1-Cyano-4-Iodobenzene

Fengxi Chemical

Specifications

HS Code	298338
Chemical Formula	C7H4IN
Molecular Weight	245.02 g/mol
Appearance	White to off - white solid
Melting Point	133 - 137 °C
Boiling Point	N/A (decomposes)
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Density	N/A
Flash Point	N/A
Stability	Stable under normal conditions, but may react with strong oxidizing agents
Cas Number	1585-07-5

As an accredited 1-Cyano-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - cyano - 4 - iodobenzene in a sealed vial, containing 5 grams of the chemical.
Storage	1 - Cyano - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially lead to degradation. Store it separately from oxidizing agents and reactive chemicals to avoid hazardous reactions.
Shipping	1 - cyano - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. It follows strict hazardous chemical shipping regulations to ensure safe transportation.

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General Information

Historical Development

1 - Cyano - 4 - Iodobenzene is also an organic compound. Its origin, at the beginning of chemists in a variety of experiments, occasionally found clues about this substance. At that time, the technology was not refined, and it was difficult to explore, only a few characteristics were known.
As the years passed, science and technology gradually emerged. Researchers analyzed its structure in more precise ways to clarify its chemical properties. Many experiments were superimposed, and the reaction mechanism was deeply understood. It has emerged in the field of synthesis, and chemists have opened up new synthetic paths with its unique properties.
With the evolution of industry, the demand for 1 - Cyano - 4 - Iodobenzene is increasing. The preparation process has been continuously improved, from simple at the beginning to high efficiency and good purity today. This compound is widely used in the fields of medicine and materials, contributing to the progress of the industry, and has made remarkable achievements along the way.

Product Overview

1 - Cyano - 4 - Iodobenzene is also an organic compound. Its color may be colorless to pale yellow, and it is often in a crystalline state. In the field of chemical synthesis, this compound is quite important. Its unique structure, the cyano group and iodine atoms are respectively connected to the specific position of the benzene ring, which gives it special chemical activity.
In the reaction, the cyanyl group can participate in many reactions such as nucleophilic substitution, and the iodine atom can also initiate various transformations due to its good departure properties. From it, many compounds with biological activity and material properties can be synthesized. It has potential applications in fine chemicals, pharmaceutical research and development, etc. The preparation of this compound requires a specific chemical process to ensure the purity and quality of the product in order to exert its effectiveness in various fields.

Physical & Chemical Properties

1 - Cyano - 4 - Iodobenzene is a special chemical substance. In terms of physical properties, it is either a solid state at room temperature, with a specific color state, or a white to light yellow crystalline powder, which is fine in appearance. Its melting point and boiling point are also key characteristics. The exact value can be obtained by measuring the melting point. This value is of great significance to its state transition under specific conditions; the boiling point is related to its vaporization during heating.
When it comes to chemical properties, cyanyl (-CN) and iodine atoms (-I) give it unique reactivity. Cyanyl can participate in many nucleophilic substitution and addition reactions, and can interact with various reagents to expand the structure of compounds. Iodine atoms are active and can initiate halogenation reactions, providing various possibilities for the chemical transformation of this substance, and may have important application value in the field of organic synthesis.

Technical Specifications & Labeling

1 - Cyano - 4 - Iodobenzene, this is what I studied. Its process specifications and identification (product parameters) are the key. To make this product, you need to follow the precise method, from the selection of raw materials to the control of the reaction, all must be good. The raw materials must be pure, and the reaction conditions such as temperature, pressure, and time must be precisely grasped.
On the label, the properties of this product should be detailed, and the color, taste, and state should be clearly marked. Its purity geometry, impurity geometry, and accurate display. In this way, we can obtain high-quality 1-Cyano-4-Iodobenzene, which can meet the needs of all parties, and can be used in industry and scientific research.

