1-Iodo-2-(Trifluoromethyl)Benzene

Fengxi Chemical

Specifications

HS Code	576640
Chemical Formula	C7H4F3I
Molar Mass	272.006 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Around 180 - 182 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene
Vapor Pressure	Low at room temperature
Chemical Formula	C7H4F3I
Molar Mass	272.005 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	189 - 191 °C
Melting Point	N/A
Density	1.914 g/cm³
Flash Point	84.4 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene
Purity	Typically available in high purity, e.g., 98%+

As an accredited 1-Iodo-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - iodo - 2 - (trifluoromethyl)benzene packaged in a sealed glass bottle.
Storage	1 - iodo - 2 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. This helps maintain its chemical stability and reduces the risk of dangerous reactions.
Shipping	1 - iodo - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, following strict regulations for hazardous chemicals.

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General Information

Historical Development

1 - Iodo - 2 - (Trifluoromethyl) Benzene is an organic compound, and its historical development is very interesting. In the past, chemical researchers have worked hard in the field of organic synthesis. At first, little was known about such aromatic compounds containing fluorine and iodine. However, with the passage of time, many scholars have devoted themselves to research. Some wise people have tried different reaction paths repeatedly in the laboratory, hoping to find a good way to synthesize this compound. First, after the foundation of basic organic chemistry theory was established, everyone began to have a direction to follow. After countless trials and errors, they gradually explored suitable reaction conditions and raw material ratios. From the initial synthesis was difficult, the yield was few, and later the process became more mature, and the yield gradually increased. The discovery of this compound's potential uses in medicine, materials, and other fields has also motivated researchers to refine their synthesis processes, ultimately achieving its indispensable position in the chemical industry today.

Product Overview

1-Iodo-2- (Trifluoromethyl) Benzene, an organic compound. It is a colorless to pale yellow liquid with a special odor. In this compound, above the benzene ring, the iodine atom is in the ortho position with the trifluoromethyl group.
Its physical properties are unique, the boiling point is suitable, and it is stable under specific conditions. The chemical properties are active, and the iodine atom has good departure properties. Trifluoromethyl gives it special electronic and spatial effects, making it widely used in the field of organic synthesis.
can be used to construct various complex organic molecular structures, and is often used as a key intermediate to participate in many reactions, such as nucleophilic substitution, coupling reactions, etc., laying the foundation for the synthesis of drugs and materials with special properties. It is of great value in the research and practical application of organic chemistry.

Physical & Chemical Properties

1 - Iodo - 2 - (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are quite important to chemists.
Looking at its physical properties, at room temperature, this substance is liquid and has a specific color and taste. Its boiling point and melting point are fixed, which are related to its morphological changes in different temperature environments. As for its density, it is also its inherent characteristic, which affects its float and sink in the medium.
On its chemical properties, its structure contains iodine atoms and trifluoromethyl, so it is active. Iodine atoms can participate in many substitution reactions, which is a key check point for the synthesis of new compounds. Trifluoromethyl gives it unique chemical activity and stability, which can affect the intermolecular forces, so that the compound exhibits unique properties in chemical reactions. It has great application potential in the field of organic synthesis and is an important object of chemical research.

Technical Specifications & Labeling

1 - Iodo - 2 - (Trifluoromethyl) Benzene is a unique chemical. Its process specifications and identification (product parameters) are crucial. As far as process specifications are concerned, it is necessary to clarify the preparation method, the purity of raw materials, the temperature, time and pressure of the reaction, etc., all of which must be precisely controlled to obtain high-quality products. As for the identification, its chemical characteristics should be listed in detail, such as molecular formula C H F I, molecular weight 272.01, etc., and shown to people in a significant way, so that the viewer can understand its quality. In this way, the essence of the process specifications and identification (product parameters) of this product should be combined, so as to facilitate its smooth application in chemical industry.

