1-Iodo-2, what is the chemical structure of 3-dibromo-5-methylbenzene?
1-Iodo-2,3-dibromo-5-methylbenzene is also an organic compound. Its molecular structure contains a benzene ring, which is a common ring structure in organic chemistry and has special stability. On the benzene ring, there are different substituents connected.
At position 1 of the benzene ring, there is an iodine atom (iodo) connected. The iodine atom has a large relative atomic mass and has a certain electronegativity, which affects the physical and chemical properties of the molecule. At position 2 and position 3, there is a bromo atom (bromo) each. The bromine atom also has a certain electronegativity, which can change the electron cloud density distribution of the benzene ring and affect the molecular reactivity. At position 5, methyl is attached. Methyl is the power supply group, which increases the electron cloud density of the benzene ring, interacts with the electron-withdrawing effects of iodine and bromine, and jointly determines the overall chemical activity of the molecule.
According to the general structure table, the benzene ring can be drawn first, shown by the hexagon, the hexagon vertex represents the carbon atom, and the carbon atoms are connected by alternating single and double bonds (in fact, the benzene ring is a large π bond structure). At the vertex of position 1, add iodine atoms; at the vertices of position 2 and position 3, add bromine atoms; at the vertex of position 5, add methyl (represented by -CH). In this way, the chemical structure of 1-iodo-2,3-dibromo-5-methylbenzene can be obtained. The uniqueness of this structure makes it useful in organic synthesis, medicinal chemistry and other fields or has specific uses and reaction characteristics.
What are the physical properties of 3-dibromo-5-methylbenzene?
1-Iodo-2,3-dibromo-5-methylbenzene is an organic compound with many physical properties. It is a solid at room temperature and pressure. Due to the relatively strong force between molecules, the molecules are closely arranged and appear solid.
Looking at its appearance, it is usually white or white-like crystalline powder, which is related to the molecular structure and the way of crystal accumulation.
When it comes to melting point, the melting point is relatively high due to the presence of halogen atoms such as iodine and bromine and methyl in the molecule, which enhances the intermolecular force. The specific melting point value will fluctuate due to factors such as purity.
Its boiling point is also higher, which is due to the large intermolecular force. To make the substance change from liquid to gaseous state, more energy needs to be input to overcome the attractive force between molecules.
This compound is insoluble in water, because it is a non-polar or weakly polar molecule, while water is a polar molecule. According to the principle of "similarity and miscibility", the polarity of the two is very different, so it is difficult to dissolve. However, it is soluble in some organic solvents, such as benzene, toluene, dichloromethane, etc. Because these organic solvents are similar to the polarity of the compound, intermolecular interactions can be formed to promote dissolution.
In terms of density, the density of the molecule is higher than that of common organic solvents and water due to the presence of relatively large atoms such as iodine and bromine in the molecule. This density characteristic has an important impact on the separation and purification of the compound and the distribution of substances in the related reaction system.
What is the main use of 3-dibromo-5-methylbenzene?
1-Iodo-2,3-dibromo-5-methylbenzene is an organic compound with a wide range of main uses.
In the field of organic synthesis, this compound has a significant role. Because of its benzene ring connected with various functional groups such as iodine, bromine and methyl, it can be used as a key intermediate. Iodine atoms are highly active and can be replaced by other nucleophiles in many nucleophilic substitution reactions, thereby forming new carbon-heteroatom bonds. For example, by reacting with nucleophiles containing nitrogen, oxygen, sulfur, etc., a series of organic compounds with special structures and properties can be synthesized, providing important basic raw materials for medicinal chemistry, materials science and other fields.
Bromine atoms are also active and can participate in many reactions. Under metal catalysis, cross-coupling reactions can be carried out, such as Suzuki coupling, Stille coupling reaction, etc., which can effectively grow carbon chains or build complex cyclic structures, greatly enriching the variety of organic compounds, and facilitating the creation of new materials and bioactive compounds.
