1 Methyl 4 Iodo 1h Pyrazole

1 - methyl - 4 - iodo - 1H - pyrazole is an organic compound, which is mostly solid and has a certain solubility in specific organic solvents. In this compound, the iodine atom is connected to the pyrazole ring, which endows the compound with many unique chemical properties due to the characteristics of the iodine atom.
First, the nucleophilic substitution reaction activity is quite high. As a good leaving group, the iodine atom is easily replaced by nucleophilic reagents under appropriate nucleophilic reagents and reaction conditions. For example, in the case of nucleophilic reagents containing hydroxyl and amino groups, the iodine atom can be replaced to form new organic compounds. This reaction is of great significance in the field of organic synthesis for the construction of complex molecular structures.
Second, it is active in metal-catalyzed coupling reactions. Like palladium-catalyzed coupling reactions, 1-methyl-4-iodo-1H-pyrazole can be coupled with other organic halide or olefin substrates to form carbon-carbon or carbon-heteroatom bonds, which help to synthesize organic materials and pharmaceutical intermediates with specific structures and functions.
Third, the presence of pyrazole rings makes it acidic. The hydrogen on the nitrogen atom of 1-methyl-4-iodo-1H-pyrazole can leave under the action of strong base to form corresponding negative ions. This negative ion can participate in various reactions as a nucleophilic reagent, which greatly enriches the reaction path and product types of the compound.
Fourth, due to the electronegativity and large volume of the iodine atom, the intermolecular force of 1-methyl-4-iodo-1H-pyrazole is unique, which affects its physical properties such as melting point and boiling point, and also plays a role in the steric resistance effect in chemical reactions, which is of great significance in terms of reaction selectivity.
Fifth, the stability of this compound needs to be maintained under specific conditions. Iodine atoms are relatively active and may cause decomposition or other side reactions under high temperature, light or specific chemical environments. Therefore, environmental factors must be paid attention to when storing and using to ensure its chemical stability.

The common synthesis methods of 1-methyl-4-iodo-1H-pyrazole are as follows:
First, 4-iodo-pyrazole is used as the starting material. Dissolve 4-iodo-pyrazole in a suitable organic solvent such as N, N-dimethylformamide (DMF). Add an appropriate amount of alkali, such as potassium carbonate, which can act as an acid binding agent and combine with the acid produced in the reaction to promote the forward progress of the reaction. After stirring well, slowly add iodomethane dropwise. This process needs to be carried out at a suitable temperature, usually controlled at room temperature to about 50 ° C. The methyl group of iodomethane will replace the hydrogen on the nitrogen atom of pyrazole, thereby generating 1-methyl-4-iodine-1H-pyrazole. After the reaction, the target product can be obtained by conventional post-treatment means, such as dilution with water, organic solvent extraction, drying the organic phase, distillation to remove the solvent, etc.
Second, 1-methylpyrazole is used as the raw material. Place 1-methylpyrazole in the reaction vessel and add a suitable halogenating reagent, such as N-iodosuccinimide (NIS). The reaction is carried out under the condition of light or the presence of an initiator with dichloromethane as the solvent. The iodine atom in N-iodosuccinimide selectively replaces the hydrogen atom at the 4-position of 1-methylpyrazole to generate 1-methyl-4-iodine-1H-pyrazole. After the reaction is completed, the product can be obtained by filtering to remove insoluble matter, washing the organic phase, drying, and concentration.
Third, it can be synthesized by constructing a pyrazole ring. React with iodoformamidine under basic conditions with an appropriate β-dicarbonyl compound. First, the β-dicarbonyl compound is mixed with the base in a solvent to form an enolate intermediate. After adding iodoformamidine, the cyclization reaction of the two occurs to construct the pyrazole ring structure, and methyl and iodine atoms are introduced to generate 1-methyl-4-iodine-1H-pyrazole. After the reaction is completed, the pure product is obtained by separation and purification.

