1-iodo-4,4,4-trifluorobutane

1-Iodo-4,4,4-trifluorobutane, Chinese name 1-iodo-4,4,4-trifluorobutane, its main uses are as follows:
In the field of organic synthesis, this compound plays a crucial role. Its molecular structure contains iodine atoms and trifluoromethyl, which endows it with unique reactivity. Iodine atoms are excellent leaving groups, which are easy to break off in many chemical reactions, thereby promoting the occurrence of nucleophilic substitution reactions. With this property, chemists can carefully select nucleophilic reagents to achieve the construction of various organic compounds with special structures and functions.
For example, in the process of constructing fluorinated drug molecules, 1-iodine-4,4,4-trifluorobutane can be used as a key synthetic building block. Trifluoromethyl has strong electron-absorbing properties, which can significantly change the electron cloud distribution of molecules, thereby affecting the physical, chemical and biological activities of compounds. After the introduction of trifluoromethyl into many drug molecules, their lipophilicity, metabolic stability and interaction with biological targets are optimized. 1-iodine-4,4,4-trifluorobutane can introduce trifluorobutyl into target molecules through nucleophilic substitution reactions, providing an important way to create new fluorinated drugs.
Furthermore, in the field of materials science, 1-iodine-4,4,4-trifluorobutane also has its uses. Fluorinated organic materials often have excellent chemical stability, low surface energy and excellent electrical properties. 1-iodine-4,4,4-trifluorobutane can be used as a starting material to participate in the synthesis process of polymer materials. Through polymerization or other organic reactions, trifluorobutyl structural units are introduced into the polymer main chain or side chain, thereby endowing the material with unique properties such as waterproof, oil-proof, chemical corrosion resistance, etc., which have potential applications in coatings, plastics, electronic materials and other fields.

1-Iodo-4,4,4-trifluorobutane (1-iodo-4,4,4-trifluorobutane) is an organic compound with unique physical properties. Now let me tell you in detail.
Looking at its properties, under normal temperature and pressure, 1-iodo-4,4,4-trifluorobutane is often a colorless to light yellow transparent liquid. This form is convenient for it to mix and interact with other substances in many chemical reaction systems. Due to the shape of the liquid, the intermolecular contact is more complete and uniform.
When it comes to odor, this substance emits a weak and special odor. Although this odor is not strong and pungent, it is also one of its important physical markers. In a laboratory environment, trained chemical practitioners may use this odor to initially identify this substance.
The boiling point of 1-iodine-4,4,4-trifluorobutane is about 100-105 ° C. The boiling point value indicates the energy conditions required to convert it from a liquid state to a gaseous state. At this temperature, the molecule obtains enough energy to overcome the intermolecular forces and escape from the liquid level to a gaseous state. This boiling point characteristic is of great significance in chemical operations such as distillation and separation, and can be separated and purified according to the difference between its boiling point and the boiling point of other substances.
Its density is about 1.85 g/cm3, which is higher than that of common water (the density of water is about 1 g/cm3). This density characteristic determines that when mixed with less dense liquids such as water, it will sink to the bottom. This phenomenon has a significant impact on operations such as liquid-liquid extraction, which is related to the stratification situation and the design of subsequent separation steps.
In terms of solubility, 1-iodine-4,4,4-trifluorobutane is insoluble in water. Because water is a polar molecule, and 1-iodine-4,4,4-trifluorobutane is relatively weak in polarity, according to the principle of "similar miscibility", the two are insoluble. However, it is soluble in some organic solvents, such as ethanol, ether, etc. This solubility characteristic facilitates its application as a reactant or solvent in organic synthesis reactions, and can participate in various chemical reactions in organic solvent systems.
In addition, the vapor pressure of 1-iodine-4,4,4-trifluorobutane also has a specific value within a certain temperature range. The vapor pressure reflects the difficulty of volatilization. Moderate vapor pressure means that it is volatile at room temperature, but not very volatile. This characteristic not only affects the measures to prevent volatilization loss during storage, but also is related to the supply of reactant vapor in some gas phase reactions.

