1 Tert Butyl 4 Iodobenzene

1- (tert-butyl) -4-iodobenzene is a key raw material commonly used in the field of organic synthesis. It is widely used in the organic synthesis industry.
First, it can be used as a key building block for building carbon-carbon bonds. Through palladium-catalyzed cross-coupling reactions, such as Suzuki reaction and Stangler reaction, 1- (tert-butyl) -4-iodobenzene can be cleverly combined with various organometallic reagents containing boron and tin to efficiently construct diverse biphenyl derivatives. Such biphenyl structures are of great significance in the fields of medicinal chemistry and materials science, or play a key role in the development of new active pharmaceutical ingredients, or in organic optoelectronic materials, helping to improve the photoelectric properties of materials.
Second, in the process of synthesizing complex natural products and compounds with specific biological activities, 1- (tert-butyl) -4-iodobenzene can also play an important role. Through a series of organic reactions, the complex structure of the target molecule is gradually built, and then a solid material foundation is provided for the research and development of new drugs and bioactive molecules.
Third, in the field of materials science, 1- (tert-butyl) -4-iodobenzene can be used as a starting material to prepare organic polymer materials with unique optical and electrical properties through polymerization or functional group transformation. Such materials may be applied to cutting-edge fields such as Light Emitting Diode and solar cells to promote the progress and innovation of related technologies.
In summary, although 1- (tert-butyl) -4-iodobenzene is an organic compound, it plays a key role in many important fields such as organic synthesis, drug research and development, and materials science due to its unique chemical structure, and makes outstanding contributions to the development of various fields.

There are several methods for the synthesis of 1- (tert-butyl) -4-iodobenzene.
First, 4-tert-butyl aniline is used as the starting material. First, 4-tert-butyl aniline is converted into diazonium salts by diazotization reaction. This reaction needs to be carried out at low temperature and in the presence of sodium nitrite and acid (such as hydrochloric acid). The stability of the resulting diazonium salt is poor, and then the potassium iodide solution is added, the diazonium group will be replaced by the iodine atom, resulting in 1- (tert-butyl) -4-iodobenzene. This method is relatively simple, but the diazotization reaction requires strict control of the reaction temperature and the amount of reagents. A little carelessness can < Br >
Second, we can start from 4-tert-butylphenylboronic acid. 4-tert-butylphenylboronic acid is reacted with an iodide reagent (such as N-iodosuccinimide, NIS) in the presence of a suitable catalyst (such as palladium catalyst, such as tetra (triphenylphosphine) palladium) and a base (such as potassium carbonate). This is a classic palladium-catalyzed cross-coupling reaction. The reaction conditions are relatively mild and the selectivity is quite high, but the palladium catalyst is expensive and increases the synthesis cost.
Third, tert-butylbenzene is used as the starting material. The halogenation reaction of tert-butylbenzene is carried out first. Iodine and a suitable catalyst (such as ferric chloride) are usually used to make the electrophilic substitution reaction occur on the benzene ring to generate 1- (tert-butyl) -4-iodobenzene. However, this reaction may produce by-products of ortho-substitution, and the purity of the target product needs to be improved by optimizing the reaction conditions or subsequent separation methods.
All synthesis methods have advantages and disadvantages. In practical applications, the most suitable synthesis path should be selected based on factors such as raw material availability, cost, and product purity requirements.

