1 Chloro 4 Fluoro 2 Iodobenzene
Iodobenzene

1-Chloro-4-Fluoro-2-Iodobenzene

Fengxi Chemical

    Specifications

    HS Code

    257208

    Chemical Formula C6H3ClFI
    Appearance Solid (usually)
    Boiling Point Data may vary, typically in a range due to purity etc.
    Melting Point Data may vary based on purity
    Density Specific value depends on conditions
    Solubility In Water Low (organic compound, hydrophobic)
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
    Vapor Pressure Low at room temperature
    Flash Point Relevant data depending on testing method
    Chemical Formula C6H3ClFI
    Molecular Weight 256.44
    Appearance Colorless to light yellow liquid
    Boiling Point Approximately 200 - 210 °C
    Density Around 2.0 - 2.2 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Stability Stable under normal conditions, but can react with strong oxidizing agents

    As an accredited 1-Chloro-4-Fluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - chloro - 4 - fluoro - 2 - iodobenzene packaged in a sealed glass bottle.
    Storage 1 - Chloro - 4 - fluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances to prevent chemical reactions. Label the container clearly for easy identification and safety.
    Shipping 1 - Chloro - 4 - fluoro - 2 - iodobenzene is shipped in specialized, tightly - sealed containers. It adheres to strict chemical transport regulations, ensuring safe transit to prevent leakage and potential environmental or safety hazards.
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    1-Chloro-4-Fluoro-2-Iodobenzene
    General Information
    Historical Development
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important compound in the field of organic synthesis. Back in the past, chemical pioneers gradually involved this compound when exploring the synthesis path of organic halides. At that time, the conditions were difficult, and the experiments were repeated. Initially, the yield of synthesizing this compound was quite low, but the ancestors were determined. With the evolution of chemical theory and the improvement of experimental technology, many novel synthesis methods have emerged. From the early complicated and inefficient process, to the optimization of reaction conditions and the search for suitable catalysts, the synthesis efficiency has been significantly improved. The historical development of this compound is like a history of chemical exploration, witnessing the unremitting spirit of chemists to break through difficulties and pursue progress, laying an important foundation for the subsequent development of organic synthetic chemistry.
    Product Overview
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important compound in organic synthesis. This substance has a unique chemical structure. Three halogen atoms, chlorine, fluorine and iodine, coexist on the benzene ring. Its physical properties, at room temperature or in a solid state, have a certain melting point and boiling point. Due to the difference in electronegativity of halogen atoms, it shows a certain polarity.
    In terms of chemical properties, halogen atoms have different activities. Chlorine atoms can undergo nucleophilic substitution reactions. When encountering suitable nucleophilic reagents, they can be replaced to form new carbon-heteroatomic bonds. Although fluorine atoms have strong electronegativity, which reduces the electron cloud density of the benzene ring, it also brings unique selectivity to the reaction. Iodine atoms are relatively active and can participate in coupling reactions under specific conditions, which is of great significance for the construction of complex organic molecular structures. Due to its structural properties, it has potential application value in pharmaceutical chemistry, materials science and other fields, or can be used as a key intermediate to help create new compounds.
    Physical & Chemical Properties
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an organic compound. Its physical and chemical properties are quite important. Looking at its physical properties, at room temperature, this substance may be in a liquid state with a specific color and odor. As for the boiling point, due to the intermolecular force, it is in a certain temperature range, which is conducive to separation and purification.
    In terms of its chemical properties, chlorine, fluorine and iodine atoms give their unique activities. Chlorine atoms can undergo nucleophilic substitution reactions. Due to the electronegativity of chlorine and the atomic radius, they are easily attacked by nucleophilic reagents. Fluorine atoms change the distribution of molecular electron clouds, which affects the reactivity and selectivity. Although iodine atoms are relatively large, they also participate in many reactions, such as coupling reactions. This compound may have important uses in the field of organic synthesis and can be used as a key intermediate for the preparation of more complex organic molecules, promoting the development of organic chemistry.
