1 Iodo 3 3 3 Trifluoropropane

1-Iodo-3,3,3-trifluoropropane (1-iodo-3,3,3-trifluoropropane) is widely used in the field of organic synthesis.
First, it can be used as a raw material for the synthesis of fluorine-containing compounds. The introduction of fluorine atoms into organic molecules can often change the physical and chemical properties of compounds, such as improving stability, lipophilicity, etc. The iodine atoms in 1-iodo-3,3,3-trifluoropropane are active. They can be introduced into target molecules through substitution reactions and interact with many nucleophiles to obtain fluorine-containing organic compounds with special properties. It is of great significance in the creation of medicines and pesticides. For example, in the development of new drugs, fluorine-containing structural units can optimize the ability of drug molecules to bind to targets and enhance drug efficacy.
Second, it is also used in the field of materials science. The fluoropolymer prepared from this raw material can make the material have excellent chemical resistance, low surface energy and heat resistance due to the properties of fluorine atoms. If a fluorine-containing coating material is prepared and coated on the surface of an object, it can protect it from chemical attack and has a self-cleaning effect. The low surface energy makes it difficult for stains to adhere.
Furthermore, in the study of the mechanism of organic synthesis reactions, 1-iodine-3,3,3-trifluoropropane can be used as a model compound. Its reactivity and unique structure make it convenient for scientists to explore the laws and characteristics of nucleophilic substitution, elimination and other reactions in fluorine-containing systems, and contribute to the improvement and development of organic synthetic chemistry theory.

1-Iodo-3,3,3-trifluoropropane is an organic compound with unique physical properties. It is a liquid at room temperature, and its properties are different from common alkanes due to its molecular structure containing iodine and trifluoromethyl.
Looking at its properties, 1-iodo-3,3,3-trifluoropropane is often colorless to light yellow transparent, with a certain volatility, audible in the air and weak special odor.
Talking about the melting point and boiling point, the boiling point of the compound is about 118-120 ° C due to the introduction of iodine atoms and trifluoromethyl, which is significantly higher than that of propane. This intermolecular force is enhanced by the large volume of iodine atoms and the electronegativity of trifluoromethyl. The melting point is about -70 ° C, which is relatively low, indicating that the order of time division in the solid state is limited.
When it comes to density, the density of 1-iodo-3,3,3-trifluoropropane is greater than that of water, about 1.9 g/cm ³. This is due to the large atomic weight of iodine atoms, which increases the molecular weight, and the compact structure of trifluoromethyl, resulting in an increase in the mass per unit volume.
In terms of solubility, it is difficult to dissolve in water, because water is a polar molecule, and 1-iodo-3,3,3-trifluoropropane molecules are relatively weak in polarity. According to the principle of "similar miscibility", the two are difficult to miscible. However, in organic solvents such as ethanol, ether, and acetone, the compound has good solubility. Due to the interaction of van der Waals forces with organic solvent molecules, it is advantageous for it to disperse in solvents.
The vapor pressure of 1-iodo-3,3,3-trifluoropropane has a certain value at room temperature, which means that it will partially evaporate into a gaseous state in a closed system and reach equilibrium with the liquid state. This property affects its storage and use, and attention should be paid to sealing to prevent volatile loss and leakage.
In summary, 1-iodo-3,3,3-trifluoropropane presents unique physical properties due to its special structure, which are of great significance for its synthesis, storage, transportation, and application.

1-Iodo-3,3,3-trifluoropropane is an organic halide, which has both a halogen atom and a fluoroalkyl group. Its chemical properties are unique and interesting.
The iodine atom in this compound has good activity. Due to its relatively low C-I bond energy, it is prone to heterocracking, which makes the carbon atom partially positively charged and vulnerable to attack by nucleophiles. Nucleophilic substitution is one of its common types of reactions. For example, when reacting with sodium alcohol, the iodine atom can be replaced by an alkoxy group to form a corresponding ether compound; when reacting with sodium cyanide, the iodine atom will be replaced by a cyanide group, and the product can be converted into carboxylic acid after hydrolysis.
Furthermore, due to the presence of strong electron-absorbing trifluoromethyl in the molecule, it will have a significant impact on the reactivity. The powerful electron-withdrawing effect of trifluoromethyl can reduce the density of the electron cloud of the carbon atom connected to it, making the carbon atom more susceptible to attack by nucleophiles. At the same time, this structural feature also affects the physical properties of the molecule, such as enhancing the polarity of the molecule, and also has an effect on its boiling point and solubility.
In addition, in the elimination reaction, 1-iodo-3,3,3-trifluoropropane can also be expressed. In the presence of suitable bases, elimination reactions can occur to eliminate hydrogen iodide and generate unsaturated compounds containing carbon-carbon double bonds. The generated double bond is affected by trifluoromethyl, and the electron cloud distribution will change, resulting in the unsaturated compound exhibiting unique reactivity and showing different chemical behaviors in subsequent addition reactions.
1-iodo-3,3,3-trifluoropropane is widely used in the field of organic synthesis due to its special structure. It can be used as a key intermediate in the construction of various fluorinated organic compounds, which contributes to the research and application of organic chemistry.

