1-Iodo-4-(Trifluoromethyl)Benzene

Fengxi Chemical

Specifications

HS Code	954532
Chemical Formula	C7H4F3I
Molecular Weight	272.009
Appearance	Colorless to light yellow liquid
Boiling Point	204 - 206 °C
Density	1.919 g/cm³
Flash Point	82.4 °C
Solubility	Insoluble in water, soluble in organic solvents
Refractive Index	1.526 - 1.528
Chemical Formula	C7H4F3I
Molar Mass	268.005 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Around 195 - 197 °C
Density	Data may vary, but in the range of halogenated aromatics
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene
Flash Point	Data may vary, but typical for flammable organic liquids
Vapor Pressure	Low at room temperature

As an accredited 1-Iodo-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - iodo - 4 - (trifluoromethyl)benzene in a sealed, labeled glass bottle.
Storage	1 - iodo - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and vapor release. Avoid contact with incompatible substances. Store at ambient temperature, protected from direct sunlight.
Shipping	1 - iodo - 4 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent spills and exposure during transit.

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General Information

Historical Development

1-Iodine-4- (trifluoromethyl) benzene is also an organic compound. At the beginning, chemists devoted themselves to exploring the properties of substances and seeking a way to synthesize them. At first, it was limited to skills, and it was difficult to make this thing. However, the ambition of scholars is perseverance and unremitting research. After a long time, after repeated experiments, they gradually obtained the wonderful method of synthesis.
The method used in the past was complicated and inefficient, and the yield was quite low. However, chemists were not discouraged. With the advance of science and technology, new techniques emerged one after another. Later, there were improved methods, using precise means to control the reaction process, the yield increased, and the quality was also excellent. Therefore, the preparation of 1-iodine-4 - (trifluoromethyl) benzene has been perfected day by day, and it has been gradually used in the fields of chemical industry and medicine, contributing to the well-being of mankind.

Product Overview

1-Iodo-4- (Trifluoromethyl) Benzene is also an organic compound. It may be a colorless to pale yellow liquid with a special odor. Among this compound, the iodine atom is connected to the benzene ring containing trifluoromethyl, and the structure is unique. Its physical properties, such as boiling point and melting point, all have specific values due to the interaction of atoms in the molecule. It has active chemical properties and can be used as a key intermediate in many organic reactions. Due to its fluorine-containing properties, it endows the compound with special chemical stability and hydrophobicity. In the field of organic synthesis, it is often an important starting material for the preparation of fluorinated drugs and materials. It helps chemists create novel and unique compounds, opening up a broad path for chemical research and industrial applications.

Physical & Chemical Properties

1-Iodo-4- (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance is in a liquid state, with a clear and transparent color and a special odor. Its boiling point is quite different, about a certain temperature range, which is due to the force between molecules. As for chemical properties, because its structure contains iodine atoms and trifluoromethyl groups, it is active. Iodine atoms are prone to substitution reactions. When encountering nucleophiles, they are often replaced by nucleophiles. This is a key step in organic synthesis. Trifluoromethyl groups have strong electron-absorbing properties, which affect the distribution of electron clouds in molecules, reduce the density of electron clouds in benzene rings, and change the activity of electrophilic substitution reactions. From this perspective, 1-Iodo-4- (Trifluoromethyl) Benzene is widely used in the field of organic chemistry due to its unique physical and chemical properties. It can be used as a raw material for the synthesis of many important compounds and is also one of the focuses of chemical research.

Technical Specifications & Labeling

1 - Iodo - 4 - (Trifluoromethyl) Benzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, from the selection of raw materials, high-purity starting materials need to be selected to ensure the accuracy and efficiency of the reaction. The reaction conditions also need to be strictly controlled, and the temperature, pressure and reaction time all have specific requirements. If the reaction temperature should be maintained at a certain range, the reaction can proceed smoothly and produce high-purity products.
In terms of identification (product parameters), the purity must meet specific standards, and the impurity content must be strictly controlled. The appearance is also clearly specified, and a specific color state should be exhibited. And it is necessary to label clear physical and chemical properties parameters, such as melting point, boiling point, etc., so that users can accurately understand their characteristics, operate reasonably in subsequent applications, and ensure product quality and safety.

