1 Ethyl 4 Iodo 1h Pyrazole

1 - ethyl - 4 - iodo - 1H - pyrazole is also a compound. The reaction can be determined as follows:
This compound is a pyrazole core framework. Pyrazole is a five-membered compound, composed of three carbon atoms and nitrogen atoms, and has the characteristics of common properties, so that it has a certain degree of characterization. On the first carbon, there is an ethyl ($C_2H_5 $) group. This ethyl group is formed from the fifth carbon atom and forms the first nitrogen atom of the pyrazole atom. On the fourth carbon, there is an iodine atom. The iodine atom has the properties of large atoms and half atoms, and the properties of whole molecules, such as properties, anti-activity, etc., all have important effects.
For example, the synthesis of 1-ethyl-4-iodo-1H-pyrazole is composed of pyrazole, ethyl at 1 position, and iodine at 4 positions. This special property gives its unique physical properties. It is suitable for multiple domains such as synthesis and physicochemistry, or has a research value.

1 - ethyl - 4 - iodo - 1H - pyrazole is an organic compound with unique physical properties. It is a solid or liquid, depending on environmental conditions. At room temperature and pressure, or as a crystalline solid, the appearance is usually white to light yellow powder or crystal, fine texture, this is due to the intermolecular force to make it orderly arrangement.
When it comes to melting point, due to the structure containing atoms such as nitrogen and iodine, the intermolecular force is complex, including hydrogen bonds, van der Waals forces, etc., the melting point is relatively high, or between tens and hundreds of degrees Celsius. The exact melting point must be determined experimentally, and different purity and determination methods or values vary.
In terms of boiling point, it is affected by molecular mass and intermolecular forces, and its boiling point is higher. Molecules contain ethyl and iodine atoms, which increase mass and polarity, resulting in increased intermolecular forces. Higher energy is required to overcome the attractive force to boil the liquid. The boiling point may be above 200 degrees Celsius, depending on the experimental determination.
In terms of solubility, 1-ethyl-4-iodo-1H-pyrazole is slightly soluble in water. Because water is a polar solvent, although the compound contains polar nitrogen atoms, ethyl and iodine atoms reduce the overall polarity and interact weakly with water. However, it is easily soluble in organic solvents, such as ethanol, dichloromethane, acetone, etc. Due to the adaptation of these organic solvents to the intermolecular forces of the compound, it can effectively disperse and dissolve.
In addition, the density of the compound is greater than that of water, because its molecular weight is large, the atoms are closely arranged, and the unit volume mass is relatively high. In the fields of chemical and pharmaceutical research and development, these physical properties affect its separation, purification and application. For example, when developing drugs, choose the appropriate solvent according to the solubility to help it absorb and distribute, and control the reaction conditions and separation process according to the melting point and boiling point to ensure quality and yield.

1-Ethyl-4-iodo-1H-pyrazole, Chinese name 1-ethyl-4-iodo-1H-pyrazole, is a class of organic compounds that have a wide range of uses in the field of organic synthesis.
One of its main uses is as a key building block for building complex organic molecules. Organic synthesis is like a delicate "molecular architecture". Chemists want to build complex and functional organic molecular buildings, and 1-ethyl-4-iodo-1H-pyrazole is often used as the cornerstone. Due to its unique chemical structure, it contains pyrazole rings and specific substituents, giving it unique reactivity. Chemists can perform various chemical modifications on it by selecting suitable reaction conditions and reagents, such as nucleophilic substitution reactions, coupling reactions, etc. Just like skilled craftsmen according to the design blueprint, this block is precisely spliced with other molecular fragments to build target molecules with specific functions and structures, such as new drug molecules, functional material molecules, etc.
Furthermore, in the field of medicinal chemistry, 1-ethyl-4-iodine-1H-pyrazole also plays an important role. Drug development seems to be seeking a precise "key" to open the door to disease treatment. This compound is often used as the core structure of the lead compound due to the biological activity advantage of the pyrazole ring. Researchers can modify and optimize its structure, regulate its interaction with biological targets, and improve the pharmacological activity, pharmacokinetic properties and safety of drugs. Many studies have shown that compounds containing pyrazole structure have shown good activities in anti-tumor, anti-inflammatory and antibacterial aspects. 1-ethyl-4-iodine-1H-pyrazole may provide a possible path for the development of new specific drugs.
In addition, in the field of materials science, 1-ethyl-4-iodine-1H-pyrazole also has potential applications. With the advance of science and technology, the demand for functional materials is increasing. The compound may emerge in the fields of optoelectronic materials, sensor materials and other fields due to its unique electronic structure and chemical properties. For example, through rational molecular design and synthesis, it may be constructed into a sensor material that is sensitive to specific substances or physical quantities, like a keen "sensing antenna", which can achieve highly sensitive detection of specific substances in the environment; or it can be applied to the organic Light Emitting Diode (OLED) material system to improve the luminescence performance and contribute to the development of new display technologies.

