1-Iodo-3-Methoxybenzene

Fengxi Chemical

Specifications

HS Code	715218
Chemical Formula	C7H7IO
Molar Mass	236.034 g/mol
Appearance	Solid (likely white or off - white)
Physical State At Room Temperature	Solid
Melting Point	Data needed
Boiling Point	Data needed
Solubility In Water	Insoluble (organic compound, non - polar groups dominate)
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, dichloromethane
Density	Data needed
Odor	Typical organic odor (data may vary)
Stability	Stable under normal conditions but can react with strong oxidizing agents

As an accredited 1-Iodo-3-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 1 - iodo - 3 - methoxybenzene packaged in a sealed glass bottle.
Storage	1 - iodo - 3 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and exposure to air and moisture. Label the container clearly to avoid misidentification. This storage method helps maintain its chemical stability and reduces safety risks.
Shipping	1 - iodo - 3 - methoxybenzene is shipped in well - sealed, corrosion - resistant containers. These are carefully packed in sturdy outer boxes with appropriate cushioning. Shipments follow strict chemical transportation regulations to ensure safety.

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General Information

Historical Development

1 - Iodo - 3 - Methoxybenzene is an organic compound. It has been traced back to its origin for a long time. In the past, the chemical masters studied the properties and changes of substances, and explored this compound one after another. At the beginning, it was limited to skills and cognition, but little was known about its preparation and characteristics.
After the age of delay, science and technology advanced, and chemical methods improved. Scholars have made many achievements in reaction mechanism and synthesis path. The method of preparing 1 - Iodo - 3 - Methoxybenzene has become more complicated and accurate, and the yield and purity have also been improved.
Today, this compound is widely used in the fields of medicine and materials. Reviewing its historical evolution, it really depends on the unremitting research of scholars of all dynasties to obtain today's cognition and application, adding a bright pearl to the road of chemistry.

Product Overview

1 - Iodo - 3 - Methoxybenzene is an organic compound. Its color may be colorless to light yellow liquid, with a special odor. The structure of this compound, on the benzene ring, the iodine atom and methoxy group are one bit each, and the layout is consistent.
Its preparation method may be through a specific chemical reaction process. In the field of organic synthesis, specific reagents and conditions are often used to prompt the reaction of related raw materials to obtain this product.
1 - Iodo - 3 - Methoxybenzene is quite useful in the research of organic chemistry and chemical production. It is a key intermediate in organic synthesis and can be converted into a variety of derivatives through various reactions, which are used in the preparation of medicines, pesticides and fine chemicals, etc. It is of great significance to promote the development of organic synthetic chemistry.

Physical & Chemical Properties

1-Iodo-3-Methoxybenzene, organic compounds are also. Its physical properties, at room temperature, are liquid, transparent in color, and have a slightly specific smell. Its boiling point is quite high, about 200 degrees. This characteristic makes it possible to use distillation when separating and purifying. As for the density, it is slightly heavier than water, placed in water and sank at the bottom.
In terms of its chemical properties, iodine atoms are highly active and can participate in nucleophilic substitution reactions. The presence of methoxy groups affects the electron cloud distribution of the benzene ring, increasing the density of the electron cloud adjacent to the benzene ring, which is conducive to the occurrence of electrophilic substitution reactions. And its stability is acceptable under normal conditions, but when it encounters strong oxidizing agents, strong acids and bases, etc., it will also undergo corresponding chemical reactions, exhibiting rich chemical changes. It is of great value for research and application in the field of organic synthesis.

Technical Specifications & Labeling

1 - Iodo - 3 - Methoxybenzene is also a product of transformation. Its technical quality (product quality) is essential. If you want to create this product, you must abide by the law of precision. First, the quality of raw materials must be good and good, so as to ensure its quality. On the contrary, the quality, strength, etc., all need to be controlled. If the heat is not good, the quality of the product or the quality.
Its quality should not be ignored either. On the bright surface, it is necessary to determine its chemical and physical properties, such as melting and boiling, solubility, etc. On the package, there also needs to be a clear label, indicating the product name, quality, and batch, so that it can be tracked. In this way, the products of 1-Iodo-3-Methoxybenzene can be guaranteed to be the same, and they can be used for engineering and scientific research.

