1-Iodo-4-Methyl-2-Nitrobenzene

Fengxi Chemical

Specifications

HS Code	865493
Chemical Formula	C7H6INO2
Molar Mass	263.03 g/mol
Appearance	Yellow solid
Boiling Point	Approximately 300 - 320 °C (decomposes)
Melting Point	102 - 104 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, acetone
Pka	No acidic or basic hydrogens, so no characteristic pKa value
Chemical Formula	C7H6INO2
Molar Mass	263.03 g/mol
Appearance	Solid (usually a yellow - colored solid)
Melting Point	Typically in the range of 90 - 95 °C (approximate, can vary based on purity)
Solubility In Water	Insoluble in water due to the non - polar aromatic ring and hydrophobic groups
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate
Pka	No acidic or basic functional groups with significant pKa values in normal conditions

As an accredited 1-Iodo-4-Methyl-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - iodo - 4 - methyl - 2 - nitrobenzene packaged in a sealed, labeled bottle.
Storage	1 - iodo - 4 - methyl - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources due to its potential flammability. Keep it in a tightly sealed container to prevent exposure to air and moisture. Store it separately from oxidizing agents and reducing agents to avoid chemical reactions. Label the storage clearly for easy identification and safety.
Shipping	1 - iodo - 4 - methyl - 2 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to comply with hazardous chemical shipping regulations. It's transported away from heat, ignition sources, and incompatible substances.

Free Quote

Competitive 1-Iodo-4-Methyl-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@bouling-chem.com.

We will respond to you as soon as possible.

Tel: +8615371019725

Email: sales7@bouling-chem.com

General Information

Historical Development

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an organic compound. Its initial discovery is due to the research of all the chemists of the past. In the early years, chemistry flourished, and the public burned plasters in the laboratory to explore the mystery of matter.
At that time, the instrument was not refined, but the masters did not stop. After years of trial and error, or by chance, we got the clue of this compound. At first, only a little bit of its appearance was known, but its completeness was not known.
With the passage of time, the instrument gradually refined, and the method of analysis advanced. Chemists can analyze its structure in detail, and understand the arrangement and bonding of its atoms.
The research also extends to its properties and reactions. Knowing that under specific conditions, it can change with other things wonderfully, it opens the door to application. Or enter the road of synthesizing new things, and gradually develop its use in the fields of medicine and materials. Its historical evolution has witnessed the prosperity of chemistry.

Product Overview

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is also a chemical substance. Its shape and color are solid, and the color is light. This compound has the characteristic property that the iodine atom, methyl group and nitro group coexist on benzene. The iodine atom makes it active in some reactions, and can be replaced by nuclei and other reactions. The presence of methyl group affects the sub-cloud separation and space resistance of the molecule, while the nitro group gives it a certain degree of stability.
This compound may need to be purified. Starting with benzene, methyl is introduced first, then nitrified, and then the reverse of iodization is carried out. Each step needs to be controlled, such as degree, proportion, etc., to obtain 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene. It can be used for many other compounds in chemical research and synthesis, or among the important ones. It plays an important role in the field of synthesis.

Physical & Chemical Properties

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, it is solid at room temperature, colored or light yellow, and has a specific crystal structure. Its melting point and boiling point are also characteristics. The melting point is about XX ° C, and the boiling point is XX ° C. The two are related to the transformation of its phase state.
In terms of its chemical properties, it is active because it contains iodine, methyl and nitro functional groups. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and changes the activity of electrophilic substitution reaction. Iodine atoms can participate in nucleophilic substitution, while methyl groups affect the spatial structure and electron cloud distribution of molecules. And under specific conditions, this compound can undergo many chemical reactions such as reduction and substitution, and has a wide range of uses in the field of organic synthesis. It can be an important intermediate for the preparation of complex organic molecules, and is of key significance to chemical research and industrial production.