The preparation method of 1-iodo-3,3,3-trifluoropropane (1-iodo-3,3,3-trifluoropropane) is ancient and is described in detail below.
First, 3,3,3-trifluoropropane is used as the starting material. In a suitable reaction vessel, 3,3,3-trifluoropropane is introduced into a solution containing hydrogen iodide (HI). This reaction requires control of temperature and pressure. Generally speaking, the temperature should be maintained near room temperature and the pressure should be slightly higher than normal pressure. The double bond of 3,3,3-trifluoropropane reacts with hydrogen iodide, and the reaction mechanism follows the Markov rule. Due to the strong electron-absorbing effect of trifluoromethyl, the hydrogen atom of hydrogen iodide tends to be added to the carbon atom with more hydrogen in the double bond, while the iodine atom is added to the other end, resulting in 1-iodo-3,3,3-trifluoropropane. The reaction formula is as follows: CF
Second, it can be started from 3,3,3-trifluoropropanol. First, 3,3,3-trifluoropropanol is reacted with phosphorus triiodide (P I). This reaction can be carried out under mild conditions. Phosphorus triiodide undergoes a substitution reaction with alcohol hydroxyl groups. Phosphorus atoms combine with hydroxyl oxygen atoms, and iodine atoms replace hydroxyl groups to form 1-iodo-3,3,3-trifluoropropane and phosphoric acid (H 🥰 PO 🥰). The chemical reaction equation is: 3CF 🥰 CH 🥰 OH + P I 🥰 → 3CF 🥰 CH 🥰 CH 🥰 I + H 🥰 PO 🥰.
Third, 1-chloro-3,3,3-trifluoropropane can also be used as a raw material. React 1-chloro-3,3,3-trifluoropropane with sodium iodide (NaI) in acetone solution. This reaction is a substitution reaction of halogen atoms. Acetone, as a solvent, can promote the reaction to form 1-iodo-3,3,3-trifluoropropane. Chloride ions and sodium ions combine to form sodium chloride precipitation, thereby promoting the equilibrium of the reaction. The reaction equation is: CF
The above preparation methods have their own advantages and disadvantages, and they need to be followed according to the actual situation, such as the availability of raw materials, cost, and difficulty in controlling reaction conditions.

1 - iodo - 3,3,3 - trifluoropropane is an organic compound. During storage and transportation, many matters need to be paid attention to so that security is safe.
First, it is related to storage. This compound should be stored in a cool and ventilated warehouse. Because it is more sensitive to heat, high temperature is easy to decompose or cause other chemical reactions. The warehouse temperature should be maintained within a specific range and must not be too high. And keep away from fire and heat sources. Open flames and high temperature heat sources may trigger danger. At the same time, it needs to be stored separately from oxidants and alkalis to avoid mixed storage. Because the compound is in contact with oxidants, it may react violently, and uncontrollable chemical reactions may also occur with alkalis. It is necessary to keep the container sealed to prevent it from evaporating and escaping, which will not only damage the substance itself, but also cause harm to the environment and personnel.
Second, about transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. Packaging materials should be able to effectively prevent the leakage and volatilization of the compound. During transportation, relevant transportation regulations should be strictly adhered to, and the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. During the transportation, it should be protected from sun exposure, rain exposure, and high temperature. Summer transportation should be carried out in the morning and evening to avoid high temperature periods. If a leak occurs during transportation, personnel from the leaked contaminated area should be quickly evacuated to a safe area and isolated, and access should be strictly restricted. Emergency personnel should wear self-priming filter gas masks (full masks) and gas suits to cut off the source of leakage as much as In the event of a small leakage, it can be adsorbed or absorbed by sand or other non-combustible materials; in the event of a large leakage, it is necessary to build a dike or dig a pit for containment, cover it with foam, reduce the vapor hazard, and then transfer it to a tanker or a special collector with an explosion-proof pump for recycling or transportation to a waste disposal site. In this way, the safety of 1-iodo-3,3,3-trifluoropropane during storage and transportation can be ensured.