    Technical Specifications & Labeling
    Today there is a product called 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. The preparation of this product is related to technical specifications and identification (product parameters), which is the key.
    To make this product, you need to follow a precise method. The choice of materials must be appropriate, and the proportion must be appropriate. When reacting, temperature, duration, etc. are all important. Only by controlling the temperature at an appropriate degree and being punctual can the reaction be smooth and the product is pure.
    Identify this product and list the parameters in detail. From its color and shape, to its purity and content, it should be clear. In this way, the person who uses it should understand its nature and use it correctly. Technical specifications are strictly adhered to, and the identification is accurate and accurate, so as to ensure the quality of this product, which is beneficial to the user and beneficial to the industry.
    Preparation Method
    The method of making 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is related to the raw materials and production process, reaction steps, and catalytic mechanism.
    First take an appropriate amount of fluorobenzene and use it as the starting material. Place fluorobenzene in a reactor, add an appropriate amount of catalyst, such as the catalytic system formed by iron filings and iodine elemental. Heat up to a suitable temperature, about 60 to 80 degrees Celsius, and slowly introduce chlorine gas. At this time, the chlorine atom preferentially replaces the hydrogen atom in the ortho-position of the fluorine atom on the benzene ring through the electrophilic substitution reaction. Because the fluorine atom is an ortho-para-position group, and the ortho-position electron cloud density is relatively high During the
    reaction process, the temperature and the ratio of the reactants need to be strictly monitored. When the reaction is basically completed, the unreacted raw materials and products are separated by vacuum distillation. Then the column chromatography is further purified to obtain pure 1-Chloro-4-Fluoro-2-Iodobenzene. The key to this preparation method is to precisely control the reaction conditions to ensure the activity of the catalytic system, so as to improve the yield and purity of the product.
    Chemical Reactions & Modifications
    In the field of Wenfu Chemistry, the reaction and modification of 1-Chloro-4-Fluoro-2-Iodobenzene are studied by us. In the past, to make this product, we often encountered difficulties. The initial method, the reaction is slow, and the yield is quite low, and there are many impurities.
    However, today is different from the past. After various studies, a new way is gradually emerging. With a special catalyst, supplemented by suitable temperature and pressure, the reaction rate is greatly increased, and the yield is also improved. There is also a way to solve the problem of impurity clumping in the past. After the optimized process, the purity of the product is unprecedented.
    And the modification technique is also beneficial. According to different needs, different groups can be introduced to change their properties. Or increase its stability, or change its solubility, all can be desired. This chemical change, like a stroke of genius, makes 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene more widely used in various fields, and contributes to the advancement of science and technology.
    Synonyms & Product Names
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, its synonymous name and the name of the commodity are quite important. In the course of my chemical research, the name is related to the research.
    The name of the husband is synonymous, so it is widely known, which is the knowledge of all scholars. 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, or it is called o-chloro-p-fluoroiodobenzene, which is named according to the common law because of its atomic position. Or there is another name, which is known to chemists, in order to facilitate academic exchanges, so that everyone knows that it is the same thing.
    As for the name of the commodity, the merchant uses it to mark the market, so that the sale and circulation can be carried out. Or it has the name of the trade name, attached with a unique brand, but its quality is still this 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. These two names, synonymous names and commodity names, although different, actually refer to the same. In the industry of chemistry, they complement each other and cannot be neglected. Let researchers know their different names, and users know their similarities, and promote the prosperity of chemistry together.
    Safety & Operational Standards
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene Safety and Practice
    Husband 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important substance in chemical research. When using, safety should be paid attention to first.
    This substance has certain chemical activity, comes into contact with the skin, or causes irritation, so when operating, be sure to wear protective gloves to prevent skin contact with it. If you accidentally touch it, rinse with plenty of water as soon as possible and seek medical attention as appropriate.
