention to. It should avoid densely populated areas, schools, hospitals and other densely populated places, and drive according to the prescribed route. Do not stop in residential areas and densely populated areas. Transportation personnel should also be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can respond promptly and properly to ensure transportation safety.

1-chloro-3-iodobenzene impact on the environment and human health

1-Chloro-3-iodobenzene is one of the organic halides. Its impact on the environment and human health cannot be ignored.
In the environment, this substance has high stability due to halogen atoms and is not easy to be degraded by natural forces. If released in the environment, or accumulated in soil or water bodies. In soil, it can hinder the uptake of nutrients and moisture by plant roots, causing plant growth to be hindered, or stunted, or even withered. In water bodies, it can endanger aquatic organisms. Or cause physiological disorders in fish, shellfish and other organisms, interfering with their reproductive, respiratory and immune systems. If the fertility of fish is reduced, the rate of larval deformity will increase. In the long run, the balance of aquatic ecology will be broken and biodiversity will be greatly reduced.
As for human health, 1-chloro-3-iodobenzene can be ingested into the human body through respiration, skin contact or diet. After entering the body, or damage the nervous system of the human body. It often causes headaches, dizziness, fatigue, and even can cause memory loss, insomnia, etc. It may also harm organs such as the liver and kidneys. The liver is the hub of human metabolism and the function of renal excretion. This substance may interfere with the normal metabolism and excretion of the liver and kidney, making it difficult to excrete toxins in the body, resulting in abnormal liver and kidney function. Changes in relevant indicators can be seen during blood and urine tests. And it may be potentially carcinogenic. Long-term exposure to this substance may increase the risk of cancer, such as induced liver cancer, kidney cancer, etc.
Therefore, 1-chloro-3-iodobenzene has many adverse effects on the environment and human health. Its production, use and disposal must be carried out with caution to prevent it from causing serious harm to the environment and human body.