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What is the main use of 1- (tert - butoxycarbonyl) -4-iodopiperidine?
1- (tert-butoxycarbonyl) -4-iodopiperidine is a crucial chemical substance in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. The construction of many drug molecules depends on its participation. Due to the activity of iodine atoms in its structure, it can be combined with other functionalized molecules through coupling reactions and other means to construct complex compound structures with specific pharmacological activities.
In the field of materials science, 1- (tert-butoxycarbonyl) -4-iodopiperidine also has extraordinary performance. It can be used to prepare functional polymer materials. By introducing it into the main chain or side chain of the polymer, the material is endowed with unique properties, such as improving the solubility and thermal stability of the material, or even endowing it with special optical and electrical properties.
Furthermore, this compound is also a commonly used model substrate in the study of organic synthesis methodologies. Researchers have developed novel and efficient organic synthesis strategies by exploring and optimizing various reaction conditions. In palladium-catalyzed cross-coupling reactions, 1 - (tert-butoxycarbonyl) - 4 - iodopiperidine is often selected to explore the effects of different ligands, bases and reaction temperatures on the yield and selectivity of the reaction, thus providing an important theoretical and practical basis for the development of organic synthetic chemistry.
What are the synthesis methods of 1- (tert - butoxycarbonyl) -4-iodopiperidine
The common methods for synthesizing 1 - (tert-butoxycarbonyl) - 4 - iodopiperidine include the following.
First, piperidine is used as the starting material. First, piperidine is reacted with di-tert-butyl dicarbonate. This reaction is mild and can be carried out under alkaline conditions. For example, triethylamine is used as a base in a suitable organic solvent, such as dichloromethane. The nitrogen atom of piperidine will be protected by tert-butoxycarbonyl to obtain 1 - (tert-butoxycarbonyl) piperidine. Subsequently, iodine atoms are introduced through a halogenation reaction. N-iodosuccinimide (NIS) can be used as the iodizing reagent. Under suitable conditions, such as light or the presence of an initiator, NIS will react with 1- (tert-butoxycarbonyl) piperidine, and introduce iodine atoms at the 4-position of the piperidine ring to obtain 1- (tert-butoxycarbonyl) -4-iodopiperidine.
Second, 4-piperidone can also be used as the starting material. First, 4-piperidone is reacted with di-tert-butyl dicarbonate, which is also assisted by basic substances to protect the nitrogen atom of the piperidine ring to form 1- (tert-butoxycarbonyl) -4-piperidone. Then the carbonyl group is reduced, and a reducing agent such as sodium borohydride can be selected. In an alcohol solvent, the carbonyl group is reduced to a hydroxyl group to obtain 1- (tert-butoxycarbonyl) -4-hydroxypiperidine. Finally, the hydroxyl group is converted into an iodine atom, and the iodizing reagent such as phosphorus iodide (PI 🥰) or under the action of triphenylphosphine and iodine elemental substance, the hydroxyl group can be replaced by an iodine atom to achieve the synthesis of 1- (tert-butoxycarbonyl) -4-iodopiperidine.
Furthermore, a suitable substituted pyridine can be used as the starting material. After hydrogenation, the pyridine ring is reduced, and then the tert-butoxycarbonyl protection of the nitrogen atom is carried out. The subsequent steps are similar to the above method. Iodine atoms are introduced through halogenation and other reactions, and the final target product is 1- (tert-butoxycarbon
What are the physical properties of 1- (tert - butoxycarbonyl) -4-iodopiperidine
1 - (tert-butoxycarbonyl) -4 -iodopiperidine is an important compound in organic chemistry. Its physical properties are of great value to explore.
Looking at its morphology, it is mostly white to light yellow solids under normal conditions. This color and morphology are its external characteristics and can be one of the important clues for identifying this substance.
The melting point is about a specific temperature range, which is crucial for the identification and purification of compounds. Since the melting point is an inherent characteristic of the substance, a specific compound has its own specific melting point, so the determination of the melting point can be used to determine the purity and authenticity of the compound.
Furthermore, solubility is also one of its important physical properties. In common organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., it exhibits good solubility. This property makes it possible to select suitable solvents in the process of organic synthesis to promote the progress of related chemical reactions. Its dissolution behavior in organic solvents is closely related to the functional groups in the molecular structure. The presence of tert-butoxycarbonyl and iodine atoms affects the interaction force between molecules, which in turn determines its solubility.
