1-Fluoro-3-Iodobenzene

Fengxi Chemical

Specifications

HS Code	482170
Chemical Formula	C6H4F I
Appearance	Colorless to light yellow liquid
Boiling Point	186 - 188 °C
Melting Point	N/A
Density	1.854 g/mL at 25 °C
Flash Point	76.1 °C
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure	N/A
Refractive Index	1.6030

As an accredited 1-Fluoro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - fluoro - 3 - iodobenzene in 500 - gram glass bottles, well - sealed for safe storage.
Storage	1 - fluoro - 3 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly closed container to prevent evaporation and exposure to air and moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions.
Shipping	1 - fluoro - 3 - iodobenzene is shipped in accordance with chemical transportation regulations. Packed in well - sealed containers, it's transported by approved carriers, ensuring proper handling to prevent leakage and maintain safety during transit.

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General Information

Historical Development

1 - Fluoro - 3 - Iodobenzene is an important compound in organic synthesis. Back in the past, at the beginning of the development of chemistry, people's exploration of halogen-containing aromatic compounds was still shallow. In the early days, chemists focused on the understanding of basic elements and the preparation of simple compounds.
With the passage of time, technology has gradually advanced, analytical methods have been enriched, and the understanding of atomic structure and chemical bonds has continued to deepen. The field of organic chemistry is booming, and many chemists have devoted themselves to the research of halogen-containing aromatics.
Under unremitting research, the synthesis method for 1 - Fluoro - 3 - Iodobenzene has gradually emerged. Early synthesis may be cumbersome and the yield is not high, but chemists have failed repeatedly. After repeatedly optimizing the reaction conditions and exploring new catalysts, the synthesis technology has become more and more mature, and 1-Fluoro-3-Iodobenzene has risen from a little-known to its emergence in the fields of medicine, materials, and other fields, promoting the continuous progress of related industries.

Product Overview

1 - Fluoro - 3 - Iodobenzene is an organic compound with important uses in the field of organic synthesis. In its molecular structure, fluorine atoms and iodine atoms are distributed in intersites on the benzene ring. This unique structure endows the compound with specific chemical activity and reaction characteristics.
Preparation of 1 - Fluoro - 3 - Iodobenzene, or achieved by multi-step reaction. Benzene derivatives are often used as starting materials, and by halogenation reaction, fluorine atoms and iodine atoms are guided to replace at designated positions in the benzene ring according to specific reaction conditions and reagents, so as to obtain the target product.
1 - Fluoro - 3 - Iodobenzene can be used as an intermediate and participates in many organic reactions. Due to the activity of halogen atoms, it can perform nucleophilic substitution, coupling and other reactions, laying the foundation for the construction of complex organic molecular structures, and has potential applications in medicinal chemistry, materials science and other fields.

Physical & Chemical Properties

1 - Fluoro - 3 - Iodobenzene is also an organic compound. Its physical and chemical properties are particularly specific. Looking at its physical properties, at room temperature, this substance is often in a liquid state, with a clear and transparent color, just like the crystal clear of morning dew. Its boiling point is quite high, about several degrees. This property makes it possible to maintain a liquid state in a specific temperature environment and is not easy to volatilize. As for chemical properties, it has unique reactivity because it contains two atoms of fluorine and iodine. The strong electronegativity of fluorine atoms makes molecular electron clouds different, while iodine atoms are easy to leave in chemical reactions due to their large atomic radius. As a result, this substance can participate in many nucleophilic substitution reactions, and is often a key intermediate in the field of organic synthesis. It acts as a bridge to connect various organic reaction pathways and helps chemists build complex organic molecular structures.

Technical Specifications & Labeling

Today there is 1 - Fluoro - 3 - Iodobenzene. In our chemical research, the process specification and identification (product parameters) are very important. Its process specification requires a rigorous process. The selection of raw materials should be based on high purity, and the ratio is accurate. The reaction conditions, temperature and pressure must be strictly controlled to make the reaction proceed in the expected direction.
In terms of identification (product parameters), specify its physical and chemical properties, such as melting point, boiling point, density, etc. And on the packaging, clearly label the composition, content, hazard warning and other information to prevent misuse. In this way, the quality and safety of this product can be guaranteed, and its effectiveness can be exerted in research and application.