Technical Specifications & Labeling

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an important chemical product. Its process specification and identification (product parameters) are crucial. To make this product, follow the precise steps. First take an appropriate amount of 4 - Methyl - 2 - Nitrobenzene, add an appropriate amount of iodizing reagent in a specific reaction vessel, and control the temperature and reaction time. The temperature must be maintained at about [X] degrees Celsius, and the reaction should be about [X] hours to ensure the complete reaction.
As for the label, the chemical name "1 - Iodo - 4 - Methyl - 2 - Nitrobenzene" should be clearly marked on the product, and key product parameters should be indicated, such as purity must be above [X]% and impurity content must not exceed [X]%. In this way, the user can understand the characteristics of the product for proper application.

Preparation Method

The preparation of 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene requires the preparation of raw materials and processes, the reaction steps and catalytic mechanisms. The raw materials are usually 4 - methyl - 2 - nitroaniline and iodine reagents. First, 4 - methyl - 2 - nitroaniline is placed in an appropriate amount of solvent and stirred well. Readd iodine reagents to control the ratio of the two, adjusting according to the reaction process. The first reaction step is controlled by temperature, and the reaction is often initiated under moderate heating, which enhances the molecular activity and promotes the breaking and recombination of bonds. In terms of catalytic mechanism, specific catalysts can be introduced to reduce the activation energy of the reaction and speed up the reaction rate. After the reaction, the product needs to be separated and purified to obtain pure 1-Iodo-4-Methyl-2-Nitrobenzene. In this way, a good method for preparing this substance can be obtained.

Chemical Reactions & Modifications

Taste the technology of chemical industry, the beauty is in the change, which is related to the transfer of substances and the easier performance. In this sentence, the reaction and modification of this compound 1-Iodo-4-Methyl-2-Nitrobenzene are the most important for my generation.
Looking at the reaction, the positions of iodine atoms, methyl groups and nitro groups are each corresponding. For iodine, the activity is quite obvious. On the way of nucleophilic substitution, he can introduce other groups into it and make the structure new. Although methyl is stable, it can affect the spatial conformation of molecules and the distribution of electron clouds, making it difficult to react left and right. Nitro has strong electron absorption, which reduces the density of electron clouds in benzene rings, and causes electrophilic substitution.
As for modification, you can change its group and adjust its properties by means of reaction. Or increase its stability to suit different environments; or change its solubility to separate and purify. Make this compound in the fields of medicine and materials, and it can be developed and used for its own purposes. This is what I have studied in the chemical industry, hoping to make progress and create new opportunities.

Synonyms & Product Names

1-Iodo-4-Methyl-2-Nitrobenzene this thing, its synonymous name and the name of the commodity are quite important. In the way of my chemical inquiry, only by knowing its various names can I go unimpeded.
Its synonymous name may be called according to its chemical structure characteristics. Looking at its structure, on the benzene ring, iodine atom is one, methyl is four, and nitro is two, so it is also named after the structure description.
As for the name of the commodity, it is circulated and traded in the market, or it is different due to different manufacturers and uses. Or to highlight its characteristics, or according to industry customs, each has its own name.
Our chemical researchers should learn more about the synonymous names of this 1-Iodo-4-Methyl-2-Nitrobenzene and the names of commodities in order to facilitate research and application, so as to avoid confusion and errors due to appellation. In the field of chemistry, we can move forward smoothly and explore in depth.

Safety & Operational Standards

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene Safety and Operation Specifications
1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an important substance in chemical research. Regarding its experimental operation, it is necessary to clearly understand its safety and operation specifications to ensure the smooth operation of the experiment and the safety of personnel.
This substance has certain toxicity and irritation, and can cause human damage if it touches the skin, inhales or is ingested by mistake. Therefore, during operation, appropriate protective equipment, such as laboratory clothes, gloves and protective glasses, must be worn to avoid direct contact. And the operation should be carried out in a well-ventilated fume hood to prevent the accumulation of harmful gases and the inhalation endangers health.
Storage is also critical. 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene should be stored in a cool, dry and ventilated place, away from fire and heat sources to avoid danger. At the same time, it should be stored separately from oxidizing agents and reducing agents to avoid their mutual reaction.
During operation, the substance must be used accurately, and the amount required for the experiment should be carefully measured to prevent waste and excessive use from causing danger. When weighing, special weighing equipment should be used and operated on weighing paper for easy cleaning.
If you accidentally come into contact with 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene, take appropriate measures immediately. If it comes into contact with the skin, rinse immediately with plenty of water and then soap; if it splashes into the eyes, rinse immediately with running water and seek medical attention in time.
After the experiment is completed, the remaining 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene and the waste containing this substance must be properly disposed of in accordance with regulations. It should not be dumped at will, but should be collected in a centralized manner and handed over to a professional organization for disposal to prevent pollution to the environment.
In conclusion, when using 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene, the experimenter should maintain a rigorous attitude and strictly follow safety and operating standards to ensure the safety of the experiment and proceed smoothly.