1 - (tert-butyl) - 4 - iodobenzene is also an organic compound. Its physical properties are quite important to chemists.
First of all, under room temperature, 1- (tert-butyl) - 4 - iodobenzene is colorless to light yellow liquid. The view is clear. If placed under light, it can be seen that it is slightly flooded, like a firefly glow. Because of its molecular structure, it has a specific reflection and refraction of light. < Br >
When it comes to melting point, the melting point of this substance is relatively low, between -30 ° C and -20 ° C. Therefore, in ordinary low temperature environments, it is not easy to condense into a solid state, just like the agility of water, often in a flowing state.
The boiling point is higher, roughly in the range of 230 ° C to 240 ° C. To make it boil and vaporize, a higher temperature needs to be applied, just like to make the Hidden Dragon ascend to the sky, it must be calcined by fire.
Its density is slightly higher than that of water. If it is placed in the same place as water, it can be seen that it slowly sinks to the bottom of the water, just like a pearl sinking into the abyss. This is due to its intermolecular force and atomic weight.
In terms of solubility, 1- (tert-butyl) -4-iodobenzene has good solubility in organic solvents, such as ethanol, ether, chloroform, etc., and can be fused with it, just like the water of fish; However, in water, the solubility is very small, and the two are like a merchant, and it is difficult to phase, which is caused by the difference between the polarity of its molecules and the polarity of water molecules.
In addition, the volatility of 1- (tert-butyl) -4-iodobenzene is weak. In air, its molecules dissipate slowly, unlike light smoke. This property is also related to the strength of intermolecular interactions.
In summary, the physical properties of 1 - (tert-butyl) -4 -iodobenzene are determined by its unique molecular structure, and these properties have a crucial impact on organic synthesis, chemical production and other fields.

1 - (tert-butyl) -4 -iodobenzene is also an organic compound. It has unique chemical properties and is related to many organic synthesis reactions, which is very important in the field of chemistry.
In this compound, tert-butyl and iodine atoms are attached to the benzene ring. Tert-butyl is a large substituent and has a steric hindrance effect. Due to the large size of tert-butyl, it can affect the spatial structure and reactivity of molecules. In many reactions, it can prevent other reagents from approaching specific positions in the benzene ring, resulting in changes in reaction selectivity. For example, in electrophilic substitution reactions, the steric hindrance of tert-butyl can guide new substituents into positions where the relative steric hindrance of the benzene ring is small,
Furthermore, the iodine atom also has important chemical properties in 1- (tert-butyl) -4-iodobenzene. The iodine atom is a halogen atom with certain electronegativity. It can change the electron cloud density distribution of the benzene ring, reduce the electron cloud density of the benzene ring and the para-position, thereby affecting the electrophilic substitution reaction activity of the benzene ring. And the iodine atom is often a good leaving group in organic synthesis. Under appropriate reaction conditions, such as nucleophilic substitution reaction, the iodine ion can leave with a pair of electrons, so that the benzene ring reacts with the nucleophilic reagent to form a new organic compound. This property provides an effective way to construct complex organic molecular structures.
In addition, the physical properties of 1- (tert-butyl) -4-iodobenzene also affect its chemical behavior. Its solubility, melting point, boiling point and other physical properties determine the reaction state of the compound under different solvents and temperature conditions. In organic solvents, its solubility can affect the reaction rate and reaction process. Suitable solvents can promote the contact between the reactants and accelerate the reaction. < Br >
1 - (tert-butyl) -4 -iodobenzene tert-butyl and iodine atoms have unique steric resistance effects, electronic effects and leaving group characteristics. These chemical properties make it widely used in the field of organic synthetic chemistry. It can be used to construct various organic molecular structures and provide an important material basis for the development of organic chemistry.

The price range of 1- (tert-butyl) -4-iodobenzene in the market is difficult to determine. This is due to the fickle market conditions, and the price is determined by many factors.
First, the state of supply and demand has a huge impact. If there are many people who want it, and the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price will fall. For example, at some time and place, many chemical companies compete for this product to make a specific drug, resulting in a large increase in demand. Second, the manufacturing cost is also the key. The price of raw materials, the simplicity of production processes, and the amount of energy consumption are all related to costs. If the raw materials are expensive, or the production requires high-end and complex processes, the cost will be high, and the price will not be low.
Third, the quality grade will also determine the price. High purity, the price must be higher than low purity. For example, high purity 1- (tert-butyl) -4-iodobenzene required for scientific research is often higher than industrial grade, because of its strict requirements on impurity content.
Fourth, market competition also has an impact. If there are many merchants in the market and the competition is fierce, it is for customers, or there is a price reduction; if the market is close to monopoly, the price may be controlled by the monopolist.
According to past market conditions and the price laws of similar compounds, the price may range from a few yuan per gram to tens of yuan. However, this is only an approximate number. The actual price needs to be consulted in real time from chemical raw material suppliers, chemical reagent sales platforms, etc., to obtain accurate prices.