Preparation Method

To prepare 1 - Iodo - 3 - Methoxybenzene, the method is as follows:
Raw materials and production process: Using m-methoxybenzene as the starting material, through diazotization reaction, this is the key step. Take an appropriate amount of m-methoxybenzene, dissolve it in dilute acid, cool it to a specific low temperature, and slowly add sodium nitrite solution dropwise to generate diazonium salts. This process requires precise temperature control and drip speed to prevent side reactions.
Reaction steps: After the diazonium salt is formed, add potassium iodide solution, the diazonium group is replaced by iodine atoms, and the crude product of 1 - Iodo - 3 - Methoxybenzene is precipitated. This reaction needs to be fully stirred to ensure complete reaction. Catalytic mechanism: In the reaction, sodium nitrite interacts with acid to form nitrous acid, which reacts with m-methoxyaniline to form diazonium salts. Iodine ions in potassium iodide attack diazonium salts as nucleophiles to achieve group substitution. The whole process requires strict control of conditions to obtain a purer product.

Chemical Reactions & Modifications

Yu Taste is dedicated to the research of chemical substances, and recently focused on 1-Iodo-3-Methoxybenzene. Its chemical reaction and modification are really the key.
In chemical reactions, the iodine atom of 1-Iodo-3-Methoxybenzene is active and is often the starting point of the reaction. When it encounters nucleophiles, iodine is easily replaced, opening the formation of new bonds. In this process, the control of reaction conditions is of paramount importance, and temperature and solvent can affect the rate of reaction and the purity of the product.
When it comes to modification, in order to make it have different properties, different groups are often introduced. If a nitrogen-containing group is connected, it can change its electron cloud distribution and affect its chemical activity. Or add long-chain alkyl groups to improve its solubility and lipophilicity. This is a way to improve the application value of 1-Iodo-3-Methoxybenzene, and I will continue to study it to explore more possibilities.

Synonyms & Product Names

1-Iodo-3-Methoxybenzene, the synonyms and trade names of this thing are important items in my chemical research. Looking at the ancient books, the names of chemical substances often vary with the changes of time and regional differences.
In today's chemical industry, 1-Iodo-3-Methoxybenzene also has another name. In its synonyms, or named according to its structural characteristics, such as benzene ring as the base, iodine and methoxy as the substituent, or named after its derivation path. As for the name of the product, each merchant has its own ingenious name in order to recognize its characteristics and facilitate its promotion.
There is a selling point of exquisite craftsmanship, giving the product a unique name, so that the smell can associate with its excellent quality; there are also application field-oriented, naming reveals its scope of application. Our chemical researchers need to be familiar with many terms of this object in order to facilitate academic communication, experimental exploration, accurately identify and use 1-Iodo-3-Methoxybenzene, and promote the process of chemical research.

Safety & Operational Standards

1 - Iodo - 3 - Methoxybenzene is a chemical commonly used in organic synthesis. During its experimental operation and use, safety and operating practices are of paramount importance and must not be taken lightly.
The first word is safe, 1 - Iodo - 3 - Methoxybenzene may have certain toxicity and irritation. If it comes into contact with the skin, rinse with a large amount of water immediately, and then seek medical treatment as appropriate to avoid residual diseases. If it enters the eyes, it is necessary to rinse quickly with a large amount of flowing water or normal saline to ensure that there is no residue in the eyes, and then seek medical attention in time. When operating, it must be carried out in a well-ventilated environment. The best choice is to operate in a fume hood, which can effectively avoid inhaling its volatile gaseous substances, thereby reducing the damage to the respiratory tract.
Furthermore, when discussing the operating specifications, when using 1-Iodo-3-Methoxybenzene, it is necessary to use clean and dry appliances to prevent impurities from mixing and affecting its quality and experimental results. The weighing process should be accurate and accurate. The appropriate amount of medicine should be accurately weighed according to the experimental needs to avoid waste and prevent experimental deviation due to dosage deviation. When storing, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical properties, contact with oxidants may cause a violent reaction, and the storage temperature should not be too high to avoid deterioration.
After the experiment is completed, the unused 1-Iodo-3-Methoxybenzene should not be discarded at will, and should be properly disposed of in accordance with the laboratory waste disposal regulations. The utensils used should also be cleaned in time to remove residual drugs for next use. Only by strictly following safety and operating practices can we ensure the smooth progress of the experiment and protect the safety and health of the experimenters.

