1-Fluoro-2-Iodobenzene

Fengxi Chemical

Specifications

HS Code	123661
Chemical Formula	C6H4F I
Appearance	colorless to light yellow liquid
Boiling Point	186 - 188 °C
Melting Point	N/A
Density	1.826 g/cm³
Flash Point	79.4 °C
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure	Low
Refractive Index	1.606

As an accredited 1-Fluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 mL of 1 - fluoro - 2 - iodobenzene packaged in a sealed, chemical - resistant glass bottle.
Storage	1 - Fluoro - 2 - iodobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of a material resistant to corrosion. Store it separately from oxidizing agents and incompatible substances. Avoid long - term exposure to light as it may cause decomposition. Regularly check storage conditions and containers for integrity.
Shipping	1 - fluoro - 2 - iodobenzene is shipped in sealed, corrosion - resistant containers. Special handling is required due to its chemical nature. Shipment follows strict regulations for hazardous chemicals to ensure safety during transit.

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General Information

Historical Development

1 - Fluoro - 2 - Iodobenzene is also an organic compound. It is gradually emerging in the field of chemistry. Back in the past, chemists investigated the method of organic synthesis, and studied the preparation of halogenated aromatics many times.
At the beginning, the synthesis method was still simple, but the accuracy and efficiency were not high. As the years passed, the chemical technology improved, the control of the reaction conditions became better, and the catalytic system was constantly innovated.
As for 1 - Fluoro - 2 - Iodobenzene, in the past, the raw materials were rare, the steps were cumbersome, and the yield was quite low. After several generations of scholars, new catalysts were developed, and the reaction path was optimized, which made the synthesis of this compound more convenient and the yield was greatly improved. From the early difficult exploration to the maturity of the current process, the development of 1-Fluoro-2-Iodobenzene is the continuous exploration of chemical research.

Product Overview

1 - Fluoro - 2 - Iodobenzene is a key compound in the field of organic synthesis. Its properties are colorless to pale yellow liquids with unique physical and chemical properties. The fluorine and iodine atoms of this compound give it special reactivity and play a key role in many chemical reactions.
In organic synthesis, 1 - Fluoro - 2 - Iodobenzene is often an important starting material. With its nucleophilic substitution activity of iodine atoms, it can react with a variety of nucleophiles to form carbon-heteroatomic bonds. The presence of fluorine atoms can significantly affect the distribution of electron clouds in molecules, thereby changing the selectivity and rate of reactions.
In addition, 1-Fluoro-2-Iodobenzene also has potential applications in the field of medicinal chemistry. Due to its special structure, it may be used as a key structural fragment of lead compounds. Chemical modification and optimization have led to the development of new drugs. In-depth study of its properties and reactions may open up new avenues for organic synthesis and drug development.

Physical & Chemical Properties

1 - Fluoro - 2 - Iodobenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, it is mostly liquid at room temperature and has a special odor. Its boiling point and melting point vary depending on the force between molecules. The boiling point can vaporize the substance at a specific temperature, and the melting point is related to the transition between solid and liquid states.
In terms of chemical properties, fluorine and iodine atoms in this compound have special activities. Fluorine atoms have high electronegativity, which changes the density distribution of electron clouds in the benzene ring, which affects the activity of electrophilic substitution reactions. Although iodine atoms are larger than fluorine atoms, they can also participate in a variety of chemical reactions, such as coupling reactions, and can be used to construct carbon-carbon bonds, which is of great significance in the field of organic synthesis. The physical and chemical properties of this compound lay the foundation for its application in many fields such as chemical industry and medicine.

