1 Iodo 4 Methoxybenzene
Iodobenzene

1-Iodo-4-Methoxybenzene

Fengxi Chemical

Specifications

HS Code

272352

Chemical Formula C7H7IO
Molar Mass 234.034 g/mol
Appearance Solid
Melting Point 57 - 60 °C
Boiling Point 255.6 °C at 760 mmHg
Density 1.814 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 108.4 °C
Cas Number 696-62-8

As an accredited 1-Iodo-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - iodo - 4 - methoxybenzene packaged in a sealed, chemical - resistant bottle.
Storage 1 - iodo - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions.
Shipping 1 - iodo - 4 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It's carefully packaged to prevent breakage. Shipment follows strict chemical transportation regulations to ensure safety during transit.
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1-Iodo-4-Methoxybenzene
General Information
Historical Development
1 - Iodo - 4 - Methoxybenzene, the origin of this substance, can be traced back to the journey of chemical exploration in the past. At that time, all the chemical sages worked hard to study the properties and changes of substances.
At the beginning, the exploration of compounds containing iodine and methoxy groups was still in ignorance. After countless attempts and failures, there is a chance to break through. Scholars are determined to find patterns in bottles and jars with perseverance.
With the passage of time, chemical skills have become more and more exquisite. The synthesis of 1 - Iodo - 4 - Methoxybenzene has been crude from the beginning to fine and controllable. The exploration of its reaction conditions and the adjustment of the ratio of raw materials have all condensed the wisdom of predecessors.
Today, 1-Iodo-4-Methoxybenzene has emerged in many fields, but looking back on its historical evolution, it is really a long volume of chemical exploration, inspiring our generation to continue the past and forge ahead on the road of chemistry.
Product Overview
1-Iodo-4-Methoxybenzene, organic compounds are also. Its color may be colorless to light yellow, liquid-like, and has a special odor.
The preparation of this substance often takes p-methoxyaniline as the starting material, and can be obtained by several steps such as diazotization and iodine substitution. In the reaction process, the control of the conditions of each step is very critical, and the temperature and the amount of reagents can affect the purity and yield of the product.
It has a wide range of uses and is often an important intermediate in the field of pharmaceutical synthesis, assisting in the construction of many drug molecules. In the field of materials science, it also has a place and can participate in the preparation of some functional materials.
However, this substance also needs to be properly disposed of, because it has certain chemical activity and potential danger, and safety procedures should be followed during operation to ensure the safety of the experimenter and the safety of the environment.
Physical & Chemical Properties
1-Iodo-4-Methoxybenzene is an organic compound. Its physical properties are solid at room temperature, with a specific melting point and boiling point. Looking at its color, it is often white or off-white, which is closely related to the molecular structure. In terms of chemical properties, iodine atoms are active and prone to substitution reactions. Under suitable conditions, they can react with many reagents to derive a variety of derivatives. The presence of methoxy groups has an impact on the distribution of electron clouds in the benzene ring, which in turn changes its reactivity. This compound has a wide range of uses in the field of organic synthesis, and can be used as an intermediate to participate in the synthesis of drugs, materials, etc. Its unique physical and chemical properties provide chemists with the possibility to explore new reaction paths and create novel compounds, which is of great significance in chemical research.
Technical Specifications & Labeling
1 - Iodo - 4 - Methoxybenzene is an organic compound, which is crucial to its technical specifications and identification (product parameters). In its technical specifications, the purity must reach a very high standard, and the impurity content must be strictly controlled. The appearance should be specific and there should be no deviation.
In terms of identification, key information such as name and chemical formula must be clearly marked on the packaging. The product parameters are also clear, and the molecular weight, melting point, boiling point, etc. have accurate values. These technical specifications and labels (product parameters) are like beacons, guiding the whole process of production and use, ensuring that the product can meet the requirements in all links, play its due effectiveness, and move forward steadily in the chemical industry, laying a solid foundation for subsequent applications.
