1-Iodo-4-Nitrobenzene

1-Iodo-4-nitrobenzene is p-iodinitrobenzene, and its main use is quite extensive. In the field of organic synthesis, this is a crucial intermediate. The nitro and iodine atoms attached to the guiphenyl ring have unique reactivity. The nitro group can be converted into an amino group through many reactions such as reduction. This amino group is of great significance in the synthesis of nitrogen-containing organic compounds, such as the preparation of various drugs and dyes. The iodine atom is extremely active and can participate in many nucleophilic substitution reactions. Through the action of different nucleophiles, various functional groups can be introduced into the benzene ring, and then complex organic molecules can be constructed.
In the field of medicinal chemistry, p-iodinitrobenzene is a compound derived from a series of reactions, or has unique physiological activities. For the creation of antibacterial and anti-inflammatory drugs, they are often used as starting materials to lay the foundation for the synthesis of molecules with precise pharmacological activities.
In the field of materials science, polymer materials or functional materials synthesized by p-iodinitrobenzene also show specific properties. For example, some photoelectric materials, the specific structure introduced by p-iodinitrobenzene can optimize the electronic transmission properties and optical properties of materials, making them emerging in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., to play a key role.
In conclusion, 1-iodo-4-nitrobenzene plays a pivotal role in many fields such as organic synthesis, medicinal chemistry, and materials science due to its unique structure and reactivity, and has made outstanding contributions to promoting the development of various fields.

1-Iodo-4-nitrobenzene, or 1-iodine-4-nitrobenzene, has the following physical properties:
1-iodine-4-nitrobenzene is a light yellow crystal, which is quite pure, like fine sand, but has a regular crystal shape. Although its smell is not strong and pungent, it also has a unique smell, which can be clearly detected in a confined space.
In terms of melting point, it is between 172 ° C and 174 ° C. When the temperature gradually rises, the originally solid crystal, like ice in spring, slowly melts into a flowing liquid. Its boiling point is quite high, about 318.5 ° C, and a strong heat source is required to make it boil and turn into a gaseous state.
The solubility of this substance in water is very small, just like oil and water, it is difficult to blend. However, in organic solvents, such as ethanol, ether, etc., it has good solubility and can be evenly dispersed, just like fish entering water, free.
Its density is greater than that of water. If it is placed in water, it will sink like a stone in the sea and sink directly. And its vapor pressure is low, and its volatilization is not significant at room temperature and pressure. Under specific conditions such as light or heat, its physical state or stability may change, and it needs to be properly stored in a cool, dry and dark place to prevent deterioration.

1-Iodo-4-nitrobenzene, Chinese name 1-iodine-4-nitrobenzene, is a kind of organic compound. It has many chemical properties, which are detailed as follows:
1. ** Nucleophilic Substitution Reactivity **: In this compound, the position of iodine atom and nitro group on the benzene ring makes the iodine atom activity prominent. Because the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring decreases through conjugation and induction effects, especially the electron cloud density of the iodine atom in the adjacent and para-position decreases significantly. Such structural characteristics make the iodine atom vulnerable to nucleophilic reagents and nucleophilic substitution reactions occur. If sodium hydroxide aqueous solution is used as nucleophilic reagent, under heating conditions, iodine atoms can be replaced by hydroxyl groups to generate 4-nitrophenol; if sodium alcohol is used as nucleophilic reagent, iodine atoms can be replaced by alkoxy groups to obtain corresponding ether compounds.
2. ** Reduction Reaction Characteristics **: Intramolecular nitro groups can undergo reduction reactions. Under suitable reducing agents and reaction conditions, nitro groups can be gradually reduced. For example, with iron and hydrochloric acid as reducing agents, nitro groups are first reduced to nitroso groups, and then reduced to amino groups to generate 1-iodine-4-aminobenzene. This reaction is of great significance in organic synthesis, because amino groups can further derive a variety of functional groups and expand the use of compounds.
3. ** Derivation of halogenation reaction **: Although there are iodine atoms in the molecule, halogenation reactions can still occur at other positions on the benzene ring under certain conditions. Because the nitro group is the meta-site group, the newly introduced halogen atoms will mainly enter the nitro meta-site. For example, under the catalysis of Lewis acid, reacting with bromine can generate 1-iodine-3-bromo-4-nitrobenzene.
4. ** Stability depends on reaction conditions **: 1-iodine-4-nitrobenzene is relatively stable under conventional conditions. However, when exposed to high temperatures, strong oxidants or active nucleophiles, corresponding chemical reactions will occur. Its reactivity and product selectivity are closely related to reaction conditions such as temperature, solvent, catalyst, etc. For example, in nucleophilic substitution reactions, polar aprotic solvents can usually accelerate the reaction process, because they can effectively dissolve nucleophiles and stabilize their negative ions, enhancing nucleophilicity.