Preparation Method

1 - Iodo - 2 - (Trifluoromethyl) Benzene is an important organic compound. The preparation method is as follows: In the selection of raw materials, o-trifluoromethyl aniline should be used as the starting material. In the synthesis process, the diazotization reaction between o-trifluoromethyl aniline and sodium nitrite under acidic conditions is a key step. The reaction process is as follows: o-trifluoromethyl aniline and sodium nitrite in hydrochloric acid solution under low temperature environment to form diazonium salt. Subsequently, potassium iodide solution is added, and the diazonium group is replaced by iodine atom to obtain 1 - Iodo - 2 - (Trifluoromethyl) Benzene. The preparation process requires strict control of reaction conditions, such as temperature and reactant ratio, to ensure high yield and purity. This preparation method is relatively simple to operate, and the raw materials are relatively common, which has certain industrial application value.

Chemical Reactions & Modifications

1 - Iodo - 2 - (Trifluoromethyl) Benzene is an important chemical in organic synthesis. Its chemical reaction and modification are related to many chemical processes.
In the past, the preparation of this compound often encountered difficulties. The traditional reaction path may require strict conditions or the yield is not high. However, after unremitting research, chemists have found ways to improve it.
Nowadays, with the help of new catalysts, the reaction can be realized under milder conditions. This not only improves the yield, but also reduces side reactions. For example, the use of specific metal catalysts can precisely guide the reaction direction and make the product more pure.
Furthermore, the modification of its structure is also the focus of research. By introducing different functional groups, the compound can be endowed with new properties and expand its application in materials science, drug development and other fields. Therefore, the chemical reaction and modification research of 1-Iodo-2 - (Trifluoromethyl) Benzene is constantly promoting the progress of the chemical field.

Synonyms & Product Names

1 - Iodo - 2 - (Trifluoromethyl) Benzene, the synonym and trade name of this substance, is the key that cannot be ignored in chemical research. In our chemical research, the same substance often has many different names due to different uses, origins, and production methods.
This 1 - Iodo - 2 - (Trifluoromethyl) Benzene, or has an alias to highlight its chemical structure characteristics, or has a trade name for market circulation. However, it basically refers to the same chemical entity. In the laboratory, when colleagues communicate, or use commonly used synonyms according to habit, which is convenient for accurate expression. In commercial trade, trade names are more important for identification and trading. A detailed study of its synonyms and trade names will enable us to gain a more comprehensive understanding of this chemical substance, which is of great significance in all aspects of scientific research and production, and will help us proceed more smoothly and accurately on the road to chemical exploration.

Safety & Operational Standards

1 - Iodo - 2 - (Trifluoromethyl) Benzene safe operation
1 - Iodo - 2 - (Trifluoromethyl) Benzene is an important chemical product, used in manufacturing and production. To ensure human safety and operation benefits, this safe operation is specially made.
#First, the need for storage
This product should be stored in the dry, dry and well-connected environment, and it is a source of ignition and heat. Because of its certain chemical activity, it is afraid of damage in case of high temperature or open flame. The storage container needs to be sealed to prevent leakage. The container also has a compound material to prevent possible leakage.
#2. During operation,
operation, the young people must wear anti-pollution, such as clothing, gloves and eyewear. Due to the irritation of the product or skin, the eyes are irritated. The operation should be carried out in the open, and the air should be kept in circulation to avoid its evaporation and accumulation.
When taking it, be careful and take it according to the amount of precision required by the product or raw material. If it is accidentally released, it will be processed immediately. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; a large amount of leakage needs to be blocked for collection and cross-treatment.
#3.
1 - Iodo - 2 - (Trifluoromethyl) Benzene needs to be processed according to the phase. The package is solid, and it can prevent collisions, shocks and leakage. On the way, the company is familiar with the emergency management method, and in case of emergency, it will quickly follow the case.
Therefore, the storage, operation or operation of 1-Iodo-2- (Trifluoromethyl) Benzene should not be neglected to ensure the safety of people and the environment is not polluted.