Preparation Method

1-Iodo-4- (Trifluoromethyl) Benzene is an important compound in organic synthesis. The preparation method is as follows:
Raw materials and production process: With p-trifluoromethyl aniline as the starting material, the amino group is converted into a diazonium salt through diazotization reaction. This diazonium salt has poor stability and needs to be operated at low temperature. Subsequently, a substitution reaction occurs with potassium iodide, and the diazonium group is replaced by an iodine atom to generate the target product 1-Iodo-4- (Trifluoromethyl) Benzene.
Reaction steps: Dissolve p-trifluoromethyl aniline in an appropriate amount of acid solution, cool it to a low temperature, slowly add sodium nitrite solution dropwise, and carry out a diazotization reaction. Strictly control the reaction temperature and dropwise rate to ensure the stable formation of After that, the potassium iodide solution is added to heat up the reaction, which prompts the substitution reaction to proceed fully.
Catalytic mechanism: In the diazotization reaction, the acid solution provides protons, which contribute to the protonation of the amino group, and the sodium nitrite forms nitrous acid, which then reacts with the protonated amino group to form a diazonium salt. During the substitution reaction, iodine ions attack the diazonium salt as a nucleophile, prompting the diazonium group to leave, completing the substitution and generating 1-Iodo-4- (Trifluoromethyl) Benzene.

Chemical Reactions & Modifications

Today there is a substance named 1-Iodo-4- (Trifluoromethyl) Benzene. In the field of chemistry, its reaction and modification are related to many wonders.
The reaction can vary depending on different reagents and conditions. In case of a certain reagent, or nucleophilic substitution, the halogen atom translocates into a different structure. The speed of this reaction depends on the activity and temperature of the reagent. When the temperature rises, the molecules are active and the reaction is faster; the reagent activity is strong, and the reaction is also promoted.
On its modification, chemical means can be used to add groups to the benzene ring to adjust its properties. Add hydroxyl groups to increase its hydrophilicity; add alkyl groups to change its fat solubility. The power of modification can expand the use of this substance, and it can be used in the fields of medicine, materials, etc. Chemists study its reaction and modification, hoping to uncover chemical mysteries and create more beneficial substances for the world.

Synonyms & Product Names

1 - Iodo - 4 - (Trifluoromethyl) Benzene, also known as p-trifluoromethyl iodobenzene. It is widely used in the field of chemical synthesis.
There are many other names for p-trifluoromethyl iodobenzene, which vary according to industry, region and habit. In organic synthesis, it is often called trifluoromethyl iodobenzene, which directly describes its structure and composition, highlighting the substitution of trifluoromethyl and iodine atoms on the benzene ring.
It is also known as 4-iodine-1-trifluoromethylbenzene, which is named according to the substitution position and type, which is clear and clear. Furthermore, there are also those in the industry who are called by their English abbreviation TFMIB, which is concise and convenient, and is conducive to communication.
This compound, due to different names, all refer to the same substance. In chemical research and production, researchers and producers need to be familiar with its many aliases to avoid miscommunication and hindrance to research or production. Its many synonymous names also reflect the diversity and complexity of chemical substance naming, but they all accurately refer to this important chemical raw material.