1-Iodo-4,4,4-trifluorobutane is an organic compound, and the stability of its chemical properties depends on multiple factors. This compound contains C-I bonds and C-F bonds. The bond energy of C-I bonds is relatively low, and the iodine atom is used as the leaving group, which makes this bond easier to break. It exhibits high activity in processes such as nucleophilic substitution reactions, which is one of the important factors affecting its stability.
However, the C-F bond is completely different. Its bond energy is quite high, the fluorine atom is extremely electronegative, and the electrons are tightly bound, which gives a certain stability to the molecular structure. In 1-iodo-4,4,4-trifluorobutane, the electron cloud density of carbon atoms connected to iodine atoms may be reduced due to the strong electron-absorbing effect of fluorine atoms, which further affects the stability of C-I bonds and is more susceptible to attack by nucleophiles.
Under common chemical reaction conditions, if there are nucleophiles, the iodine atoms in 1-iodo-4,4,4-trifluorobutane may be replaced, showing unstable characteristics. However, when there are no specific reaction conditions, properly stored, and no substances that react with it, this compound can remain relatively stable for a certain period of time. If there are active nucleophiles, strong oxidizing agents or high temperatures in the environment, its stability will be greatly reduced, and chemical reactions will easily occur and molecular structures will be changed.
Overall, the chemical stability of 1-iodo-4,4,4-trifluorobutane is not absolute, and will vary depending on the specific environment and reaction conditions. Under suitable conditions, it can maintain a certain stability; but when specific conditions are triggered, or reactions occur rapidly, showing an unstable side.

1-Iodo-4,4,4-trifluorobutane is an organic compound, and the preparation method is common. There are several ends.
First, it can be obtained by reacting 4,4,4-trifluoro-1-butanol with iodizing reagents. Among them, the iodizing reagents are often hydrogen iodide or phosphorus triiodide. Taking hydrogen iodide as an example, 4,4,4-trifluoro-1-butanol and hydrogen iodide under suitable conditions, according to the nucleophilic substitution reaction mechanism, the alcohol hydroxyl group is replaced by an iodine atom to generate 1-iodo-4,4,4-trifluorobutane. When reacting, pay attention to factors such as reaction temperature, proportion of reactants and reaction time. Usually, moderate heating can speed up the reaction rate, but the temperature is too high, or side reactions may occur. And the proportion of reactants needs to be properly prepared to ensure that the reaction proceeds in the direction of generating the target product.
Second, it can be prepared by halogen exchange reaction of halogenated hydrocarbons. For example, 4,4,4-trifluoro-1-chlorobutane is selected to react with iodized salts (such as potassium iodide) in a suitable solvent. This reaction relies on the difference in nucleophilicity of halogen ions. The nucleophilicity of iodine ions is stronger than that of chloride ions, so ion exchange occurs, and chloride ions are replaced by iodine ions to generate 1-iodo-4,4,4-trifluorobutane. The solvent selected must have good solubility to the reactants and products, and does not participate in the reaction, such as acetone. During the reaction process, stirring rate, temperature and other conditions will also affect the reaction process and product yield.
Third, trifluoroethylene and iodine alkanes are used as raw materials and prepared by addition reaction under the action of a specific catalyst. This reaction requires a high catalyst, which needs to be able to effectively catalyze the addition reaction and have good selectivity to reduce side reactions. Control of reaction conditions is also critical, and factors such as temperature and pressure will affect the reaction result. Under suitable temperature and pressure, trifluoroethylene is added to iodine alkanes to generate 1-iodo-4,4-trifluorobutane.
The preparation of 1-iodo-4,4,4-trifluorobutane has advantages and disadvantages. In practice, according to factors such as raw material availability, cost, and product purity requirements, the appropriate method is carefully selected, and the reaction conditions are finely adjusted to obtain satisfactory product yield and purity.

1-Iodo-4,4,4-trifluorobutane is an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Because the compound may be flammable, it may cause combustion risk in case of open flame or hot topic. The warehouse temperature should not be too high, usually not exceeding 30 ° C, to prevent the material from changing its properties due to excessive temperature.
Furthermore, its packaging must be sealed and must not come into contact with air. Because it may react with components in the air, such as oxygen, the quality will change. And it should be stored separately from oxidizers, acids, etc., and should not be mixed. The oxidizing agent is highly oxidizing, and the acid chemistry is active. It coexists with 1-iodo-4,4,4-trifluorobutane, or triggers dangerous chemical reactions.
During transportation, make sure that the container does not leak, collapse, fall, or damage. The means of transportation must follow the specified route and do not stop in residential areas and densely populated areas. Because if it leaks, it may cause harm to the environment and people. When transporting, it should also be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Once there is a situation, it can be dealt with in time.
In conclusion, the storage and transportation of 1-iodo-4,4,4-trifluorobutane must be carried out in strict accordance with regulations, paying attention to details such as environmental, packaging and transportation specifications to ensure safety and prevent problems before they occur.