In addition, the stability of the compound cannot be ignored. Under normal storage conditions, it has a certain stability. When exposed to extreme conditions such as strong acids, strong bases or high temperatures, its structure may change. The characteristics of this stability need to be fully considered when storing and using the compound to ensure that its chemical properties are constant.
It can be seen from the above that the physical properties of 1- (tert-butoxycarbonyl) -4-iodopiperidine, from morphology, melting point, solubility to stability, play a pivotal role in its application in organic synthesis, drug development and other fields.
What is the market price of 1- (tert - butoxycarbonyl) -4-iodopiperidine
"1- (tert-butoxycarbonyl) -4-iodopiperidine", that is, 1- (tert-butoxycarbonyl) -4-iodopiperidine, its market price often fluctuates due to a variety of factors. This substance is an important intermediate in organic synthesis in the chemical raw material market, and is often used in the preparation of fine chemicals such as medicine and pesticides.
Its price is mainly affected by the cost of raw materials. If the price of raw materials such as tert-butoxycarbonyl, phosgene, and 4-iodopiperidine required for preparation rises, the cost of "1- (tert-butoxycarbonyl) -4-iodopiperidine" will increase, and the price will rise. If the price of tert-butanol increases due to oil price fluctuations or its own supply and demand imbalance, the cost of this product will also rise.
The market supply and demand relationship is also key. If the demand for drugs containing this intermediate in the field of pharmaceutical research and development increases sharply, the demand exceeds the supply, and the price will rise. On the contrary, if the demand in related industries is weak and the supply exceeds the demand, the price will easily fall.
The production process and technical level have a significant impact. Advanced and efficient processes can reduce production costs and improve product quality and output. If enterprises master the optimization process, they can produce at a lower cost, and the price may be more competitive.
Product quality and purity also affect the price. High-purity products are more popular in high-end pharmaceutical synthesis needs, and the price is relatively high. 99% purity products are several yuan or even tens of yuan higher per gram than 95% purity products.
Regional differences have an impact on prices that cannot be ignored. Different regions have different levels of economic development, logistics costs, and market competition, resulting in different prices. In economically developed and highly competitive areas, prices may be more transparent and reasonable; in remote areas, prices may be higher due to factors such as high logistics costs.
Overall, the market price ranges from tens to hundreds of yuan per gram, which needs to be determined according to the above factors. Buyers should carefully observe market dynamics and choose more suppliers to obtain reasonable prices.
1- (tert - butoxycarbonyl) -4-iodopiperidine during storage and transportation
1 - (tert-butoxycarbonyl) - 4 - iodopiperidine is a compound commonly used in organic synthesis. During storage and transportation, it is necessary to pay attention to many matters to avoid changes in its properties and affect subsequent use.
First, when storing, it should be placed in a cool and dry place. This compound is prone to hydrolysis in case of moisture, resulting in the shedding of tert-butoxycarbonyl, which in turn affects its structure and activity. And it is not suitable if the temperature is too high. High temperature may cause its decomposition, so it is necessary to strictly control the temperature. The optimal storage temperature should be maintained between 2-8 ° C. This temperature range can effectively maintain its stability.
Second, the air in the storage environment should also be paid attention to. Due to its sensitivity to oxidation, long-term exposure to air, iodine atoms may be oxidized, causing the compound to deteriorate. Therefore, it is recommended to store in an inert gas environment, such as a nitrogen atmosphere, to isolate oxygen and ensure its quality.
Third, the transportation process is equally critical. It should be ensured that the packaging is tight to prevent leakage. Because of its certain toxicity and irritation, leakage will not only endanger the environment, but also pose a threat to the health of transporters. Packaging materials need to have good sealing and corrosion resistance. Glass bottles or special plastic containers can be used, supplemented by cushioning materials to prevent packaging damage due to collision during transportation.
Fourth, the label must be clearly marked. On the storage and transportation containers, the name, nature, hazard and emergency treatment information of the compound should be clearly marked. In this way, in the event of an unexpected situation, relevant personnel can quickly take correct measures to reduce losses. In short, proper storage and transportation are essential to the quality and safety of 1- (tert-butoxycarbonyl) -4-iodopiperidine, and must not be neglected.