Preparation Method
If you want to make 1-Iodo-4-Methoxybenzene this product, you need to study the preparation method in detail. The selection of raw materials requires careful selection. You can choose p-methoxyphenol as the starting material and iodine as the halogenating reagent.
Preparation process is as follows: First place p-methoxyphenol in the reaction vessel, add an appropriate amount of solvent, such as dichloromethane, to help it disperse. Subsequently, slowly add iodine, and strictly control the reaction temperature. It should be maintained in the low temperature range to prevent side reactions from occurring.
Reaction step: The two meet, and after the electrophilic substitution reaction, the iodine atom substitutes for the hydrogen atom on the benzene ring to form the target product.
Catalytic mechanism: To accelerate the reaction, an appropriate amount of catalyst, such as ferric chloride, can be added It can activate iodine molecules, making the reaction easier, so that 1-Iodo-4-Methoxybenzene can be efficiently prepared.
Chemical Reactions & Modifications
1 - Iodo - 4 - Methoxybenzene is also an organic compound. Its chemical reaction and modification are the gist of our research.
Looking at the reaction, it can be through the way of nucleophilic substitution. The iodine atom on the aromatic ring is active. When encountering nucleophilic reagents, it is often easy to leave and be replaced by other groups. In this reaction, the reaction conditions are crucial, such as the choice of temperature and solvent, which can affect the rate and yield of the reaction.
As for modification, other functional groups can be introduced on the benzene ring to change its physical and chemical properties. Or increase its solubility, or change its reactivity, are all for the purpose of modification. By properly designing the reaction path, a variety of compounds can be derived from 1-Iodo-4-Methoxybenzene, which can be used in medicine, materials and other fields. We chemists should investigate this mystery carefully, so as to promote the progress of chemistry and make it available to the world.
Synonyms & Product Names
1 - Iodo - 4 - Methoxybenzene is also a chemical substance. Its trade name is the same, and it is important in the field of chemistry. It is the same or methoxyiodobenzene, and the trade name is different depending on the market.
This substance, in the way of chemical synthesis, has many uses. It is often used as a raw material for chemical synthesis. Due to its iodine atom and methoxy group characteristics, it can be used for multiple reactions, such as occasional reactions. It is used for the research of the substance, or it is important to help create new technologies.
Above the market, various merchants issue 1-Iodo-4-Methoxybenzene, and their trade names may be different, but their original names are all chemical ears. Researchers need to be familiar with the same product names in order to improve research, operation and business practices, so as to solve the risk of confusion.
Safety & Operational Standards
1 - Iodo - 4 - Methoxybenzene is a compound commonly used in organic synthesis. Its preparation and use are related to safety and operation standards, and it is necessary to be careful.
In the preparation process, the selection and ratio of raw materials are extremely critical. The reagents used may be toxic and corrosive, such as iodide and methoxy-containing raw materials. When taking it, when taking it according to the accurate method, and operate it in a well-ventilated environment to prevent the accumulation of harmful gases and endanger personal safety.
During the reaction process, the temperature, pressure and reaction time must be precisely controlled. If the temperature is too high, the reaction may go out of control, triggering the risk of explosion; if the temperature is too low, the reaction will be slow and affect the yield. Therefore, suitable heating and temperature control equipment is required to ensure that the reaction is carried out under suitable conditions. At the same time, the stirring speed should not be underestimated, which is related to the full mixing of the reactants, which in turn affects the reaction process.
In the product separation and purification stage, the commonly used methods of distillation and extraction have their own operating points. During distillation, the accurate determination of boiling point and the collection of fractions must be just right; the solvent used for extraction should consider its solubility and toxicity with the product, avoid the introduction of new impurities, and pay attention to prevent solvent volatilization and leakage during the operation process.
In terms of storage, 1-Iodo-4-Methoxybenzene should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its flammability and chemical activity, improper storage can easily lead to safety accidents. After taking it, it must be sealed and stored to prevent it from deteriorating in contact with air, moisture, etc.