Technical Specifications & Labeling

1 - Fluoro - 2 - Iodobenzene is an important raw material in organic synthesis. Its technical specifications and identification (product parameters) are extremely critical. The appearance of this product should be a colorless to slightly yellow transparent liquid with no visible impurities. The purity needs to be above 99%, which is related to its effect in various reactions. The moisture content should not exceed 0.1%. Excessive moisture will interfere with the reaction process. The boiling point is about 180 - 185 ° C, the melting point is - 10 - 0 ° C. The accurate melting boiling point can be used as the basis for identification. In terms of identification, the packaging should be clearly marked with the product name, molecular formula C - H - FIN, CAS number and other key information for accurate identification and use to ensure product quality and safety.

Preparation Method

To prepare 1-Fluoro-2-Iodobenzene, the raw materials and production process are very critical. O-iodoaniline is taken as the initial raw material, and the amino group is converted into a diazonium salt through diazotization reaction. First, an appropriate amount of sodium nitrite reacts with o-iodoaniline in a low temperature and acidic environment to form a diazonium salt intermediate.
Then the fluorination reaction is carried out, which is a key step. Mix the generated diazonium salt with fluoroborate acid to form a fluoroborate salt, which is decomposed by heating to obtain the target product 1-Fluoro-2-Iodobenzene. The reaction mechanism lies in the reactivity of the diazonium salt, which allows fluorine atoms to effectively replace the diazonium group.
The whole preparation process requires precise control of the reaction conditions. The low temperature environment can prevent the decomposition of diazonium salts and ensure the smooth progress of the reaction, so that 1-Fluoro-2-Iodobenzene can be efficiently prepared.

Chemical Reactions & Modifications

1 - Fluoro - 2 - Iodobenzene is an important compound in organic synthesis. Its chemical reaction and modification are very important in the field of chemical research.
Looking at its chemical reaction, in the nucleophilic substitution reaction, the iodine atom has high activity and is easily replaced by many nucleophilic reagents. This reaction can be achieved at a moderate temperature and reaction time with suitable bases and nucleophilic reagents. For example, with alkoxides as nucleophilic reagents, in polar aprotic solvents, substitution can occur smoothly to generate corresponding ether compounds.
When it comes to modification, its physical and chemical properties can be effectively adjusted by introducing different substituents. The electron cloud density and selectivity of 1-Fluoro-2-Iodobenzene can be enhanced by introducing the donating radical at a specific position in the benzene ring. With this modification, 1-Fluoro-2-Iodobenzene may show more unique properties and application potential in the field of drug synthesis and materials science.

Synonyms & Product Names

1 - Fluoro - 2 - Iodobenzene This product, with the same trade name, has the value of investigation. In the field of chemical research, the name of many products is often expressed differently due to the region, or the direction of research.
1 - Fluoro - 2 - Iodobenzene, or 2 - iodine - 1 - fluorobenzene, this is the name according to the order of its atoms. For chemical industries, merchants or give them special trade names, aiming to recognize their characteristics or products in the market. For example, a chemical industry, or because of its degree of quality, production and manufacturing, uses the trade name "refined fluoroiodobenzene" to refer to the same product.
The number of trade names in the same category reflects the transformation of chemical materials in different situations. Researchers need to know their respective names in order to communicate the text, clarify the direction, and have important significance for the application of chemical research.

Safety & Operational Standards

1 - Fluoro - 2 - Iodobenzene is also a chemical substance. Our generation should be cautious about its safety and operating practices.
This chemical is dangerous. If it is not handled properly, it may cause accidents. Therefore, when handling, strict procedures must be followed.
First safety protection. The operator must wear suitable protective clothing, gloves, and goggles to prevent the substance from touching the skin and eyes. It may be irritating to the skin and eyes.
Furthermore, the operating environment should be well ventilated. This chemical may evaporate harmful gases. Handling in a well-ventilated place can reduce the accumulation of harmful gases and ensure the health of the operator.
As for the operating specifications, when weighing, use precise instruments to ensure the accuracy of the quantity. And the mixing and reaction steps should follow the established process. During the heating process, pay special attention to the control of heat and temperature to prevent overreaction.
Storage should also not be ignored. 1 - Fluoro - 2 - Iodobenzene should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Classified storage to prevent mutual reaction.
Disposal is also in accordance with regulations. It should not be discarded at will. When in accordance with relevant environmental regulations, it should be properly handled to avoid pollution.
All of these are important for the safety and operation of 1-Fluoro-2-Iodobenzene, and the operator must abide by them to ensure safety and avoid disasters.

