1 Iodo 3 Trifluoromethyl Benzene

1-Iodo-3- (trifluoromethyl) benzene, Chinese name 1-iodo-3- (trifluoromethyl) benzene, its main uses are as follows:
This compound is widely used in the field of organic synthesis. First, it can be used as an important synthetic intermediate. Because of its high activity of iodine atoms in its structure, it can participate in many nucleophilic substitution reactions. For example, it reacts with carbon-containing nucleophiles, such as organometallic reagents (Grignard reagent, lithium reagent, etc.), to form carbon-carbon bonds, which is helpful in the synthesis of complex aromatic compounds and is of great significance in the fields of medicinal chemistry and materials science. Taking drug development as an example, nucleophilic substitution reactions can be used to access specific functional groups to endow target compounds with specific biological activities.
Second, it also has important uses in material synthesis. Due to the introduction of trifluoromethyl, it can significantly change the physical and chemical properties of molecules, such as enhancing the lipophilicity, thermal stability and chemical stability of compounds. When preparing high-performance organic materials, such as optoelectronic materials and polymer materials, 1-iodine-3- (trifluoromethyl) benzene can be used as a key monomer to introduce trifluoromethyl into the main chain or side chain of the polymer through polymerization or other reaction paths to improve the properties of the material.
Thirdly, in the field of organometallic chemistry, this compound can participate in metal-catalyzed coupling reactions, such as Suzuki coupling reaction, Heck coupling reaction, etc. Through such reactions, various functional groups can be precisely introduced into the benzene ring to realize the construction of complex organic molecules, providing a powerful synthesis method for new functional materials, total synthesis of natural products and other fields.

1-Iodo-3- (trifluoromethyl) benzene, Chinese name 1-iodine-3- (trifluoromethyl) benzene, is an organic compound with specific physical properties, detailed as follows:
1. ** Properties **: Under normal conditions, this compound is mostly colorless to light yellow liquid, with a pure, transparent appearance and no visible impurities. This property is related to the properties of the benzene ring, iodine atom and trifluoromethyl in the molecular structure. The combination of these groups allows the molecule to exhibit specific physical aggregation states and optical properties.
2. ** Boiling point **: Its boiling point is about 180 - 182 ° C. The intermolecular force has a significant effect on the boiling point. The presence of benzene ring provides a certain van der Waals force. The iodine atom and trifluoromethyl increase the molecular mass and polarity, enhance the intermolecular force, and cause the boiling point to rise.
3. ** Melting point **: The melting point is about -35 ° C. Molecular arrangement regularity and force strength determine the melting point. In the molecular structure of the compound, although the benzene ring provides a certain planar regularity, the spatial distribution of trifluoromethyl and iodine atoms destroys part of the regularity, and the force is moderate, so the melting point is low.
4. ** Density **: The density is about 1.82 g/mL. The density is related to the molecular weight and the degree of packing compactness between molecules. Iodine atoms and trifluoromethyl groups increase the molecular weight, and the specific molecular structure makes the molecule pack compactly, resulting in a higher density.
5. ** Solubility **: Slightly soluble in water, easily soluble in organic solvents, such as ethanol, ether, dichloromethane, etc. Water is a polar solvent. The polarity of this compound is relatively weak due to the influence of benzene ring, iodine atom and trifluoromethyl group. According to the principle of "similar miscibility", it is difficult to dissolve in water; while the polarity of organic solvents is similar to that of this compound, so it can be miscible.
6. ** Vapor pressure **: At a specific temperature, there is a certain vapor pressure, The vapor pressure is related to the tendency of molecules to escape from the liquid surface. The intermolecular force and temperature determine the vapor pressure. When the temperature increases, the molecular energy increases, the escape tendency increases, and the vapor pressure increases.