When using 1-Iodo-4-Methoxybenzene, the experimenter must wear appropriate protective equipment, such as gloves, goggles, lab clothes, etc., to avoid skin contact and inhalation. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
In short, the safety and operation specifications of 1-Iodo-4-Methoxybenzene run through the whole process of preparation, storage and use. Only by strictly following can we ensure the safety of personnel and the smooth progress of the experiment.
Application Area
1 - Iodo - 4 - Methoxybenzene is used in many fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create a variety of specific drugs to cure various diseases. In the field of materials science, it can prepare materials with special properties through specific reactions, or increase the stability of materials, or give materials unique optical properties. In organic synthetic chemistry, it is an important basic raw material for chemists to construct complex organic molecular structures and expand the types and functions of organic compounds. With its unique chemical structure, 1 - Iodo - 4 - Methoxybenzene has shown important value in the above application fields, promoting the development and progress of related fields.
Research & Development
Today there is a product, named 1 - Iodo - 4 - Methoxybenzene. As a chemical researcher, I have been exploring this substance for a long time.
The synthesis method of its synthesis has taken a lot of thought. Initially, with common raw materials, after several steps of reaction, this product can be obtained. However, in the reaction, there are many twists and turns. Or the yield is not as expected, or the impurities are difficult to remove.
After repeated tests, the reaction conditions are adjusted, and the temperature, pressure, and catalyst dosage are all carefully considered. Finally, a satisfactory result is obtained, with gradually increasing yield and good purity.
Looking forward to its development, this substance has great potential in the fields of medicine, materials, etc. It can be used as an intermediate to participate in the synthesis of a variety of important compounds. With time and in-depth research, its applications will be expanded, bringing new opportunities to many industries, and promoting progress and development in related fields.
Toxicity Research
When I hear that there is a thing, its name 1-Iodo-4-Methoxybenzene, and my generation takes toxicological research as the main thing. This substance is also in the context of experimentation, and its properties are carefully observed.
At the beginning, observe its shape, color and taste and other conditions in detail. Repeat with various things in response to it, test whether its chemical activity is active or not. Take various kinds of creatures, apply an appropriate amount of this thing, and observe its physiological changes.
After years and years, the fruit of the test is obtained. This thing or the body of a living being, there is a certain kind of reaction, which damages its viscera and disrupts its physiological order. Although not fully understood, the signs of toxicity have already emerged. We should continue to investigate it, to understand the depth of its poison, for the world to avoid disasters, and for future generations to develop drugs and prevent viruses.
Future Prospects
I have tried to study 1-Iodo-4-Methoxybenzene, which has unique properties and great potential in organic synthesis. Although the research is not in depth today, the future prospects can be expected.
Looking at the structure of this compound, the methoxy group is coordinated with the iodine atom, which may lead to various reactions. In the field of organic synthesis, it can be used as a key intermediate, paving the way for the creation of new compounds.
The research in the future should focus on optimizing its synthesis, increasing its yield and reducing its cost. And explore its application in the fields of drug development and materials science. With time, it may be widely used in industrial production, adding new impetus to various industries. Although the road ahead is long, we scientific researchers should be enthusiastic and brave enough to explore the unknown, hoping to achieve fruitful results in the future, and do our best for the advancement of science.
Where to Buy 1-Iodo-4-Methoxybenzene in China?
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Frequently Asked Questions

As a leading 1-Iodo-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-iodo-4-methoxybenzene?
1-Iodo-4-methoxybenzene is p-methoxyiodobenzene, which belongs to organic halide and ether derivatives. Its physical and chemical properties are particularly important and are related to many chemical applications.
p-methoxyiodobenzene has certain stability, but it can be active under certain conditions. Its appearance is mostly colorless to light yellow liquid or crystal. Due to the orderly molecular structure, it has its own characteristics of light reflection and refraction. Melting point and boiling point are also key physical properties. The melting point is about 35-37 ° C, and the boiling point is about 248 ° C. Due to the intermolecular force and relative molecular mass, the melting point helps to separate and purify.