    Its odor may affect the respiratory tract. The operation should be in a well-ventilated place, or with the help of ventilation equipment, so that the air can circulate and avoid inhaling harmful gases. If inhalation is uncomfortable, go to a place with fresh air as soon as possible, and seek medical assistance if necessary.
    Furthermore, it is related to the operating specifications. When taking it, use an accurate measuring tool and take the amount required by the experiment, not more or less, so as to ensure the accuracy of the experiment. And during the taking process, the action should be stable to avoid splashing.
    Storage is also key. It should be placed in a cool, dry and ventilated place, away from fire and heat sources to prevent danger. At the same time, it needs to be stored in categories with other chemical substances to avoid mutual reactions.
    After use, the leftovers should not be discarded at will. Dispose of them according to chemical waste treatment regulations, and avoid polluting the environment.
    In this way, strict safety and operation standards can be strictly observed in the research and application of 1-Chloro-4-Fluoro-2-Iodobenzene, ensuring safety, achieving accuracy, and becoming the goal of research.
    Application Area
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a special compound. In many application fields, it shows unique efficacy.
    In the field of pharmaceutical research and development, because of its specific chemical structure, or can participate in the construction of drug molecules, it helps to synthesize compounds with special pharmacological activities, which is expected to open up new paths for disease treatment.
    In the field of materials science, this compound may be used as a key raw material for the preparation of materials with special properties. With its unique reactivity, it endows materials with novel physical and chemical properties, such as optical and electrical properties, and may have extraordinary applications in electronic devices, optical materials, etc.
    Furthermore, in organic synthesis chemistry, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is often used as an important intermediate. With the different reactivity of chlorine, fluorine and iodine atoms, chemists can use this to construct complex organic molecular structures, greatly expand the possibility of organic synthesis, and provide a powerful tool for the creation of new compounds.
    Research & Development
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a key compound in organic synthesis. As chemical researchers, we are very concerned about its research and development.
    The synthesis of this compound requires exquisite chemical skills. After many experimental investigations, we tried different reaction paths and conditions. Select suitable halogenating reagents, adjust the reaction temperature, time and solvent, and hope to obtain high-purity products.
    Studying its properties is essential to expand the application field. After spectral analysis, its structure and characteristics were clarified to provide a basis for the analysis of the reaction mechanism.
    Looking forward to its development, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is expected to shine in the fields of medicine, materials and so on. We will continue to study, optimize the synthesis method, improve the quality of the product, so as to promote its wide application and contribute to the progress of the chemical field.
    Toxicity Research
    Today there is a substance, named 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, I am a chemist to observe its toxicity. This substance has a unique structure and contains elements such as chlorine, fluorine and iodine. Chlorine may denature proteins and damage human body cells; fluorine compounds are often highly corrosive and can erode the skin and injure mucous membranes; although iodine is needed by the human body, the state of iodine in this compound is abnormal, or the body may cause adverse reactions.
    Observe its reactive activity, or react with various substances in the body, disrupting physiological and biochemical processes. After preliminary investigation, exposure to this substance may cause redness, swelling and itching of the skin. If inhaled, it may hurt the respiratory tract, causing cough and asthma. Although its long-term effects are not detailed, the suspicion of toxicity should not be underestimated. It is necessary to study its characteristics with caution, understand its harm, and prevent it from hurting people.
    Future Prospects
    In the future, this is an important guide for our research on 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. In today's world, technology is changing with each passing day, and chemical research is also advancing. For 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, it is certain that it will be able to achieve a more refined environment.
    First, the method of improvement is expected to be innovated. Or borrow new rice technology, or use refined molecular methods to make the product invisible, so that the quality of the product can be increased again. Second, the increase in the amount of energy is also large. Or develop efficient catalysts, or change the reverse components to promote its synthesis faster and more.
    Furthermore, the use of this product has also been expanded. In the field of research, it may become the cornerstone of new research, to overcome the power of disease; in the field of materials, or the raw materials of new materials, to improve the characteristics of materials. In particular, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene, the light of the future, we are diligent in our research, in order to uncover more secrets and create more beautiful technologies.
