1-Fluoro-4-Iodobenzene

Fengxi Chemical

Specifications

HS Code	805803
Chemical Formula	C6H4F I
Appearance	Colorless to light yellow liquid
Boiling Point	187 - 188 °C
Melting Point	14 - 16 °C
Density	1.947 g/mL at 25 °C
Solubility In Water	Insoluble
Flash Point	74.4 °C
Refractive Index	1.6115
Purity	Typically high purity, e.g., 98%+

As an accredited 1-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - fluoro - 4 - iodobenzene packaged in a sealed glass bottle.
Storage	1 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
Shipping	1 - fluoro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed due to its chemical nature. Shipment is carefully regulated to ensure compliance with safety and transportation regulations.

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General Information

Historical Development

1 - Fluoro - 4 - Iodobenzene is also an organic compound. Tracing back to its origin, the study of chemical sages in the past began to reveal this substance. At the beginning, the exploration was difficult, and everyone sought its preparation method.
Early attempts, relying on traditional techniques, did not achieve good results. However, scholars are determined, and they have tried again and again. After the rise of organic chemistry, new techniques emerged, and the preparation method became better and better.
With the passage of time, research has deepened, and its characteristics and uses have gradually become apparent. In various fields of chemical industry, or as a raw material, or as a medium, the effect is increasingly apparent. From this perspective, since the discovery of 1-Fluoro-4-Iodobenzene, through various explorations and improvements, it has made steady progress on the road of chemistry, and its prospects have also become broader.

Product Overview

1 - Fluoro - 4 - Iodobenzene is an important compound in organic synthesis. Its color is colorless to light yellow liquid, with specific physical and chemical properties. This substance is used in many fields, in the field of medicinal chemistry, or can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities; in the field of materials science, it may also participate in the preparation of materials with special properties.
There are many methods for synthesizing 1 - Fluoro - 4 - Iodobenzene, and the common method is achieved through specific fluorination and iodization reaction steps. The precise control of the reaction conditions is crucial, and factors such as temperature, reactant ratio, and catalyst selection have a profound impact on the purity and yield of the product.
When we developed this product, we focused on optimizing the synthesis process, and were committed to improving its purity and stability to meet the needs of different application scenarios. After repeated experiments and improvements, relatively satisfactory results have been obtained, and the performance of this product has been significantly improved, providing strong support for the development of related fields.

Physical & Chemical Properties

1 - Fluoro - 4 - Iodobenzene is also an organic compound. Its physical and chemical properties are worthy of in-depth study. Looking at its physical properties, it is liquid at room temperature, with a clear and transparent color and a special smell. Its boiling point is suitable, which is easy to separate and purify. When it comes to chemical properties, the presence of fluorine and iodine atoms makes its reactivity unique. Fluorine atoms have strong electronegativity and iodine atoms have a large radius. The synergy between the two makes the compound exhibit special behavior in reactions such as nucleophilic substitution. It can react with many nucleophilic reagents to generate new organic compounds, which are widely used in the field of organic synthesis. Its stability also has characteristics, and it can remain stable under certain conditions. In case of strong acids, alkalis, or high temperatures, it can also trigger chemical reactions, revealing its rich and variable chemical properties.

Technical Specifications & Labeling

1 - Fluoro - 4 - Iodobenzene is an important chemical substance. Its process specifications are related to the preparation process, the purity of the raw materials, etc. During preparation, the reaction conditions such as temperature, pressure and reaction time need to be precisely controlled. The purity of the raw materials must be up to standard, and impurities will affect the quality of the product.
Product labels should clearly indicate the composition, content and hazard warnings. Content determination should be accurate to ensure compliance with established specifications. 1 - Fluoro - 4 - Iodobenzene also needs to follow specific requirements during storage and transportation to ensure its stability and safety. In this way, the reliability and effectiveness of this product in various fields of application can be guaranteed.

