1h Indazol 3 Amine 4 Iodo

1H-pyrrole-3-formaldehyde is an organic compound with unique chemical properties. In its structure, the pyrrole ring is a nitrogen-containing five-membered heterocyclic ring, which has aromaticity, because the π electron in the ring satisfies the 4n + 2 rule. This aromaticity makes the pyrrole ring relatively stable, which affects the reactivity and physical properties of the compound.
The aldehyde group of 1H-pyrrole-3-formaldehyde (-CHO) is a strongly reactive functional group. The carbon-oxygen double bond in the aldehyde group is polar, the carbon is partially positively charged, and the oxygen is partially negatively charged. The aldehyde group is electrophilic and easily reacts with nucleophiles.
Nucleophilic addition reaction is one of its important reaction types. For example, under acid catalysis with alcohols, aldehyde groups can undergo nucleophilic addition with alcohol hydroxyl groups to generate hemiacetals, and further react to form acetals. This reaction is often used as a means of carbonyl protection in organic synthesis, because acetals are stable under basic and neutral conditions, and can be hydrolyzed and restored to aldehyde groups under acidic conditions.
The aldehyde group of 1H-pyrrole-3-formaldehyde can also be oxidized to carboxyl groups by various oxidants to obtain 1H-pyrrole-3-formic acid. Common oxidants such as potassium permanganate, potassium dichromate, etc. At the same time, aldehyde groups can also be reduced to hydroxyl groups under the action of specific reducing agents to generate 1H-pyrrole-3-methanol.
In addition, the hydrogen atom on the pyrrole ring of 1H-pyrrole-3-formaldehyde has a certain acidity. Because the electronegativity of nitrogen atom is larger than that of carbon, the electron cloud density distribution on the pyrrole ring is uneven, and the acidity of α-hydrogen atom is enhanced. Under the action of strong bases, protons can be taken away to form corresponding carbon negative ions, and then reactions such as nucleophilic substitution or nucleophilic addition occur.
In short, 1H-pyrrole-3-formaldehyde has rich chemical properties due to the interaction between pyrrole ring and aldehyde group. It is widely used in organic synthesis, medicinal chemistry and other fields, and provides an important intermediate for the synthesis of complex organic compounds.

1H-pyrrole-3-formaldehyde is an organic compound with unique physical properties and is widely used in many fields. The following are its main physical properties:
1. ** Appearance and properties **: At room temperature and pressure, 1H-pyrrole-3-formaldehyde usually appears light yellow to yellow solid, and the color often varies depending on purity, preparation method and storage conditions. The crystalline form of this compound is also special. The crystallization conditions are different, and the crystal shape and size are different. However, it generally has a regular geometric shape, reflecting the orderly arrangement of internal molecules.
2. ** Melting point and boiling point **: The melting point is about 61-65 ° C, which is relatively low. The melting point is an important physical parameter of solid compounds, indicating that at this temperature, the compound changes from solid to liquid. Its melting point is low, which means that it can be melted with only moderate heating. The boiling point is about 234-236 ° C, and the boiling point is higher, indicating that a higher temperature is required to vaporize it. The higher boiling point is due to the strong interaction forces between molecules, such as hydrogen bonds, van der Waals forces, etc., which make it difficult for the molecules to break away from the liquid state and become gaseous.
3. ** Solubility **: 1H-pyrrole-3-formaldehyde is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. In ethanol, by virtue of intermolecular interactions, such as hydrogen bonds, dipole-dipole interactions, etc., the compound molecules can interact with ethanol molecules and disperse in ethanol solutions. The poor solubility in water is due to the weak interaction between the compound molecules and water molecules, which cannot overcome the forces such as hydrogen bonds between water molecules, making it difficult to disperse in water.
4. ** Density **: Its density is about 1.22 g/cm ³, and the density reflects the mass per unit volume of matter. This value indicates that the mass-to-volume ratio of this compound in the solid state is similar to that of other similar organic compounds, reflecting the compactness of molecular structure and atomic mass distribution.
5. ** Odor **: 1H-pyrrole-3-formaldehyde has a special odor, which is difficult to describe accurately. It is similar to many organic aldehyde compounds and has a certain irritation, but its odor intensity and characteristics vary slightly at different concentrations.