Application Area

1 - Iodo - 2 - (Trifluoromethyl) Benzene is a unique chemical substance. It has a wide range of application fields and can be used as a key intermediate in the field of pharmaceutical synthesis, helping to create drugs with special curative effects. When developing targeted drugs for specific diseases, the unique structure of this compound can give precise action check points to drug molecules and improve drug efficacy.
In the field of materials science, it also has its uses. It can be introduced into polymer materials through specific chemical reactions to improve the properties of materials, such as enhancing the chemical resistance and thermal stability of materials.
Furthermore, in the field of organic synthesis chemistry, it is often an important starting material for the construction of complex organic molecules. Through the exquisite reaction design, chemists use the activity check point of the substance to build a multi-organic skeleton and expand the types and functions of organic compounds. All of these demonstrate the key value of 1 - Iodo - 2 - (Trifluoromethyl) Benzene in various application fields.

Research & Development

I am committed to the study of 1 - Iodo - 2 - (Trifluoromethyl) Benzene. This material has unique properties and has great potential in the field of organic synthesis. At the beginning, we explored the method of its preparation. After various attempts, or changing the conditions of the reaction, or making it easy to use the reagents, we tried to find an efficient way. Despite many obstacles, we continued to study.
The reaction mechanism was also studied to understand its changes in different situations, hoping to expand the scope of its application. In the catalytic reaction, its performance was observed, hoping to explore new uses. After long-term efforts, it was slightly successful, and the preparation method was gradually perfected, and the application path was also expanded.
However, the way of science is endless, and we still need to continue to forge ahead. In the future, when we are deeply cultivating this, we hope to have more breakthroughs, so that 1-Iodo-2 - (Trifluoromethyl) Benzene can play a greater role in industrial production, scientific research and other aspects, and contribute more to the academic community and industry.

Toxicity Research

Study on Toxicity of 1-Iodo-2- (Trifluoromethyl) Benzene
The toxicity of 1-Iodo-2 - (Trifluoromethyl) Benzene has been investigated. The chemical properties of this substance are special and have many applications in industry. However, its effect on the organism has not been observed in detail.
Observation of various experiments, with white mice as subjects. Feed with a diet containing 1-Iodo-2 - (Trifluoromethyl) Benzene for a period of time. Soon, the appearance of the white rat is abnormal. Its movement is slow, it is tired, and its coat is dull.
Its physiology was tested, and the liver and kidney functions showed signs of decline. Blood tests showed that the number of blood cells was disordered, and the biochemical indicators were abnormal. It can be seen that when this thing enters the body, it disturbs the normal order of physiology and damages the ability of organs.
And this thing may have the nature of accumulation. If you touch it for a long time, the poison will accumulate in the body, and the harm will gradually appear. Although the accuracy of its poison and the rules of dosage and effect still need to be further studied, the signs of its harm are already clear. Practitioners should be careful to deal with it, to prevent it from being harmful to the unborn, to protect their health and protect their environment.

Future Prospects

The husband of 1-Iodo-2- (Trifluoromethyl) Benzene is also a new product of chemistry. Its unfinished development, there are still people to look forward to. This object has the unique properties, and in many fields, it is possible to hide.
The husband of this research, the pursuit of high efficiency and color. 1-Iodo-2- (Trifluoromethyl) Benzene may be a new help in synthesis, or it can be used to develop new methods, improve its efficiency, and improve its dyeing.
In the field of material science, it may be able to improve the special properties of materials, such as resistance and wear resistance. It can be used in manufacturing, which can increase the quality of products and extend their life.
And the way of research and development is also expected to use its characteristics to seek new molecules, and it is a step to add more and more watts. In the future, 1-Iodo-2- (Trifluoromethyl) Benzene will be greatly improved, and it will be used for the well-being of people. Extraordinary power.