    Historical Development
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a special chemical substance. Back in the past, when chemical research was first emerging, the exploration and understanding of various substances was still in the unknown stage. At that time, scholars had limited understanding of organic halides, let alone halogenated aromatics with complex structures.
    With the passage of time, chemical techniques have become increasingly refined. Many chemists have devoted themselves to the study of halogenated benzene derivatives. After repeated experiments and derivations, they have gradually clarified the characteristics of such substances. 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene has gradually become important in the field of organic synthesis due to its unique atomic combination and spatial structure. Although it only existed in theoretical conception in the early days, it was successfully prepared with the refinement of experimental methods. Its historical evolution is like a pearl that gradually shines in the long river of chemistry, from concealment to prominence, witnessing the vigorous development of chemical research.
    Product Overview
    1-Chloro-4-fluoro-2-iodobenzene is also an organic compound. It is above the benzene ring, and the three atoms of chlorine, fluorine and iodine occupy one place each. The chlorine atom is listed in one, the fluorine atom is in four, and the iodine atom is in two positions.
    The color state of this compound is at room temperature, or it is a colorless to slightly yellow liquid, with certain volatility and a special odor. It has good solubility in organic solvents, such as ethanol, ether, dichloromethane, etc.
    Because of the presence of halogen atoms in its structure, it has active chemical properties. In the field of organic synthesis, it is often used as a key intermediate. Or it can interact with many nucleophiles through nucleophilic substitution reactions to form novel carbon-carbon bonds and carbon-hetero bonds, thus laying the foundation for the creation of complex organic molecules. Or participate in metal-catalyzed reactions to expand its application in organic synthesis.
    Physical & Chemical Properties
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is mostly liquid, volatile, and can be dissipated in the air. Its color may be colorless and transparent, or slightly yellow, due to the influence of impurities. Its taste is pungent, and it can be felt by smelling.
    When it comes to chemical properties, it is active and reactive because it contains halogen atoms of chlorine, fluorine and iodine. In nucleophilic substitution reactions, halogen atoms are easily replaced by nucleophiles. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds. And because of the difference of electronegativity of halogen atoms, the electron cloud distribution is uneven, which changes the electron cloud density of benzene ring, affects its aromaticity and reactivity, and is widely used in the field of organic synthesis. It can produce a variety of functional organic materials through a series of reactions.
    Technical Specifications & Labeling
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an organic compound. The technical specifications and labeling (product parameters) of this compound need to be treated strictly.
    Its technical specifications, the purity of the first ingredient, should reach a very high standard, and the impurity content must be minimal to ensure the quality of the product. The synthesis process is also crucial. It must go through precise steps, from the selection of raw materials to the control of reaction conditions, and must not be lost. The reaction temperature, time and amount of catalyst all have a profound impact on the purity and yield of the product.
    As for the identification (product parameters), clearly mark its chemical structure so that the user can see it at a glance. Indicate the physical properties, such as melting point, boiling point, density, etc., for easy reference in application. Toxicity and safety precautions should not be omitted to ensure the safety of users. In this way, 1-Chloro-4-Fluoro-2-Iodobenzene can be properly used in various fields.
    Preparation Method
    Now I want to make 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene. The first way to make it is to prepare raw materials. When based on compounds containing chlorine, fluorine and iodine. In the raw materials, choose the appropriate one to combine the phases.
    The preparation process is to make the benzene compounds containing chlorine and fluorine meet the iodine-containing reagents. In the reaction step, the temperature and pressure must be controlled to make the two phase and. In a specific reaction vessel, let it slowly respond. At first, the two may be difficult to combine quickly, but then after adjusting the temperature and pressure, they can gradually respond.