1H-pyrrole-3-formaldehyde, although not directly described in the traditional techniques and materials involved in Tiangong Kaiwu, is widely used in today's chemical synthesis and various industries.
First, it is a key intermediate in drug synthesis. To cover the molecular structure of a drug, a specific structural fragment is often required to fit the target. The pyrrole ring and aldehyde group of 1H-pyrrole-3-formaldehyde can be synthesized by chemical synthesis to form a drug active molecule with other compounds. For example, some drugs with antibacterial and anti-inflammatory effects, during the synthesis process, 1H-pyrrole-3-formaldehyde may be used as the starting material, and after multi-step reaction, it gradually becomes the final product with pharmacological activity.
Second, in the field of materials science, it also has its use. The research and development of organic optoelectronic materials often seeks compounds with specific optoelectronic properties. 1H-pyrrole-3-formaldehyde may be integrated into the molecular system of organic optoelectronic materials by means of modification, polymerization, etc., which affects the properties of charge transport and fluorescence emission of materials. For example, in the creation of organic Light Emitting Diode (OLED) materials, its structural characteristics may be used to optimize the luminous efficiency and stability of materials.
Third, in the preparation of fine chemical products, 1H-pyrrole-3-formaldehyde is also indispensable. The synthesis of fine chemicals such as fragrances and dyes often relies on their unique structures and introduces specific functional groups to give the products the desired aroma, color and other properties. For example, dyes with specific structures can be obtained with good dyeing properties and color fastness through a series of reactions with 1H-pyrrole-3-formaldehyde as raw materials.

The synthesis of 1H-pyrrole-3-carboxylic acid has attracted much attention in the field of organic synthesis. There are many ways to synthesize it, and each has its own advantages and disadvantages. Under the paradigm of "Tiangong Kaiji", it is described in ancient Chinese as follows:
First, pyrrole can be reacted with suitable carboxylating reagents under specific reaction conditions. For example, an acyl halogen reagent is selected, and with the help of an alkaline catalyst, the nitrogen atom of pyrrole or the carbon atom at a specific position undergoes a nucleophilic substitution reaction with it. Among them, the choice of basic catalysts is crucial, such as weak bases such as potassium carbonate and sodium carbonate, or strong bases such as sodium hydride and potassium tert-butyl alcohol, all of which need to be used according to the activity of the reaction substrate and the selectivity of the expected product. The reaction temperature is also a key factor, either slowly reacting at room temperature, or heating to a moderate temperature to promote its rapid travel, but if the temperature is too high, there is a risk of side reactions.
Second, by introducing carboxyl groups while constructing pyrrole rings. For example, compounds containing carboxyl groups and other suitable raw materials are used to react in multiple steps to construct pyrrole structures. First, a carboxyl-containing and active methylene compound such as ethyl acetoacetate can be combined with ammonia and another carbonyl compound through a series of reactions such as condensation and cyclization to obtain 1H-pyrrole-3-carboxylic acid. In this process, the conditions of the condensation reaction need to be precisely controlled, and the choice of solvent should not be underestimated. Organic solvents such as ethanol and toluene have an impact on the process of the reaction and the purity of the product.
Third, the method of metal catalysis is used. Transition metal catalysts, such as palladium and copper, are used to catalyze the coupling reaction of halogenated pyrrole with carboxyl-containing nucleophiles. The activity of metal catalysts and the structure of ligands have a profound impact on the efficiency and selectivity of the reaction. At the same time, the alkali and additives in the reaction system can also affect the smoothness of the reaction. In this method, precise regulation of reaction parameters can improve the yield and purity of the product.
These synthesis methods are selected by organic synthesizers according to the availability of reaction materials, the difficulty of controlling reaction conditions, the purity and yield of the product, etc., in order to obtain 1H-pyrrole-3-carboxylic acid efficiently and with high quality.

In today's market, the price of 1H-pyrrole-3-formaldehyde is quite popular. This is a particularly important organic compound, which is widely used in the fields of medicine, pesticides, and materials, so its price is also important to the industry and researchers.
Looking at the current market conditions, the price of 1H-pyrrole-3-formaldehyde is actually influenced by many factors. The price of its raw materials is a clue. If the production and supply of raw materials changes, the price will fluctuate accordingly. If the harvest of raw materials is poor, or the supply channel is blocked, the cost will rise and the price of 1H-pyrrole-3-formaldehyde will also rise.
Furthermore, the preparation technology is also related to the price. If the new technology is developed, it can reduce energy consumption and increase productivity, and its cost can be reduced, and the price may be reduced. On the contrary, if the technology is sluggish and the consumption is large, the price will be difficult to lower.
The supply and demand of the market is also the cardinal of the price. If the market demands a boom in 1H-pyrrole-3-formaldehyde, but the supply is insufficient, the price will rise; if the demand is weak and the supply is surplus, the price will fall. If pharmaceutical research and development suddenly soars, the demand for it will increase greatly, but the production will not be met, the price will be high.
There is the shadow of policies and regulations again. Environmental protection regulations, trade policies, etc., can lead to changes in prices. If environmental protection becomes stricter, and producers increase spending in order to comply with regulations, the price may rise; trade barriers arise, import and export are hindered, and the price can also be disrupted.
In summary, the current price of 1H-pyrrole-3-formaldehyde in the market cannot be covered in one word. It often fluctuates between hundreds of yuan per kilogram, but due to the above reasons, it is high and low at times, and it is not constant. Industry and researchers, when they closely observe market conditions, technological changes, and political regulations, can know the trend of their prices and find good strategies.