Application Area

1 - Fluoro - 2 - Iodobenzene is an important raw material for organic synthesis, and its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize a variety of special drugs. Through specific chemical reactions, the active molecular structure of drugs can be constructed to cure various diseases. In the field of materials science, it can participate in the preparation of functional materials with special properties, such as photoelectric materials, to give unique photoelectric properties to materials. In the research and development of pesticides, it also has important uses, which can synthesize pesticides with high insecticidal and bactericidal properties to ensure the healthy growth of crops. Its unique chemical structure makes it show great application potential in many fields, promoting the continuous progress and development of related industries.

Research & Development

In recent years, I have been focusing on the research of 1-Fluoro-2-Iodobenzene in the field of chemistry. This compound has a unique structure and unique properties, which is of great research value.
Initially, analyze its molecular structure, study the bonding state of each atom, and explore the root cause of its stability. Then, try various synthesis methods. Either take the classical path, or create an innovative formula, and after repeated attempts, we can get an optimization strategy to improve yield and purity.
Application exploration is also the focus. In medicinal chemistry, it is hoped that it will be the cornerstone of the creation of new drugs; in materials science, it is hoped that the properties of materials can be improved. Although I encountered severe reaction conditions and frequent side reactions on the way, I adhered to the spirit of research and made unremitting efforts.
Today, the research on 1-Fluoro-2-Iodobenzene is getting better. In the future, based on this, we will expand and innovate, and reach a new realm in the process of scientific research, contributing to the development of chemistry.

Toxicity Research

The toxicity of 1 - Fluoro - 2 - Iodobenzene is a chemical research substance. Although this substance has its use in chemical industry, the toxicity cannot be ignored.
After various experiments, its effect on organisms was observed. Small animals were taken as samples and fed food containing this substance for a long time, and it was seen that its behavior was abnormal. Or slow movement, or less food, and even organ changes.
And observe its impact on the environment. If it is released into water, aquatic organisms are harmed. Algae growth is blocked, fish and shrimp are also uncomfortable.
The conclusion of the study, 1 - Fluoro - 2 - Iodobenzene is toxic. During production and use, strict regulations should be followed to prevent their release, in order to protect the safety of organisms and the environment.

Future Prospects

Today there is a thing named 1 - Fluoro - 2 - Iodobenzene. Looking at its properties, its chemical characteristics are unique and it has the potential for scientific research. Our generation looks forward to its future as a chemical researcher, full of hope.
This substance may be able to open up new paths in organic synthesis. It can be used as a key intermediate and is the cornerstone of the creation of novel compounds. Its structure is exquisite, fluorine and iodine atoms coexist, giving it a variety of reactions. In the future, efficient synthesis methods may be available to make its preparation easier and cheaper.
In the field of materials, it also has great opportunities to show its skills. With its unique electronic properties, it may be able to give birth to new functional materials, which can be used in photoelectric and sensing terminals, adding force to the advancement of science and technology.
Although the road ahead is long, we firmly believe that with time and unremitting research, 1 - Fluoro - 2 - Iodobenzene will shine, create a new situation in the field of scientific research and practicality, benefit the world, and live up to our expectations for the future.

Where to Buy 1-Fluoro-2-Iodobenzene in China?

As a trusted 1-Fluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main physical properties of 1-fluoro-2-iodobenzene?