    Catalytic mechanism is also important. Selecting the appropriate catalyst and putting it in the middle can promote the reaction speed. The power of the catalyst can reduce the energy barrier of the reaction and make the synthesis of the raw material more smooth. In this way, after various adjustments, the raw material is gradually reduced to 1-Chloro-4-Fluoro-2-Iodobenzene, and the desired product can be obtained.
    Chemical Reactions & Modifications
    There is now a product named 1-Chloro-4-Fluoro-2-Iodobenzene. In the field of chemistry, its reaction and modification are crucial.
    Looking at the reaction, it often changes depending on the reagents and conditions encountered. When it comes to nucleophiles, halogen atoms may be substituted, depending on the genus of the reagent's nucleophilicity, reaction temperature, and solvent.
    As for modification, it is designed to adjust its physical and chemical properties. Or introduce specific groups to increase its stability, solubility, or change its reactivity. By chemical means, this compound can be used in materials, medicine, and other industries to develop its talents.
    All of this depends on the ingenuity and practice of chemists to understand the laws of their reactions and improve their modification methods, so that they can be used by the world and gain all kinds of karma.
    Synonyms & Product Names
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is an important chemical substance. In the field of chemical research, it is crucial to explore its synonyms and trade names.
    The synonyms of this compound may vary from region to region and academic school to school. It may be named after its chemical structure characteristics, or it may be called according to the preparation method or application scenario. As for product names, different manufacturers have different names in order to highlight product characteristics and position the market.
    In laboratory research and industrial production, accurate recognition of its synonyms and trade names can ensure correct communication and proper operation. If we don't know its many terms, it may lead to wrong procurement of raw materials and disordered experimental procedures, which will affect research progress and production efficiency. Therefore, chemical researchers need to carefully review various literature materials to fully grasp the synonyms and trade names of 1-Chloro-4-Fluoro-2-Iodobenzene, and promote the development of chemical research and related industries.
    Safety & Operational Standards
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a special chemical substance, which needs to be explained in detail in terms of its safety and operating practices.
    When handling this substance, the first choice is the environment. A well-ventilated place must be selected to prevent the accumulation of volatile gases and damage to the health of the operator. If operating in a confined space, the gas is difficult to disperse and is prone to dangerous conditions such as poisoning.
    Furthermore, the operator's protection must not be ignored. In front of professional protective clothing, such as chemical-resistant protective clothing, it can prevent substances from coming into contact with the body. Hands also need to wear special gloves, mostly made of nitrile, which have good resistance to a variety of chemicals. The face should be equipped with a protective mask to prevent substances from splashing and hurting the eyes and face.
    For storage, this substance should be stored in a cool, dry place away from fire sources and oxidants. Because of its certain chemical activity, it may cause violent reactions such as combustion or even explosion when exposed to heat or oxidants. Storage containers should also be carefully selected. They must be made of corrosion-resistant materials and well sealed to prevent leakage.
    If a leak unfortunately occurs, do not panic. First, evacuate the surrounding personnel quickly, set up warning signs, and prevent unrelated people from approaching. Then, according to the amount of leakage and site conditions, adopt appropriate cleaning methods. A small amount of leakage can be adsorbed by materials with good adsorption properties, such as vermiculite, activated carbon, etc., and then properly collected and disposed of. When there is a large amount of leakage, the emergency system should be activated and the professionals should be notified to deal with it.
    During the operation, the established procedures must also be strictly followed. For example, when weighing, use precise instruments, and the action is slow to prevent material spillage. Mixing and reaction steps, more temperature control and time control, according to accurate proportions, to ensure the safe and efficient operation of the reaction. Only in this way can the use of 1-Chloro-4-Fluoro-2-Iodobenzene ensure the safety of personnel and smooth operation.
    Application Area
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is a special chemical substance that shows its important value in many application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs with unique curative effects. Due to the characteristics of molecular structure, it can participate in a variety of chemical reactions and precisely construct pharmaceutical active ingredients.
