What are the chemical properties of 1-ethoxy-4-iodobenzene?

1-ethoxy-4-iodobenzene is 1-ethoxy-4-iodobenzene, and its chemical properties are quite interesting. This is an organic compound. On the benzene ring, one is connected by an ethoxy group, and the other is connected by an iodine atom.

In terms of reactivity, the electron cloud density of the benzene ring changes due to the presence of ethoxy groups. The ethoxy group is the power supply group, which can increase the electron cloud density of the benzene ring. Therefore, in the electrophilic substitution reaction, the electrophilic reagent is easy to attack the neighbor and the para-position. For example, when halogenation, nitrification, sulfonation and other reactions occur, the new substituent mostly falls in the ortho and para-position of the ethox

Looking at the iodine atom again, although it is also connected to the benzene ring, it is relatively easy to leave. In the presence of suitable nucleophiles, the iodine atom can be replaced by the nucleophilic reagent, thereby generating new organic compounds. In this process, the nucleophilic reagent attacks the carbon site attached to the iodine atom, and the iodine ion leaves to complete the substitution.

Its physical properties cannot be ignored. Because the molecule contains benzene ring, ethoxy group and iodine atom, it has a certain lipid solubility. At room temperature, it may be a liquid or solid state, depending on specific conditions. Its physical parameters such as boiling point and melting point are affected by intermolecular forces, including van der Waals force, dipole-dipole interaction, etc. Molecular polarity is caused by the distribution of ethoxy and iodine atoms, which affects their solubility and the way they interact with other compounds. Overall, the chemical properties of 1-ethoxy-4-iodobenzene are closely related to their structure and have important applications in the field of organic synthesis.

What are the common synthetic methods of 1-ethoxy-4-iodobenzene?

1-Ethoxy-4-iodobenzene is a common compound in organic synthesis. There are several common methods for its synthesis.

One is the etherification of halogenated aromatics. Using p-iodophenol and bromoethane as raw materials, under alkaline conditions, the nucleophilic substitution reaction can occur between the two. The function of the base is to convert p-iodophenol into phenoxy negative ions to enhance its nucleophilicity. Commonly used bases, such as potassium carbonate, sodium hydroxide, etc. During the reaction, p-iodophenol, bromoethane and alkali are placed in an appropriate solvent, such as N, N-dimethylformamide (DMF), acetone, etc., heated and stirred to generate 1-ethoxy-4-iodobenzene. This reaction condition is relatively mild and the operation is relatively simple.

The second is obtained by the iodization reaction of aryl borate esters. First, p-ethoxyphenylboronic acid is reacted with an appropriate halogenating reagent. Among the halogenating reagents, iodine sources such as iodine elemental, N-iodosuccinimide (NIS), etc. can be selected. The reaction is carried out in the presence of a suitable catalyst, such as palladium catalyst. This method has high selectivity and can effectively prepare the target product.

Third, 4-iodoaniline is used as the starting material, which is synthesized by diazotization reaction and then substitution reaction with ethanol. First, 4-iodoaniline and sodium nitrite are diazotized under acidic conditions to form a diazonium salt. Then the diazonium salt is mixed with ethanol, heated to react, and the amino group is replaced by ethoxy to obtain 1-ethoxy-4-iodobenzene. However, this process needs to pay attention to the control of the diazotization reaction conditions to prevent side reactions.

The above synthesis methods each have their own advantages and disadvantages. The experimenter should choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product, in order to achieve the purpose of efficient synthesis of 1-ethoxy-4-iodobenzene.

In what areas is 1-ethoxy-4-iodobenzene applied?

1-Ethoxy-4-iodobenzene is also an organic compound. It has applications in many fields.

In the field of medicinal chemistry, such iodine-containing compounds with benzene rings and ethoxy groups may be key intermediates for the creation of new drugs. Because iodine atoms have unique electronic effects and spatial effects, they may change the interaction between compounds and biological targets, helping to develop drugs with specific pharmacological activities, such as antibacterial, antiviral, and anti-tumor drugs. For example, by rationally designing reactions, 1-ethoxy-4-iodobenzene can be coupled with compounds containing specific active groups, or innovative drugs that have curative effects on specific diseases can be prepared. < Br >
In the field of materials science, it also has something extraordinary. Due to the rigid structure of benzene rings, the specific properties of ethoxy groups, and the special effects of iodine atoms, it can be used to synthesize polymer materials with special properties. If this is used as a raw material, it can be polymerized to produce materials with specific optical and electrical properties. It can be used in optoelectronic devices, such as organic Light Emitting Diode (OLED), to optimize the luminous efficiency and stability of the device; or it can be used to prepare new conductive materials to improve the electrical conductivity of materials.