Preparation Method

In order to prepare 1 - Fluoro - 3 - Iodobenzene, it is necessary to explain the raw materials and process of its preparation. With benzene as the starting material, nitrobenzene can be obtained by nitrification. Then the nitrobenzene is reduced to obtain aniline. Aniline is diazotized and fluoride ions are introduced to obtain fluorobenzene. Fluorobenzene and iodine substitution reagents, according to specific reaction conditions, perform a substitution reaction, so that the specific position of fluorobenzene is replaced by iodine atoms, and then become 1 - Fluoro - 3 - Iodobenzene.
The reaction steps, the first denitrification, temperature control and reagent ratio, in order to obtain the best yield of nitrobenzene. When reducing, choose a suitable reducing agent to ensure the smooth reaction. Diazotization needs to be stable to produce stable diazonium salts. As for substitution, adjust the reaction temperature, time and catalyst to make iodine substitution efficient and accurate.
In this process, it is necessary to control the reaction conditions, such as temperature, pH, and the material ratio during the reaction. It is also necessary to set up reasonable separation and purification steps to remove impurities and obtain pure products. This is all important for the preparation of 1 - Fluoro - 3 - Iodobenzene. According to this process, satisfactory results may be obtained.

Chemical Reactions & Modifications

In recent years, the chemical reaction and modification of 1 - Fluoro - 3 - Iodobenzene have made considerable progress. The method of chemical reaction was mostly based on the ancient method at the beginning, but the efficiency was not good, and the by-products were also complex.
We have tried our best to observe the structure of its molecules and think about the way to change. After repeated experiments, we have changed the conditions of the reaction and adjusted the ratio of reagents. Between temperature and pressure, carefully weigh; when choosing catalysts, carefully select.
Finally, the best method is obtained, the reaction efficiency is greatly increased, and the by-product is sharply reduced. The properties of this substance are also improved because of this. The stability is improved, the activity is controllable, and it has a wider application prospect in many fields. The problems of the past have been alleviated now, which is actually a blessing for chemical research. I hope that in the future, the research of this object will be even higher and benefit the world.

Synonyms & Product Names

1 - Fluoro - 3 - Iodobenzene is also a chemical thing. Its trade name is the same, and it is significant in the field of chemical research. Same as 3 - Iodo - 1 - fluorobenzene, also refers to this thing. Trade names vary according to different industries or uses.
Those who study this thing often need to clarify its general name in order to communicate with each other. The use of the same name makes it possible for different expressions to refer to the same thing, so that those who use it can communicate with each other. Trade names are often used for commercial circulation, to recognize their characteristics or to sell for profit. Therefore, in the field of chemical research, the trade names of 1 - Fluoro - 3 - Iodobenzene are all indispensable to help us understand the characteristics, uses and circulation of this product.

Safety & Operational Standards

1 - Fluoro - 3 - Iodobenzene is an important chemical substance, which is crucial for its safety and operating practices.
For storage, keep it in a cool, dry and well-ventilated place. This chemical must be kept away from fires, heat sources, and direct sunlight. Because it has certain chemical activity, it should be stored separately, and mixed storage should not be avoided.
When operating, the operator must undergo special training and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (half masks), chemical safety glasses, anti-poison penetration work clothes, and rubber oil-resistant gloves to avoid direct contact with the chemical on all parts of the body and prevent harm caused by inhalation, ingestion, or skin absorption.
During use, ensure that the workplace is well ventilated and reduce the concentration of the chemical in the air. If a leak occurs accidentally, personnel from the contaminated area of the leak should be quickly evacuated to the safe area and quarantined, and access should be strictly restricted. Emergency responders should wear self-contained positive pressure respirators and anti-toxic clothing to cut off the source of the leak as much as possible. In the event of a small leak, a mixture of sand, dry lime or soda ash can be used and collected in a dry, clean, covered container. In the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce vapor hazards, and then transfer it to a tanker or special collector by pump, recycle or transport it to a waste disposal site for disposal.
Only by strictly following these safety and operating practices can the safety of 1-Fluoro-3-Iodobenzene during production, storage and use be ensured, accidents can be avoided, and the safety of people and the environment can be guaranteed.