    In the field of materials science, this substance has also emerged. Or it can be synthesized by a specific process and integrated into new materials, endowing materials with excellent characteristics such as unique optical and electrical properties, so as to meet the needs of high-end technology for special materials.
    Furthermore, in the field of organic synthetic chemistry, 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene provides an effective path for the synthesis of complex organic compounds by virtue of its activity of chlorine, fluorine and iodine atoms, promoting organic synthetic chemistry to new heights, expanding the diversity of compounds, and laying a solid chemical foundation for the development of various industries.
    Research & Development
    In recent years, I have been studying 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene in the field of chemistry. Its properties are very different, and it is quite promising in the process of organic synthesis.
    At the beginning, study its structure, analyze the wonder of its bonding, and understand the rules of its atomic arrangement. Then explore the properties of its reaction, try various conditions, and hope to get the best method. After repeated experiments, I feel that the genus of temperature and solvent has a huge impact on its reaction.
    When used as a suitable temperature and good agent, it should be fast and pure, and the yield is quite good. Also consider its environmental protection, and strive to reduce waste and consumption, which is suitable for the time.
    Although there is progress now, the road ahead is still far away. To expand its use, push it widely, and develop its capabilities in the fields of medicine and materials. With unremitting research, it is hoped that the use of this material will be promoted, and the progress of chemistry will be for the benefit of the world.
    Toxicity Research
    Recently, the toxicity of 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is the most important thing to study. To observe its chemical properties, in the molecular structure, the atoms of chlorine, fluorine and iodine coexist, or cause special toxicology.
    Ancient research toxicity depends on the response of organisms. If you feed it with insects, observe its growth, movement and stop, and see what is the difference. Or take green plants and apply it to see its condition and color change.
    1 - Chloro - 4 - Fluoro - 2 - Iodobenzene toxicity, or due to the nature of halogen atoms. Chlorine, fluorine and iodine are active and easily react with other substances in the living body, or disrupt its biochemical process. If it disturbs the metabolism of cells, hinders the function of enzymes, and causes diseases in the body.
    The study of toxicity is not a day's work. When carefully examining and accumulating all kinds of data, we can find out the depth of its toxicity, and provide solid evidence for the use of this substance or the prevention of its harm.
    Future Prospects
    Husband 1 - Chloro - 4 - Fluoro - 2 - Iodobenzene is also a chemical product. I am a chemical researcher, and every time it is not yet developed, I hope. This compound has unique properties, or can be used in many domains, such as manufacturing and materials, and is widely used.
    In the field of manufacturing, it is expected to use its characteristics to develop new technologies and reduce diseases. The wonders of its performance may help the material to target pathogens more, increase efficiency and reduce side effects. In the material industry, it may be possible to improve the new energy of materials, such as improving its performance and light properties, and expand the use of materials in Xinjiang.
    We are working hard to explore its secrets, hoping to make this happen, and to make this compound available for the benefit of the world. It will become the cornerstone of undeveloped development and lead to a new process of science and technology.
    Where to Buy 1-Chloro-4-Fluoro-2-Iodobenzene in China?
    As a trusted 1-Chloro-4-Fluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Chloro-4-Fluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-chloro-4-fluoro-2-iodobenzene?
    1-chloro-4-fluoro-2-iodobenzene, Chinese name 1-chloro-4-fluoro-2-iodobenzene, is widely used and has its own impact in many fields.
    First, in the field of pharmaceutical synthesis, its role is crucial. Taking the development of anti-cancer drugs as an example, researchers use the unique chemical structure of 1-chloro-4-fluoro-2-iodobenzene as a key intermediate. Through a series of delicate chemical reactions, molecular structures with specific activities can be constructed. Medicinal chemists have carefully designed reaction pathways, taking advantage of the differences in the reactivity of chlorine, fluorine and iodine atoms on the compound, and ingeniously splicing with other organic molecules, thereby synthesizing new drug molecules with targeted inhibitory effects on cancer cells, providing a powerful chemical weapon for tackling cancer problems.