Safety & Operational Standards

1 - Iodo - 4 - (Trifluoromethyl) Benzene is an important chemical compound in organic chemistry. Safety and operating standards are of paramount importance during its experimental preparation and use.
First of all, it is about safety. This compound has certain chemical activity, or poses potential hazards to the human body and the environment. The experimenter must wear professional laboratory clothes, protective gloves and goggles to prevent it from coming into contact with the skin and eyes. Because it may be irritating, if it is inadvertently touched, it should be rinsed with plenty of water immediately and treated according to the specific situation.
Furthermore, operating standards. Operating in a well-ventilated environment is best carried out in a fume hood to ensure the timely discharge of harmful gases and avoid inhalation by the experimenter. When taking this compound, it is necessary to use a precise measuring tool, and strictly control the dosage according to the experimental requirements to avoid waste and danger due to improper dosage.
For storage, 1-Iodo-4 - (Trifluoromethyl) Benzene should be placed in a cool, dry place away from sources of ignition and oxidants. Storage containers should be well sealed to prevent it from evaporating or reacting with air components.
For waste treatment, waste containing this compound should not be discarded at will. It needs to be sorted and collected according to laboratory regulations, and then handled by professional institutions in suitable methods to prevent pollution to the environment. Only by strictly following these safety and operating practices can we ensure the safety and smooth operation of the experiment, while protecting the environment and the health of the experimenters.

Application Area

1-Iodo-4- (Trifluoromethyl) Benzene is an important raw material in organic synthesis. It has a wide range of application fields and is often a key intermediate in the synthesis of specific drug molecules in the field of medicinal chemistry. The iodine atom and trifluoromethyl on the genbenzene ring give the compound unique chemical activity and properties, and can participate in a variety of chemical reactions to realize the construction of specific structures of drug molecules.
In the field of materials science, this compound also has its uses. Through specific chemical reactions, it can be introduced into the structure of polymer materials to improve the properties of materials, such as improving the stability and corrosion resistance of materials. This is due to its special chemical structure, which makes the material have unique physical and chemical properties.
In addition, in the field of fine chemicals, 1-Iodo-4- (Trifluoromethyl) Benzene is often used as an important starting material for the synthesis of fine chemicals, assisting in the synthesis of many high-value-added products to meet different industrial and scientific research needs.

Research & Development

In recent years, I have focused on the research of 1-Iodo-4- (Trifluoromethyl) Benzene. This compound has unique properties and wide applications, and has potential in the fields of medicine and materials.
Initially, explore its synthesis method. After many attempts, trying different raw materials and conditions, I have encountered repeated setbacks, and the yield has not reached expectations. However, I was not discouraged, and repeatedly studied ancient books and cutting-edge literature, and finally obtained the optimization method. With specific reagents, precise temperature and duration were controlled, and the yield was significantly improved.
Then, study its properties. After careful testing, its chemical activity, stability and other characteristics were revealed, which laid the foundation for subsequent applications.
As for development, looking forward to the future, I hope to join hands with you to expand its application. In the development of new drugs, or become a key intermediate; in material innovation, or give new properties to materials. With this material, it will add new color to the academic and industry, and promote progress in related fields.

Toxicity Research

I will study the toxicity of 1-Iodo-4- (Trifluoromethyl) Benzene. It is an organic halide, containing fluorine, iodine and other elements. Looking at various experiments, its impact on organisms should not be underestimated.
In small animal experiments, it may cause physiological abnormalities. After entering the body, it may interfere with cell metabolism and damage the organs. The reason for its toxicity is that the halogen atoms in the cap structure are active, easy to interact with biological macromolecules, causing protein, nucleic acid and other abnormalities.
And this substance is also difficult to degrade in the environment, long-term accumulation or ecological harm. Although it is widely used at present, the study of toxicity is still shallow, and it is urgent to explore in depth to clarify its harm and determine preventive measures to ensure the well-being of all beings and the tranquility of the environment.

Future Prospects

In the field of chemical engineering, 1-Iodo-4- (Trifluoromethyl) Benzene has deep potential, and its future prospects are limitless.
Its unique structure, fluorine and iodine atoms are cleverly connected, giving extraordinary characteristics. In the road of materials science, it may open up new paths. With its chemical activity, it can make materials with special functions, or be used in electronic components to improve its performance, strong and durable, stable and efficient, making electronic devices more delicate.
The path of pharmaceutical research and development also has opportunities. With its special chemical properties, it may become the key to the development of new drugs. Or it can accurately act on lesions, heal diseases, and bring good news to patients.
However, the road ahead also needs to be cautious. During research and development, it is necessary to consider the environmental impact, optimize the process, and strive for green environmental protection. In this way, 1-Iodo-4- (Trifluoromethyl) Benzene can shine in the future, benefit the world, and open a new chapter in chemical industry and technology.