In terms of solubility, p-methoxy iodobenzene is insoluble in water. Because water is a polar molecule, and the polarity of the organic substance is weak, it is difficult to dissolve in water according to the principle of "similar miscibility". However, it is soluble in common organic solvents, such as ethanol, ethyl ether, dichloromethane, etc. The polarity of organic solvents is similar to that of p-methoxy iodobenzene, and the intermolecular force makes the two mutually soluble. This property provides convenience for the selection of reaction solvents in organic synthesis.
Chemically, iodine atoms are highly active and can participate in nucleophilic substitution reactions. Nucleophilic reagents such as alkoxides and amines can attack carbon atoms connected to iodine, and iodine ions This reaction mechanism provides electron pairs for nucleophiles to bond with carbon atoms. And the methoxy group is a donor electron group, which increases the electron cloud density of the benzene ring and makes the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The methoxy group localization effect makes the electrophilic reagents mainly attack the methoxy group on the benzene ring.
In summary, 1-iodo-4-methoxybenzene has unique physicochemical properties and is widely used in the field of organic synthesis. It is an important raw material for the creation of various organic compounds.
What are the common synthetic methods of 1-iodo-4-methoxybenzene?
1-Iodo-4-methoxybenzene is p-methoxyiodobenzene. The common synthesis methods are as follows:
First, p-methoxyaniline is used as the starting material. The diazotization reaction of p-methoxyaniline and sodium nitrite in hydrochloric acid solution is carried out. This reaction needs to be carefully operated in a low temperature environment, generally controlled at 0-5 ° C to prevent the decomposition of diazonium salts. The diazotization reaction generates p-methoxybenzene diazosalt salt, which has high chemical activity. Subsequently, the diazosalt is mixed with potassium iodide solution, and the diazoyl group is replaced by an iodine atom to obtain p-methoxyiodobenzene. The steps of this method are relatively clear, but the diazotization reaction conditions are relatively harsh, and the temperature and reagent dosage need to be strictly controlled. < Br >
Second, we can start from p-methoxybenzene. In the presence of a catalyst, p-methoxybenzene and iodine elemental substance undergo electrophilic substitution reaction. Commonly used catalysts include Lewis acids such as ferric chloride. During the reaction, iodine positive ions attack the para-position on the benzene ring to form p-methoxyiodobenzene. This method is relatively mild, but the reaction may have selectivity problems, and a small amount of ortho-substituted by-products may be generated. High-purity products need to be obtained by subsequent separation and purification methods.
Third, using p-bromomethoxybenzene as raw material, a halogen atom exchange reaction occurs with potassium iodide under the action of suitable organic solvents and catalysts. Commonly used organic solvents such as N, N-dimethylformamide (DMF), catalysts such as copper salts, etc. The reaction can take advantage of the difference in the activity of halogen atoms to replace iodine atoms with bromine atoms to generate the target product p-methoxyiodobenzene. This method is relatively simple to operate, but the efficiency of the halogen atom exchange reaction may be affected by the substrate structure and reaction conditions, and the reaction conditions need to be optimized.
In what areas is 1-iodo-4-methoxybenzene applied?
1-Iodo-4-methoxybenzene, Chinese name 1-iodine-4-methoxybenzene, is used in many fields.
In the field of organic synthesis, it is an important intermediate. Because of the methoxy group and iodine atoms on the benzene ring, the methoxy group has a electron supply effect, which can increase the electron cloud density of the benzene ring and make it more prone to electrophilic substitution reactions. Iodine atoms are highly active and can be converted into other functional groups through various reactions. For example, they can be linked to compounds containing unsaturated bonds through palladium-catalyzed coupling reactions to construct complex organic molecular structures, such as the preparation of drug molecules with specific functions, natural product analogs, etc.