    Second, in the field of materials science, 1-chloro-4-fluoro-2-iodobenzene also plays an important role. When preparing high-performance organic optoelectronic materials, because they contain halogen atoms, they can have a significant impact on the electronic structure and molecular arrangement of the materials. Researchers introduce them into polymer or small molecule material systems, which can precisely regulate the optical and electrical properties of materials. For example, the synthesis of organic Light Emitting Diode (OLED) materials with specific emission wavelengths, or the preparation of organic semiconductor materials with high mobility, can be used in new generation display technology and electronic devices to promote the continuous progress of materials science.
    Third, in the field of pesticide synthesis, 1-chloro-4-fluoro-2-iodobenzene also plays a role that cannot be ignored. When developing new and efficient pesticides, using them as the starting material and using the reaction characteristics of halogen atoms, compounds with unique insecticidal, bactericidal or herbicidal activities can be synthesized. These new compounds can precisely target specific physiological targets of crop pests or weeds, enhancing the effectiveness of pesticides while reducing their negative impact on the environment, thus contributing to the sustainable development of agriculture.
    What are the physical properties of 1-chloro-4-fluoro-2-iodobenzene?
    1-Chloro-4-fluoro-2-iodobenzene is an organic halogenated aromatic hydrocarbon, and its physical properties are quite unique. This compound is at room temperature and pressure, or in a liquid state, due to its intermolecular force. Looking at its color, or colorless to light yellow, the texture is clear, and it has a certain volatility, which can slowly dissipate in the air.
    When it comes to boiling point, due to the presence of chlorine, fluorine, and iodine atoms in the molecule, the intermolecular force is enhanced. Its boiling point is higher than that of benzene, about 200 ° C. This is due to the introduction of halogen atoms, which increases the polarity of the molecules. The intermolecular forces are mainly van der Waals forces and dipole-dipole forces, so more energy is required to overcome these forces and cause the boiling point to rise.
    In terms of melting point, due to the spatial distribution of halogen atoms on the benzene ring, or the orderly arrangement of molecules is changed, the melting point may be in a relatively low range, or between -20 ° C and 0 ° C. Due to the halogen atoms destroying the original symmetry of the benzene ring, the degree of molecular accumulation is changed, and the lattice energy is affected, so the melting point is changed.
    In terms of solubility, 1-chloro-4-fluoro-2-iodobenzene is a non-polar or weakly polar molecule, so it has good solubility in non-polar or weakly polar organic solvents, such as ether, chloroform, carbon tetrachloride, etc. However, in polar solvents, such as water, the solubility is very small, because of "similar miscibility". Water is a strongly polar molecule, which is incompatible with the intermolecular forces of the compound, so it is difficult to dissolve.
    The density is higher than that of water. Due to the large relative atomic weight of halogen atoms, the molecular weight increases, resulting in an increase in unit volume mass. In the field of organic synthesis, its physical properties have an important impact on the reaction conditions, separation and purification steps. During the synthesis process, it is necessary to select the appropriate reaction solvent and determine the separation method according to its boiling point, solubility and other properties to achieve the best synthesis effect.
    What is the chemical synthesis method of 1-chloro-4-fluoro-2-iodobenzene?
    In the synthesis of 1-chloro-4-fluoro-2-iodobenzene, the following method is often followed. The starting material can be selected from a suitable aromatic compound, such as p-fluorochlorobenzene.
    The first step is to introduce iodine atoms. This may be achieved by electrophilic substitution. The reaction of p-fluorochlorobenzene with an iodine source, such as iodine elemental ($I_2 $), in the presence of an appropriate oxidant and catalyst. The commonly used oxidant can be a mixed acid of concentrated sulfuric acid and nitric acid, and the catalyst can be potassium iodide ($KI $). In the reaction, nitric acid can oxidize iodine to an intermediate of high-valent iodine. This intermediate has stronger electrophilicity and can be electrophilically substituted with the benzene ring of p-fluorochlorobenzene. Iodine atoms are introduced into the ortho-position to obtain 1-chloro-4-fluoro-2-iodobenzene precursor.
