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What are the main uses of 1- (tert - butyldimethylsilyloxy) -2-iodoethane?
1 - (tert-butyl dimethylsiloxy) -2 -iodoethane, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
Because of its unique structure, tert-butyl dimethylsiloxy has good stability and protection, while iodine atoms are quite active and easy to cause many chemical reactions. For example, in the reaction of building carbon-carbon bonds, iodine atoms can be combined with various nucleophiles or metal-organic reagents through reaction mechanisms such as nucleophilic substitution and metal catalytic coupling, thereby realizing the construction of complex organic molecules.
Furthermore, in the field of medicinal chemistry, this compound may be used to synthesize drug molecules with specific biological activities. It can be used as a starting material to introduce other functional groups through a series of chemical transformations to meet the requirements of drug design for molecular structure and activity.
In the field of materials science, this compound may also be applied. Through the chemical reactions it participates in, it may be able to prepare organic materials with special properties, such as functional polymers. In short, 1 - (tert-butyl dimethylsiloxy) -2 - iodoethane plays an important role in organic synthesis, drug development and material preparation, providing a key material basis for many chemical research and practical applications.
What are the synthesis methods of 1- (tert - butyldimethylsilyloxy) -2-iodoethane
The synthesis method of 1 - (tert-butyl dimethylsiloxy) - 2 - iodoethane, although the ancient book "Tiangong Kaiwu" does not directly mention this substance, it can be deduced from the ancient French words with reference to the idea of the process in the book.
To obtain this compound, you can first take ethane derivatives containing hydroxyl groups, whose hydroxyl groups can react with tert-butyl dimethylchlorosilane under appropriate conditions. This reaction requires a suitable medium, such as anhydrous ethyl ether or dichloromethane and other inert organic solvents, to ensure the smooth progress of the reaction. Alkali substances, such as imidazole or triethylamine, are also required, which act as acid binding to advance the reaction in the direction of forming silicone ethers. In this way, 1 - (tert-butyl dimethylsiloxy) ethane derivatives can be obtained.
Then, the derivative is converted into 1- (tert-butyl dimethylsiloxy) -2 -iodoethane. Halogenation reaction can be used to select suitable iodizing reagents, such as sodium iodide and dimethyl sulfate system, or triphenylphosphine and iodine combination, etc. During the reaction, attention should be paid to the control of temperature and reaction time. If the temperature is too high, side reactions may occur; if the time is too short, the reaction will not be completed. At the appropriate temperature and time, the reactants are fully applied, and the impurities are removed by separation and purification methods, such as column chromatography or recrystallization, to obtain 1- (tert-butyl dimethylsiloxy) -2 -iodoethane. Although this method of synthesis is explained in ancient Chinese, it also needs to be combined with modern chemical knowledge and experimental skills to achieve it smoothly.
What are the physical properties of 1- (tert - butyldimethylsilyloxy) -2-iodoethane?
1- (tert-butyl dimethylsiloxy) -2-iodoethane is a key reagent in organic synthesis. Its physical properties are unique and worth exploring.
Looking at its properties, it is a colorless to light yellow transparent liquid under normal conditions. This color and morphology are more common in organic compounds, but it is also one of the important characteristics to distinguish this substance.
When it comes to boiling point, the presence of siloxy and iodine atoms in the molecule has a great influence on the intermolecular forces, causing its boiling point to be in a specific range, about a certain temperature (the specific value varies depending on the test conditions). This boiling point characteristic is crucial when separating and purifying the compound. When performing operations such as distillation, it is necessary to precisely control the temperature so that 1- (tert-butyldimethylsiloxy) -2-iodoethane can be effectively separated.
Its melting point is also a significant physical property. The level of the melting point reflects the tightness of the molecular arrangement and the strength of the interaction. The melting point of the compound determines its physical state at different temperatures, and has certain requirements for storage and use conditions. If the storage temperature is improper, or its state changes, it will affect the use effect.
Furthermore, the density is also a property that cannot be ignored. Its density value reflects the quality of the substance per unit volume. When it comes to solution preparation, reaction material measurement, etc., the density data provides a basis for accurate calculation. By accurately measuring the density, the purity of the compound can be judged, and the density often changes due to the presence of impurities.
In terms of solubility, 1- (tert-butyldimethylsiloxy) -2-iodoethane is soluble in a variety of organic solvents, such as common ether, dichloromethane, etc. This solubility characteristic provides convenience for its application in organic synthesis reactions. When selecting the reaction solvent, the solubility can be based on its solubility to fully mix the reactants and promote the smooth progress of the reaction.
The physical properties of this compound are related to each other and affect its application in the field of organic synthesis. It is of great significance in chemical research and industrial production.
1- (tert - butyldimethylsilyloxy) -2-iodoethane What are the precautions during storage and transportation?
1 - (tert-butyl dimethylsiloxy) - 2 - iodoethane, during storage and transportation, there are many things to pay attention to, which must not be ignored.
This compound is chemically active and has special properties. When storing, the temperature and humidity of the first environment. It should be placed in a cool and dry place. Due to high temperature and humidity, it may cause chemical reactions to occur, which affects the quality. If the environment is humid, moisture may interact with the compound, causing reactions such as hydrolysis, causing its structure to change and lose its original properties.
and need to avoid direct light. Under light, the substance may induce luminescent chemical reactions, resulting in decomposition or deterioration. Therefore, the storage container should be made of light-shielding materials, such as brown glass bottles, to block light and ensure its stability.
Storage should also pay attention to isolation from other chemicals. 1- (tert-butyl dimethylsiloxy) -2 -iodoethane or with some oxidizing agents, reducing agents, acids, alkalis, etc. react violently, causing danger. Therefore, it should be stored in categories according to its chemical properties to prevent mixed storage.
As for transportation, the packaging must be solid and reliable. Because of its certain danger, the packaging must be able to withstand bumps and vibrations during transportation without breaking and leaking. And the outside of the package should be clearly marked with warning signs, indicating its characteristics and precautions.
The means of transportation should also be clean, and no substances that can react with them should be left. During transportation, closely monitor the environmental conditions to ensure that the temperature, humidity, etc. are within the appropriate range to ensure the safety of transportation, so that 1- (tert-butyldimethylsiloxy) -2-iodoethane can be delivered to the destination safely.
What is the approximate market price of 1- (tert - butyldimethylsilyloxy) -2-iodoethane?
1 - (tert - butyldimethylsilyloxy) - 2 - iodoethane is also a matter of transformation. To know its market value, it is difficult to reduce. Its cost is often affected by many factors, such as the quality of raw materials, the complexity of methods, the supply and demand, and the transformation of markets.
If the raw materials are used, if the materials used are expensive, or the collection is not easy, the cost of this compound will increase, and the cost will also be high. If the method is complex, it needs to be reversed in multiple steps, or special products and components are used, which will also increase the cost and decrease the price.
The supply and demand are especially important. If the market demand for this product is very high, and the supply is limited, the price will be high; on the contrary, if the supply is limited, the price will be easy to fall. And the market is instantaneous, the decline of the market, and the integrity of the policy can all affect it.
Therefore, if you want to know the market of 1 - (tert - butyldimethylsilyloxy) - 2 - iodoethane, you need to pay attention to the market of the chemical industry, and test the market of multiple businesses, in order to get the price. At this moment, if you want to say that its large price is fixed, because it is normal, only by relying on the situation of the lower market can you have a close judgment.