Preparation Method

1 - Cyano - 4 - Iodobenzene is an important compound in organic synthesis. Its preparation method is related to raw materials, production process, reaction steps and catalytic mechanism.
The selection of raw materials, when using p-iodobenzoic acid and cuprous cyanide is appropriate. The properties of p-iodobenzoic acid are stable and easy to obtain, and cuprous cyanide can provide cyanide groups in the reaction. The combination of the two is the foundation for the synthesis.
In the production process, it is necessary to react in a suitable organic solvent. The p-iodobenzoic acid and cuprous cyanide are placed in a high boiling point and moderate polarity organic solvent, such as N, N-dimethylformamide (DMF), in a specific ratio. This solvent can effectively dissolve the reactants and promote the reaction.
The reaction steps are as follows: First, the reaction system is heated to a certain temperature, about 150-180 ° C, and the constant temperature is maintained to allow the two to fully react. This process requires continuous stirring to make the reactants contact evenly and the reaction is sufficient.
In terms of catalytic mechanism, an appropriate amount of potassium iodide can be added as a catalyst. Potassium iodide can accelerate the substitution reaction of cyano groups in cuprous cyanide with iodine atoms in p-iodobenzoic acid, reduce the reaction activation energy, and increase the reaction rate and yield. In this way, 1-Cyano-4-Iodobenzene can be obtained by these methods.

Chemical Reactions & Modifications

Taste the wonders of chemistry, related to the change of matter, should also be studied with sex. Today, 1-Cyano-4-Iodobenzene is discussed. Its chemical reaction often involves the characteristics of cyanyl and iodine atoms. Cyanyl activity is quite strong, in many reactions, it can lead to structural changes, or form new bonds, and expand the structure of molecules. Iodine atoms, because of their large atomic radius and appropriate electronegativity, can be used as leaving groups, initiating nucleophilic substitutions, etc.
However, if you want the changeability of its properties, you should find ways to improve it. Or adjust the reaction environment, control the temperature, pressure, and solvent to suit the reaction, and increase the yield and purity. Or the catalytic agent can be used to reduce the energy barrier, so that the stress rate increases and the secondary stress is less. After this, it is expected that the chemical reaction and properties of 1-Cyano-4-Iodobenzene will have a deeper solution, so that it is widely used in chemical and pharmaceutical fields.

Synonyms & Product Names

1 - Cyano - 4 - Iodobenzene is an important chemical substance. The discussion of its synonyms and trade names is of great significance in chemical research. For this substance, its synonyms or words containing specific chemical descriptions are used to accurately define its chemical structure and properties. Trade names often vary according to manufacturers and market positioning.
In chemical classics, the records of synonyms can provide researchers with multiple perspectives and help them understand the properties of the substance. The existence of trade names reflects its application and value in the commercial field. If you want to explore 1 - Cyano - 4 - Iodobenzene, synonyms can guide researchers to trace its historical evolution and cognition at different stages of research; trade names can reveal its circulation and practical use in the chemical market. Therefore, it is essential to fully grasp the chemical essence and application of 1 - Cyano - 4 - Iodobenzene by scrutinizing its synonyms and trade names.