Historical Development

1 - Iodo - 4 - (Trifluoromethyl) Benzene is also an organic compound. Looking back in the past, its research and development process is quite meaningful. At the beginning, chemists worked hard in the field of organic synthesis to make compounds with this special structure. At that time, the technology was not mature, and it was not easy to obtain raw materials, but the ambitions of the ancestors were as solid as a rock.
Over the years, the theory of organic chemistry has gradually enriched, and the experimental methods have become increasingly new. Chemists use ingenious concepts and unremitting attempts to improve the synthesis path. Or optimize the reaction conditions to make the conversion of raw materials more efficient; or find new catalysts to reduce the reaction barrier. After numerous trials and errors, a relatively stable synthesis method was obtained, and the yield and purity of 1 - Iodo - 4 - (Trifluoromethyl) Benzene also steadily increased, emerging in the field of organic synthesis, paving the way for subsequent scientific research and application.

Product Overview

1-Iodo-4- (Trifluoromethyl) Benzene is an important compound in organic synthesis. Its appearance is colorless to pale yellow liquid, and it has unique physical and chemical properties. In the field of chemistry, this compound exhibits extraordinary reactivity due to the special combination of iodine atom and trifluoromethyl in its structure.
Iodine atom, as a good leaving group, can participate in many nucleophilic substitution reactions, greatly expanding its application in organic synthesis reactions such as the construction of carbon-carbon bonds and carbon-heteroatom bonds. The strong electron-absorbing properties of trifluoromethyl not only affect the electron cloud distribution of molecules, but also change their chemical activity, and endow compounds with special physical properties, such as enhanced lipid solubility. Due to its unique properties, 1-Iodo-4- (Trifluoromethyl) Benzene has potential applications in the fields of medicine, pesticides, and materials science, providing a key foundation for many cutting-edge research and innovation.

Physical & Chemical Properties

1 - Iodo - 4 - (Trifluoromethyl) Benzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, at room temperature, this substance is mostly colorless to light yellow liquid with a special odor. Its boiling point is about [X] ° C, its melting point is at [X] ° C, and its density is about [X] g/cm ³. It is insoluble in water, but it is easily soluble in many organic solvents, such as ethanol, ether, etc.
When it comes to chemical properties, the iodine atom in this compound is quite active and easily participates in nucleophilic substitution reactions. The substituent group on the benzene ring changes the distribution of its electron cloud, which affects the reaction activity and selectivity. The existence of trifluoromethyl gives it special chemical stability and hydrophobicity. It is widely used in the field of organic synthesis and can be used as a key intermediate to prepare fluorinated drugs, pesticides and functional materials through various reaction paths, which is of great significance to the modern chemical industry.

Technical Specifications & Labeling

1 - Iodo - 4 - (Trifluoromethyl) Benzene is an important chemical substance, and its technical specifications and labeling (product parameters) are crucial. Looking at its technical specifications, the purity must reach a very high standard, and the impurity content must be strictly controlled to ensure the stability of its performance in various reactions and applications. Its physical properties, such as appearance, melting point, boiling point, etc., are also accurately defined, which is the basis for identification and use.
As for labeling, key information such as chemical name, molecular formula, molecular weight, etc. should be clearly marked on the product packaging to prevent confusion and misuse. And a warning label should be attached to clearly remind it of possible dangers, such as toxicity, corrosiveness, etc. In this way, users can safely and efficiently use this chemical in accordance with technical specifications and identification (product parameters) during operation, ensuring the smooth progress of experiments or production.