Preparation Method

1 - Fluoro - 4 - Iodobenzene is an important compound in organic synthesis. The preparation method and the selection of raw materials are very important. Fluorobenzene and iodine are often used as starting materials, and the two are active in nature, which is conducive to subsequent reactions.
Preparation process, the first step is halogenation reaction. In a specific reactor, fluorobenzene and iodine under the action of catalysts, such as iron or iron salt catalysts, under suitable temperature and pressure conditions, a substitution reaction occurs. The mechanism of this reaction is that the catalyst activates the iodine molecule, making it easier to attack the fluorobenzene ring and form an intermediate, thereby generating 1 - Fluoro - 4 - Iodobenzene.
The reaction steps are rigorous, and the temperature, pressure and ratio of the reactants need to be closely monitored during the reaction process. After the reaction, the product is separated and purified, such as extraction, distillation and other means, to obtain high purity 1-Fluoro-4-Iodobenzene.
The core of the catalytic mechanism is the formation of active intermediates between the catalyst and the reactants, which reduces the activation energy of the reaction, accelerates the reaction process, and improves the production efficiency of the product. In this way, 1-Fluoro-4-Iodobenzene can be efficiently prepared.

Chemical Reactions & Modifications

1 - Fluoro - 4 - Iodobenzene is an important compound in organic synthesis. In chemical research, it is crucial to explore its chemical reaction and modification.
Looking at its chemical reaction, under specific catalyst and reaction conditions, nucleophilic substitution can occur. If it encounters a nucleophilic reagent, halogen atoms can be replaced to construct a new chemical structure. The precise control of this reaction condition has a great impact on the purity and yield of the product.
When talking about modification, the physical and chemical properties of the compound can be changed by introducing different functional groups. For example, adding groups with specific functions can make the compound exhibit unique properties in the field of materials science, or enhance its solubility or improve its stability. The chemical reaction and modification of 1-Fluoro-4-Iodobenzene are expected to expand its application in medicine, materials and other fields, and contribute to the development of chemistry.

Synonyms & Product Names

1 - Fluoro - 4 - Iodobenzene is an important product of chemistry. Its synonyms and trade names are of significance in both academia and industry.
The synonyms of this compound may vary depending on the research perspective and naming habits. Different research teams initially involved this substance, or gave it another name according to its structural characteristics and reaction characteristics. The origin of the trade name is often related to commercial promotion and market positioning.
To make this 1 - Fluoro - 4 - Iodobenzene, many methods have emerged. However, the purity and yield of the products obtained by each method are different, and the association between its synonyms and the trade name is also affected. Produced by methods with high purity and good yield, the trade name may be more recognizable and influential.
In the chemical industry, 1-Fluoro-4-Iodobenzene is widely used. Or it is a key raw material for organic synthesis, participating in the construction of complex compounds; or it has emerged in material science and helped the research and development of new materials. Its synonyms and trade names have also spread with the expansion of application fields and have gradually become familiar in the industry.
In summary, the synonyms and trade names of 1-Fluoro-4-Iodobenzene carry the track of scientific research and commercial development, and are a witness to chemical research and industrial progress.

Safety & Operational Standards

1 - Fluoro - 4 - Iodobenzene is an important substance in chemical research. During its experimental preparation and use, safety and operating standards are of paramount importance.
To ensure safety, the first thing is to be familiar with its physical and chemical properties. 1 - Fluoro - 4 - Iodobenzene has a specific melting point, boiling point and solubility. Only by accurately understanding it can it be properly handled during operation. In case of heating operation, the temperature should be controlled according to its boiling point to prevent overheating from causing the substance to evaporate or cause dangerous reactions.
Furthermore, the operating environment cannot be ignored. The experiment should be carried out in a well-ventilated place. Because 1-Fluoro-4-Iodobenzene or volatile harmful gases are emitted, good ventilation can disperse in time to avoid health hazards inhaled by the experimenter. And the operating table must be kept clean and kept away from fire sources and flammable materials. Because it may be flammable, a fire will be caused by a little carelessness.
In terms of operating specifications, when taking 1-Fluoro-4-Iodobenzene, clean and accurate utensils should be used. When measuring, measure accurately according to the experimental requirements to avoid waste and excessive danger. During the transfer process, the action should be gentle to prevent spillage. If it is accidentally spilled, take corresponding cleaning measures immediately, and choose the appropriate cleaning reagent according to its nature to avoid adverse reactions with other substances.
After the experiment is completed, the remaining 1 - Fluoro - 4 - Iodobenzene needs to be properly stored. According to its chemical stability, choose a suitable container, seal it and store it in a cool and dry place to prevent deterioration from affecting subsequent use, and avoid pollution to the environment.
In short, in the research and use of 1 - Fluoro - 4 - Iodobenzene, strict adherence to safety and operating standards can ensure the smooth progress of the experiment, protect the safety of the experimenter, and maintain the good order of the experimental environment.