1 - fluoro - 2 - iodobenzene is an organic compound with specific physical properties. Its properties are mostly colorless to pale yellow liquids at room temperature. It is clear and transparent when viewed. When placed in sunlight, it can be seen to flow with a slight luster, as if it contains mysterious energy.
This compound has a special smell, not pungent and intolerable, but also has a unique smell. When smelled, it is impressive. The boiling point of 1 - fluoro - 2 - iodobenzene is about 180 - 185 ° C. When the temperature gradually rises, the molecules can break free from their bonds and change from liquid to gas, just like a bird that breaks free from a cage. The melting point is around -20 ° C. Below this temperature, it solidifies like a slumber, and the shape changes from a flowing liquid to a solid state, and the structure tends to be stable.
Its density is higher than that of water, about 1.95-2.05 g/cm ³. If it is co-located with water, it will enter the water like a sunken stone and slowly sink to the bottom. 1-fluoro-2-iodobenzene has very low solubility in water, and it seems to be incompatible with water. The two are difficult to blend, because it is a non-polar or weakly polar substance, while water is a polar molecule, and it is difficult to dissolve according to the principle of "similar miscibility". But it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc., just like finding the same kind, and can be intimately mixed with it, regardless of each other.

What are the common synthetic methods of 1-fluoro-2-iodobenzene?

1-Fluoro-2-iodobenzene is also a common compound in organic synthesis. The synthesis methods are many different, and now it is the method of Jun Chen.
First, the halogen exchange method. Using 1-chloro-2-iodobenzene as a substrate, the reaction is heated with potassium fluoride in an appropriate solvent, such as dimethyl sulfoxide (DMSO), and a catalyst such as crown ether. Among them, the crown ether can complex with potassium ions to increase the activity of fluorine ions, so that the halogen exchange reaction can proceed smoothly. The reaction mechanism is nucleophilic substitution, fluorine ions attack the carbon-halogen bond, and the chlorine leaves, so 1-fluoro-2-iodobenzene is obtained. < Br >
Second, the diazonium salt method. First, the o-iodoaniline is used as the starting material, and the diazonium salt is obtained by the diazotization reaction, which reacts with sodium nitrite and hydrochloric acid at low temperature. Then, the diazonium salt is reacted with fluoroboronic acid to form a diazonium salt of fluoroboronic acid, which is heated and decomposed to obtain 1-fluoro-2-iodobenzene. This process requires strict temperature control to prevent the decomposition of the diazonium salt from getting out of control. The key to the diazotization reaction is the slow dropwise addition of sodium nitrite and the maintenance of low temperature to ensure the stable formation of the diazonium salt.
Third, the metal catalysis method. Using metals such as palladium or nickel as catalysts, o-iodofluorobenzene can be prepared by reacting o-iodophenylboronic acid with fluorinated aromatic hydrocarbons in an organic solvent in the presence of bases. Metal catalysts can activate aromatic rings and promote the formation of carbon-carbon and carbon-halogen bonds. The function of bases is to assist in the formation of active centers of catalysts and neutralize the acids generated by the reaction.
All synthesis methods have their own advantages and disadvantages. The raw materials of the halogen exchange method are easy to obtain, but the reaction conditions may be harsh; the diazonium salt method is slightly more complicated, but the selectivity is good; the metal catalytic method is efficient, but the cost of the catalyst may be considered. Experimenters should choose the best one and use it according to actual needs.

What are the applications of 1-fluoro-2-iodobenzene in organic synthesis?