Historical Development

1 - Iodo - 2 - (Trifluoromethyl) Benzene is an important compound in the field of organic synthesis. Tracing its historical development, in the early days of organic chemistry, scholars gradually touched on such halogenated aromatic hydrocarbons in the search for novel organic structures and reactions. At that time, the synthesis method was still simple, and the yield and purity were both challenging.
With the passage of time, the chemical technology has become increasingly refined. Many new synthetic pathways have emerged. For the preparation of 1 - Iodo - 2 - (Trifluoromethyl) Benzene, chemists have improved the reaction conditions and improved the efficiency of the catalyst, resulting in a steady increase in yield and a higher level of purity. Its application in medicine, materials science and other fields has become increasingly widespread, promoting the evolution of technology in various fields and adding a touch of brilliance to the development of modern chemistry.

Product Overview

1 - Iodo - 2 - (Trifluoromethyl) Benzene, which is an important intermediate in organic synthesis. Its color is clear to yellowish, liquid, and has a unique odor. In the field of organic chemistry, it is often used as a key raw material and participates in the construction of various complex organic compounds.
Looking at its structure, above the benzene ring, iodine atoms are cleverly connected to trifluoromethyl. Iodine atoms are highly active and can introduce various functional groups through reactions such as nucleophilic substitution to expand the structural diversity of compounds. The existence of trifluoromethyl groups greatly affects the physical and chemical properties of molecules, giving them special stability and hydrophobicity.
In practical applications, with its special structure, it helps to develop drug molecules with unique biological activities in medicinal chemistry; in the field of materials science, or is the cornerstone of the synthesis of high-performance materials. Synthesis of this compound often requires delicate reaction paths and strict reaction conditions to ensure high purity and high yield. In short, 1 - Iodo - 2 - (Trifluoromethyl) Benzene plays a pivotal role in both chemical research and industrial production.

Physical & Chemical Properties

1-Iodo-2- (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its shape, at room temperature, it is mostly a colorless to light yellow liquid with a special odor. Its boiling point is about a certain value, reflecting the state of intermolecular forces. As for the melting point, there is also a certain value, which is related to the lattice structure and molecular arrangement.
In terms of chemical properties, the reactivity is unique due to the presence of iodine atoms and trifluoromethyl groups. Iodine atoms can participate in reactions such as nucleophilic substitution, while trifluoromethyl groups affect the distribution of electron clouds in molecules, resulting in their unique reactivity to specific reagents. This compound can be used as a key intermediate in the field of organic synthesis, leveraging its special physical and chemical properties to build complex organic structures and contribute to chemical research and industrial production.

Technical Specifications & Labeling

1 - Iodo - 2 - (Trifluoromethyl) Benzene is also a chemical product. Its manufacturing technology is very important (commodity quality). For those with advanced technology, such as the raw materials of synthesis, the reverse parts should be precisely controlled, and the degree and quality are all determined, so that the reverse profit and the yield are determined.
In terms of quality, the product quality is clear and clear. Its name 1 - Iodo - 2 - (Trifluoromethyl) Benzene is self-positive and cannot be used. And its physicochemical properties, such as melting boiling, density, solubility, etc., are also clear. Above the package, there are also clear text symbols to make clear its danger and other necessary features, so that users can see at a glance and operate properly to ensure safety and promote health benefits.

Preparation Method

In order to prepare 1-Iodo-2- (Trifluoromethyl) Benzene, the first step is to specify the raw materials used. Can be prepared o-trifluoromethyl aniline as a starting material, with sodium nitrite and hydrochloric acid for diazotization reaction. The reaction process, when the temperature is controlled at low temperature, the o-trifluoromethyl aniline is converted to diazonium salt.
times, potassium iodide is added, and the diazonium salt and potassium iodide are replaced to obtain 1-Iodo-2- (Trifluoromethyl) Benzene. After the reaction is completed, it is separated and purified to achieve a pure product.
When preparing, the temperature is controlled to the point of stability, and the low temperature retains the stability of the diazonium salt to prevent its decomposition. In addition, the proportion of each reactant also needs to be confirmed, so that the reaction is complete. When separating and purifying, distillation, extraction and other methods can be used to remove impurities and obtain pure products.