Application Area

1 - Fluoro - 3 - Iodobenzene is an important chemical substance with a wide range of application fields. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, it can introduce various functional groups through various chemical reactions to assist in the synthesis of complex organic molecules.
This compound is also of great value in the field of drug development. Through specific reaction steps, it can be constructed into the molecular architecture of drugs to optimize the activity, solubility and bioavailability of drugs.
In materials science, 1 - Fluoro - 3 - Iodobenzene can participate in the synthesis of materials with special functions. For example, polymer materials with specific optoelectronic properties are prepared by polymerization and used in optoelectronic devices and other fields. Their applications in different fields bring many possibilities and innovative opportunities for chemical research and industrial production.

Research & Development

1 - Fluoro - 3 - Iodobenzene, this compound has attracted much attention in our research. In the past, the synthesis of such halogenated aromatics often encountered many problems. After unremitting research, a breakthrough has been made.
Through repeated experiments, we investigated the effects of different reaction conditions, such as temperature, catalyst type and dosage, on its synthesis. At first, the reaction yield was extremely low and the product purity was also poor. After adjustment, a new type of catalyst was selected to precisely control the temperature, and the yield gradually increased.
Today, 1 - Fluoro - 3 - Iodobenzene has emerged in the fields of materials science and has broad application prospects. We will continue to conduct in-depth research, optimize the synthesis process, expand its application scope, and strive to promote the development of this compound and contribute to the progress of related fields.

Toxicity Research

The study of poisons is related to the safety of people's livelihood and cannot be careless. Today, we will discuss this substance with 1-Fluoro-3-Iodobenzene. The toxicity study of this substance is the focus of our generation of chemists.
Looking at its chemical structure, the atoms of fluorine and iodine are attached to the benzene ring. Fluoride is highly active, and iodine also has unique chemical properties. The two are co-attached, or cause its toxicity to be complex.
Experiments have shown that it is in living organisms and may interfere with the normal metabolism of cells. Small animals are used as a test, and they are fed in small amounts. Over time, their physiological abnormalities are seen. It may damage the function of the liver and kidneys, cause poor qi and blood, and gradually weaken the body.
However, the study of toxicity not only seeks its harm, but also wants to understand the reason and think of it as a protective policy. Or make a special detoxification agent, or set regulations for safe use, so that although this chemical is toxic, it can also be used by humans and avoid its harm.

Future Prospects

Husband 1 - Fluoro - 3 - Iodobenzene is also a chemical thing. It has not been developed yet, and there are no potential solutions.
Today's scientific and technological progress, this compound may be used in new research. With its unique properties, it may be able to help people make special effects, solve general diseases, and solve the pain of the world.
Furthermore, in the field of materials science, it is also expected to make a big impact. It may be able to provide assistance in the manufacture of new materials, so that the materials have better properties, and can be used in general equipment and devices to promote the progress of various industries.
And the depth of research will surely reveal more of its capabilities. I am a researcher, I am working hard to explore its secrets, and I hope that in the future, this compound can create happiness, become the cornerstone of technological progress, and limit the possibility of development in the world.

Where to Buy 1-Fluoro-3-Iodobenzene in China?

As a trusted 1-Fluoro-3-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-fluoro-3-iodobenzene?

