What is the chemical structure of 1-iodo-3- (methylsulfanyl) benzene?
1 - iodo - 3 - (methylsulfanyl) benzene is also a compound. The reaction can be determined as follows:
This compound is based on benzene. Benzene is a six-membered carbon atom, and it is formed into a flat surface in the form of six-carbon atoms, which has a special aromaticity.
In the 1-carbon position of benzene, there is an iodine atom. The iodine atom is a prime atom, whose atomic number is large, and the atomic weight of the phase is also large. It has the properties of the phase. It can often be used as a deradicalization in the reaction.
And in the 3-carbon position of benzene, it is connected to the (methylsulfanyl) group. In this group, the sulfur atom is the methyl phase, and the carbon phase of the benzene atom is the carbon phase. The sulfur atom is slightly more stable than the carbon atom, and its daughter has a lone son, so that this group exhibits a certain degree of nucleation or donation in the antidote.
Therefore, the chemical reaction of 1-iodo-3 - (methylsulfanyl) benzene is formed by benzene, iodine atom and (methylsulfanyl) group, and the parts are influenced by each other, which determines the physical and chemical properties of the chemical compound. It may have its specific uses and antidote characteristics in the field of synthesis and other fields.
What are the main uses of 1-iodo-3- (methylsulfanyl) benzene?
1-Iodo-3- (methylsulfanyl) benzene, Chinese name 1-iodine-3-methylthiobenzene, is widely used.
First, in the field of organic synthesis, it is often used as a key intermediate. Because of its high reactivity of both iodine atoms and methyl thio groups in the molecule, it can participate in a variety of chemical reactions. For example, in palladium-catalyzed cross-coupling reactions, iodine atoms can be coupled with other organometallic reagents to help build carbon-carbon bonds. This reaction is of great significance in the synthesis of complex organic molecular architectures and helps to synthesize aromatic compounds with diverse structures. These compounds are important in the fields of medicinal chemistry and materials science.
Second, in the process of drug development, 1-iodine-3-methylthiobenzene plays a unique role. Its chemical structure properties make it an important starting material for the design and synthesis of new drugs. Medicinal chemists can modify and modify the compound by introducing other functional groups, and then adjust its biological activity and pharmacokinetic properties, in order to obtain lead compounds with specific pharmacological activities and can treat specific diseases, laying the foundation for the birth of new drugs.
Third, in the field of materials science, this compound also has a place. Due to its sulfur atom and aromatic ring structure, it shows potential in the preparation of organic semiconductor materials. Through rational molecular design and synthesis strategies, it can be integrated into the material system to improve the electrical and optical properties of materials, providing the possibility for the development of new high-performance organic electronic materials, such as organic Light Emitting Diodes, organic field effect transistors, etc., to promote technological innovation in the field of materials science.
What are the physical properties of 1-iodo-3- (methylsulfanyl) benzene?
1-Iodo-3- (methylsulfanyl) benzene, Chinese name 1-iodine-3-methylthiobenzene, this is an organic compound. Looking at its physical properties, it usually appears liquid at room temperature and pressure, which is caused by the specific conditions of intermolecular forces. It has a certain degree of volatility, and when placed in the air, some molecules can escape the liquid surface.
Its color is almost colorless to light yellow. This color characteristic may be related to the electron transition in the molecular structure. The molecular structure causes it to absorb and reflect specific wavelengths of light, resulting in this color.
Smell it, it has a special odor, which is derived from the chemical properties of groups such as methylthio, and the unique chemical structure of methylthio gives this odor characteristic to the compound.
As for solubility, it is difficult to dissolve in water because its molecules are non-polar or weakly polar, and water is a polar solvent. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in common organic solvents, such as ethanol, ether, chloroform, etc., because these organic solvents and 1-iodine-3-methylthiobenzene molecules can form van der Waals forces and other interactions, so as to achieve dissolution. In addition, the density of the compound may be slightly higher than that of water, and when mixed with water, it will sink to the bottom of the water. This density characteristic is closely related to its molecular composition and structure. The presence of heavier atoms such as iodine atoms in the molecule increases the mass of the substance per unit volume.
What are the synthesis methods of 1-iodo-3- (methylsulfanyl) benzene?
1-Iodo-3- (methylsulfanyl) benzene is 1-iodo-3-methylthiobenzene. There are many ways to synthesize this compound, which are described in detail below.
One of them is to use 3-methylthioaniline as the starting material. Shilling 3-methylthioaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. This reaction needs to be strictly controlled at temperature to prevent the decomposition of diazonium salts. Subsequently, the diazonium salt is mixed with potassium iodide solution, and the diazonium group is replaced by an iodine atom to obtain 1-iodo-3-methylthiobenzene. In this process, the control of the conditions of the diazotization reaction is extremely critical, and factors such as temperature and the proportion of reactants will affect the reaction process and product purity.
The second can be started from 3-bromoanisulfide. In the presence of metal catalysts such as palladium catalysts, and iodizing reagents such as cuprous iodide, under the action of suitable solvents and bases, a halogen atom exchange reaction occurs. Among them, the choice of solvent, the type and amount of base, and the activity of the catalyst all have a significant impact on the reaction effect. A suitable solvent can promote the dissolution and mass transfer of the reactants, while a base can help to adjust the pH of the reaction system and ensure the smooth progress of the reaction.
Or 3-chlorobenzyl sulfide is used as a raw material, and potassium iodide is added in a specific organic solvent to heat the reaction. The phase transfer catalyst can promote the transfer of ionic reactants between two incompatible phases and increase the reaction rate. This reaction requires attention to temperature control. If the temperature is too high or too low, it may lead to side reactions or slow reaction rates.
In addition, 3-methylthiobenzoic acid is used as the starting material, which is first converted into the corresponding acyl chloride, and then converted into aryl iodide through a series of reactions, and finally the target product 1-iodine-3-methylthiobenzene can be obtained. This route has a little more steps, and each step of the reaction requires fine operation to ensure the yield and product quality of each step, and avoid the formation of impurities.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the cost of raw materials, the difficulty of reaction conditions, product purity and yield, and choose a reasonable synthesis method.
What are the precautions for storing and transporting 1-iodo-3- (methylsulfanyl) benzene?
1 - iodo - 3 - (methylsulfanyl) benzene is an organic compound. During storage and transportation, several precautions need to be carefully observed.
First storage environment. This compound should be stored in a cool, dry and well-ventilated place. Due to high temperature, or its chemical properties change, it may cause decomposition or other chemical reactions. If it is in a humid environment, moisture or interaction with the compound will affect its purity and quality.
Second discussion on packaging materials. When using suitable packaging materials to prevent leakage. If storing in glass containers, pay attention to its chemical resistance and prevent damage to the container due to collision. If using plastic packaging, the selected plastic should not react with the compound to ensure the integrity of the package.
When transporting, safety is of paramount importance. This compound may be dangerous, and it needs to be operated in accordance with relevant regulations and standards during transportation. Transportation personnel should be familiar with its characteristics and emergency response methods, and can respond quickly and properly in the event of an accident such as leakage.
At the same time, avoid co-storage and co-transportation with oxidizing substances, strong acids and alkalis, etc. Because its chemical structure contains iodine and thiomethyl, it may cause severe oxidation reactions in case of oxidizing substances; in case of strong acids and alkalis, chemical reactions may also occur, endangering transportation safety.
Storage and transportation of 1-iodo-3 - (methylsulfanyl) benzene requires careful attention to the environment, packaging, personnel handling, and chemical compatibility to ensure process safety and maintain compound quality.