Furthermore, in the field of organic synthetic chemistry, 1-ethoxy-4-iodobenzene is an important synthetic block. Iodine atoms can participate in a variety of classical organic reactions, such as Suzuki reaction, Heck reaction, etc., to construct complex organic molecular structures. Chemists can use it to react with different reagents such as boric acid or olefins to efficiently synthesize organic compounds with diverse structures, expand the scope of organic synthesis, and provide a powerful tool for the development of organic synthetic chemistry.

What are the physical properties of 1-ethoxy-4-iodobenzene?

1-Ethoxy-4-iodobenzene, Chinese name 1-ethoxy-4-iodobenzene, its physical properties are as follows:

This compound is often colorless to light yellow liquid at room temperature, and its appearance is ordinary but it has unique properties. It has a specific odor, but the relevant literature has less accurate description of its odor, only briefly describing that its odor is different from common odorless or ordinary odor substances.

When it comes to the melting point, the melting point is about -25 ° C, and the boiling point is between 270-272 ° C. The melting point is low, causing it to be stored in a liquid state at room temperature; the boiling point is quite high, indicating that the intermolecular force is strong, and more energy is required to make it boil.

The density of this compound is about 1.625g/cm ³, which is greater than that of common water. If mixed with water, it will sink to the bottom.

In terms of solubility, 1-ethoxy-4-iodobenzene is insoluble in water. Because it is an organic compound, the molecular polarity is weak, while water is a polar solvent. According to the principle of "similar miscibility", the two are insoluble. However, in common organic solvents, such as ethanol, ether, chloroform, etc., it has good solubility. Because organic solvents are mostly non-polar or weakly polar, they are similar to the polarity of the compound, so they can be miscible.

In addition, 1-ethoxy-4-iodobenzene has a certain volatility. Although the volatility is not very strong, it will also be partially volatile in an open environment after a certain period of time.

Its physical properties are the basis for research and application. In the fields of organic synthesis, medicinal chemistry, etc., its physical properties are relied on to achieve separation, purification and optimization of reaction conditions.

What is the market price of 1-ethoxy-4-iodobenzene?

1-ethoxy-4-iodobenzene, that is, 1-ethoxy-4-iodobenzene, the market price of this substance is often changed due to many factors, and it is difficult to generalize.

The first to bear the brunt is the difficulty of production and preparation. Synthesis of 1-ethoxy-4-iodobenzene requires specific organic synthesis steps. If the raw materials are rare, or the synthesis process is complicated, the reaction conditions are demanding, such as precise temperature control, strict anhydrous and anaerobic environment, etc., the cost must be high, and its price is also expensive.

Furthermore, the market supply and demand relationship has a great impact. If the market demand for this product is strong at a certain time, such as in medicine, material synthesis and other fields, the demand will increase sharply, and the supply is limited, the price will rise; on the contrary, if the demand is low and the supply is sufficient, the price will decline.

In addition, the purity of the product also affects the price. High purity of 1-ethoxy-4-iodobenzene is difficult to prepare, which can meet the strict requirements of high-end scientific research and pharmaceutical production, and its price is high; low purity, preparation is relatively easy, and it is used in scenes with low requirements, and the price is low.

Generally speaking, in the scientific research reagent market, the price per gram of 1-ethoxy-4-iodobenzene in small packages and high purity may range from tens to hundreds of yuan. In the industrial field, the price fluctuates greatly depending on the batch size. If the batch is large, the unit price may decrease due to the scale effect, or thousands of yuan per kilogram. However, these are all approximate numbers. The actual price will vary depending on factors such as time, place, quality and quantity. If the purchaser wants to know the exact price, he should consult the relevant suppliers in detail to obtain an accurate quotation.