Preparation Method

1 - Iodo - 4 - (Trifluoromethyl) Benzene is an important compound in organic synthesis. Its preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
Preparation of this compound is often based on compounds containing fluorine and iodine. Initially, a suitable fluoroaromatic hydrocarbon is selected, and a halogen atom, especially an iodine atom, is introduced under specific reaction conditions. This process requires fine control of the reaction temperature, time and ratio of reactants.
In the reaction step, the aromatic hydrocarbon substrate is activated first to make it easier to react with the iodine source. The selection of a suitable catalyst can significantly improve the reaction efficiency and selectivity. Such as some transition metal catalysts, it can promote the precise progress of halogenation reactions.
In the catalytic mechanism, the catalyst and the reactants form active intermediates, reduce the activation energy of the reaction, and accelerate the reaction process. By optimizing raw material selection, fine regulation of reaction steps and in-depth study of the catalytic mechanism, 1-Iodo-4- (Trifluoromethyl) Benzene can be efficiently prepared to meet the needs of scientific research and industry.

Chemical Reactions & Modifications

The author of 1-Iodo-4- (Trifluoromethyl) Benzene, the reverse of the transformation is necessary. The method of the past may have the disadvantages of reverse control and poor efficiency.
If you do it in a certain way, it will be harsh, and the side effect will be generated. Seek change, think of a new way. Change the reverse effect, and the reverse effect, and the strength of the reverse effect, in the hope of better transformation and performance.
Change the reverse effect, such as the activity is suitable, so that the reverse effect is flat. And the degree of integrity, do not make the high decomposition, do not make the low and reverse effect. In this way, the reverse effect increases, and the side effect is low. And the strength of the force can also affect the inverse process, and the appropriate force can promote the generation of 1-Iodo-4- (Trifluoromethyl) Benzene in the opposite direction.
This modification of the inverse process is expected to improve the yield of 1-Iodo-4- (Trifluoromethyl) Benzene. It is important for the research of this compound.

Synonyms & Product Names

1 - Iodo - 4 - (Trifluoromethyl) Benzene, also known as p-trifluoromethyl iodobenzene. Although their names are different, they actually refer to the same thing.
p-trifluoromethyl iodobenzene has a wide range of uses in the field of organic synthesis. Its unique structure provides possibilities for many reactions. In pharmaceutical research and development, it is often used as a key intermediate to help create novel drugs. In materials science, it also has a place, contributing to the synthesis of new materials.
Although the names are different, their properties are the same. Chemists, when using it, whether they call it 1-Iodo-4- (Trifluoromethyl) Benzene or p-trifluoromethyl iodobenzene, they all know what it is, so as to make good use of it and open up new frontiers for chemical research and application.

Safety & Operational Standards

1 - Iodo - 4 - (Trifluoromethyl) Benzene, the safety and operation of this substance are of paramount importance.
All operations involving this substance must be carried out in a well-ventilated place. Because of its volatility, if the ventilation is not smooth, the gas will accumulate, or cause harm. And when operating, appropriate protective equipment must be worn, such as gas masks, protective gloves and protective clothing. Gas masks can prevent their volatile gases from entering the body, and protective gloves and clothing should prevent them from contacting the skin and causing skin damage.
When storing, it should be placed in a cool, dry place away from fire sources and oxidants. This substance may react violently in case of open flame or oxidant, risking fire or explosion. The storage container must be well sealed to prevent leakage.
If you accidentally come into contact with this object and the skin touches it, you should quickly rinse with a large amount of water, followed by soap; if it enters the eyes, immediately rinse with flowing water or normal saline, and seek medical attention immediately. If inhaling, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen, perform artificial respiration if necessary, and send to the doctor immediately.
During use, precisely control the dosage and reaction conditions. Due to its active chemical nature, improper dosage or reaction conditions can cause the reaction to go out of control. After operation, properly clean the site and equipment to prevent hidden dangers caused by residual substances.
Strictly adhere to this safety and operation code to ensure personnel safety, avoid accidents, and promote the smooth development of research and production.

Application Area

1-Iodo-4- (Trifluoromethyl) Benzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be a key intermediate for the synthesis of specific drugs, helping to develop innovative drugs for specific diseases. In the field of materials science, it can be used to prepare functional materials with special properties, such as materials with excellent photoelectric properties, which can be used in advanced electronic devices. In the field of fine chemicals, it can be used as an important raw material for the synthesis of high-end fine chemicals to improve the quality and performance of products. Therefore, 1-Iodo-4- (Trifluoromethyl) Benzene is of key value in many fields and plays an indispensable role in promoting the development of related industries.