1-Fluoro-2-iodobenzene is widely used in organic synthesis. It can be used as an important synthetic building block, participating in various organic reactions, thereby building complex organic molecular structures.
First, in metal-catalyzed coupling reactions, 1-fluoro-2-iodobenzene is often a key substrate. Such as Suzuki coupling reaction, it can form carbon-carbon bonds with aryl boric acid under the action of palladium catalyst and base to obtain biaryl compounds. This reaction is of great significance in the fields of medicinal chemistry and materials science, and can be used to create new drug molecules. It can also contribute to the synthesis of optoelectronic materials.
Furthermore, in the Ullmann reaction, 1-fluoro-2-iodobenzene can also react with phenols and amines under copper catalysis to generate corresponding aryl ethers or aryl amines. This reaction is an effective way to construct aryl heteroatomic bonds, and has a remarkable position in organic synthesis chemistry. It has applications in the total synthesis of agrochemicals and natural products.
In addition, 1-fluoro-2-iodobenzene can participate in nucleophilic substitution reactions. Due to the differences in the activities of fluorine and iodine atoms, nucleophilic substitution can selectively occur, introducing different functional groups, providing various possibilities for molecular modification, and playing an indispensable role in the synthesis of fine chemicals.
Overall, 1-fluoro-2-iodobenzene is a valuable organic compound in the field of organic synthesis because it can participate in a variety of reactions. It provides an important means and path for organic synthesis chemists to construct various complex and special organic molecules.

What are 1-fluoro-2-iodobenzene storage conditions?

1 - fluoro - 2 - iodobenzene is an organic compound, and its storage conditions are very critical. This substance should be stored in a cool, dry and well-ventilated place. Because the cool environment can reduce the risk of reaction or decomposition due to excessive temperature; dry place can avoid contact with water vapor, prevent adverse reactions such as hydrolysis caused by moisture; good ventilation can disperse volatile gases that may leak in time, and keep the storage environment safe.
Furthermore, keep away from fire and heat sources. 1 - fluoro - 2 - iodobenzene or flammable, in case of open flame, hot topic can easily cause combustion or even explosion, so be sure to keep away from fire sources and store it in a fireproof area. < Br >
Because it is a chemical, it should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. This is due to the chemical properties or activity of 1-fluoro-2-iodobenzene, contact with the above substances or cause violent chemical reactions, resulting in dangerous accidents.
Storage containers also need to be strictly selected. Good sealed containers should be used to prevent leakage. Commonly used glass or metal containers, depending on specific characteristics and requirements. And the name, nature and hazard of the substance should be clearly marked on the outside of the container for access and management.
Storage sites should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. In the event of a leak or fire, it can be responded to in time to reduce the hazard. The temperature and humidity of the storage environment should also be regularly monitored and regulated to ensure that storage requirements are met. In this way, 1-fluoro-2-iodobenzene can be properly stored to ensure its quality and storage safety.

What are the safety precautions for 1-fluoro-2-iodobenzene?

1 - fluoro - 2 - iodobenzene is an organic compound. The safety precautions for it are as follows:
- ** Toxic Hazard **: This compound may be toxic and can be poisoned by inhalation, ingestion or skin contact. It is irritating to the eyes, skin and respiratory mucosa. Long-term or large-scale contact may damage the liver, kidneys and other organs. During operation, strict protection must be taken and it must never be exposed to the body.
- ** Fire Explosion **: Although it is not extremely flammable and explosive, it is still dangerous in case of hot topics or open flames. In storage and use, open flames and hot topic sources are strictly prohibited, and fire extinguishing equipment suitable for organic compound fires should be prepared, such as dry powder fire extinguishers and carbon dioxide fire extinguishers.
- ** Storage Requirements **: It should be stored in a cool and well-ventilated place, away from fire and heat sources. It should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous reactions. The storage container must be sealed to prevent leakage.
- ** Operation Note **: The operation must be carried out in the fume hood to reduce the concentration in the air. Operators should wear protective clothing, protective gloves and goggles, and gas masks if necessary. Be careful during operation to prevent leakage caused by damage to the container. < Br > - ** Leak Emergency **: In the event of a leak, immediately evacuate unrelated personnel and isolate the leak area. Emergency responders wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Small leaks are absorbed with inert materials such as sand and vermiculite; large leaks, embankment or dig a pit for containment, and transfer to a tanker or special collector for recycling or transportation to a waste disposal site for disposal.