1-Iodo-4-nitrobenzene is p-iodinitrobenzene. The common synthesis methods are as follows:
First, nitrobenzene is used as the starting material. First, nitrobenzene is reacted with iodine and suitable oxidants under appropriate reaction conditions. For example, in the presence of sulfuric acid and heated environment, an appropriate amount of iodine and nitric acid are added. Sulfuric acid plays a role in providing an acidic environment and promoting the reaction, and nitric acid acts as an oxidant to prompt iodine to replace the hydrogen atom on the benzene ring. Nitro is a meta-locator in nitrobenzene, and this reaction can selectively introduce iodine atoms at the para-position of nitro. After a series of complex electron cloud distribution and reaction intermediate conversion processes, p-iodinitrobenzene is finally formed. After the reaction is completed, the product needs to be separated and purified by means of distillation, extraction, recrystallization, etc.
Second, aniline is used as the starting material. First, aniline reacts with acetyl chloride or acetic anhydride, and acetylates to form acetaniline. This can protect the amino group and prevent it from overreacting in subsequent reactions. After that, acetaniline and iodine react in a suitable solvent under the action of a catalyst, and iodine atoms are introduced into the benzene ring to form p-iodoacetaniline. The catalyst here is usually some metal salts, such as iron salts, which can reduce the activation energy of the reaction and speed up the reaction rate. Finally, p-iodoacetaniline is hydrolyzed under acidic or alkaline conditions, and the acetyl group is removed, resulting in p-iodonitrobenzene. After hydrolysis, it is also necessary to use separation and purification methods to obtain pure products.
Third, p-nitroaniline can also be started from p-nitroaniline. P-nitroaniline is reacted with sodium nitrite in an acidic solution at low temperature to form a diazonium salt. Subsequently, the diazonium salt reacts with potassium iodide solution, and the diazonium group is replaced by an iodine atom to form p-nitroiodobenzene. The diazotization reaction requires strict control of the reaction temperature, usually at low temperature (0-5 ° C), to prevent the decomposition of diazonium salts. During the whole process, the precise control of the reaction conditions at each step and the effective separation and purification of the product are essential to obtain high-purity p-iodonitrobenzene.

1 - iodo - 4 - nitrobenzene is p-iodinitrobenzene, which is dangerous. When storing and transporting, pay attention to the following matters:
###Storage
1. ** Environmental selection **: It should be placed in a cool and ventilated warehouse. Because p-iodinitrobenzene is easily decomposed by heat and causes danger, the warehouse temperature should not be too high, usually should be controlled below 30 ° C. And good ventilation can disperse harmful gases that may leak in time to avoid their accumulation.
2. ** Keep away from fire and heat sources **: It is strictly forbidden to have open flames, smoking and other behaviors in the storage area. Because p-iodonitrobenzene is a flammable substance, it can cause combustion or even explosion in case of open flames and hot topics. All kinds of fire and heat sources are potential dangerous factors.
3. ** Packaging sealing **: Make sure that the packaging is intact and well sealed. This substance is exposed to air, or interacts with moisture, oxygen, etc., causing quality changes or dangerous reactions. If the packaging is damaged, it is easy to leak, endangering the surrounding environment and personal safety.
4. ** Classified storage **: Do not mix with oxidants, edible chemicals, etc. Iodinitrobenzene comes into contact with oxidants, or causes a violent oxidation reaction, causing a combustion explosion; mixed with edible chemicals, once leaked, or cause food contamination, endangering human health.
5. ** Storage area protection **: The storage area should be equipped with suitable materials to contain leaks, such as sand, vermiculite and other adsorbent materials. And obvious warning signs should be set up to show dangerous characteristics and precautions.
###Transportation
1. ** Packaging Specifications **: Transportation packaging must comply with relevant regulations. Commonly used packaging materials include iron drums, plastic drums, etc., to ensure that the packaging is strong, resistant to vibration, collision and friction, and to prevent leakage due to package damage during transportation.
2. ** Selection of means of transportation **: Use clean, dry, odor-free and safety-compliant means of transportation. Do not use tools that have transported toxic and harmful substances and have not been thoroughly cleaned to avoid cross-contamination. Transport vehicles should be equipped with corresponding fire-fighting equipment.
3. ** Qualifications of drivers and escorts **: Drivers and escorts must undergo special training, familiar with the dangerous characteristics of p-iodonitrobenzene, emergency treatment measures, etc., and strictly abide by traffic rules and safe operating procedures during transportation.
4. ** Avoid sun exposure and rain exposure **: The transportation process should be protected from sun exposure and rain, because sun exposure can cause the temperature to rise and accelerate the decomposition of substances; rain exposure or damage the package to moisture, causing leakage. When necessary, transportation vehicles should be equipped with shading and rain protection facilities.
5. ** Emergency Preparedness **: Emergency rescue equipment and medicines should be prepared during transportation, and detailed emergency plans should be formulated. In the event of an accident such as a leak, it can be dealt with quickly and scientifically to reduce the damage.