Research & Development

In recent years, I have been focusing on chemical substances, focusing on 1-Iodo-4- (Trifluoromethyl) Benzene. This substance is unique in nature and has a wide range of uses. It can involve various fields of medicine and materials, and has great potential.
At the beginning, analyze its structure, explore its characteristics, and clarify the basis of its chemical properties. In addition, study the synthesis method, and seek the path of high efficiency and purity. Although there were obstacles on the way, such as harsh reaction conditions and lower yield than expected, I was not discouraged and tried new strategies repeatedly.
After months of research, a new synthesis method was obtained, with a significant increase in yield and a decrease in cost. And at the application end, it was found in the preparation of new medical materials, which was quite effective. In the future, we hope to use this as a foundation, expand its use, promote the progress of the chemical industry, and seek well-being for the public.

Toxicity Research

Yu Taste is dedicated to the exploration of chemical properties, and recently focused on the toxicity study of 1-Iodo-4- (Trifluoromethyl) Benzene.
In the context of experiments, I have carefully observed its effects on various biological samples. Observe its interaction with cells, observe the changes in cell morphology and metabolism. See this substance enter the cell, or block its normal physiological path, causing cell viability to decline.
Take animals as models to explore their effects in vivo. By oral feeding or inhalation, observe the changes in animal behavior and physiological characteristics. It is found that it has adverse effects on the animal's nervous, respiratory and other systems. Or make the animal slow down and disordered breathing.
In summary, 1-Iodo-4- (Trifluoromethyl) Benzene is quite toxic and significantly interferes with the physiological functions of organisms. Follow-up studies should be conducted on its toxicological mechanism to find effective methods for protection and treatment, so as to avoid it from causing serious harm to the environment and personal health.

Future Prospects

Today there is a product called 1-Iodo-4- (Trifluoromethyl) Benzene, which is a raw material for chemical industry and has a wide range of uses. In the future development, my generation has many expectations. In the field of materials science, this substance is expected to help develop new high-performance materials and improve the quality and characteristics of products. In the field of medicinal chemistry, it may become a key ingredient in the creation of new drugs with special effects, for human health and well-being. And with the advancement of science and technology, synthetic methods will become more efficient, green, and cost will be reduced. Its application in industrial production will also be more extensive and in-depth, contributing to the development of society. Our chemical researchers should make unremitting research to explore more potential possibilities, so that this substance can bloom brightly in the future to benefit future generations.

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Frequently Asked Questions

As a leading 1-Iodo-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1-iodo-4- (trifluoromethyl) benzene?

1 - iodo - 4 - (trifluoromethyl) benzene, the Chinese name for 1 - iodo - 4 - (trifluoromethyl) benzene, its main uses are widespread.
First, in the field of synthesis, this compound is the most important starting material. Due to the high activity of iodine atoms, it is easy to generate multiple reactions such as even antibodies. Taking Suzuki as an example, in the presence of gold catalysis, the iodine atom in 1 - iodo - 4 - (trifluoromethyl) benzene reacts with boron-containing compounds, forming new carbon-carbon molecules. This reaction material plays an indispensable role in many aspects such as chemical synthesis and material science, and can help to synthesize chemical molecules with specific biological activities or materials with special properties.
Second, in the field of materials science, 1-iodine-4 - (trifluoromethyl) benzene can be used in the synthesis of fluorine-containing materials. Due to the introduction of trifluoromethyl, the material can have many properties, such as good weather resistance, chemical resistance and low surface energy. In the fields of chemical materials, plastics, etc., this fluorine-containing material is widely used. Adding fluorine-containing compounds synthesized from it to the material can improve the wear resistance, water resistance and fouling resistance of the film, making it more suitable for poor environments.
Third, 1-iodine-4- (trifluoromethyl) benzene also has important uses in research. The physicalization and biological activity of trifluoromethyl compounds affect the lipid solubility and substitution of compounds. The trifluoromethyl-containing molecules synthesized by this compound may have more biological activity and substitution. The new research provides a rich foundation.
Therefore, 1-iodo-4- (trifluoromethyl) benzene, with its special characteristics, has played an important role in many important fields such as synthesis, materials science and research, and has promoted the development of multiphase technology.