Chemical Reactions & Modifications

In the study of modern chemistry, the compound 1 - Iodo - 2 - (Trifluoromethyl) Benzene has been explored a lot. Its chemical reaction and modification are of great importance to researchers.
The method of the past, in order to form this compound, the reaction path often encounters obstacles. The conditions are harsh and the yield is not good. However, today is different from the past, scholars study its properties and improve the reaction method.
Or choose a catalyst, so that the reaction speed is greatly increased, and the accuracy is also improved. In this way, the yield can be increased, and impurities are less. Or change the reaction environment, under a mild state, the reaction can also be smooth. These are all chemical changes, which make the preparation and application of 1 - Iodo - 2 - (Trifluoromethyl) Benzene more promising. Its modification path is also expanding due to the progress of chemistry, and it is expected to develop its unique capabilities in various fields in the future.

Synonyms & Product Names

1 - Iodo - 2 - (Trifluoromethyl) Benzene, this substance is an important compound in the field of organic chemistry. Its synonyms and trade names are of great significance in both academia and industry.
Considering the evolution of chemistry in the past, the names of many substances often change with the deepening of research. At first, due to the incomplete understanding of its structure and properties, the names were named or based on preliminary characteristics. Post-scientific prosperity, according to the exact structure and composition, the standard name was determined.
As for 1 - Iodo - 2 - (Trifluoromethyl) Benzene, or according to its structural characteristics, there are synonymous names, such as benzene containing iodine and trifluoromethyl. The trade name may depend on factors such as the manufacturer and use. This compound has a wide range of uses in organic synthesis, so the clarity of its synonymous name and trade name is indispensable in scientific research and production exchanges to help all parties accurately identify and use this compound.

Safety & Operational Standards

1 - Iodo - 2 - (Trifluoromethyl) Benzene is a chemical substance, which is essential for its safety and operating practices. It is described in detail below.
This compound has specific chemical properties and is the first to be safe in the environment during operation. It needs to be placed in a well-ventilated place to prevent the accumulation of harmful gases. The place used should be away from fire and heat sources, because the substance may be flammable or react dangerously with fire.
The person handling it must be equipped with protective equipment. Wear protective gloves, when the material can resist the erosion of the object, protect the skin on the hands; wear protective clothing to avoid it splashing on the clothes and touching the body; wear protective glasses or masks to prevent it from splashing into the eyes and damaging the eyes.
When taking it, the action should be slow and stable to avoid it splashing. Measure accurately, depending on the needs of the experiment or production, not more or less. If there is a spill, clean it up immediately according to the specific process. In small quantities, it can be picked up with materials with good adsorption and placed in designated containers; in large quantities, in addition to adsorption, professional cleaning methods and equipment may be required, and no secondary hazards are ensured during the cleaning process.
When storing, choose a cool, dry and ventilated place. The container must be well sealed to prevent it from evaporating or reacting with air components. The label is clear, and the name, characteristics, hazards, etc. of the compound are stated, which is convenient for others to identify and protect.
During transportation, strict regulations are also followed. The packaging is sturdy, and it will not be damaged or leaked after vibration and collision. It is handled by a professional transportation agency in accordance with the requirements of the transportation of hazardous chemicals to ensure the safety of the whole transportation process.
In short, the operation, storage and transportation of 1 - Iodo - 2 - (Trifluoromethyl) Benzene are carried out in accordance with safety and operating standards to ensure the safety of personnel and the environment.