1-Ethyl-4-iodo-1H-pyrazole, that is, 1-ethyl-4-iodo-1H-pyrazole, has the following common synthesis methods.
First, 4-iodo-pyrazole is used as the starting material. 4-iodo-pyrazole reacts with halogenated ethane in an appropriate organic solvent under basic conditions. Commonly used bases such as potassium carbonate, sodium carbonate, etc., acetonitrile, N, N-dimethylformamide (DMF) and other organic solvents can be selected. During the reaction, the ethyl group in the halogenated ethane undergoes nucleophilic substitution reaction with the nitrogen atom of 4-iodopyrazole under the action of alkali, thereby obtaining 1-ethyl-4-iodopyrazole-1H-pyrazole. This reaction condition is relatively mild, and the reaction process is easier to control. However, the cost of 4-iodopyrazole raw materials may be higher, which has a certain impact on the reaction economy.
Second, pyrazole is used as the starting material. Pyrazole first undergoes N-ethylation reaction under appropriate conditions. Commonly used ethylation reagents include diethyl sulfate, ethane halides, etc., which also react in a basic environment. After 1-ethylpyrazole is formed, the iodization reaction is carried out. The iodization reaction can be carried out by iodine elemental substance, iodine substitution reagents such as N-iodosuccinimide (NIS), etc., in the presence of suitable catalysts such as Lewis acid. The raw material pyrazole of this route is relatively easy to obtain, but the reaction steps are increased, and the reaction conditions of each step need to be precisely controlled to ensure high yield and purity.
Third, synthesized by cyclization reaction. Chain compounds containing suitable substituents are used as raw materials to form pyrazole rings through intramolecular cyclization. For example, specific alkenyl hydrazine compounds and iodoacetyl ethyl esters are used under the action of basic catalysts to undergo intramolecular cyclization reactions, and ethyl and iodine atoms are introduced at the same time to directly construct 1-ethyl-4-iodine-1H-pyrazole structures. This method has relatively compact steps and high atomic economy, but the preparation of raw materials may be more complicated, and the reaction conditions are demanding. In-depth research on the design of reaction substrates and the optimization of reaction conditions is required.

1 - ethyl - 4 - iodo - 1H - pyrazole is an organic compound. When using it, many things need to be paid attention to.
First, safety protection is very important. This compound may be toxic and irritating. When exposed, be sure to wear suitable protective equipment, such as gloves, goggles and laboratory clothes, to prevent it from contacting the skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately and seek medical attention according to the specific situation. It is also crucial to operate in a well-ventilated environment to avoid inhaling its volatile gases to prevent damage to the respiratory tract. If used in the laboratory, you should use equipment such as a fume hood to discharge volatile substances in time.
Second, storage conditions should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its chemical properties or making it react under improper conditions, it can cause danger. Storage containers should also be well sealed to prevent them from deteriorating in contact with air, moisture, etc.
Third, during chemical reactions, it is necessary to precisely control the reaction conditions. Different reaction conditions, such as temperature, pH, reaction time, etc., have a great impact on the reaction results. It is necessary to strictly control various parameters according to specific reaction requirements to achieve the expected reaction effect and avoid accidents due to runaway reaction. For example, some reactions are extremely sensitive to temperature, and a slight deviation may lead to more side reactions and lower product purity.
Fourth, during use, its chemical properties should be fully understood. Know the various reactions it may participate in, and avoid mixing with incompatible substances to prevent dangerous reactions. At the same time, the operation process should be strictly standardized, follow relevant experimental operating procedures and safety guidelines, and must not change the operation process at will to ensure the safety of the use process.