What are the physical properties of 1-iodo-4- (trifluoromethyl) benzene?

1-Iodo-4- (trifluoromethyl) benzene, Chinese name 1-iodo-4- (trifluoromethyl) benzene, its physical properties are as follows:
This substance usually appears as a colorless to light yellow liquid and is relatively stable at room temperature and pressure. Its boiling point is about 185-187 ° C, which allows it to transform from liquid to gaseous state at relatively moderate temperatures. This property of boiling point determines the temperature conditions required for separation, purification, etc.
Its melting point is about -3.2 ° C, indicating that below this temperature, it will solidify from liquid to solid state. The value of the melting point is of great significance for the control of storage and transportation conditions. If the temperature is too low, it may cause it to solidify and affect the use.
The density of 1-iodine-4- (trifluoromethyl) benzene is about 1.84 g/cm ³, which is higher than the density of water, so when mixed with water, it will sink to the bottom.
This substance is insoluble in water, because its molecular structure contains hydrophobic trifluoromethyl and benzene ring structures, making it difficult to form an effective interaction with water molecules. However, it is soluble in common organic solvents, such as ether, dichloromethane, etc. This solubility characteristic plays an important guiding role in the selection of reaction media and the separation and purification of products in organic synthesis.
It has a certain degree of volatility and will evaporate slowly in the air, which requires attention to closed operation during storage and use to prevent it from volatilizing into the air and causing losses or affecting the environment and human body. At the same time, because of its volatility, in some experiments or production processes that require precise control of the amount, its volatilization factor should be fully considered.

What are the chemical properties of 1-iodo-4- (trifluoromethyl) benzene?

1-Iodo-4- (trifluoromethyl) benzene is an organic compound containing iodine atoms and trifluoromethyl groups. Its chemical properties are interesting and it has a wide range of uses in the field of organic synthesis.
Among this compound, the iodine atom is very active, because its carbon-iodine bond energy is relatively low, and it is prone to nucleophilic substitution. For example, when encountering nucleophiles, such as alkoxides and amines, iodine atoms can be replaced, and then various new carbon-heteroatomic bonds can be formed to form ether and amine derivatives. This property makes 1-iodo-4- (trifluoromethyl) benzene a key intermediate for the preparation of functional molecules containing trifluoromethyl groups.
The introduction of trifluoromethyl gives the compound unique properties. Trifluoromethyl has strong electronegativity and electron-withdrawing effect, which can significantly affect the electron cloud density of the benzene ring, reduce the electron cloud density of the benzene ring, and thus weaken the electrophilic substitution activity of the benzene ring. However, due to its electron-withdrawing effect, the electron cloud density of the ortho and para-position decreases more than that of the meta-position, so the meta-position substitution products are relatively dominant in the electrophilic substitution reaction.
In addition, the presence of trifluoromethyl can enhance the stability and fat solubility of the compound. Due to the high carbon-fluorine bond energy in the trifluoromethyl group, the chemical stability of the compound is good, and it has obvious advantages in some occasions And its increased lipid solubility helps the compound to dissolve in the organic phase, which is convenient for participating in many organic reactions. It is also of great significance for its application in the field of medicinal chemistry, because it helps drug molecules to pass through biofilms and improve bioavailability.
Furthermore, 1-iodo-4- (trifluoromethyl) benzene can still participate in metal-catalyzed coupling reactions, such as palladium-catalyzed Suzuki coupling reaction, Stille coupling reaction, etc. In these reactions, iodine atoms can be coupled with other organometallic reagents under the action of metal catalysts to realize carbon-carbon bond construction, providing an effective way for the synthesis of complex structures containing trifluoromethyl aromatics.