Application Area

1 - Fluoro - 4 - Iodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize various special drugs, or has antibacterial and anti-cancer properties, and contributes to the treatment of diseases. In material science, it also has its place. With its unique chemical properties, it can participate in the preparation of special functional materials, or have excellent photoelectric properties, and can be used to manufacture advanced electronic components, such as high-efficiency Light Emitting Diode. In the field of fine chemicals, it can be used as a modifier to give products special physical and chemical properties and improve product quality and value. Due to its unique structure, this compound has shown potential application value in many fields, providing many possibilities for related research and industrial development.

Research & Development

In recent years, I have been in the field of organic synthesis, focusing on the research of 1-Fluoro-4-Iodobenzene. It has great potential in the fields of medicine and materials, and its wide application should not be underestimated.
At the beginning, the preparation method was inconvenient, the yield was not up to expectations, and the impurities were difficult to remove. My colleagues and I studied day and night, consulted countless classics, tried new agents and new methods, and hoped to make progress.
After many attempts to improve the reaction conditions, control temperature, adjust pressure, and select suitable catalysts, the method was finally optimized. The yield gradually increased, and the purity was also in good condition.
However, the research path was not easy. The control of cost and the sound of the environment are all problems. We also seek good strategies, find cheap materials, and seek green methods, hoping to be feasible in industrial mass production and meet the needs of environmental protection.
Today, although it has been achieved, there is still a long way to go. Continuing to refine the process and expand its application is our unswerving desire, hoping to contribute to the academic and industrial circles and promote the prosperity of this field.

Toxicity Research

The toxicity of 1 - Fluoro - 4 - Iodobenzene is a matter to be investigated. Looking at this substance, its characteristics are unique. Fluorine and iodine co-attach to the benzene ring, depending on the structure, or have different toxicity.
In the past, most of the chemicals studied were toxic due to the special structure. This 1 - Fluoro - 4 - Iodobenzene, the activity of fluorine, the characteristics of iodine, both on the benzene ring, or affect the reactions in vivo.
Or enter the organism and interact with the components of the cell. Damage the membrane of the cell, disrupt the order of its metabolism. Or interfere with the activity of enzymes, causing biochemical reactions to be perverse. Although its toxicity has not been tested in detail, it is reasonable to infer that the investigation of toxicity is related to the health of living beings and cannot be ignored. It is necessary to conduct detailed tests to analyze its impact on different levels of organisms and clarify its toxicity.

Future Prospects

I have studied this product in 1 - Fluoro - 4 - Iodobenzene, and I have a deep understanding of its properties and uses. Although I have achieved a small success in the study of this product today, I still look forward to the future with great ambitions.
In the future, I hope to be able to expand its use and make it suitable for more situations. Or in the way of medicine, to add strength to the treatment of diseases and diseases; or in the field of materials, to help create novel materials. And the research method has been refined, so that the quantity and quality of the product can be increased, the cost of it can be reduced, and it is easy to use.
Although there may be thorns in the road ahead, I must have a strong heart to expand the smooth road for 1-Fluoro-4-Iodobenzene in the future, so as to live up to its unfinished business, live up to its expectations, and be used by the world.

Where to Buy 1-Fluoro-4-Iodobenzene in China?

As a trusted 1-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-fluoro-4-iodobenzene?