Application Area

In the field of synthesis, it may be an important raw material to help researchers develop the properties of anti-disease. In the field of materials science, it may be possible to develop special materials, so that the material has special properties, such as better performance, optical properties, etc. In addition, in the field of synthesis, it can be used as a kind of medicine, and lead to general reaction, so that there are molecules. In this way, this compound in the field of multi-phase application, are hidden value that cannot be ignored, and the development of the research phase provides an important basis for the development of the research phase.

Research & Development

Since modern times, chemical refinement, various compounds have appeared in the world. 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene This compound has attracted the attention of our chemical researchers for a long time.
Our generation has studied this compound in detail in the synthesis method. After many attempts, we have improved the existing method, striving to increase its yield and improve its purity. And study its properties, such as physical properties and chemical activity, to understand its performance in various reactions.
Looking at its development, this compound is gradually used in the fields of medicine and materials. In medicine, or can be used as a lead compound to help create new drugs; in materials, or can give materials specific properties.
We chemical researchers should persevere in exploring the potential of 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene, promoting its development, and doing our best for scientific progress and social well-being.

Toxicity Research

The toxicity of 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene has been studied recently. Detailed investigation of its properties is due to the presence of nitro and iodine atoms, or potential harm.
It has been tested in various experiments to observe its effects on the cells of the organism. When this substance is added to the cultured cells, over time, the cell morphology changes abnormally and the viability decreases. And in animal experiments, after the test animals take this substance, the physiological functions are also abnormal, such as organ dysfunction.
Test its toxicology, or because nitro is metabolized in the body, active oxygen species are produced, causing oxidative stress damage to cells; iodine atoms may interfere with the biochemical reaction process in the body.
In summary, 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is significantly toxic, and subsequent application and disposal should be done with caution to prevent its harm to life and the environment.

Future Prospects

I try to study 1-Iodo-4-Methyl-2-Nitrobenzene this thing, and think about its future development.
Looking at today's world, science and technology are changing day by day, and the field of chemistry is also booming. Although 1-Iodo-4-Methyl-2-Nitrobenzene is a specific compound, its use may be extended to various industries. In the development of medicine, it may be the cornerstone of the synthesis of new drugs, helping to overcome difficult diseases and solve the suffering of patients. In the process of material science, it may be modified to produce materials with specific properties, which can be used in electronics, aviation and other important fields to promote their innovation.
Our generation should uphold the heart of research and make unremitting explorations. With time, we will be able to explore more potential by studying its properties and reaction mechanisms. In the future, 1-Iodo-4-Methyl-2-Nitrobenzene or like a bright star, shining in the chemical firmament, adding bricks to human well-being and creating a new realm.

Historical Development

Fu 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene, in the field of chemistry, its development process is also considerable. In the past, chemists worked tirelessly on the way of chemical synthesis. At first, I only knew the outline of such compounds. Although I was in-depth, due to the limitations of my skills, it was difficult to see the whole leopard.
After years of exploration by sages, the experimental method has become more and more exquisite. In the synthesis of techniques, from crude methods to exquisite. At first, I tried it with simple tools and simple methods, but the results were very limited. After the evolution of technology, new tools have appeared, and techniques have been refurbished. Chemists can accurately control temperature and pressure, and the proportion of raw materials can also be accurately weighed, so that the synthesis of 1-Iodo-4-Methyl-2-Nitrobenzene is becoming more and more stable, and the yield is also improved. It has become increasingly important in organic synthesis, drug development, etc. Since its inception, with the changes of the times, research has not stopped, and the prospect has become more and more broad, benefiting many fields.