Furthermore, the presence of 5-methyl has an impact on the electron cloud distribution and spatial structure of molecules, which can change the physical and chemical properties of compounds. In drug development, this structural modification may affect the ability of drugs to bind to targets, improving the activity, selectivity and pharmacokinetic properties of drugs.
In the field of materials science, through specific reactions and modifications of this compound, materials with unique optical and electrical properties can be prepared, such as organic optoelectronic materials, which contribute to the development of related fields.
In short, 1-iodo-2,3-dibromo-5-methylbenzene has shown important uses in many fields such as organic synthesis, drug development, and materials science, promoting continuous progress and innovation in various fields.
What are the synthesis methods of 1-iodo-2, 3-dibromo-5-methylbenzene?
The synthesis of 1-iodine-2,3-dibromo-5-methylbenzene is an important subject in the field of organic synthesis. To obtain this compound, there are many ways to do it.
First, 5-methylbenzene can be used as the starting material. Using aromatic halogenation reaction, liquid bromine is used as the bromine source, and in the presence of appropriate catalysts such as iron powder or iron tribromide, bromine atoms are introduced into the benzene ring at specific positions to generate 2,3-dibromo-5-methylbenzene. Then, the obtained product is reacted with an iodide reagent. Common iodine substitutes such as potassium iodide and hydrogen peroxide mixed system, in a suitable solvent such as dichloromethane, react at a mild temperature to introduce iodine atoms into the benzene ring to obtain 1-iodine-2,3-dibromo-5-methylbenzene.
Second, you can also start from 1-methyl-4-iodobenzene. It is first brominated with a brominating reagent. If N-bromosuccinimide (NBS) is used as a brominating agent, in the presence of an initiator such as benzoyl peroxide, it is heated and refluxed in an inert solvent such as carbon tetrachloride to selectively introduce bromine atoms at the ortho-position of the benzene ring to achieve the synthesis of 1-iodine-2,3-dibromo-5-methylbenzene.
Furthermore, 1-iodine-2-bromobenzene can be used as a raw material. Methyl is first introduced into the benzene ring. This step can be achieved by means of Fu-gram alkylation reaction, using chloromethane as alkylation reagent and anhydrous aluminum trichloride as catalyst, under low temperature conditions, reacting in a suitable solvent such as carbon disulfide to generate 1-iodine-2-bromo-5-methylbenzene. Subsequently, it is re-brominated, liquid bromine and catalyst are selected, and bromine atoms are further introduced at specific positions in the benzene ring to obtain the final target product 1-iodine-2,3-dibromo-5-methylbenzene.
Each of these synthetic methods has its own advantages and disadvantages. Experimenters need to weigh and choose the appropriate method according to the actual situation, such as the availability of raw materials, the ease of control of reaction conditions, and the high or low yield.
1-Iodo-2, 3-dibromo-5-methylbenzene What are the precautions during storage and transportation?
1-Iodo-2,3-dibromo-5-methylbenzene is an organic compound. During storage and transportation, the following things should be noted:
First, the storage place should be dry and cool. This compound may cause reactions such as hydrolysis in water or high humidity, causing it to deteriorate. And if the temperature is too high, it may also promote decomposition or other chemical reactions, so it should be placed in a lower temperature.
Second, it should avoid contact with oxidants. Because its structure contains halogen atoms such as iodine and bromine, it has certain activity, and it is easy to cause oxidation reactions when exposed to oxidants, or the danger of combustion or even explosion.
Third, the storage container must be well sealed. The compound may be volatile to a certain extent, and poor sealing will cause it to escape, not only causing material loss, but also volatile gaseous substances may be toxic, endangering the environment and human health.
Fourth, the transportation process should prevent vibration and collision. Violent vibration or collision or damage to the container, causing the compound to leak. And this compound is active, contact with air, moisture, etc. after leakage, or cause dangerous reactions.
Fifth, transportation and storage should strictly follow relevant regulations and standards. Because it is a hazardous chemical, from packaging labels to operating specifications, there are clear regulations, and only by acting in accordance with regulations can safety be ensured and accidents can be avoided.