1 - iodo - 3 - (trifluoromethyl) benzene is m-iodine trifluorotoluene. The common synthesis methods are as follows:
First, m-trifluoromethyl aniline is used as the starting material. First, m-trifluoromethyl aniline is diazotized with sodium nitrite in a hydrochloric acid solution. This reaction needs to be carried out in a low temperature environment to prevent the decomposition of diazonium salts. After the diazotization is completed, the resulting diazonium salt solution is slowly added to the potassium iodide solution, and the reaction is heated. The diazonium group will be replaced by iodine atoms to obtain m-iodine trifluorotoluene. The advantage of this method is that the reaction conditions are relatively mild and the raw materials are relatively easy to obtain. However, the diazotization reaction requires strict control of temperature and reagent dosage, and it is easy to cause side reactions if the operation is not careful.
Second, m-bromotrifluorotoluene is used as the raw material. Under the action of the catalyst, such as palladium catalyst, halogen exchange reaction occurs with potassium iodide. This reaction usually needs to be carried out in an organic solvent, such as N, N-dimethylformamide (DMF). During the reaction, the reaction temperature and time need to be strictly controlled to ensure that the reaction is fully carried out. The advantage of this method is that the operation is relatively simple and the product purity is also high. However, palladium catalyst is expensive, the cost is high, and the catalyst recovery is difficult, which is not conducive to industrial production.
Third, trifluorotoluene is used as the starting material. In the presence of an initiator, a free radical substitution reaction occurs with iodine under light or heating conditions. Although this reaction is simple to operate, the reaction selectivity is poor, and a variety of substituted products are often generated, and the separation and purification are complicated, resulting in relatively low yields. In practical applications, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, yield and product purity according to specific needs and conditions, and choose a suitable synthesis method.

1 - iodo - 3 - (trifluoromethyl) benzene is an organic compound. During storage and transportation, the following general matters should be paid attention to:
One is storage. This compound should be stored in a cool and well-ventilated place. Because heat can easily cause changes in its chemical properties, or even cause danger, it is extremely important to avoid heat. At the same time, it is necessary to ensure that the storage place is dry, because if it encounters water vapor, or chemical reactions such as hydrolysis, it will damage the quality. The storage container must be well sealed to prevent it from evaporating and escaping, and it can also block the intrusion of external impurities. And it should be stored separately from oxidants, strong bases and other substances, because this compound may react violently with these substances, creating a safety hazard.
The second is about transportation. During transportation, the compound must be properly packaged, and the packaging materials used should be able to effectively resist vibration, collision and friction, so as to avoid leakage due to package damage. Transportation vehicles need to be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. The temperature must be strictly controlled during transportation, and it must not be exposed to high temperature environments. And transportation personnel should be familiar with the characteristics and emergency treatment methods of this compound, and in the event of an accident, they can respond quickly and correctly. In short, whether it is storing or transporting 1-iodo-3 - (trifluoromethyl) benzene, safety must be the top priority, and relevant regulations and operating procedures must be strictly followed to ensure the safety of personnel and the environment.

1-Iodo-3- (trifluoromethyl) benzene, Chinese name 1-iodo-3- (trifluoromethyl) benzene, the impact of this substance on the environment and human health cannot be ignored.
At the environmental end, 1-iodo-3- (trifluoromethyl) benzene has a certain volatility, escapes into the atmosphere, or participates in photochemical reactions, affecting the atmospheric chemical balance. Its solubility in water is limited, but once it enters the water body, it is easily adsorbed on suspended particles or sediments due to hydrophobicity, and persists for a long time, which will harm aquatic ecology. It is highly toxic to aquatic organisms, or causes algae, fish and other organisms to suffer growth and development, and even die, breaking the food chain and ecological balance of aquatic ecology. In soil, it will reduce soil microbial activity, inhibit crop nutrient absorption, and affect soil fertility and crop yield and quality.
As for human health, 1-iodine-3- (trifluoromethyl) benzene can be ingested into the body through respiratory tract, skin contact or accidental ingestion. Its vapor irritates the eyes and respiratory mucosa, causing eye pain, tears, cough, breathing difficulties, etc. Long-term exposure may damage the nervous system, causing headaches, dizziness, fatigue, and memory loss. Animal experiments have shown that it may be potentially carcinogenic, and long-term exposure or increased the risk of human cancer. Because of its fat solubility, it is easy to accumulate in human adipose tissue and difficult to excrete. Over time, the accumulation in the body increases and the health risk also increases.
Therefore, when producing and using 1-iodine-3- (trifluoromethyl) benzene, strict safety measures should be taken to reduce its harm to the environment and human health.