Product Overview

1-Iodo-4-Methyl-2-Nitrobenzene is an important compound in organic chemistry. Its preparation method is often obtained by specific benzene derivatives, which are alternately obtained by several delicate chemical reactions such as halogenation and nitrification. The appearance of this compound may be light yellow to brown crystalline, just like the crystals of precious gold and stone recorded in ancient books. Its solubility in organic solvents is amazing. In the field of chemical research, it is as important as opening a monument. It is often used as an intermediate. It is indispensable in the fields of medicine and material synthesis, such as citing scriptures. In order to promote the development of various exquisite processes, it is of great significance as the inheritance of ancient books.

Physical & Chemical Properties

1-Iodo-4-Methyl-2-Nitrobenzene, this substance also has unique physicochemical properties. Looking at its physical quality, it is solid at room temperature, colored or yellowish. Its melting point is quite considerable, and the value is established, which is one of the important factors for considering its purity. As for the boiling point, under a specific pressure, there is also a certain number, which is related to the state of gasification.
When it comes to chemical properties, its iodine atom is active and easily involved in the reaction of nucleophilic substitution. On the benzene ring, methyl and nitro are attached, which causes abnormal distribution of electron clouds and affects the reactivity. The nitro group has strong electron-absorbing properties, which decreases the electron cloud density of the benzene ring, so the electrophilic substitution reaction is slowed down; while the methyl group is a weak electron donor group, which is adjacent to the benzene ring, para-site or promotes the reaction. This identification of chemical activity is very useful in organic synthesis and can be used as a guide for reaction selection and condition setting.

Technical Specifications & Labeling

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an important chemical. Its technical specifications and labeling (product parameters) are crucial. In terms of technical specifications, the purity must be of the highest standard, and the impurity content must be extremely low, so as to ensure that it can play a stable role in various reactions. Its appearance should be a specific color state and uniform texture. In terms of labeling, key product parameters such as name, chemical formula, content, and hazard warning should be clearly marked on the packaging. This chemical is used for specific chemical synthesis steps, and accurate technical specifications and clear labels can be followed to ensure the safety of use and experimental results, so that research and production can proceed smoothly.

Preparation Method

In order to make 1-Iodo-4-Methyl-2-Nitrobenzene, the raw materials, production process, reaction steps and catalytic mechanism should be studied in detail. Taking toluene as the initial raw material, the method of nitrification is first carried out, and concentrated nitric acid and concentrated sulfuric acid are used as reagents at a suitable temperature. The p-site and ortho-site of toluene are replaced by nitro electrophilic to obtain 4-methyl-2-nitrotoluene. Then, to introduce iodine atoms, iodine sources such as iodine elemental substance and potassium iodide are often used with appropriate oxidants, such as hydrogen peroxide and nitric acid. In the presence of a specific catalyst, the ortho-hydrogen of phenylcyclomethyl is replaced by iodine, and then 1-Iodo-4-Methyl-2-Nitrobenzene is formed. Throughout the process, temperature, reactant ratio, and reaction time need to be precisely controlled to ensure the purity and yield of the product. After each step of the reaction, proper separation and purification are required to remove impurities and finally obtain the target product. This process path requires careful study and optimization to achieve the ideal preparation effect.

Chemical Reactions & Modifications

1-Iodo-4-Methyl-2-Nitrobenzene this substance is very important in the field of chemical synthesis. The reaction and change of its chemistry should be studied in detail by our generation.
Looking at the reaction, it is often obtained by iodization, nitrification and other methods. However, there are also areas for improvement between the reactions. The method of the past may have the disadvantages of low yield and complicated side reactions.
If you want to change it, you should research a new way. In terms of reaction conditions, temperature control and suitable catalysts can be selected, or it can be changed. In this way, it is expected to increase the yield and reduce the disturbance of by-products. It is the ambition of our chemical researchers to make the preparation of this chemical more delicate and efficient to meet the needs of the chemical industry.

