1 Iodooctadecane

1-Iodooctadecane, Chinese name 1-iodooctadecane, is an organic compound that has important uses in various fields.
First, in the field of organic synthesis, it is often used as an alkylation reagent. Due to its high reactivity of iodine atoms in the molecule, it can react with many nucleophilic reagents, thereby introducing octadecane into the target molecule, and then synthesizing organic compounds with complex structures. For example, when preparing surfactants with special structures, 1-iodooctadecane can react with nucleophilic reagents containing hydrophilic groups to obtain surfactants with both long-chain alkyl hydrophobic moieties and hydrophilic moieties. This is widely used in daily chemicals, oil extraction and other industries.
Second, in the field of materials science, it also plays a key role. It can be used to prepare self-assembled monolayer materials. 1-iodooctadecane molecules can form a regularly arranged monolayer structure on a solid surface by chemical bonding or physical adsorption, which has a significant effect on regulating the surface properties of materials, such as wettability and adhesion. For example, the construction of a self-assembled monolayer formed by 1-iodooctadecane on the surface of some metal materials can enhance the corrosion resistance of the material, because the monolayer can block the contact of external corrosive substances with the metal surface.
Third, in the field of drug development, 1-iodooctadecane can be used as a raw material for drug carriers. The long-chain alkyl structure can endow the drug carrier with specific lipophilicity, which is helpful for the transportation and delivery of drugs in vivo. For example, linking it to some therapeutically active molecules can improve the solubility and bioavailability of drugs, making it easier for drugs to pass through the biofilm and reach the target of action, thereby enhancing the therapeutic effect.
In conclusion, 1-iodooctadecane plays an important role in many fields such as organic synthesis, materials science, and drug development due to its unique structure and reactivity, and has made great contributions to promoting technological progress and innovation in various fields.

1-Iodooctadecane, that is, 1-iodostadecane, is an organic compound. Its physical properties are as follows:
In appearance, it usually shows a colorless to light yellow liquid state, with a pure texture and no visible impurities. This is due to its long carbon chain in the molecular structure and moderate intermolecular forces, which maintain a liquid state at room temperature.
The boiling point is quite high, about 237 ° C (1.33kPa). Due to the large molecular weight and long carbon chain of this substance, there is a strong van der Waals force between molecules. To make the molecules break free from each other and become gaseous, more energy needs to be supplied, so the boiling point is high. The melting point of
is 28-30 ° C. Under this temperature range, the thermal motion energy of molecules decreases, the orderly arrangement between molecules is enhanced, and the liquid state is converted to a solid state. The density of
is about 1.05g/cm ³, which is slightly higher than the density of water. Due to the large relative atomic weight of iodine atoms in the molecule, its unit volume mass is larger.
In terms of solubility, it is difficult to dissolve in water. Because it is a non-polar organic compound, and water is a polar solvent, according to the principle of "similar miscibility", the polarity difference between the two is large, and the interaction force is weak, so it is difficult to dissolve. However, it is soluble in many organic solvents, such as ether, benzene, chloroform, etc. Because these organic solvents are also non-polar or weakly polar, they can be miscible with each other due to the intermolecular force of 1-iodostadecane.
In addition, 1-iodostadecane is volatile to a certain extent, but due to the large intermolecular force, the volatility is relatively weak. At room temperature and pressure, it can evaporate slowly in the air, and when the temperature rises, the volatilization rate accelerates.