Safety & Operational Standards

1 - Cyano - 4 - Iodobenzene is a chemical substance, and it needs to be discussed in detail in terms of its safety and operating standards.
On the safe side, 1 - Cyano - 4 - Iodobenzene has certain chemical activity and latent risk. Its cyano group (-CN) contains highly toxic. Although the chemical properties of this compound are relatively stable, once the reaction occurs, the cyanide group will dissociate, escape hydrogen cyanide gas or form cyanide ions, which is most harmful to humans and animals. Inhalation, ingestion or skin absorption can endanger life. The iodine atom of its iodobenzene part makes the molecule have a certain polarity and reactivity. When encountering specific chemicals, it may cause violent reactions, causing fires, explosions and other accidents. This compound may be irritating, contact with the skin, eyes or respiratory tract, can cause redness, swelling, pain, allergies and other uncomfortable symptoms.
In terms of operating specifications, operation 1 - Cyano - 4 - Iodobenzene, the experimenter must wear professional protective equipment, such as laboratory clothes, protective gloves, goggles and gas masks, etc., to prevent skin contact and inhalation. The operation should be carried out in a well-ventilated fume hood, and the harmful gases that may be generated should be discharged in time. To take the compound, use an accurate weighing instrument, follow the specified dosage, and do not increase or decrease at will. When mixing and reacting, operate according to the established order and conditions, add reactants slowly, and closely observe the reaction process to prevent sudden violent reactions. After the experiment is completed, the waste containing 1 - Cyano - 4 - Iodobenzene should be collected according to the regulations and handled by professional institutions. It should not be discarded at will to avoid polluting the environment.
In short, the operation of 1 - Cyano - 4 - Iodobenzene requires a cautious attitude at all times and strict follow of safety and operation standards to ensure the safety of personnel and the smooth experiment.

Application Area

1 - Cyano - 4 - Iodobenzene is also a material for chemical engineering. Its application in various fields is extensive. In the field of research and development, it can be used to improve the development of new technologies, and it is expected to solve the problem. In the field of materials science, it can be used to synthesize special materials, with the special properties of materials, such as increasing their qualitative or changing their characteristics. And in the field of synthesis, it is often important to develop elements to help the delicate construction of molecules and expand the possibility of chemical synthesis. In addition, 1 - Cyano - 4 - Iodobenzene has the power to be used in multiple fields, such as a spoon, to improve the application of new technologies, and to promote the development of technology.

Research & Development

Since modern times, chemistry has been refined, and new things have emerged one after another. 1 - Cyano - 4 - Iodobenzene This substance is also of great importance to us, and we have studied it in detail.
We study its structure, explore its properties, and want to understand its ability in various reactions. At the beginning, the experiments were difficult, and the results were very small, but we were not discouraged. We tried all methods, and after years and months, we finally got results.
Looking at this substance today, it has great potential in organic synthesis. It can be used as a key intermediate to induce reactions to form other substances. Or it can be used to create new drugs to treat diseases in the world; or it can help the generation of new materials to meet various needs.
However, the road of research is long and arduous. Although progress has been made, there are still many unknowns. We should continue to study, unremitting, hoping to understand its secrets to the best of our ability, so as to promote the development of this substance, for the advancement of chemistry, for the benefit of the world, and to exhaust our wisdom.

Toxicity Research

The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Now take 1-Cyano-4-Iodobenzene as an example.
The toxicity of this substance needs to be investigated in detail. Or between experiments, observe its impact on various substances. If you test it with a small object, observe its physiological changes and how it acts. Or observe its combination with other substances, and the new substance produced is toxic or not.
It also examines its existence in the environment for a long time and the rules of migration. If it is scattered in water and soil, it should be investigated that it is harmless to living things. If its qi escapes in the air, it must also be observed that it is stained on the atmosphere and harmful to humans and animals.
The study of toxicity is related to the safety of everyone and the peace of the environment. Only with a rigorous state and a scientific method can we obtain its true meaning and make chemical products beneficial but not harmful.

Future Prospects

Husband 1 - Cyano - 4 - Iodobenzene is also a new product of transformation. Its properties are unique, and its strength is extraordinary in the process of multiplication and reaction.
If it is not developed yet, it will definitely be able to make new research and development easier. Today, it is often sought for high-efficiency and low-toxicity recipes. This compound may be able to improve its characteristics and help the molecules of the compound, so that the effect is obvious and the side effects are minimal.
And in the field of materials, it is also expected to be exposed. Or it can be used as the cornerstone of special functional materials, such as light materials, to improve its performance, so as to improve the quality of materials under the technology.
And in the way of synthesis, 1 - Cyano - 4 - Iodobenzene can be used as an important tool to expand the synthesis path, create more novel molecules, add color to the world, and promote the development of technology.