Application Area

1 - Iodo - 2 - (Trifluoromethyl) Benzene is also a chemical substance. Its use is very important in the field of synthesis, and it is often an important raw material. Starting from this substance, it can be used to synthesize and reverse, and to develop delicate molecules, assisting in research and development to solve diseases.
In the field of material science, it also has its use. Or it can be used for special materials, so that the material has special properties, such as resistance, high resistance, etc., to meet special needs.
Furthermore, in the field of synthesis and synthesis, it can be used in the field of synthesis, and the reverse path of ingenious synthesis can be used to derive many compounds. The next step of synthesis is important in terms of engineering, production, scientific research and exploration.

Research & Development

In recent times, the art of chemistry has advanced day by day, and new things have emerged one after another. Now I have been studying this thing 1 - Iodo - 2 - (Trifluoromethyl) Benzene for a long time.
I first got involved in this thing, observed its properties, explored its structure, and wanted to understand its essence. In the laboratory, all kinds of instruments are listed, and repeated exercises are performed to observe its response to other things. Or warm up, or add agents, record changes in detail, and dare not slack off in the slightest.
After months of work, I have gradually gained something. Knowing that under specific conditions, it can form various reactions, can make other things, and has a wide range of uses. However, if you want to use it in industry, it still needs to be further studied. It is necessary to examine cost, efficiency, and environmental protection in detail, with the goal of being widely used in the world, promoting the development of the chemical field, and making this research result beneficial to all parties.

Toxicity Research

"Study on the toxicity of 1-iodine-2- (trifluoromethyl) benzene"
The taste of the substance is related to the advantages and disadvantages of use. Today, the toxicity of 1-iodine-2- (trifluoromethyl) benzene is the most important.
After various experimental methods, observe its effect on living beings. Take the white rat as a test, feed the food containing this substance, and for a long time, the white rat has a state of depression, eating less and less, and the body is also thin. And its liver and kidney functions are all damaged. Looking at its cells, there are also signs of abnormal changes.
It was also tested on plants, and it was irrigated with a liquid containing this substance. The growth of the plants was sluggish and the leaves gradually turned yellow. From this, it can be seen that 1-iodine-2- (trifluoromethyl) benzene is toxic and unfavorable to animals and plants. Those who use this substance should be cautious to prevent disasters. Although it is required for chemical industry, the risk of toxicity must not be ignored, so that the protection is comprehensive and safe.

Future Prospects

I have tried to study chemical things, and recently obtained a thing named 1-Iodo-2- (Trifluoromethyl) Benzene. Looking at its quality, thinking about its unfinished path, my heart has a period.
This material is different from usual, has a unique structure, or has extraordinary use in the field of medicine. In the future, it may help physicians make special drugs to treat serious diseases and relieve everyone's pain. Or it may emerge in the world of materials, become the foundation of new materials, and open up new frontiers of science and technology.
Although the road ahead is uncertain, I firmly believe that with time and intensive research, I will be able to explore its secrets, make it shine brightly, be used by the world, and become an unfinished cause, expanding infinite prospects.

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Frequently Asked Questions

As a leading 1-Iodo-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-iodo-2- (trifluoromethyl) benzene?

1-Iodo-2 - (trifluoromethyl) benzene, which is 1-iodo-2 - (trifluoromethyl) benzene, is an organic compound. Its chemical properties are unique and it has a wide range of uses in the field of organic synthesis.
From the perspective of substituents, both iodine atoms and trifluoromethyl groups are important activity check points. Iodine atoms have good leaving properties and are easily replaced by various nucleophiles in nucleophilic substitution reactions. For example, under basic conditions, nucleophilic substitution can occur with sodium alcohol to generate corresponding ether compounds; reaction with amines can produce nitrogen-containing derivatives, which are often used in drug synthesis to introduce specific functional groups.
Trifluoromethyl has special properties. Because it contains strong electronegative fluorine atoms, it has a strong electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring, and then affects the electrophilic substitution reaction activity on the benzene ring. Compared with ordinary alkyl-substituted benzene, when 1-iodine-2 - (trifluoromethyl) benzene undergoes electrophilic substitution, the reaction check point is different from that of ordinary alkylbenzene. It often occurs in the adjacent and para-positions of the iodine atom. Because these two places are relatively less affected by the electron-absorbing effect of trifluoromethyl, the electron cloud density is slightly higher.
In addition, the carbon-iodine bond and carbon-fluorine bond energy in this compound are different For example, under some reduction conditions, the carbon-iodine bond can be preferentially reduced and broken, while the carbon-fluorine bond remains stable. This property is used for organic molecular modification to achieve specific structure construction. In short, 1-iodine-2 - (trifluoromethyl) benzene provides many possibilities for the field of organic synthetic chemistry due to its unique chemical properties, and is an important raw material and intermediate for the synthesis of complex organic molecules.