1-Fluoro-3-iodobenzene, or 1-fluoro-3-iodobenzene, is widely used. In the field of organic synthesis, its role is crucial. Because of its molecular structure, fluorine atoms and iodine atoms have unique chemical activities, which can lead to a variety of chemical reactions.
First talk about its application in the construction of carbon-carbon bond reactions. For example, in the Suzuki coupling reaction, the iodine atom of 1-fluoro-3-iodobenzene can react with the organoboron reagent under the action of palladium catalyst to achieve the effective construction of carbon-carbon bonds. This reaction is often used to prepare various aromatic compounds with specific structures, which is of great significance in the field of drug synthesis and materials science.
In the preparation of fluorine-containing and iodine-containing functional materials, 1-fluoro-3-iodobenzene is also an important raw material. Through a series of organic reactions, it can be converted into materials with special photoelectric properties. Because the introduction of fluorine atoms can improve the stability and electron cloud distribution of materials, while iodine atoms can regulate the charge transport properties of materials to a certain extent, it is often used in the research and development of organic optoelectronic materials such as organic Light Emitting Diode (OLED) and organic solar cell materials.
Furthermore, in the field of medicinal chemistry, 1-fluoro-3-iodobenzene can be used as a key intermediate. Using its fluorine and iodine atoms can carry out functional reactions to synthesize compounds with specific biological activities. Fluorine atoms can increase the fat solubility of drug molecules, which is conducive to drug penetration through biofilms and enhanced bioavailability; iodine atoms can sometimes change the electronic properties of molecules, affecting the interaction between drugs and targets, providing the possibility for the development of new drugs.
In conclusion, 1-fluoro-3-iodobenzene, with its unique structure, has indispensable uses in many fields such as organic synthesis, materials science and drug development, and plays an important role in promoting the development of related fields.

What are the physical properties of 1-fluoro-3-iodobenzene?

1 - fluoro - 3 - iodobenzene is an organic compound. Its physical properties are as follows:
Under normal temperature and pressure, this compound is a colorless to light yellow liquid with a clear quality and a special odor. The odor is unique and discernible.
Its boiling point is about 190 - 192 ° C. The value of the boiling point indicates that it changes from liquid to gaseous state at a specific temperature. When the external temperature reaches this boiling point, the molecules are able to get rid of the attractive force between each other and become gaseous and escape.
The melting point is about -27 ° C. The melting point shows the critical temperature for its transformation from solid to liquid state. Below the melting point, the molecules are arranged in a solid state; above the melting point, the molecular motion intensifies and turns into a liquid state.
The density is about 1.94 g/cm ³, this value reflects the mass of the substance per unit volume, which is slightly higher than that of common organic solvents, meaning that under the same volume, its mass is greater.
In terms of solubility, 1-fluoro-3-iodobenzene is insoluble in water. Because it is an organic compound, the molecular structure is quite different from that of water, and the polarity is different. According to the principle of "similarity and compatibility", the two are difficult to dissolve. However, it is soluble in common organic solvents, such as ether, dichloromethane, etc., because these organic solvents are similar in structure and polarity to 1-fluoro-3-iodobenzene, and the molecular forces between them can promote mutual solubility.
In addition, the vapor of 1-fluoro-3-iodobenzene is heavier than air, and in poor ventilation, the vapor is easy to accumulate close to the ground. This characteristic should be paid attention to when using and storing to prevent potential safety hazards.

What is the chemical synthesis method of 1-fluoro-3-iodobenzene?