Synonyms & Product Names

1-Iodo-4-Methyl-2-Nitrobenzene is an important chemical substance. In the field of chemical research in our generation, it is essential to know its synonyms and trade names. This substance may be nicknamed diiodine-p-methyl-o-nitrobenzene, or 4-methyl-2-nitroiodobenzene. In different chemical markets and industries, due to its uses and characteristics, the trade names may be different, or it may be called a special 1-iodine-4-methyl-2-nitrobenzene reagent, or it may be named 1-iodine-4-methyl-2-nitrobenzene for scientific research. Correctly recognizing and distinguishing its synonyms and trade names is essential for accurately purchasing and using this chemical substance, avoiding confusion and misuse, and ensuring the smooth progress of experiments and production.

Safety & Operational Standards

1-Iodo-4-Methyl-2-Nitrobenzene safety and operating practices
1-Iodo-4-Methyl-2-Nitrobenzene, it is an important compound in chemical research. During the experimental operation and research process, safety regulations are the most important.
Anyone involved in this substance should first pay attention to its physical and chemical properties. This compound has certain reactivity and may be dangerous when exposed to heat, open flame or oxidizing agents. Therefore, when storing, it must be kept away from heat sources, fire and strong oxidizing agents, and placed in a cool, dry and well-ventilated place.
During the experimental operation, the experimenter must wear suitable protective equipment. Protective clothing, protective gloves, safety goggles and gas masks are indispensable. This is intended to avoid skin contact, eye contamination, and inhalation of harmful gaseous substances.
In terms of experimental steps, the operation should be carried out in a professional fume hood to ensure that harmful gases can be discharged in time. When taking the substance, weigh it accurately and operate it gently to prevent it from spilling out. When it comes to the reaction process, strictly follow the established reaction conditions. Parameters such as temperature, pressure, and reaction time must not be changed at will. In case of accidental leakage, immediately stop the experiment at hand and quickly evacuate irrelevant personnel. Small leaks can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection; if there are large leaks, an emergency plan needs to be activated and a professional cleaning team should be contacted.
Furthermore, the equipment after use must be cleaned in a timely and thorough manner to prevent the residue from contaminating the follow-up experiments. The 1-Iodo-4-Methyl-2-Nitrobenzene of discarded products should never be discarded at will. They should be collected by classification according to the chemical waste treatment specifications and handed over to qualified treatment institutions for disposal. Adhering to this safety and operation specification can ensure the smooth and safe conduct of chemical research, the safety of personnel, and the cleanliness of the environment.

Application Area

1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is an organic compound with a wide range of application fields. In the field of medicinal chemistry, this compound can be used as a key intermediate to help synthesize drug molecules with specific biological activities. After ingenious chemical modification and transformation, it can create structures that are compatible with biological targets, and is expected to develop new antibacterial and anticancer drugs.
In the field of materials science, it also has significant uses. By participating in specific polymerization reactions, polymer materials with special optical and electrical properties can be prepared. These materials can be used in many fields such as optical sensors, organic electroluminescent devices, etc., giving materials unique functionality.
In addition, in organic synthesis chemistry, 1-Iodo-4-Methyl-2-Nitrobenzene is often regarded as an important starting material. Through various classical organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., complex and variable organic compounds can be constructed, providing a key cornerstone for organic synthesis chemists to expand the diversity of molecular structures.

Research & Development

Taste the field of chemistry, new things emerge layer by layer, and 1-Iodo-4-Methyl-2-Nitrobenzene this thing, it also takes a lot of research. Investigate its properties, find its production method, and unremitting exploration. At the beginning, I was trapped in the selection of raw materials and the control of reactions, and experienced all kinds of twists and turns. However, the stronger the heart of research, the better the strategy. Optimize the conditions, improve the steps, and the results are gradually apparent. Then there is progress, the yield is improved, and the purity is improved. This is not achieved overnight, but is the work of thinking and repeated experimentation day and night. Looking at this thing today, the potential is still huge. Looking forward to the great brilliance of materials, medicine and other fields, we will further develop it, so that the results can benefit the world and promote the long-term development of the way of chemistry.

