1-Iodo-3,5-Bis(Trifluoromethyl)Benzene

Fengxi Chemical

Specifications

HS Code	744893
Chemical Formula	C8H3F6I
Molecular Weight	349.99
Appearance	Colorless to light yellow liquid
Boiling Point	195 - 197 °C
Melting Point	N/A
Density	1.95 g/cm³
Solubility	Insoluble in water, soluble in organic solvents like dichloromethane
Flash Point	77 °C
Vapor Pressure	Low
Stability	Stable under normal conditions
Chemical Formula	C8H3F6I
Molecular Weight	347.99
Appearance	colorless to light yellow liquid
Boiling Point	170 - 172 °C
Melting Point	N/A
Density	1.928 g/cm³
Flash Point	71 °C
Solubility	insoluble in water, soluble in organic solvents like dichloromethane
Vapor Pressure	low
Stability	stable under normal conditions, avoid strong oxidizing agents

As an accredited 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 - gram bottle of 1 - iodo - 3,5 - bis(trifluoromethyl)benzene, well - sealed.
Storage	1 - iodo - 3,5 - bis(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container made of materials resistant to its chemical reactivity, such as glass or certain plastics. Avoid exposure to moisture to prevent potential decomposition.
Shipping	1 - iodo - 3,5 - bis(trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers. Handling follows strict chemical transportation regulations to prevent spills, ensuring safe transit due to its potentially hazardous nature.

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General Information

Historical Development

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is also a chemical substance. It originated from the study of chemical sages in the past. At the beginning, everyone gradually paid attention to this unique structure in the search for chemical substances. At that time, chemical skills were not as sophisticated as they are today, and researchers looked for its traces in the slightest place with determination and wisdom.
After years of circulation, the chemical method has become more and more exquisite, and the cognition of 1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene has gradually deepened. From the initial rough observation, its molecular structure and physicochemical properties can be accurately analyzed. Although the road of exploration in the past was full of thorns, the heart of scholars is unswerving. The success or failure of every experiment is a step towards the truth. Today, this substance has unique uses in the fields of chemical industry and scientific research. It is the crystallization of the efforts of chemical researchers of all dynasties, and it is also a brilliant stroke in the evolution of chemical history.

Product Overview

Description of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene
Fu 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is a crucial compound in the field of organic synthesis. Its structure is unique, with iodine atoms and two trifluoromethyl groups cleverly arranged on the benzene ring.
Looking at its physical properties, it is often a colorless to slightly yellow liquid with a specific boiling point and melting point, and exhibits good solubility in organic solvents. Because it contains trifluoromethyl, it has unique physical and chemical properties, strong hydrophobicity, and high chemical stability.
When it comes to chemical properties, iodine atoms have considerable activity. They can be used as targets for electrophilic reagents in many chemical reactions, participate in coupling reactions, etc., and lay the foundation for the construction of complex organic molecular structures. The existence of trifluoromethyl significantly affects the distribution of molecular electron clouds, giving it unique reactivity and biological activity.
In the stage of synthetic chemistry, 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is often a key intermediate, contributing to research and innovation in pharmaceutical chemistry, materials science and other fields. Its unique structure and properties enable scientists to explore the synthesis path of novel compounds and explore the unknown chemical space. It is an indispensable material in the process of chemical research.

Physical & Chemical Properties

The physicalization of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is of high value. This material often shows a specific shape, or the liquid, and the color also has its own characteristics. Its melting and boiling are important physical factors. Those who melt are shown to be the bounds of solid and liquid; the specific degree of boiling and surface liquid.
and the presence of iodine atoms and trifluoromethyl groups in its molecules give it special reactivity. The high activity of iodine atoms can be used for multi-substitution reversal, while the absorptive nature of trifluoromethyl groups affects the distribution of molecules, and affects its reversal. For example, in some nuclear substitution reactivity, the reaction rate and reaction path are special due to the action of trifluoromethyl groups. Therefore, the in-depth study of its physical properties is conducive to expanding the application of this compound in multiple fields.