Application Area

1 - Iodo - 3 - Methoxybenzene is an organic compound with important applications in many fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to participate in the construction of molecular structures with unique pharmacological activities through specific chemical reactions, helping to create new drugs and contributing to human health. In the field of materials science, with its special chemical structure, it can participate in the preparation of materials with specific optoelectronic properties, such as for advanced material systems such as organic Light Emitting Diode (OLED), to promote the progress of display technology. Furthermore, in the field of fine chemicals, this compound can also be used to synthesize high-end fragrances or special functional additives to improve the quality and performance of related products. All these applications demonstrate the key value of 1-Iodo-3-Methoxybenzene in various fields, and its research and development prospects are broad, which is expected to bring new opportunities for the development of many industries.

Research & Development

In the field of organic chemistry, I have studied the genus of halogenated aromatics, and now I have detailed the research and progress of 1-Iodo-3-Methoxybenzene.
Initially, 1-Iodo-3-Methoxybenzene was prepared, often starting with m-methoxyaniline, after diazotization, and then co-reaction with potassium iodide to obtain this product. Although this approach can be achieved, the steps are cumbersome and the stability of diazoides is poor, so the operation needs to be careful.
Later, a new path was developed, and m-methoxybenzene was used as the base, and iodine was introduced by halogenation reaction. After many tests, the temperature, time and amount of reagents of the reaction were adjusted, and the optimum conditions were obtained, and the yield was higher than before.
Its application is also wide, and it is used in medicine and pharmaceuticals. It is a key intermediate and can help form molecules with special efficacy. In agrochemistry, it is involved in the production of new pesticides to increase their efficacy and environmental protection.
Looking forward, I hope to find a simpler, more efficient and green method. For example, with the new achievements of catalysis, the energy consumption of the reaction can be reduced, and the generation of pollution can be reduced, so that the preparation and use of 1-Iodo-3-Methoxybenzene can be more sustainable and more effective in various fields.

Toxicity Research

Study on toxicity of 1-Iodo-3-Methoxybenzene
The nature of all poisons is related to the safety of living beings, and it needs to be carefully investigated in the production and use of substances. This study 1-Iodo-3-Methoxybenzene the toxicity of this chemical substance cannot be ignored.
At first, looking at its structure, iodine and methoxy are attached to the benzene ring, or because of its functional group, the biological effect is different. In animal experiments, after entering the body, or disturbing the physiological order. If ingested orally, the stomach or suffer from it, the mucosa is damaged, and the transportation and transformation are abnormal. And it may enter the bloodstream, reach the viscera, liver, kidney or be the target, and the metabolic ability may decline.
It is also tested by cell experiments. When cells are cultured in vitro, the addition of this substance can show changes in cell morphology and proliferation. Or cause apoptosis, affect gene expression, and block biochemical pathways. Although the specific toxicity mechanism is not fully understood, various signs suggest that it poses a potential threat to the living system. To study the toxicity of this substance, in order to avoid harm and seek profit, it can be used for industrial and scientific research purposes to maintain health and environmental safety.

Future Prospects

I have tried to study this material in 1-Iodo-3-Methoxybenzene. Looking at the present, although there have been various achievements, the road ahead is still long, and the future prospects are also quite promising.
This product may open up new paths in the field of chemical industry. With its characteristics, it may be used to create new materials. Its exquisite structure can lead to unique properties, and it may have extraordinary performance in electronic and optical materials.
It also has potential in the process of pharmaceutical research and development. Its chemical activity may become a key element in the synthesis of new drugs, bringing new opportunities to overcome difficult diseases.
Furthermore, in the field of catalytic reactions, it may be able to emerge. Its unique chemical properties may act as an efficient catalyst to improve the efficiency and selectivity of the reaction.
In the future, we should deeply study its mechanism and expand the scope of application. With unremitting efforts, we hope to make 1-Iodo-3-Methoxybenzene shine brightly and bring benefits to the world.

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Frequently Asked Questions

As a leading 1-Iodo-3-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-iodo-3-methoxybenzene?