Where to Buy 1-Cyano-4-Iodobenzene in China?

As a trusted 1-Cyano-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Cyano-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 1-cyano-4-iodobenzene?

1-Cyano-4-iodobenzene is one of the organic compounds. Its chemical properties are interesting and have unique reaction characteristics.
The first word is its cyanyl group, which has a high reactivity. The electron cloud density of the carbon-nitrogen triple bond in the cyanyl group is quite high, so that the compound can participate in many nucleophilic substitution reactions. In the case of nucleophilic reagents, the carbon atoms of the cyanyl group can be attacked, causing the cyanyl group to be converted. If under basic conditions, the cyanyl group can be hydrolyzed into a carboxyl group. This process passes through the amide intermediate to form an amide first, and then further hydrolyzed into a carboxylic acid.
Looking at its iodine atom, iodine is a halogen element, which has considerable electronegativity. In 1-cyano-4-iodobenzene, the iodine atom changes the electron cloud distribution of the benzene ring. The electron cloud density of the adjacent and para-sites of the iodine atom is relatively reduced, which makes the benzene ring more prone to electrophilic substitution, and mainly occurs in the meta-site. In addition, the C-I bond is relatively weak, and the iodine atom is easy to leave, which can participate in nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents such as sodium alcohol, the iodine atom can be replaced by alkoxy groups to form corresponding ether compounds.
At the same time, the conjugation system of 1-cyano-4-iodobenzene also affects its chemical properties. The conjugation of the cy This conjugation effect also affects the reactivity of the substituents on the benzene ring, reducing the electron cloud density of the cyano o and para-sites more than that of the meta-sites, thereby affecting the regioselectivity of the electrophilic substitution reaction.
In short, the interaction between the cyano group and the iodine atom of 1-cyano-4-iodobenzene, coupled with the influence of the conjugation system, endows the compound with diverse chemical properties, and has a wide range of uses in the field of organic synthesis. A variety of organic compounds can be prepared through different reaction paths.

What are the main uses of 1-cyano-4-iodobenzene?

1-Cyano-4-iodobenzene, an organic compound, is widely used in many fields.
First, in the field of organic synthesis, it can be called a key intermediate. Due to the high reactivity of cyano and iodine atoms, a wide variety of organic compounds can be derived through various chemical reactions, such as nucleophilic substitution reactions, and many nucleophilic reagents. For example, when reacted with alcohols under suitable conditions, corresponding esters can be formed; when reacted with amines, it is expected to construct nitrogen-containing organic compounds. Such reactions pave the way for the synthesis of various complex organic molecules, which is of great significance in the fields of medicinal chemistry, materials science and other fields.
Second, in the field of drug research and development, this compound also plays an important role. Due to its unique structure, it may be used as a lead compound to lay the foundation for the development of new drugs. Researchers can modify and optimize its structure, and by adjusting the types and positions of substituents, they hope to obtain compounds with specific biological activities, such as those with antibacterial, antiviral, anti-tumor and other pharmacological activities, to contribute to human health.
Third, in the field of materials science, 1-cyano-4-iodobenzene also shows potential application value. Through rational molecular design and synthesis strategies, it can be introduced into polymer materials to improve the properties of materials. Such as enhancing the stability of materials, adjusting the electrical properties of materials, etc., thus providing the possibility for the development of new functional materials, which may shine in the fields of electronic devices and optical materials.
In short, 1-cyano-4-iodobenzene occupies an important position in many fields such as organic synthesis, drug development, and materials science due to its unique chemical structure and reactivity, providing a broad space and infinite possibilities for the development of various fields.

What are 1-cyano-4-iodobenzene synthesis methods?