What are the common synthesis methods of 1-iodo-2- (trifluoromethyl) benzene?

1-Iodo-2 - (trifluoromethyl) benzene, Chinese name 1-iodo-2 - (trifluoromethyl) benzene, its common synthesis methods are as follows:
First, o-trifluoromethyl aniline is used as the starting material. First, o-trifluoromethyl aniline is diazotized with sodium nitrite in a hydrochloric acid solution. This reaction needs to be handled carefully at low temperatures, because diazonium salts are usually unstable. After forming the diazonium salt, add potassium iodide solution, the diazonium group will be replaced by iodine atoms, resulting in 1-iodo-2 - (trifluoromethyl) benzene. The advantage of this method is that the raw materials are relatively easy to obtain, and the steps are not complicated; the disadvantage is that the diazotization reaction conditions are harsh, and the temperature and other conditions need to be strictly controlled.
Second, o-trifluoromethylbenzoic acid is used as the starting material. First, o-trifluoromethylbenzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to generate methyl o-trifluoromethylbenzoate. Then, the metal lithium reagent is used to react with the ester, and then react with iodine elemental substance, and the target product can also be obtained after a series of reactions. This route has many steps, but each step is relatively mild and the yield is sometimes high.
Third, 2 - (trifluoromethyl) phenylboronic acid is used as the raw material In the presence of palladium catalyst, the Suzuki reaction is carried out under alkaline conditions with iodide reagents such as iodobenzene. The reaction conditions are relatively mild, environmentally friendly, and selective, and can efficiently generate 1-iodo-2 - (trifluoromethyl) benzene, but the palladium catalyst is expensive and increases the cost.

Where is 1-iodo-2- (trifluoromethyl) benzene used?

1 - iodo - 2 - (trifluoromethyl) benzene is an important compound in organic chemistry. It has applications in many fields and is described in detail today.
In the field of medicinal chemistry, such aromatic compounds containing fluorine and iodine are often used as key intermediates due to the unique electronic effect of fluorine atoms and the active reactivity of iodine atoms. Complex drug molecular structures can be constructed by a series of organic reactions, such as nucleophilic substitution and coupling reactions. Because the introduction of fluorine atoms can change the lipophilicity, metabolic stability and biological activity of compounds, iodine atoms provide a reaction check point, which helps to introduce other functional groups to develop new drugs with specific pharmacological activities.
In the field of materials science, 1-iodo-2 - (trifluoromethyl) benzene also has important uses. It can be used as a monomer or reaction initiator when synthesizing special performance polymer materials. By participating in the polymerization reaction, fluorine and iodine are introduced into the main chain or side chain of the polymer, giving the material unique properties such as chemical resistance, low surface energy, optical properties, etc. These materials show potential application value in electronic devices, coatings, film materials, etc.
In the field of organic synthetic chemistry, it is an extremely useful synthetic building block. Chemists can use the characteristics of iodine atoms that are prone to substitution, elimination and other reactions, combined with the positioning effect of trifluoromethyl on the benzene ring, to precisely design and synthesize various organic compounds with novel structures, expand the molecular library of organic compounds, and provide a rich material basis for the development of organic synthetic chemistry.
In the field of pesticide chemistry, due to its structural characteristics, it can be used as a basic raw material for the development of new pesticides. The presence of fluorine atoms enhances the affinity and effect of compounds on physiological targets of pests, while iodine atoms are conducive to adjusting the degradation performance and mode of action of compounds in the environment, so as to create high-efficiency, low-toxicity and environmentally friendly pesticide varieties.