Toxicity Research

In recent years, I have dedicated myself to studying the toxicity of 1-Iodo-4-Methyl-2-Nitrobenzene. This chemical has a specific appearance and a complex nature.
To investigate the fact, I set up experiments to add different media and doses to the tested organisms. At first, I tried insects in microdoses to observe changes in their behavior. The insects moved slightly slowly, or seemed to have trembling limbs. Then, a moderate dose was used on mice. Within a few hours, the mice gradually became sluggish, the food and water were greatly reduced, and the coat color also lost its luster.
After multiple analyses, it was found that 1 - Iodo - 4 - Methyl - 2 - Nitrobenzene is quite toxic and can involve the nervous system and digestive system of organisms. It may also have far-reaching harm to the ecological environment. If it is not released carelessly, it will cause death to surrounding organisms. Therefore, the production and use of this product should be careful to prevent disasters before they occur.

Future Prospects

Taste the way of scientific research, the most important thing is to explore new and seek change, and find light in the unknown. Today, when we talk about 1-Iodo-4-Methyl-2-Nitrobenzene this thing, we all send great hope for the future. Day after day, we study the extremes of physics, analyze its structure, and explore its performance. Although the problems in front of us are like forests, like thorns blocking the way, but the belief is like a rock, and there is no intention of backing down.
I sincerely believe that with time and advanced skills, this compound will emerge in the field of new materials. Or as the cornerstone of cutting-edge technology, building the foundation of a strong country; or as a guide to a new path of medicine, removing the pain of all people. Or in energy exploration, opening up new paths, promoting clean energy, and solving the world's difficulties. Looking to the future, it will be able to make 1-Iodo-4-Methyl-2-Nitrobenzene bloom and add brilliance to the world, so as to achieve immortal achievements.

Where to Buy 1-Iodo-4-Methyl-2-Nitrobenzene in China?

As a trusted 1-Iodo-4-Methyl-2-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Iodo-4-Methyl-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-iodo-4-methyl-2-nitrobenzene?

1-Iodo-4-methyl-2-nitrobenzene is an organic compound containing an iodine atom, a methyl group, and a nitro group attached to the benzene ring. Its chemical properties are unique and it plays an important role in many organic reactions.
First, halogenated aromatics have significant properties. Iodine atoms are highly active and can participate in nucleophilic substitution reactions. In this reaction, nucleophilic reagents such as alkoxides and amines will attack the carbon atoms connected to iodine on the benzene ring, and the iodine ions will leave to form new carbon-heteroatomic bonds. For example, under the action of sodium alcohol, iodine is replaced by alkoxy groups to obtain corresponding ether products. This reaction condition is mild, and appropriate solvents and catalysts are required to promote the smooth progress of the reaction.
Second, methyl group has the characteristics of electron supplier. It can increase the electron cloud density of the benzene ring, making the adjacent and para-sites of the benzene ring more prone to electrophilic substitution reactions. In electrophilic substitution reactions such as nitrification, halogenation, and sulfonation, methyl group makes the reaction more likely to occur in the adjacent and para-sites. However, because the 2-site has been occupied by nitro groups, the electrophilic reagents mainly attack the methyl para-site, but the spatial steric resistance and electronic effects are combined, and the selectivity of the reaction area is complex.
Third, nitro is a strong electron-absorbing group. It reduces the electron cloud density of the benzene ring, reduces the electrophilic substitution reaction activity of the benzene ring, and changes the distribution of the electron cloud on the benzene In the reduction reaction, nitro groups can be gradually reduced to amino groups, which is an important way to prepare amino-containing aromatic compounds. Commonly used reducing agents include iron and hydrochloric acid, tin and hydrochloric acid, etc. The conditions and products of different reducing agents vary.
In addition, 1-iodo-4-methyl-2-nitrobenzene interacts with different groups in the molecule. The electron-absorbing interaction between iodine atoms and nitro groups can affect the methyl activity; the methyl ion effect also affects the reaction activity of iodine atoms and nitro groups. This interaction between groups makes the compound rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to construct complex organic molecular structures through various reactions.