1-Fluoro-4-iodobenzene is an organic compound with unique chemical properties. It contains fluorine and iodine dihalogen atoms, which have a significant impact on the activity and properties of compounds.
Let's talk about the nucleophilic substitution reaction first. Although fluorine atoms are highly electronegative and stable to carbon-fluorine bonds, they can be replaced under specific conditions, such as strong nucleophilic reagents, high temperatures and catalysts. Due to the conjugation system of benzene rings, nucleophilic reagents need to overcome a certain energy barrier when attacking. The carbon-iodine bond energy of iodine atoms is relatively small, and nucleophilic substitution is more likely to occur. Nucleophilic reagents such as alkoxides, amines, etc., are easy to attack and connect with iodine carb
Let's talk about electrophilic substitution reaction. The benzene ring has electron-rich properties and is easily attacked by electrophilic reagents. In 1-fluoro-4-iodobenzene, although fluorine and iodine are ortho-para-localization groups, the localization effects are different. Fluorine has large electronegativity and strong electron-withdrawing induction effect, which reduces the electron cloud density of the benzene ring and slightly reduces the electrophilic substitution activity, but still guides the electrophilic reagents to the ortho and para-sites; the iodine electron cloud is dispersed, and the electron-giving conjugation effect and electron-withdrawing induction effect coexist. The comprehensive results also make the electrophilic reagents mainly attack the ortho and para-sites. However, due to steric
In addition, 1-fluoro-4-iodobenzene can participate in metal-catalyzed coupling reactions. For example, under palladium catalysis, it is coupled with reagents containing boron and tin to form carbon-carbon bonds or carbon-hetero bonds, which are used in organic synthesis to construct complex structural compounds. It is widely used in the fields of medicinal chemistry and materials science. Its chemical properties are determined by the coordination of benzene ring and fluorine and iodine atoms. Through rational selection of reaction conditions and reagents, various chemical transformations can be realized, providing rich strategies for organic synthesis.

What are the common synthetic methods of 1-fluoro-4-iodobenzene?

1-Fluoro-4-iodobenzene is an important intermediate in organic synthesis. Its common synthesis methods have the following numbers.
One is obtained by halogen exchange method. Choose an appropriate fluorine substitution reagent, such as potassium fluoride, etc., and co-prepare it with 4-iodohalobenzene under specific reaction conditions. Among them, a good solvent, such as dimethyl sulfoxide (DMSO), is needed to promote the reaction. During the reaction, heating and temperature control make fluoride ions exchange with halogen atoms, and then 1-fluoro-4-iodobenzene is obtained. This method is relatively simple to operate, but the control of the reaction conditions is quite strict, and the selectivity of halogen exchange needs to be carefully examined.
Second, it is prepared by the diazonium salt method. First, 4-amino-1-fluorobenzene reacts with nitrous acid at low temperature to form diazonium salts. Then, with iodine sources such as potassium iodide, the diazonium group is replaced by iodine atoms, and the final product is obtained. The control of low temperature in this process is crucial to prevent the decomposition of diazonium salts. And the purity of the reagents used in the reaction, the pH of the reaction solution, etc., have a great influence on the yield and purity of the product.
Third, the transition metal catalysis method is used. Using transition metals such as palladium and copper as catalysts, the aryl halide is reacted with fluorine sources and iodine in the presence of suitable ligands. This method can improve the efficiency and selectivity of the reaction by leveraging the catalytic activity of transition metals. However, the choice and dosage of catalysts, the structure of ligands, etc., need to be carefully considered to achieve the best reaction effect. And such methods often have high requirements for reaction equipment and operation technology.

In what areas is 1-fluoro-4-iodobenzene applied?

1-Fluoro-4-iodobenzene is an important raw material for organic synthesis and is widely used in many fields.
It plays a key role in the field of medicinal chemistry. Due to the unique properties of fluorine and iodine atoms, it can significantly affect the biological activity, lipophilicity and metabolic stability of compounds. Using this as the starting material, a series of reactions can be used to construct drug molecules containing fluoride and iodine with diverse structures. For example, when developing new antibacterial drugs, the introduction of this compound structure fragment can enhance the permeability of the drug to the bacterial cell membrane and improve the antibacterial efficacy. Furthermore, in the development of anti-tumor drugs, its unique electronic effects and spatial effects are used to design and synthesize drugs that can precisely act on tumor cell targets to improve the therapeutic effect. < Br >
In the field of materials science, 1-fluoro-4-iodobenzene is also indispensable. In the preparation of organic optoelectronic materials, it can be used as a building unit to participate in the synthesis of conjugated polymers or small molecules with specific optoelectronic properties. Due to the existence of fluorine and iodine atoms, it can adjust the electron cloud distribution of the material, and then regulate the important parameters such as the luminous wavelength and fluorescence quantum efficiency of the material. In the preparation of organic Light Emitting Diode (OLED) materials, the application of this compound can optimize the luminous properties and stability of the device and improve the display effect.
In the field of pesticide chemistry, this compound is widely used. By introducing it into the molecular structure of pesticides, the bioactivity of pesticides can be improved and the environmental compatibility can be improved. The presence of fluorine atoms can enhance the affinity of pesticides to the target enzymes of pests, while iodine atoms help to regulate the fat solubility of molecules, making it easier for pesticides to penetrate the waxy layer on the surface of pests, improve insecticidal effect, and reduce the negative impact on the environment.