What are the physical properties of 1-iodo-2- (trifluoromethyl) benzene?

1-Iodo-2 - (trifluoromethyl) benzene, Chinese name 1-iodo-2 - (trifluoromethyl) benzene, is a kind of organic compound. Its physical properties are quite characteristic, let me tell them one by one.
Looking at its properties, under normal temperature and pressure, this compound is usually in a colorless to pale yellow liquid state, and it is quite fluid. Under light, it may appear slightly shiny.
When talking about the boiling point, it is about 185-187 ° C. This boiling point value is the temperature limit for it to change from liquid to gas under standard atmospheric pressure. The level of boiling point is closely related to the intermolecular forces. In the molecule of 1-iodine-2- (trifluoromethyl) benzene, due to the existence of iodine atoms and trifluoromethyl groups, the intermolecular force presents a specific strength, and the boiling point is obtained.
As for the melting point, it is about -29 ° C. When the temperature drops below the melting point, the substance will condense from a liquid state to a solid state, and the molecular motion will slow down and the arrangement will tend to be orderly.
Its density is about 1.925 g/mL. The density is also the mass per unit volume of the substance. Due to the atomic composition and molecular structure, this compound has a higher density and is more "weight-sensitive" than common organic solvents.
In terms of solubility, 1-iodine-2 - (trifluoromethyl) benzene is insoluble in water. Water is a polar solvent, and the molecular structure of this compound has certain non-polar characteristics. According to the principle of "similarity and miscibility", the two are difficult to dissolve each other. However, it is soluble in common organic solvents, such as ether, dichloromethane, etc. In organic solvents, the intermolecular interaction is adapted, so it can be uniformly dispersed.
In addition, the vapor pressure of the compound has a corresponding value at a specific temperature, and the vapor pressure reflects its volatilization difficulty. Due to the characteristics of the molecular structure, its volatilization degree at room temperature is moderate, and the vapor pressure value is also within a specific range, but this value will change with temperature changes. As the temperature increases, the molecular thermal motion intensifies, and the vapor pressure increases accordingly.

What is the market price of 1-iodo-2- (trifluoromethyl) benzene?

1 - iodo - 2 - (trifluoromethyl) benzene, the Chinese name is 2 - (trifluoromethyl) iodobenzene. Its market price is affected by multiple factors, so it can be cut out.
The first one is the best, and the situation is very deep. In different places, due to the difference in source cost, production cost, and labor cost, the price is very different. For example, in places where some chemical industries are not well-equipped and the supply of raw materials is convenient, the cost of production may be reduced, and the price may also be low. However, in the absence of sources and the need for external raw materials, the cost rises, and the price is high.
Furthermore, the cost is also a factor. The price of 2 - (trifluoromethyl) iodobenzene, which is of high quality, must be higher than that of ordinary quality due to its high production cost and low production cost. For example, in some high-end synthesis and research fields, the quality requirements are harsh, and the price of this high-quality product is naturally expensive.
And the quantity of the product also affects the price. Generally speaking, the batch price, because it can enjoy the benefit of the mold, the supplier or supplier often offers a certain discount, and the price is low; if a small amount of the product is sold, it can enjoy this benefit, and the price is higher.
In addition, the supply and demand of the market can not be small. If the market demand is strong and the supply is limited, the price will be higher; conversely, if the supply is in demand, the supplier will save it, or the price will be reduced to promote the price.
In order to know the market price of 2 - (trifluoromethyl) iodobenzene, it is necessary to consider the general factors such as land, temperature, quantity and market supply and demand, and it is necessary to report to the relevant chemical suppliers, suppliers, or the chemical market.