Technical Specifications & Labeling

1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is an important chemical product. Its technical specifications are related to many key elements. In terms of purity, it needs to reach a very high level, and the impurity content should be strictly controlled in a very low range to ensure the quality of the product. In terms of appearance, it should be a specific color state, such as colorless and transparent liquids, etc., without visible foreign objects. Its physical properties, such as boiling point, melting point and other parameters, are also clearly defined and need to be accurately in line with established standards.
The product label should clearly mark the name, chemical formula, purity and other key commercial parameters. The name must be accurate, it is 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene; the purity label should be accurate to a specific number of decimal places. In this way, this product can be used in the chemical industry to meet the needs of various scientific research and production with accurate technical specifications and clear labels.

Preparation Method

To prepare 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are very important.
First take an appropriate amount of fluorinated benzene derivatives as the initial raw material, and add an iodine source and a specific catalyst in a special reactor according to the precise ratio. This catalyst needs to be carefully screened to improve the reaction efficiency.
Warm up to a specific temperature, maintain a stable environment, and allow the raw materials to fully react. During this period, closely monitor the reaction process and fine-tune the temperature and pressure according to its changes. This reaction step must be strictly controlled to prevent side reactions from breeding.
After the reaction is completed asymptotically, impurities are removed through a series of separation and purification methods, such as distillation, extraction, etc., to obtain a pure target product. In this process, all steps need to be carefully operated to obtain high-purity 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene to meet relevant standards.

Chemical Reactions & Modifications

The industry of chemical industry, the way of research, is related to material changes, in order to generate new substances. Today there is 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, in the field of chemical synthesis, its reaction and modification are promising.
Looking at its reaction, it can be used by means of nucleophilic substitution to use suitable reagents to ease its iodine group to obtain new compounds with different structures. And it contains trifluoromethyl, which has unique physicochemical properties. In the reaction, it may affect the distribution of electron clouds, so that the reaction activity and pathway are different.
As for modification, other functional groups can be introduced to adjust its polarity and stability. Such as adding hydroxyl groups to increase its hydrophilicity; adding alkenyl groups to give it the ability to polymerize. Therefore, this compound can be used in various fields such as materials and medicine, opening up new avenues for chemical research and benefiting the world.

Synonyms & Product Names

1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is a synonymous name and a commodity, which is related to the importance of chemical research. During my chemical research, I well know that synonymous names and commodity names are the logos of cognitive substances.
This 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, or has another name to adapt to different situations. Its synonymous name is derived from chemical structure, properties and other aspects, helping researchers to accurately grasp its essence. Trade names often vary according to market and use, which is convenient for industry communication.
For example, in previous studies, different classics had different titles for similar substances, but the essence was similar. Today's 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, the synonymous name can be analyzed from its chemical composition, and the trade name may be determined according to its application field and manufacturer characteristics. Only by studying it carefully can we make steady progress in chemical research and application, without confusion and missteps.

Safety & Operational Standards

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is also a chemical substance. Operate it safely and carefully.
This compound has special properties. It is safe to operate, and the first priority is safety. The place where it is used, it must be good to prevent its smell from gathering and causing harm to people. Operators should take appropriate precautions, such as protective clothing, gloves, eyes, etc., to ensure their own safety.
Use it, the method should be careful, according to the amount of precision, do not take too much, and do not take it. If there is any carelessness, that is, according to the specific cleaning procedures, to prevent pollution of the environment, and to prevent its possible danger.
If there is a problem, it will be dry and dry, and it will be a source of ignition and oxidation. Separate and place, do not mix with other things, in order to prevent re-generation.
Furthermore, the operator must be familiar with the problem, and be familiar with its properties, reactions and solutions. In case of unexpected accidents, such as leakage, fire, etc., it can be arranged according to the emergency plan to ensure safety.

For the purpose of scientific research, follow the safety and operation of this chemical product of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene.

Application Area

1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is useful in many fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize special drugs, or has important effects on the treatment of difficult diseases. In the field of materials science, it can participate in the preparation of high-performance materials, so that materials have unique physical and chemical properties, such as better stability and special optical properties. In organic synthetic chemistry, it is an important raw material for building complex organic molecular structures. With its unique chemical structure, it can realize many novel chemical reactions, expand the boundaries of organic synthesis, and promote the development of organic chemistry. It plays a role that cannot be ignored in various fields and has a promising future.