1-Cyano-4-iodobenzene is a compound commonly used in organic synthesis. The synthesis method is roughly as follows:
First, 4-iodoaniline is used as the starting material. Shilling 4-iodoaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then, the diazonium salt is co-heated with a mixed solution of cuprous cyanide and potassium cyanide, and the diazonium group is then replaced by a cyano group to obtain 1-cyano-4-iodobenzene. This process requires attention to the control of the reaction temperature, and the diazotization reaction can proceed smoothly at low temperature to avoid the occurrence of side reactions.
Second, 4-iodobenzoic acid is used as the starting material. First, 4-iodobenzoic acid is reacted with dichlorosulfoxide to convert the carboxyl group to an acyl chloride group to obtain 4-iodobenzoyl chloride. Then 4-iodobenzoyl chloride is reacted with ammonia to form 4-iodobenzoamide. Finally, 4-iodobenzoamide is co-heated with a dehydrating agent, such as phosphorus pentoxide, to undergo a dehydration reaction, and a molecule of water is removed from the amide group and converted to a cyano group, thereby obtaining 1-cyano-4-iodobenzene. In this route, the conditions of each step of the reaction also need to be finely regulated, such as the reaction involving sulfoxide chloride, an anhydrous environment is required to prevent hydrolysis of acid chloride.
Third, 4-iodobromobenzene is used as the raw material. In the presence of suitable catalysts, such as palladium catalysts, 4-iodobromobenzene is cyanylated with zinc cyanide. In this reaction, the activity and dosage of the catalyst have a great impact on the reaction process. An appropriate amount of palladium catalyst can efficiently catalyze cyano to replace bromine atoms to generate 1-cyano-4-iodobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield, and make a prudent choice.

What are the precautions in storage and transportation of 1-cyano-4-iodobenzene?

1 - cyano-4 - iodobenzene is also a chemical substance. When it comes to storage and storage, it is necessary to pay attention to things in general, and it is difficult to keep it in the heart.
First of all, this compound should be stored. This compound is suitable for use in the room and through the room. Its property or susceptibility, so the property should not be high, and the communication is good, so it can avoid agglomeration and cause danger. The property should also be controlled in an appropriate environment to prevent it from absorbing or being damaged due to moisture. At the same time, it needs to be stored separately with oxidizing, raw materials, acids, and other substances, and must not be mixed. Because 1 - cyano-4 - iodobenzene or this substance is biochemical reaction, fire, explosion, etc. And there are no suitable materials in the storage place to contain the leakage, so as to prevent accidental leakage and management.
Repeat the inspection. Before the inspection, it is necessary to ensure the confidentiality of the container, so as to prevent the risk of damage and leakage., According to the phase of the hazardous material, If the leakage is inadvertent, it will quickly isolate the leakage pollution, restrict access, cut the fire source, the leakage amount and the situation, and take urgent measures.

1-cyano-4-iodobenzene impact on the environment and people

1-Cyano-4-iodobenzene has an impact on the environment and the human body. If this substance is scattered in the environment, it is the first to bear the brunt of the ecological balance. In the water, if it enters, it may cause harm to aquatic organisms. Causing its chemical activity, or interfering with the metabolism of aquatic organisms, impairing its ability to reproduce and grow, and even causing population wither. In the soil, or changing the chemical composition of the soil, hindering the absorption of plant roots, resulting in the withering of vegetation and reduced production.
As for the human body, there is also a great danger. Through respiration, its microparticles enter the lungs, or stimulate the respiratory tract, causing cough and asthma. Long-term exposure may damage the function of the lungs and lead to chronic diseases. If it comes into contact with the skin, it is corrosive to a certain extent, or it may cause burns, allergies, itching, redness and swelling to the skin. The harm of accidental ingestion is even worse, poisoning invades the viscera, messing with its physiological order, nausea, vomiting, abdominal pain, and even life-threatening.
The reason is that the preparation and use of 1-cyano-4-iodobenzene should be carefully and properly protected and disposed of to prevent it from harming the environment and people.