1-Iodooctadecane, or 1-iodooctadecane, has unique chemical properties. It is an organic halide containing an iodine atom and an octadecane straight-chain alkyl group.
In terms of physical properties, it is mostly liquid at room temperature. Due to the existence of long-chain alkyl groups, it has certain hydrophobicity. It is insoluble in water and can be soluble in common organic solvents such as ether and chloroform. Its molecular weight is large, the boiling point is relatively high, and it is due to strong intermolecular forces.
In terms of chemical properties, the activity of iodine atoms allows 1-iodooctadecane to participate in many reactions. In the nucleophilic substitution reaction, the iodine atom is easily replaced by the nucleophilic reagent. If it reacts with sodium alcohol, the corresponding ether compound can be formed; when reacted with sodium cyanide, the cyanyl group replaces the iodine atom to obtain the octadecarbon compound containing the cyanide group. The product can be further hydrolyzed or reduced to obtain other organic compounds.
In addition, 1-iodostadecane can also participate in the elimination reaction. Under the action of a strong base, the iodine atom is removed from the hydrogen atom on the adjacent carbon atom to form a carbon-carbon double bond to obtain the octadecarbon-containing olefin compound. This olefin can be
Due to the iodine-containing atom, 1-iodostadecane is widely used in the field of organic synthesis. It can be used as an intermediate to synthesize organic compounds with different functional groups and structures, providing an important basis for the research and practical application of organic synthetic chemistry.

There are various ways to synthesize 1-iodooctadecane. One is to react with octadecanol and an iodizing reagent. Take octadecanol and place it in a reactor, and add an iodizing reagent, such as hydrogen iodide or phosphorus triiodide. If hydrogen iodide is used, under a suitable temperature and pressure, the two begin a substitution reaction. The hydroxyl group of the alcohol is replaced by an iodine atom, and then 1-iodooctadecane is obtained. The reaction temperature and time should be controlled to prevent side reactions. If the temperature is too high, it may cause the elimination of the reaction, resulting in olefin impurities; if the time is too long, there may be a risk of excessive iodization.
Another method is to replace octadecyl halides with i Take octadecyl chloride or bromine and mix it with sodium iodide or potassium iodide in an organic solvent. Common solvents are acetone, acetonitrile, etc. The activity of halogen atoms is different. The activity of chlorine is slightly lower, and the reaction may require a slightly higher temperature and a longer time; the activity of bromine is higher, and the reaction is easier. In this reaction, the solvent is very important, and it is necessary to be able to dissolve the reactants and not react with both, so as to facilitate the reaction.
In addition, starting with octadecane, halogenated octadecane is first obtained, and then reacted with iodizing reagents to obtain 1-iodooctadecane. During halogenation, chlorine gas or bromine can be used, and the free radical substitution reaction can be carried out under light or initiator to obtain halogenated octadec After changing with iodizing reagent according to the previous method, the target product was obtained. However, the selectivity of free radical reaction is not good, or a variety of halogenated isomers are generated, and it is necessary to separate and purify well to obtain pure 1-iodooctadecane.

1 - Iodooctadecane, organic compounds are also used, and many matters must be paid attention to when using it.
First safety protection. This compound may be toxic and irritating, so when taking it, you must wear appropriate protective equipment, such as laboratory clothes, gloves and goggles, to prevent it from contacting the skin, eyes and respiratory tract and causing damage to the body. In case of inadvertent contact, rinse quickly with plenty of water, and seek medical treatment if necessary.
Furthermore, pay attention to its chemical properties. 1 - Iodooctadecane is flammable in the event of open flames and hot topics. Store and use it away from fire and heat sources, and place it in a cool and ventilated warehouse to prevent the risk of fire and explosion. And because of its certain chemical activity, avoid mixing or mixing with strong oxidants, strong alkalis and other substances to prevent violent chemical reactions.
The operation process should not be ignored. When taking this compound, it should be used in a well-ventilated environment, such as in a fume hood, so that the volatile gas can be discharged in time, reduce the concentration in the air, and reduce the harm to the human body. Use accurate measuring tools to measure, according to the amount required for experiment or production, and operate strictly. Do not increase or decrease at will, so as not to affect the results or cause safety problems. Store it properly after use, seal the container to avoid moisture absorption or reaction with air components, resulting in quality changes.
In addition, waste materials of 1-iodooctadecane should not be discarded at will. They should be collected in accordance with relevant environmental regulations and laboratory regulations, and handed over to professional treatment institutions for environmentally friendly disposal without polluting the environment. In this way, the safety, science and environmental protection of the process of using 1-iodooctadecane can be guaranteed.