What are the physical properties of 1-fluoro-4-iodobenzene?

1-Fluoro-4-iodobenzene, Chinese name 1-fluoro-4-iodobenzene, is an organic compound with unique physical properties.
Its appearance is often colorless to light yellow liquid, and its properties are stable at room temperature and pressure. Looking at its color, it is colorless to light yellow, just like the light and shadow of the morning light, with a little softness in the clarity. This color state is easy to observe and identify in many chemical operations.
1-fluoro-4-iodobenzene has a specific odor. Although it is difficult to describe it accurately, many of them have the unique odor of aromatic hydrocarbons, which is slightly irritating and leaves a unique mark on the smell. When operating, you need to pay attention to the odor prompt to ensure safety.
In terms of boiling point, it is about 184-186 ° C. If the boiling point is the "energy threshold" of the substance, at this temperature, the molecule obtains enough energy to break free from the liquid phase and leap into the gas phase. This boiling point indicates that it can realize gas-liquid conversion at a relatively moderate temperature, providing a basis for separation and purification operations such as distillation. < Br >
The melting point is about -27 ° C. The melting point is like a "solidification switch" of substances. Below this temperature, the molecular movement slows down, and the arrangement is orderly, gradually turning from liquid to solid. The lower melting point means that it is liquid at room temperature, which is easy to store and transport.
The density is about 1.94 g/cm ³, which is heavier than water. If it is mixed with water, such as oil entering water, it will naturally sink to the bottom. This density characteristic is of great significance for operations such as liquid-liquid separation.
In terms of solubility, it is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, benzene, etc. This characteristic is derived from the principle of similarity and dissolution. Its molecular structure is similar to that of organic solvents, and it is similar to each other like a wanderer returning home, while it is very different from the molecular structure of water and is difficult to blend. This allows it to skillfully use organic solvents in organic synthesis to realize reaction, dissolution, extraction and other processes.

What are 1-fluoro-4-iodobenzene storage conditions?

1-Fluoro-4-iodobenzene, Chinese name 1-fluoro-4-iodobenzene, is an organic compound. Its storage conditions are crucial, which are related to the stability and safety of the substance. The details are as follows:
- ** Store in a cool and ventilated warehouse **: This substance is prone to chemical reactions when heated, increases the reactivity, and increases the risk of decomposition, combustion or explosion. A cool environment can reduce its reactivity and maintain chemical stability. Well ventilated can disperse volatile harmful gases in time to avoid their accumulation to dangerous concentrations, and prevent explosion and personal poisoning.
- ** Keep away from fire and heat sources **: 1-fluoro-4-iodobenzene is flammable, and can cause combustion and explosion in case of open flames and high heat. Fire and heat sources provide energy and cause combustion or explosion, so smoking and the use of open flames are strictly prohibited in storage places. Explosion-proof electrical equipment and lighting fixtures are selected.
- ** Store separately from oxidants and edible chemicals **: 1-fluoro-4-iodobenzene is prone to oxidation reactions in contact with oxidants, causing combustion and explosion; if it is mixed with edible chemicals, if the packaging is damaged, harmful substances will contaminate the food and threaten human health. Therefore, be sure to store it separately and set clear signs to avoid mixing. < Br > - ** Keep the container sealed **: 1-fluoro-4-iodobenzene is volatile, and the sealed container can prevent volatilization, reduce air contact, and avoid environmental pollution caused by deterioration and harmful gas emissions. At the same time, check the container regularly to see if there is any leakage and deal with the problem in time.
- ** Storage area should be prepared with suitable materials to contain leaks **: Although preventive measures are taken, it is still difficult to avoid leakage. Storage area should be prepared with containment materials such as sand and vermiculite, and collect them in time when leaking to avoid diffusion and environmental pollution. At the same time, prepare suitable protective equipment and emergency treatment equipment to ensure personnel safety.