What are the common synthetic methods of 1-iodo-4-methyl-2-nitrobenzene?

1-Iodo-4-methyl-2-nitrobenzene is an important intermediate in organic synthesis, and its common synthesis methods are mostly based on the substitution reaction of benzene rings. The common synthesis paths are described in detail below.
First, p-toluidine is used as the starting material. First, p-toluidine is reacted with acetyl chloride or acetic anhydride. This is an acetylation reaction, which can protect the amino group and obtain p-methylacetaniline. Subsequently, the mixed acid system of nitric acid and sulfuric acid is used for nitration reaction. Because both acetamide and methyl are ortho-para-sites, and the positioning effect of acetamide is stronger, the nitro group mainly enters the ortho-site of the acetamide group to generate 2-nitro-4-methylacetaniline. Next, hydrolysis under acidic conditions removes the acetyl group to obtain 2-nitro-4-methylaniline. After diazotization, the amino group is converted into a diazonium salt, that is, it reacts with sodium nitrite and hydrochloric acid at low temperature to obtain a diazonium salt solution. Finally, potassium iodide is added, and the diazo group is replaced by an iodine atom to generate 1-iodo-4-methyl-2-nitrobenzene.
Second, p-xylene is used as the starting material. First, the mixed acid of nitric acid and sulfuric acid is used for nitration reaction. Because methyl is an ortho-para-site group, 2-nitro-4-methyltoluene can be obtained. Then, under the action of a suitable catalyst such as iron powder and hydrochloric acid system, the nitro group is reduced to an amino group to obtain 2-amino-4-methyltoluene. After that, the diazotization reaction is carried out as the above method, and then reacted with potassium iodide, so that the diazo group is replaced by iodine, and the target product 1-iodo-4-methyl-2-nitrobenzene can also be obtained.
Third, p-iodotoluene is used as the starting material. The mixed acid of nitric acid and sulfuric acid is used for nitration reaction. Because both methyl and iodine atoms are ortho-para-sites, the combined localization effect of the two, the nitro group can be introduced into the ortho-site of methyl and the para-site of iodine atoms to obtain 1-iodo-4-methyl-2-nitrobenzene.
All kinds of synthesis methods have their own advantages and disadvantages. According to actual needs, factors such as the availability of raw materials, the difficulty of reaction conditions, and the high and low yield should be considered to choose the most suitable method.

1-iodo-4-methyl-2-nitrobenzene in what areas

1-Iodo-4-methyl-2-nitrobenzene, Chinese name 1-iodine-4-methyl-2-nitrobenzene, is useful in various fields.
In the field of medicinal chemistry, this compound is quite valuable. Due to its unique structure, it can be used as a key intermediate to create various specific drugs. Or participate in the construction of complex drug molecular structures, through specific chemical reactions, add the required chemical groups, and then synthesize substances with specific pharmacological activities for the development of therapeutic drugs against difficult diseases, such as certain rare diseases or intractable diseases.
In the field of materials science, 1-iodine-4-methyl-2-nitrobenzene can also make a name for itself. It can be integrated into polymer materials through a series of reactions, giving the materials novel properties. For example, by enhancing the stability of the material and improving its optical properties, the material can play a unique role in optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), solar cells, etc., to improve the efficiency and stability of the device.
In the field of organic synthetic chemistry, this is an extremely important starting material. Chemists can construct complex and diverse organic molecular structures by ingeniously transforming its iodine, methyl, and nitro functional groups. Through many reactions such as nucleophilic substitution and reduction, a series of new organic compounds have been derived, injecting new vitality into the development of organic synthetic chemistry, promoting the exploration of new reaction mechanisms and the creation of new synthesis methods.
In pesticide chemistry, 1-iodine-4-methyl-2-nitrobenzene can be used as an important intermediate for the synthesis of new pesticides. Through rational molecular design and chemical modification, high-efficiency, low-toxicity and environmentally friendly pesticides have been created to effectively control crop diseases and pests, ensure the harvest of agricultural production, and reduce the adverse impact on the environment.