1-Iodo-3-methoxybenzene, Chinese name 1-iodo-3-methoxybenzene, is an organic compound with unique chemical properties.
It has the characteristics of halogenated aromatics, high activity of iodine atoms, and can occur a variety of reactions. When encountering nucleophiles, iodine is easily replaced. Like reacting with sodium alcohol, iodine can be replaced by alkoxy groups to form new ether compounds. This substitution reaction is based on the nucleophilic substitution mechanism. The nucleophilic reagents attack the iodine-carbon atoms on the benzene ring, and the iodine ions leave to achieve substitution.
Because of the benzene ring conjugate system, 1-iodo-3-methoxybenzene has a certain stability, and the methoxy group is the power supply group, which increases the electron cloud density of the benzene ring and improves the activity of electrophilic substitution reaction. In case of electrophilic reagents, the reaction is prone to occur in the ortho and para-position of the methoxy group. For example, in the nitration reaction, the nitro group will mainly enter the ortho and para-position of the methoxy group to generate the corresponding nitro substitution products.
In addition, 1-iodo-3-methoxybenzene can also participate in the metal-catalyzed coupling reaction. Under the action of metal catalysts such as palladium, it is coupled with compounds containing unsaturated bonds to form carbon-carbon bonds and form complex organic molecules. It is widely used in the field of organic synthesis and can synthesize complex organic compounds such as drugs and natural products.
In short, 1-iodo-3-methoxybenzene has rich chemical properties due to the existence of iodine atoms and methoxy groups. It plays an important role in many reactions in organic synthesis and provides the possibility for the synthesis of various organic compounds.

What chemical reactions are 1-iodo-3-methoxybenzene commonly used in?

1-Iodo-3-methoxybenzene (1-iodo-3-methoxybenzene) has a wide range of uses in various chemical reactions.
First, it is often seen in nucleophilic substitution reactions. Due to the high activity of iodine atoms, it is easy to be attacked and left by nucleophiles. For example, in alkaline environments, it can react with alkoxides, phenolates or amine nucleophiles. Taking alkoxides as an example, the alkoxides negative ions launch a nucleophilic attack on the carbon site attached to the iodine atom of 1-iodine-3-methoxybenzene by virtue of the lone pair electrons on the oxygen atom, and the iodine ions leave to obtain ether derivatives. In organic synthesis, this reaction is an important means for constructing carbon-oxygen or carbon-nitrogen bonds, and helps to prepare many compounds containing special functional groups.
Second, metal-catalyzed coupling reactions are also commonly used. For example, palladium-catalyzed Suzuki coupling reaction, 1-iodine-3-methoxybenzene and arylboronic acid can be coupled to form biaryl compounds in the presence of palladium catalysts, bases and ligands. This reaction is of great significance in the fields of drug synthesis and materials science. In drug research and development, it can be used to build complex aromatic ring structures, laying the foundation for the creation of drug molecules with specific biological activities; in materials science, it is helpful for the synthesis of organic materials with special optoelectronic properties.
Third, in aromatic electrophilic substitution reactions, methoxy groups act as ortho and para-sites, which can increase the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by electrophilic reagents. For example, when nitrification is carried out, the electrophilic reagent nitro positive ions will preferentially attack the ortho and para-sites of the methoxy group to generate corresponding nitro substitution products. This property helps to introduce more functional groups on the benzene ring, enrich the structure of the compound, and provide various possibilities for the subsequent synthesis of more complex organic molecules.
In summary, 1-iodine-3-methoxybenzene plays an important role in many key reactions in organic synthesis, promoting the development of drugs, materials and many other fields.

What is the preparation method of 1-iodo-3-methoxybenzene?

The method of preparing 1-iodine-3-methoxybenzene used to follow the following methods in the past. First, m-methoxyaniline was used as the starting material and prepared by diazotization and iodine substitution reaction. First take m-methoxyaniline, dissolve it in an appropriate amount of dilute acid, such as hydrochloric acid, and cool it to a low temperature, generally 0-5 ° C. In this low temperature environment, slowly add sodium nitrite solution dropwise, carry out diazotization reaction, and generate diazonium salts. This process must be precisely controlled to prevent the decomposition of diazonium salts. The resulting diazonium salt solution is mixed with potassium iodide solution, heated and reacted, and the diazonium group is replaced by iodine atoms to obtain 1-iodine-3-methoxybenzene. However, in this approach, the diazotization reaction needs to be carefully controlled, the amount of sodium nitrite and the dripping speed are greatly affected, and the stability of diazonium salt is not good, and side reactions will occur if there is a little carelessness.
Second, m-methoxybenzoic acid is used as the starting material. First, m-methoxybenzoic acid is converted to m-methoxybenzoyl chloride, which is often achieved by reagents such as sulfoxide chloride. Subsequently, m-methoxybenzoyl chloride is converted into m-methoxyaniline by Hoffman degradation reaction, and then the target product is prepared by diazotization and iodine reaction as described above. This path step is slightly complicated, but the reaction conditions of each step are relatively mild and easy to control.
Another method is to use m-methoxybenzene as the raw material. First nitrate m-methoxybenzene to obtain m-methoxynitrobenzene. After reduction reaction, the nitro group is converted into an amino group to form m-methoxyaniline, and then 1-iodo-3-methoxybenzene is obtained by diazotization and iodine substitution. In the nitration step, the mixed acid ratio of nitric acid and sulfuric acid, the reaction temperature and other factors have a great impact on the nitro position and yield of the product, and need to be carefully adjusted.
All production methods have advantages and disadvantages. Experimenters should choose the appropriate preparation method according to the actual situation, such as raw material availability, equipment conditions, cost considerations, etc.