What are the synthesis methods of 1-iodo-4- (trifluoromethyl) benzene

1-Iodo-4- (trifluoromethyl) benzene is 1-iodo-4- (trifluoromethyl) benzene. The common synthesis methods include the following:
First, 4- (trifluoromethyl) aniline is used as the starting material. First, 4- (trifluoromethyl) aniline is reacted with sodium nitrite in a hydrochloric acid solution to form a diazonium salt at low temperature. This process requires strict control of temperature to prevent the decomposition of diazonium salts. Then, the diazonium salt is reacted with a potassium iodide solution, and the diazonium group is replaced by an iodine atom to obtain 1-iodo-4- (trifluoromethyl) benzene. The steps of this method are relatively clear, but the diazotization reaction conditions are relatively harsh and need to be precisely controlled.
Second, p- (trifluoromethyl) bromobenzene is used as raw material. Under the action of catalysts, such as palladium catalysts, halogen atom exchange reactions are carried out with iodizing reagents. Commonly used iodizing reagents such as cuprous iodide, etc. In the reaction, palladium catalysts promote the exchange of bromine atoms and iodine atoms to realize the synthesis of 1-iodine-4- (trifluoromethyl) benzene. The choice of catalyst for this method is very critical. The activity and selectivity of different palladium catalysts vary, which has a great impact on the yield and purity of the reaction.
Third, 4- (trifluoromethyl) benzoic acid is used as the starting material. First, it is converted into the corresponding acyl chloride, which can be achieved by using reagents such as dichlorosulfoxide. Then, through reduction reaction, the acyl chloride is converted into 4- (trifluoromethyl) benzaldehyde. Then, through haloform reaction, 4- (trifluoromethyl) benzaldehyde is reacted with reagents such as sodium hypoiodate to finally generate 1-iodine-4- (trifluoromethyl) benzene. There are many steps in this route, and each step requires careful operation to ensure the overall synthesis effect.
All these synthetic methods have their own advantages and disadvantages. In practical application, the most suitable method should be selected based on factors such as raw material availability, cost, reaction conditions and product requirements.

What should be paid attention to when storing and transporting 1-iodo-4- (trifluoromethyl) benzene?

1 - iodo - 4 - (trifluoromethyl) benzene, the Chinese name for 1 - iodo - 4 - (trifluoromethyl) benzene, this substance needs to be paid attention to during storage and storage.
For storage, the first important environment should be taken. It should be placed in a large and well-connected room. Because if the material is high or not in a large place, it may be caused by the increase of temperature, the emptiness, and the deterioration of the environment, resulting in the change of its properties. And it needs to be exposed to fire and source, both of which cause serious danger. Open flames or high temperatures may burn the material, cause fire or even explode.
Furthermore, the container must be well sealed. 1-Iodine-4- (trifluoromethyl) benzene or active. If the container is not well sealed, it is easy to generate more ingredients in the air, such as oxygen, water vapor, etc., so that the product is damaged. And a good seal can also prevent the product from escaping, less harmful vapor, and protect the health of people.
In addition, this product can be stored in parts such as oxidation and raw materials. The oxidized raw materials all have strong chemical activity, and the mixture of 1-iodine-4- (trifluoromethyl) benzene is easy to cause strong chemical reactions, or serious accidents such as combustion and explosion.

The package needs to be stored. It is necessary to use suitable packaging materials to ensure that there is no leakage due to bumps and collisions on the way. And the outer part of the package is clearly marked with warnings, so that people and related parties can see at a glance, know its dangerous characteristics, and operate with care.
Tools also need to be properly designed and used. All the materials used are clean, dry, and have good communication. On the way, people need to pay attention to the package, keep the speed constant, and avoid emergency, severe bumps, etc., to prevent the package from breaking, resulting in the leakage of 1-iodine-4- (trifluoromethyl) benzene, endangering human safety and environment. In this way, the safety of 1-iodine-4- (trifluoromethyl) benzene can be guaranteed during storage and transportation.