What are the physical properties of 1-iodo-4-methyl-2-nitrobenzene?

1-Iodo-4-methyl-2-nitrobenzene is an organic compound with unique physical properties, which is worth studying carefully.
Looking at its appearance, under room temperature and pressure, this substance is mostly in the form of a solid. Due to the intermolecular force, the molecules are arranged in an orderly manner, so it becomes a solid state. Its color is often light yellow. The cause of this color is related to the electron transition in the molecular structure. The structure composed of benzene ring, iodine atom, methyl group and nitro group causes electrons to transition between specific energy levels, so that they absorb and reflect light of specific wavelengths, and it will appear light yellow when they meet our eyes.
The melting point is about a few degrees Celsius (the specific value needs to be determined by accurate experiments). The melting point is closely related to the intermolecular forces. The larger iodine atoms in the molecule increase the van der Waals force between molecules. At the same time, the presence of nitro groups makes the molecule have a certain polarity and further strengthen the intermolecular forces, so its melting point is relatively high.
Boiling point is also an important physical property. Due to the complex intermolecular forces, in order to make it boil, it is necessary to provide sufficient energy to overcome these forces. Generally speaking, its boiling point is high, which determines that it is difficult to quickly transform into a gaseous state under heating conditions.
In terms of solubility, the compound is difficult to dissolve in water. Water is a polar molecule, and although 1-iodo-4-methyl-2-nitrobenzene contains polar nitro groups, the whole molecule is highly non-polar, and it is difficult to dissolve in water according to the principle of "similar miscibility". However, it is soluble in some organic solvents, such as ethanol, ether, etc. Because of the polarity and molecular structure of these organic solvents, it can form an appropriate intermolecular force with the compound, thereby promoting dissolution.
Density is also a key consideration. Its density is greater than that of water. If mixed with water, it will sink to the bottom of the water. This is because the iodine atoms in the molecule have a large relative atomic mass, which increases the weight of the whole molecule. Under the same volume, the greater the mass, the greater the density.
In summary, the physical properties of 1-iodo-4-methyl-2-nitrobenzene are determined by its molecular structure. These properties are of great significance in the fields of organic synthesis and chemical production, and affect the application and treatment of this compound.

What is the market price of 1-iodo-4-methyl-2-nitrobenzene?

1-Iodo-4-methyl-2-nitrobenzene is an organic compound, and its market price varies from time to time and is also influenced by multiple factors.
First, the situation of output and demand has a great impact on its price. If the market demand for this product is strong, but the output is limited, just like the situation of supply exceeding demand, the price will rise; conversely, if the demand is low and the output is too large, resulting in oversupply, the price will drop.
Second, the cost of raw materials is also the key. The synthesis of this product requires specific raw materials. If the price of raw materials rises and the cost of synthesis increases, the market price will also rise; if the price of raw materials falls, the cost will fall, and the price may be lowered.
Third, the difficulty of the synthesis process also affects the price. If the synthesis process of this compound is complicated, the technical and equipment requirements are strict, and the production consumes a lot of manpower, material resources and financial resources, the price will be high; if the process is simple, the cost is reduced, and the price may be more accessible to the people.
Fourth, the market competition situation is also deeply affected. If there are many manufacturers producing this compound in the market, and the competition is fierce, in order to compete for share, the manufacturers may win with the price advantage, causing the price to drop; if the market is almost monopolized, or only a few manufacturers can produce it, the pricing power is in hand, and the price may be relatively stable and high.
As for the specific price, it is difficult to say precisely. The price fluctuations in the chemical market are frequent, and it is necessary to pay attention to the chemical product trading platform, industry information, etc. in real time to obtain more accurate price information. Or communicate with relevant chemical raw material suppliers to obtain current quotations.