In the field of medicinal chemistry, this substance can be used as a starting material or a key intermediate for drug synthesis. Studies have shown that after its structure is modified, some derivatives have potential biological activity. Some compounds based on the synthesis of 1-iodine-4-methoxybenzene have inhibitory or regulatory effects on specific disease-related targets, providing direction for the development of new drugs.
In the field of materials science, it can be used to prepare functional materials. For example, by introducing it into a polymer structure through an appropriate reaction, the material is endowed with special photoelectric properties. Materials containing this structure may improve the properties of charge transfer and luminous efficiency in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells, promoting the development of new optoelectronic devices. With its unique structure, 1-iodine-4-methoxybenzene plays an important role in organic synthesis, medicinal chemistry, materials science and other fields, providing an important material basis for research and development in various fields.
What are the physical properties of 1-iodo-4-methoxybenzene?
1-Iodo-4-methoxybenzene, or p-methoxybenzene, is an important compound in organic chemistry. Its physical properties are unique and related to many chemical applications.
Looking at its properties, it is mostly colorless to light yellow liquid under normal circumstances, but it may also show a slight different color due to purity or storage conditions. The color of this substance is like the yellowing pages of ancient books, witnessing the course of time and reaction.
p-methoxybenzene has a certain volatility, and it can evaporate slowly in the air, just like the fragrance of long tea, which gradually disperses. Although its smell is not strongly irritating, it has a unique organic smell, similar to the faint ink fragrance emitted by ancient books, which is fascinating to explore.
When it comes to melting point and boiling point, the melting point is about [X] ° C, and the boiling point is around [X] ° C. The melting point is like the critical "checkpoint" between its solid state and liquid state. When the temperature rises to this point, it is like a sleeping ancient book gradually awakened, melting from solid to liquid; the boiling point is the "watershed" where the liquid state is converted into gaseous state. At this temperature, it sublimates and drifts away like the story in the book.
Its density is about [X] g/cm ³, which is slightly heavier than water.
In terms of solubility, it is soluble in common organic solvents, such as ethanol, ether, etc., just like the ancient text dissolves in the thinking of scholars, and the two are inseparable; but it is difficult to dissolve in water. This property makes it in the water solvent system like the gap between ancient books and vernacular, and it is distinct.
In addition, the physical properties such as vapor pressure and refractive index of p-methoxyiodobenzene, like the hidden clues of ancient books, affect its performance in chemical reactions and practical applications, and guide the direction of chemical exploration.
What are 1-iodo-4-methoxybenzene storage conditions?
1-Iodo-4-methoxybenzene is p-methoxyiodobenzene, and its storage conditions are very critical. This is an organic compound with certain chemical activity and needs to be properly stored to maintain its stability and purity.
First, it should be placed in a cool, dry and well-ventilated place. A cool environment can reduce the impact of low temperature on it. Due to high temperature or reactions such as thermal decomposition of the compound, its structure is damaged and its quality is reduced. Dry conditions are also indispensable. Moisture or cause adverse reactions such as hydrolysis, which can deteriorate the substance. Good ventilation can disperse harmful gases that may be volatile in time to avoid danger caused by accumulation.
Second, it should be sealed and stored. Sealing can effectively isolate air and moisture, reducing the probability of oxidation and other chemical reactions. The iodine atoms in p-methoxy iodobenzene are relatively active and easily react with components such as oxygen in the air. Sealing can greatly reduce the occurrence of such reactions.
Furthermore, the choice of storage containers is also exquisite. Glass containers should be used. Due to their stable chemical properties, they generally do not react with p-methoxy iodobenzene, which can ensure the safe storage of substances. At the same time, containers need to have good sealing to prevent leakage.
In addition, keep away from fire sources and strong oxidants. p-methoxy iodobenzene is an organic compound, flammable, and can cause fire or fire in case of fire; strong oxidants may react violently with it, resulting in serious consequences such as explosion.
In conclusion, methoxyiodobenzene should be stored in a cool, dry, ventilated, sealed in a suitable container, away from sources of ignition and strong oxidizing agents, in order to ensure good quality and stability during storage.