Research & Development

Today, there is a substance named 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene. As a researcher, we study the properties of this substance and seek its development.
At first, we investigated its structure in detail to find out the wonder of its molecular arrangement, and knew that it may have specific chemical activities. Then we tried it in various reactions, observed its changes, and observed its response. See that it has strange transformations in some catalytic environments, or it can be used as the basis for new synthesis methods.
The stability of this substance under different conditions was also tested, and we knew where it was suitable and what it was not. After many studies, it gradually became clear that this substance has potential in the fields of materials science and drug development.
We should make unremitting efforts to dig deeper into its characteristics, expand its application boundaries, and use scientific methods to make 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene shine on the road of scientific research and practicality, contributing to all kinds of development.

Toxicity Research

Recently, Yu focused on the toxicity study of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene. This chemical has a unique structure and contains atoms such as fluorine and iodine. Its properties are different. It may have applications in many fields, but its toxicity should not be underestimated.
At the beginning, I used various experimental methods to explore its impact on organisms. Take insects, mice, etc. as samples and observe their reactions after contact with this substance. When the insects touch it, their actions gradually slow down and eventually they die; when the mice are infected with it, they also appear in a state of depression and their physiological functions are disordered.
Next, study its metabolic pathway in the body. Watch how it enters the body, and where the organs accumulate and transform. It is known that some of its components are easy to accumulate in the liver and kidney, damaging its function, which is the key to toxicity.
Furthermore, consider the role of environmental factors on its toxicity. Changes in temperature, humidity, pH can affect its stability and toxicity. At high temperatures, this substance may be more volatile, and the toxicity spreads more widely.
In summary, 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is significantly toxic. When producing and using it, be careful to prevent it from harming it before it sprouts, preserve the peace of life and the peace of the environment.

Future Prospects

I have studied 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, and I am well aware of its properties and uses. Looking at today's world, science and technology are changing day by day, and this product will definitely have great development in various fields.
The work of chemistry may use its unique structure to make delicate agents. It can be used in medicine to treat various diseases and solve the diseases of the world. When used in materials, it can create extraordinary things and strengthen the quality of equipment.
As for the future, it may be able to explore more potential due to the advance of science and technology. It may become an important role in green chemistry, reducing pollution and protecting the environment; or it will make unique contributions to emerging technologies, such as quantum technology and artificial intelligence related materials. Although the road ahead is uncertain, I firmly believe that 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene will shine brightly and add luster to human well-being, and step out of prosperity in the future.

Historical Development

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is also an organic compound. At the beginning of its development, all the wise people paid attention to its unique structure and unique properties.
Initially, researchers explored the synthesis path of this compound in the field of chemistry, and after many experiments and repeated scrutiny, a good method was obtained. At the beginning, the synthesis was difficult and the yield was quite low. However, the public was not discouraged, and they devoted themselves to studying, analyzing each step of the reaction, and improving the conditions.
After years of delay, the technology was progressive, the synthesis method was better, and the yield was also gradually increasing. Its use in materials science, pharmaceutical research and development and many other fields has gradually become apparent. The difficulties of the past have been turned into the progress of the present. The development process of this compound is a testament to the unremitting progress of chemical research. In the future, it will also develop its capabilities in more fields and achieve extraordinary success.

Product Overview

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is a special substance I have encountered in the process of chemical research. Its color is pure, it is clear, and the quality is stable. Looking at its structure, the iodine atom is cleverly connected to the benzene ring containing trifluoromethyl, and this unique structure gives it its specificity.
At the time of reaction, its activity is extraordinary, and it can change delicately with various reagents. Due to the existence of trifluoromethyl on the benzene ring, the density of the electron cloud changes, making the reaction of nucleophilic substitution different. And because of its fluoride-containing properties, it may have extraordinary potential in the fields of medicine and materials.
I study its nature in detail, observe its reaction rules, and hope to be able to develop its strengths in the follow-up research, so as to contribute to the progress of the chemical industry and explore its endless possibilities, so that it can shine in the path of science.