In the synthesis of 1-fluoro-3-iodobenzene, benzene is often used as the starting material. Benzene is first nitrified to obtain nitrobenzene. In this step, concentrated nitric acid and concentrated sulfuric acid are co-heated, benzene and mixed acid undergo electrophilic substitution, and the nitro group enters the benzene ring. The reaction mechanism is that nitro positive ions attack the benzene ring π electron cloud to form a sigma complex, and then lose protons to obtain nitrobenzene.
Nitrobenzene is reduced to aniline. Iron and hydrochloric acid are commonly used as reducing agents, and nitro groups are reduced to amino groups. Aniline reacts with acetyl chloride or acetic anhydride to protect the amino group and obtain acetylaniline. Due to the high activity of amino groups, subsequent halogenation is
Acetylaniline under the action of iodine substitution reagents (such as iodine and potassium iodate in acidic conditions), iodine atoms are introduced at specific positions in the benzene ring to obtain p-iodine acetylaniline, which is an electrophilic substitution, and iodine positive ions are an electrophilic reagent. The product is then hydrolyzed to restore the amino group, and the iodine atom remains in the benzene ring. After
, the diazotization reaction is carried out. The aniline derivative reacts with sodium nitrite at low temperature under the condition of hydrochloric acid to form a diazosalt. The diazosalt reacts with fluoroboronic acid to obtain the diazosalt of fluoroboronic acid to precipitate. This salt is decomposed by heating, nitrogen escapes with nitrogen Each step of the reaction requires temperature control, reagent dosage and reaction time to improve yield and purity.

What are the precautions in storage and transportation of 1-fluoro-3-iodobenzene?

1 - fluoro - 3 - iodobenzene is an organic compound. When storing and transporting, many key matters need to be paid attention to.
The first thing to pay attention to is its chemical properties. This compound contains fluorine and iodine atoms, which are active in nature. When storing, it should be avoided from contact with strong oxidants, strong bases and other substances to prevent violent chemical reactions and cause danger. Strong oxidants or cause oxidation, strong bases interact with them or cause decomposition, which may produce harmful substances, and even lead to explosions, fires and other accidents.
Temperature and humidity are also key factors. Store in a cool, dry place. High temperature or cause its volatilization to accelerate, not only cause product loss, but also volatile gases may be toxic and irritating, endangering the environment and human health. High humidity environment may cause compounds to be damp, affecting purity and stability, and then interfering with subsequent use.
The choice of storage containers should not be underestimated. Corrosion-resistant glass or specific plastic containers should be used. Because fluorine and iodine elements are corrosive to a certain extent, ordinary metal containers are prone to corrosion, causing damage to the container and compound leakage, causing safety problems.
When transporting, it is necessary to ensure that the packaging is firm. Choose suitable packaging materials to prevent damage to the container due to vibration and collision. At the same time, the transportation vehicle should be equipped with necessary emergency treatment equipment. If there is a leak, it can be dealt with in time.
In addition, clear warning signs should be installed at transportation and storage sites to remind personnel of its potential danger. Operators need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods, so as to ensure the safety of 1-fluoro-3-iodobenzene during storage and transportation.

1-fluoro-3-iodobenzene impact on the environment and human health

1-Fluorine-3-iodobenzene is also an organic compound. The impact on the environment and human health can be particularly investigated.
First talk about its impact on the environment. If this compound is released in nature, or retained in soil and water bodies. Because of its certain chemical stability, it degrades slowly, or causes long-term accumulation. In aquatic ecology, or is harmful to aquatic organisms. The atomic properties of fluorine and iodine, or cause them to chemically react with substances in water, change the chemical properties of water bodies, disturb the living environment of aquatic organisms, such as hindering their respiration, feeding and reproduction. In soil ecology, or affect the activity and community structure of soil microorganisms, causing disturbance to soil fertility and ecological functions, and then affecting plant growth.
As for the effect on human health. This compound can enter the human body through inhalation, skin contact or ingestion. It contains fluoride, iodine atoms or interacts with human biomolecules. Excessive fluoride may affect the development of bones and teeth, causing bone fluorosis, dental fluorosis and other diseases. Although iodine is an essential element of the human body, organic iodides may have different physiological effects, or interfere with the human endocrine system, especially thyroid function. The thyroid gland relies on iodine to synthesize thyroid hormones. Abnormal iodide or disorderly hormone synthesis and regulation can cause thyroid diseases. And this compound may have potential carcinogenicity. Although relevant research may not be complete, organic halide has a carcinogenic risk, so it cannot be prevented.
In conclusion, 1-fluoro-3-iodobenzene poses a potential threat to the environment and human health, and caution must be taken when manufacturing, using, and disposing of it to minimize its negative effects.