    The second step needs to ensure the selectivity and yield of the reaction. The regulation of reaction conditions is crucial, such as temperature, proportion of reactants and reaction time. If the temperature is too high, or side reactions increase, the product is impure; if the temperature is too low, the reaction rate will be delayed and take a long time. The proportion of reactants also needs to be precisely adjusted. Excessive or insufficient iodine sources can affect the formation of products.
    Furthermore, after the reaction is completed, the separation and purification of the product are indispensable. The target product in the reaction mixture can be extracted by organic solvent first, and then the product can be further purified by means of distillation and column chromatography to obtain pure 1-chloro-4-fluoro-2-iodobenzene. In this way, with delicate steps and careful operation, the synthesis of 1-chloro-4-fluoro-2-iodobenzene can be achieved.
    1-chloro-4-fluoro-2-iodobenzene What are the precautions during storage and transportation?
    1-Chloro-4-fluoro-2-iodobenzene is also an organic compound. During storage and transportation, several things need to be paid attention to.
    First words storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature is easy to decompose or cause chemical reactions, so it is important to avoid heat. If it is placed in a place under direct sunlight in hot summer or near high temperature equipment, its stability may be damaged and changes may occur. Furthermore, it needs to be stored in isolation from oxidants, strong bases and other substances. Due to the chemical activity of this compound, it encounters with oxidizing agents, or has a violent oxidation reaction, and even has the risk of ignition and explosion; coexisting with strong alkalis may also cause chemical reactions and cause deterioration.
    Times and transportation. During transportation, be sure to ensure that the packaging is complete and tightly sealed. Because 1-chloro-4-fluoro-2-iodobenzene has certain toxicity and irritation, if the packaging is damaged and leaks, it will not only damage the environment, but also endanger the health of transporters. And the means of transportation should be well ventilated to prevent the accumulation of volatile gases and cause danger. At the same time, the transportation process should be shock-proof and impact to avoid damage to the packaging and leakage of the compound. Furthermore, transportation personnel should be familiar with the dangerous characteristics of this compound and the methods of emergency response, and in case of emergencies, they can respond promptly and properly to reduce the harm.
    1-chloro-4-fluoro-2-iodobenzene impact on the environment and human health
    1-Chloro-4-fluoro-2-iodobenzene is a genus of organohalogenated aromatic hydrocarbons. This substance has a significant impact on the environment and human health.
    First, its effect on the environment. 1-chloro-4-fluoro-2-iodobenzene has considerable chemical stability and is difficult to degrade in the natural environment and can be retained for a long time. Once it enters the soil, it may change the physical and chemical properties of the soil, hinder the absorption of nutrients and moisture by plant roots, and then affect the growth and development of plants. If it flows into water bodies, it will pose a threat to aquatic ecosystems. Because of its fat solubility, it is easy to accumulate in aquatic organisms, pass through the food chain and amplify, or be toxic to higher organisms. And this substance may affect the self-purification ability of the water body and destroy the ecological balance of the water body.
    As for the impact on human health. 1-chloro-4-fluoro-2-iodobenzene can enter the human body through respiratory tract, skin contact or accidental ingestion. It may interfere with normal physiological and biochemical processes in the body. Studies have shown that halogenated aromatic hydrocarbons may have toxic effects on the human nervous system, causing symptoms such as headache, dizziness, fatigue, etc. Long-term exposure may even affect the development and function of the nervous system. At the same time, such substances may be potentially carcinogenic. Due to their special structure, they may interact with the DNA of human cells, causing genetic mutations and increasing the risk of cancer. In addition, they may also have adverse effects on the human immune system, reducing the body's resistance to diseases.
    From this point of view, 1-chloro-4-fluoro-2-iodobenzene is harmful to the environment and human health, and it needs to be properly controlled and handled to reduce its negative effects.