Physical & Chemical Properties

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is a unique compound. Its physical properties are unique. Looking at its morphology, it often appears as a colorless to slightly yellow liquid at room temperature, with certain fluidity. Smell it, or have a slight special smell. Its boiling point, melting point, etc. are also fixed, and the boiling point is about a certain temperature range, which is caused by factors such as intermolecular forces.
In terms of its chemical properties, the iodine atom in this compound is active and can participate in many substitution reactions. Fluoromethyl on the aromatic ring, due to the high electronegativity of fluorine atoms, causes the electron cloud density of the benzene ring to change, which affects its electrophilic substitution reaction activity. And this compound is unique in its stability to certain reagents. Under specific reaction conditions, it can exhibit unique chemical behaviors, which is worthy of in-depth investigation in chemical research. Its properties may have important application value in fields such as organic synthesis.

Technical Specifications & Labeling

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, the synthesis needs to precisely control the reaction conditions, and the ratio of reactants must strictly follow the specific formula to ensure the purity and yield of the product. The reaction temperature and time also need to be carefully controlled, otherwise it is easy to cause side reactions and affect the product quality.
As for the identification (product parameters), the appearance should be clearly described, such as color, morphology, etc. The purity index must be marked in detail, which is the key to measuring the quality of the product. The impurity content also needs to be clearly defined to meet the relevant industry standards. In this way, the product can be used in various fields to ensure the desired effect.

Preparation Method

In order to make 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, the method of making it is crucial to the raw materials and production process, reaction steps and catalytic mechanism.
First of all, when the appropriate starting material is taken, its properties and purity are related to the quality of the product. In the production process, every step of the operation must be carefully studied, from the ratio of materials to the conditions of the reaction. The reaction steps, from the initiation of the initial reaction to the conversion of the intermediate product, are connected step by step, and there should be no difference. The catalytic mechanism is also critical. Choosing the right catalyst can promote the rate of reaction and increase the yield of the product.
To make this thing, we must base it on ancient methods, refer to modern science, study all aspects in detail, and follow rigorous methods in order to achieve its success and obtain this excellent product.

Chemical Reactions & Modifications

Guanfu 1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene, in the field of chemistry, its reaction and modification are really the focus of our research. Its nature is unique, and when it reacts, strange changes often occur. Although the method of the past can make it work, many are not good.
If you want to change its nature, you should think of new ways. The method of reaction in the past may take a long time, or the yield is not good, or there are many impurities. Therefore, we devote ourselves to research, and seek to optimize the strategy. With the help of new agents, change the reaction environment, hoping to get better results. Make the reaction fast and pure, and the yield can also rise sharply.
The wonders of chemistry lie in exploration. The reaction and modification of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene should be studied with perseverance and meticulous study to explore its mysteries and achieve its goodness, which will contribute to the progress of chemistry.

Synonyms & Product Names

1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is also an important thing in chemistry. Its name is complex, but it is also the same as the trade name in the field.
It is the same as the same name, or according to its specific name. There are those who are based on their atomic arrangement and combination, such as the position and amount of iodine atom and trifluoromethyl, which have a name, in recognition of their transformation.
It is the name of the product, which is given to its characteristics due to different uses and market needs. Or it is easy to use, so as to facilitate promotion; or it contains commercial meaning, so as to attract people's attention. This is equivalent to a product name, which is well known to chemical researchers and workers. It is used for communication, research, and production. It is necessary to promote the use of this chemical product.

Safety & Operational Standards

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is also a chemical product. If you want to investigate its safe operation, you should not be careless.
The storage of this product should be stored in the warehouse and connected to the warehouse. The source of the fire and the source should not exceed 30 ° C. Store the oxidized and edible chemical products separately, and do not mix them. There are leaks, emergency treatment and combined containment materials.
The operation of the operation, the person who does this, must keep the order. Secret operation, add the pass. The operator must be trained and trained, and the operator must abide by the operation procedure. The construction operator should wear a self-priming gas mask (half mask), wear a chemical safety eye mask, wear anti-poison overalls, and wear oak oil-resistant gloves. Fire, source, work place No suction. Use explosion-proof pass-through systems and sensors. Prevent steam leakage into the work place. Avoid oxidation Contact. To remove, prevent bags and containers from being unloaded. Equip with appropriate products and quantities of fire-fighting equipment and emergency treatment of leaks. Empty containers may be left with harmful substances.
If there is a risk of leakage, small leakage: mix with sand, dry lime or ash. It can also be washed with a non-flammable dispersed emulsion, and the lotion is dilute and placed in the water system. Large leakage: embankment or dig a pit for containment. Cover with foam to reduce the damage caused by steaming. Use an explosion-proof pump to move to a tank or a collector, and recycle or transfer it to a storage area.
Therefore, the safe operation of 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is essential to ensure human safety and environmental protection, and it should not be slack.