What are the physical properties of 1-iodo-3-methoxybenzene?

1-Iodo-3-methoxybenzene, Chinese name 1-iodine-3-methoxybenzene, is an organic compound, which is widely used in chemical industry, medicine and other fields. Its physical properties are detailed as follows:
- ** Appearance properties **: At room temperature, 1-iodine-3-methoxybenzene is a colorless to light yellow liquid, which is clear and transparent. This state is intuitively easy to distinguish and identify. In chemical production and experimental operations, it can preliminarily judge the purity and state of the substance according to its appearance.
- ** Odor **: It has a special organic smell, but its taste is not strong. Compared with some organic compounds with strong irritation, the smell is relatively mild. This odor characteristic is also an important reference in actual operation. If the odor is abnormally strong or changed, or suggests that the substance has deteriorated or contains impurities.
- ** Melting Point and Boiling Point **: The melting point is about -3 ° C, and the boiling point is 243 - 244 ° C. The melting point is low, and it is liquid at room temperature; the boiling point is high, indicating that a higher temperature is required to vaporize it. In chemical operations such as distillation and separation, the melting point and boiling point data are crucial, so that the temperature can be precisely controlled to achieve material separation and purification.
- ** Density **: The density is about 1.728 g/mL, which is larger than water. When it comes to liquid-liquid separation operations, depending on the density difference, 1-iodine-3-methoxybenzene will sink to the bottom of the water, which is conducive to separation from water and other low-density liquids by means of liquid separation.
- ** Solubility **: Slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. This solubility characteristic is based on its molecular structure and polarity. Because water is a polar solvent, the polarity of 1-iodine-3-methoxybenzene molecules is relatively weak, so it is slightly soluble; while the polarity of organic solvents is similar to that of the compound, and it is easily soluble in such solvents according to the principle of "similar miscibility". In organic synthesis experiments, this solubility is often used to select a suitable solvent to dissolve the substance to advance the reaction or perform product separation.

What are 1-iodo-3-methoxybenzene common application fields?

1-Iodo-3-methoxybenzene, which is 1-iodine-3-methoxybenzene, is widely used in the field of organic synthesis.
First, it is often used as a key intermediate in the field of medicinal chemistry. Due to the characteristics of iodine atoms and methoxy groups in its structure, it can participate in various chemical reactions and help build complex drug molecular structures. Taking the synthesis of an anti-cancer drug as an example, 1-iodine-3-methoxybenzene introduces key active groups through specific reaction steps, and after multi-step transformation, generates drug molecules with anti-cancer activity. Its methoxy group can affect the electron cloud distribution and spatial configuration of molecules, thereby regulating the interaction between drugs and targets, and improving drug efficacy.
Second, in the field of materials science, it also shows important value. In the synthesis of organic optoelectronic materials, 1-iodine-3-methoxybenzene can be used as a basic raw material. The presence of iodine atoms can change the electron transport properties of materials, while methoxy groups can affect the stability and solubility of materials. After rational design and reaction, excellent organic Light Emitting Diode (OLED) materials or organic solar cell materials can be prepared, providing assistance for the research and development of new optoelectronic devices.
Furthermore, in the field of total synthesis of natural products, 1-iodine-3-methoxybenzene is often one of the starting materials. Natural products have complex structures and unique biological activities. During the synthesis process, the carbon skeleton and functional groups of natural products need to be gradually constructed with the help of the reactivity of this compound. For example, when a certain type of natural product with antibacterial activity is fully synthesized, 1-iodine-3-methoxybenzene is combined with other reagents in multiple steps to realize the total synthesis of natural products, laying the foundation for in-depth research on the biological activity and mechanism of action of natural products.
In summary, 1-iodine-3-methoxybenzene is an important organic compound in the fields of total synthesis of drugs, materials and natural products, which is of great significance for promoting the development of various fields.