1-Methyl-4-iodine-1H-pyrazole, an organic compound, is useful in many fields.
In the field of pharmaceutical research and development, it is often a key intermediate. Pyrazole compounds have a variety of biological activities, such as anti-inflammatory, antibacterial, antiviral and anti-tumor. 1-Methyl-4-iodine-1H-pyrazole can introduce other functional groups through specific chemical reactions to build complex active molecules. For example, it can be coupled with other molecules containing active groups through coupling reactions to develop new antibacterial drugs that can inhibit or kill specific pathogens.
In the field of materials science, it also has applications. Pyrazole derivatives can be used to prepare optoelectronic materials. 1-methyl-4-iodine-1H-pyrazole may participate in the construction of materials with specific optoelectronic properties due to its unique electronic structure and chemical properties. For example, it can be introduced into polymer systems, or the electrical and optical properties of materials can be regulated, and used to make active layer materials for organic Light Emitting Diodes (OLEDs) or solar cells to improve the performance of devices.
Furthermore, in the field of organic synthesis chemistry, it is an important synthetic building block. With the activity of iodine atoms, many reactions such as nucleophilic substitution and metal catalytic coupling can occur. Chemists can use this to form carbon-carbon bonds or carbon-heteroatomic bonds to synthesize organic molecules with novel structures and unique functions, contributing to the development of organic synthetic chemistry.

1 - methyl - 4 - iodo - 1H - pyrazole is also a matter of transformation. To know its market value, it is not easy, and it is often due to general factors.
First, supply and demand are the most important. If the demand for this thing is not enough, and the production is not enough, it will be necessary; on the contrary, if the supply is in demand, it will fall.
Second, the supply of raw materials also has a big impact. If the raw materials required for the production of 1 - methyl - 4 - iodo - 1H - pyrazole are not easy, the finished product will also be inexpensive; if the raw materials are reduced, the finished product may be less expensive.
Third, the cost of manufacturing is high. If the method is complex, high-tech work and high-tech tools are required, and the cost will be high, and the cost will also be reduced; if there is an easy and economical method, the cost may be reduced.
Fourth, the cost of the market cannot be ignored. If the market is full of this thing, the market is intense, and it is difficult to sell it, and it is difficult to sell it to customers; if there is a small family or a small family, it can be determined independently.
Now if you want to know the market, the business of chemical products, or the quality of chemical raw materials, you can get close to it. Only if it is not available, it will be available today, or tomorrow, so you need to pay attention to it to get the latest news.

1 - methyl - 4 - iodo - 1H - pyrazole is an organic compound. Its safety and toxicity are critical in many fields, such as chemical synthesis, drug development, etc.
In terms of safety, this compound is usually stable at room temperature and pressure, if properly stored in a dry, cool and well-ventilated place. However, care should be taken to avoid contact with strong oxidants, as it may cause severe chemical reactions and endanger safety. During operation, appropriate protective measures are indispensable, such as wearing protective gloves, goggles and gas masks, to avoid skin contact and inhalation risks. At the same time, good ventilation is essential to reduce the concentration of this compound in the air and reduce potential hazards.
When it comes to toxicity, although there is a lack of extensive and in-depth research at present, it can be speculated based on the characteristics of similar iodine-containing and nitrogen-containing heterocyclic compounds. The presence of iodine atoms or its biological activity and toxicity are affected. A small amount of intake or exposure may cause minor irritation symptoms, such as skin contact can cause redness and itching of the skin; inhalation of a small amount may cause respiratory discomfort, such as cough and asthma. If the intake is large, due to the structure of nitrogen heterocyclic rings, it may interfere with the metabolism of organisms and affect the normal physiological functions of cells. In animal experiments, functional changes in organs such as liver and kidney may occur. Therefore, when using and disposing of 1-methyl-4-iodo-1H-pyrazole, it is necessary to strictly follow the safety operation procedures to ensure the safety of personnel and the environment from pollution.