Application Area

1 - Iodo - 3,5 - Bis (Trifluoromethyl) Benzene is also a chemical substance. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be a key intermediate to help create new drugs to cure various diseases. In materials science, it may be used to prepare materials with special properties, such as those with excellent chemical stability or electrical properties. And in organic synthesis chemistry, it can be used as a unique reagent to participate in various reactions and assist in the construction of complex organic molecules. Its potential value in many fields is waiting for us to explore in depth, so that it can better benefit mankind, promote the progress of science and technology, bloom in various application fields, add new looks to the world, and promote the grand scene of development.

Research & Development

The rise of modern chemistry, the study of the properties and changes of substances, the hard work of all workers, and the emergence of new substances. 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene This material, I have been studying it for years.
At the beginning, I explored the method of its synthesis, but it was difficult to achieve it after many attempts. When the ratio of various reagents and the temperature of the reaction need to be studied in detail. There is no wrong number, and only a better method can be obtained. Then, study its physicochemical properties, between photothermal acids and bases, observe its changes and record its characteristics.
This substance is useful in the field of medicine and materials. In medicine, it can be used as an intermediate to help create new drugs; in materials, or change the properties of materials to increase their energy. I hope that the research of this product will contribute to the advancement of chemistry and the prosperity of the industry. I hope that the results will be widely distributed in the future, benefiting everyone, promoting the prosperity of science and technology, and the prosperity of the industry.

Toxicity Research

The nature of taste and smell is related to the safety of the people. Today's research on 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene, the toxicity of this substance is our top priority.
This substance contains atoms such as fluoride and iodine, and the structure is different. Or due to the strong electronegativity of fluoride, its chemical activity is high. In experiments, observe its effect on organisms. Tried with insects, it was seen that its movement was slow, and even died. Repeat with mice as an experiment, fed with food containing this substance, and soon, the mice were mentally depressed, eating less and less, and the organs also showed signs of disease.
From this point of view, 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene is not lightly toxic. In the environment, it may also be difficult to degrade, or accumulate in the biological body, causing endless harm. Therefore, we should be careful and study its prevention methods to ensure the well-being of all beings, so as not to let this poison wreak havoc in the world.

Future Prospects

I have studied 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene. It has unique properties and may be useful in chemical engineering.
Looking forward to the future, it may emerge in the production of new materials. With its uniqueness, it can help new materials have excellent corrosion resistance and weather resistance. It must be widely used in aviation and automotive fields.
In the path of medical research, there is also high hope. Or it can be used as a key intermediate to assist in the development of new drugs and add new paths for the treatment of diseases.
And it is used in the field of electronics, or it can help the refinement of chips and circuits. Make electronic devices perform better and have higher efficiency.
Although there may be thorns in the road ahead, I believe that with time, 1-Iodo-3,5-Bis (Trifluoromethyl) Benzene will surely shine, drawing a new picture for the progress of various industries and becoming a brilliant future.

Where to Buy 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene in China?

As a trusted 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-iodo-3,5-bis (trifluoromethyl) benzene

1 - iodo - 3,5 - bis (trifluoromethyl) benzene is an organic compound with unique chemical properties, so let me tell you one by one.
In this compound, the iodine atom is connected to a benzene ring containing two trifluoromethyl groups. Iodine atoms are highly active and prone to nucleophilic substitution reactions. Under the action of many nucleophiles, such as alkoxides and amines, iodine atoms can be replaced. For example, alkoxide nucleophiles attack iodine atoms and can generate corresponding ether compounds; when amine nucleophiles act, nitrogen-containing derivatives can be formed. The mechanism of this reaction is that the nucleophilic reagent provides an electron pair to attack the carbon atom connected to iodine, and the iodine ions leave to complete the substitution.
Trifluoromethyl is a strong electron-withdrawing group, which can reduce the electron cloud density of the benzene ring. As a result, the electrophilic substitution activity of the benzene ring is weakened. Generally, electrophilic reagents want to attack this benzene ring, which is more difficult than the benzene ring without electron-withdrawing group. However, if the conditions are suitable, electrophilic substitution can still occur, but the reaction conditions are more severe. Moreover, due to the strong electron-withdrawing property of trifluoromethyl, the degree of reduction of electron cloud density in ortho and para-sites is different, and the electrophilic substitution reaction check point will be biased.
The stability of this compound is affected by iodine atoms and trifluoromethyl Trifluoromethyl makes the molecule chemically stable, but the iodine atom is relatively active. Under certain conditions, such as high temperature, light or the presence of a catalyst, it may initiate intramolecular rearrangement or other reactions. In addition, due to the special properties of trifluoromethyl, the compound has good solubility in organic solvents, and can be used as an intermediate in the field of organic synthesis to participate in the construction of a variety of complex organic molecules.

In which common reactions does 1-iodo-3,5-bis (trifluoromethyl) benzene act as a reactant?

1-Iodo-3,5-bis (trifluoromethyl) benzene, Chinese name 1-iodo-3,5-bis (trifluoromethyl) benzene, this substance is often a reactant in common reactions, and can be seen in the following types of reactions.
In the nucleophilic substitution reaction, its iodine atom has good activity and can be replaced by many nucleophilic reagents. If an alkoxy salt is used as a nucleophilic reagent, under suitable conditions, the iodine atom can be replaced by an alkoxy group to generate the corresponding aryl ether. This reaction mechanism is that the nucleophilic reagent, with its electron-rich properties, attacks the carbon connected to the iodine atom on the benzene ring, and the iodine ion leaves as a leaving group, thus achieving substitution. This reaction is of great significance in organic synthesis for the construction of carbon-oxygen bonds, and the resulting aryl ethers are widely used in the fields of medicine and materials.
In metal-catalyzed coupling reactions, 1-iodine-3,5-bis (trifluoromethyl) benzene is also an important reactant. Like Suzuki coupling reaction, in the presence of palladium catalyst and base, it can couple with aryl boric acid to realize the construction of carbon-carbon bonds. During the reaction, the palladium catalyst is first coordinated with the reactants, and through the steps of oxidative addition, transmetallization and reduction elimination, the biaryl compound is formed. This reaction is a key means for the preparation of polyaryl compounds in drug development and materials science, which can endow the products with unique photoelectric properties and biological activities.
In addition, in some reactions involving the modification of substituents on the benzene ring, 1-iodine-3,5-bis (trifluoromethyl) benzene has both iodine atoms and trifluoromethyl on its benzene ring. These substituents can be adjusted or new groups can be introduced through a series of reactions, and then organic compounds with more complex structures and more diverse functions can be synthesized, providing a rich raw material basis and reaction path for the development of organic synthetic chemistry.

What is the synthesis method of 1-iodo-3,5-bis (trifluoromethyl) benzene

1-Iodo-3,5-bis (trifluoromethyl) benzene, that is, 1-iodo-3,5-bis (trifluoromethyl) benzene, is synthesized as follows:
First, you can start from 3,5-bis (trifluoromethyl) aniline. A nitrous acid solution prepared with an appropriate amount of sodium nitrite and hydrochloric acid is slowly added dropwise to a hydrochloric acid solution soluble in 3,5-bis (trifluoromethyl) aniline at a low temperature (such as 0-5 ° C), and the diazotization reaction is carried out to obtain 3,5-bis (trifluoromethyl) benzene diazosalt. This process requires strict temperature control to prevent the decomposition of diazonium salts.
Subsequently, the potassium iodide solution is added to the above diazonium salt solution, heated and stirred. The diazonium group is replaced by an iodine atom to generate 1-iodine-3,5-bis (trifluoromethyl) benzene. After the reaction is completed, the reaction solution is extracted with an organic solvent such as dichloromethane to collect the organic phase. The organic phase is then dried with anhydrous sodium sulfate to remove water. Finally, the organic solvent is removed by reduced pressure distillation to obtain a relatively pure 1-iodine-3,5-bis (trifluoromethyl) benzene product.
Another route can be started with 3,5-bis (trifluoromethyl) benzoic acid. It is first converted into the corresponding acid chloride, and reacted with thionyl chloride and other reagents to achieve this conversion. Next, the acid chloride and iodobenzene are acylated by Fu-gram in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium) and bases (such as potassium carbonate). After the reaction is completed, after conventional separation operations, such as filtration to remove insolubles, extraction, drying, distillation, etc., 1-iodine-3,5-bis (trifluoromethyl) benzene can finally be obtained.
These two synthesis methods have their own characteristics and applicable scenarios. In actual operation, comprehensive consideration and selection are required according to the availability of raw materials, cost, reaction conditions and many other factors.

What are the physical properties of 1-iodo-3,5-bis (trifluoromethyl) benzene

1 - iodo - 3,5 - bis (trifluoromethyl) benzene is an organic compound with unique physical properties. Its shape is usually colorless to light yellow liquid, which is relatively stable at room temperature and pressure. The boiling point of this substance is about 190 - 195 ° C. The exact value of the boiling point may vary depending on the experimental conditions and measurement methods. The boiling point is related to the intermolecular force. The presence of iodine atoms and trifluoromethyl in this compound affects the intermolecular force, causing the boiling point to be in a specific range.
Its melting point is about -30 ° C. The characteristics of the melting point reflect the temperature conditions of the molecular transition between solid and liquid states. The characteristics of the molecular structure of the compound determine its melting point. Trifluoromethyl has strong electronegativity, which affects the intermolecular forces, thereby affecting the melting point.
The density of 1-iodo-3,5-bis (trifluoromethyl) benzene is about 1.95 g/cm ³. The density is one of the characteristics of the substance, which is affected by the molecular weight and the way of molecular accumulation. In this compound, the atomic weight of iodine is large, and the structure of trifluoromethyl affects the molecular accumulation, which together determines its density.
The compound is insoluble in water. Due to the hydrophobic trifluoromethyl in its molecule, the force between it and water molecules is weak and it is difficult to miscible with water. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, etc. Due to the principle of similarity and phase dissolution, it is similar to the molecular structure and polarity of organic solvents, which is conducive to mutual dissolution.
In addition, 1-iodo-3,5-bis (trifluoromethyl) benzene has a low vapor pressure and evaporates slowly at room temperature. Vapor pressure is related to intermolecular forces and temperature. Low vapor pressure indicates that intermolecular forces are strong, and higher energy is required to transform it from liquid to gas. This property should be taken into account when storing and using this compound.

What are the application fields of 1-iodo-3,5-bis (trifluoromethyl) benzene

1-Iodo-3,5-bis (trifluoromethyl) benzene, that is, 1-iodo-3,5-bis (trifluoromethyl) benzene, is widely used in the field of organic synthesis.
First, it can be used as a key synthetic building block when building complex organic molecular structures. Because of the iodine atom and trifluoromethyl on the benzene ring, the iodine atom is highly active, and it is easy to couple with other organic groups through many classical reactions, such as the Ullmann reaction and the Suzuki reaction, etc., to achieve the construction of carbon-carbon bonds, which can help synthesize organic compounds with specific structures and functions. For example, in order to synthesize organic materials with special photoelectric properties, 1-iodine-3,5-bis (trifluoromethyl) benzene can be coupled with compounds containing alkenyl or aryl boronic acids through the Suzuki reaction to obtain the target product, which provides the possibility for the creation of new photoelectric materials.
Second, in the field of pharmaceutical chemistry, this compound also has extraordinary performance. The introduction of trifluoromethyl can significantly change the physical and chemical properties of molecules, such as lipophilicity and metabolic stability. Therefore, it can be used as an important structural fragment and integrated into potential drug molecules to optimize the drug-forming properties. For example, when developing small molecule drugs targeting specific disease targets, 1-iodine-3,5-bis (trifluoromethyl) benzene is used as a starting material, and other active groups are introduced through multi-step reactions, which is expected to obtain drug candidates with good activity and stability.
Third, in terms of materials science, 1-iodine-3,5-bis (trifluoromethyl) benzene can be used to prepare high-performance polymer materials. Through the polymerization reaction it participates in, it can endow the polymer with unique properties, such as excellent thermal stability, chemical stability and low dielectric constant. For example, in the preparation of insulating materials for the field of microelectronics, polymeric materials synthesized through polymerization can meet the stringent requirements for material properties in this field by using their special structure.