1h Indazole 5 Iodo

5-Iodine-1H-indazole is also an organic compound. It has a wide range of uses and is particularly crucial in the field of medicinal chemistry.
First, it is often an important intermediate for the creation of new drugs. Medical researchers use its unique chemical structure to modify and derive many compounds with potential biological activity, hoping to find good drugs for treating various diseases. For example, targeting specific disease-related targets, building molecules that are compatible with them, using 5-iodine-1H-indazole as the starting material, through multi-step reactions, drug molecules with precise pharmacological effects are prepared, which are often used in the development of anti-tumor, anti-viral, anti-inflammatory and other drugs.
Furthermore, in the field of materials science, it also has its uses. Due to its structural properties, it can participate in the synthesis of materials with special photoelectric properties. In the development of organic Light Emitting Diode (OLED) materials, the introduction of 5-iodine-1H-indazole can adjust the energy level structure of the material, improve the luminous efficiency and stability, and contribute to the improvement of the performance of OLED display technology. When exploring solar cell materials, it can also help optimize the light absorption and charge transport properties of materials, and contribute to the improvement of the conversion efficiency of solar cells.
In addition, in the field of organic synthetic chemistry, 5-iodine-1H-indazole provides an effective structural module for the synthesis of complex organic molecules. Organic chemists rely on the activity of their iodine atoms to carry out various coupling reactions, such as Suzuki coupling, Stille coupling, etc., to construct carbon-carbon bonds and carbon-heteroatom bonds, to achieve the efficient construction of complex organic skeletons, to expand the molecular diversity of organic compounds, and to inject vitality into the development of organic synthetic chemistry.

5-Iodine-1H-indazole is an organic compound with unique physical properties. It is mostly solid at room temperature. Due to the arrangement and interaction of atoms in the molecule, it has a certain melting point and boiling point. However, the exact melting and boiling point value will vary depending on the purity and measurement conditions. The approximate melting point is in a specific temperature range, and the boiling point is also in the corresponding temperature range. This has a great impact on its existence and application in different temperature environments.
5-Iodine-1H-indazole is often white to off-white crystalline powder with fine texture. This appearance characteristic is easy to identify and handle in various experiments and production. From the perspective of solubility, its solubility in organic solvents is different. In common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), it has a certain solubility, which can dissolve to form a uniform solution, which is conducive to participating in the chemical reaction of the solution phase; but the solubility in water is very small, because of the hydrophobicity of its molecular structure, it is difficult to interact effectively with water molecules.
The density of this compound is also an important physical property. Although the exact value needs to be accurately measured, according to its molecular composition and the law of similar compounds, the density is in a specific range, which affects its distribution and separation process in the mixture. In addition, 5-iodine-1H-indazole has certain stability and can maintain its own structure and properties under conventional conditions. However, in case of specific chemical reagents, high temperature, light, etc., it may cause chemical reactions and cause structural changes, which requires special attention when storing and using.

The synthesis of 5-iodine-1H-indazole can be found in a variety of ways. First, it can be prepared from 5-iodine-indazole-3-carboxylic acid through decarboxylation reaction. This reaction requires under specific conditions, with the force of a suitable catalyst, the carboxyl group is separated to obtain the target product. Specifically, it often requires a high temperature environment, with catalysts such as copper salts, to fully react in organic solvents, and after several hours or even days, a considerable yield can be achieved.
Second, 5-iodoaniline is used as the starting material, and it is obtained through multiple steps such as diazotization and cyclization. First, 5-iodoaniline and sodium nitrite are diazotized in an acidic environment to form diazonium salts. This diazonium salt has high activity and is then cyclized with suitable nucleophiles, such as enol ethers, under appropriate conditions to construct the ring structure of indazole. In this process, the control of reaction conditions at each step is crucial, such as reaction temperature, pH, and the ratio of reactants, all of which have a significant impact on the final yield and purity.
Or, it can be synthesized from 5-iodo2-nitrotoluene as the starting material through reduction and cyclization. The nitro group is first reduced to an amino group, and the commonly used reducing agents are iron powder, zinc powder, etc., which are reacted in acidic or neutral media. Afterwards, the indazole structure is formed by cyclization reaction. This cyclization step requires specific reagents and conditions to ensure the selectivity and efficiency of the reaction.
All these synthesis methods have advantages and disadvantages. When choosing, consider the availability of raw materials, the difficulty of reaction conditions, the level of yield, and the purity of the product to determine the best synthesis path.

I see what you are asking about the market price of 1H-indazole and 5-iodine. However, this is not an easy question to answer. It covers the price of the market, which often changes due to changes in time, place, and supply and demand.
If in the world of "Tiangong Kaiwu", if you want to know the price of this product, you must search for it in many ways. At that time, or when inquiring the merchants of various pharmaceutical shops, they often involved various rare materials, or knew the traces and prices of this product. However, 1H-indazole, 5-iodine is an unusually visible product, which may be a rare medicine or made in special workshops.
If this product is needed by the pharmacy, its price must depend on its quality and quantity. If the quality, purity and quantity are thin, the price will be high; if the mass production is slightly more abundant, the price may be slightly reduced. And at that time, the transportation is inconvenient, and the distance of the place of origin is also related to its price. If it is produced in a distant place and goes through long-distance transshipment, the price should include the cost of freight, which must be higher than that of the nearest producer.
At that time, there was a commercial state, and the wind of buying and selling and bargaining prevailed. If the buyer is a regular customer, or is good with merchants, he can also get some discounts. And the economic rise and fall of different regions varies. In prosperous places, prices may be higher than in remote areas, depending on the difference in consumption power and demand.
Although today is very different from the world of "Tiangong Kaiwu", the principle of price is the same in ancient and modern times. If you want to know the market price of 1H-indazole and 5-iodine, you should also carefully examine the market supply and demand, production difficulties, transportation costs, etc., before you can get a rough idea of their approximate price. I regret that I can't directly state the exact price. I hope you can follow this reason and go to the market for details, or you can get the real price.

5-Iodine-1H-indazole is a special chemical substance, and it is necessary to take great care with regard to its safety precautions.
This substance has potential chemical risks, its toxicity may be hazardous to health due to accidental touch, inhalation or ingestion. During operation, professional protective equipment must be worn, such as laboratory clothes, gloves and goggles, to avoid direct contact. The relevant operation should be carried out in a well-ventilated place, and if conditions permit, it is more appropriate to work in a fume hood to prevent the inhalation of harmful vapors.
5-Iodine-1H-indazole is chemically active and may react with other substances. Therefore, it is necessary to understand its chemical properties in detail and avoid mixing with incompatible substances, such as strong oxidants, strong acids, strong alkalis, etc. When storing, specific requirements should also be followed. Usually, it should be placed in a dry, cool place away from fire sources and incompatible materials, and properly sealed to prevent deterioration or dangerous reactions.
In addition, the waste generated by this substance must not be discarded at will. It should be disposed of in a proper manner in accordance with relevant regulations and standards to prevent pollution to the environment.
Operators should also be familiar with the emergency treatment process. If a leak occurs accidentally, corresponding measures should be taken immediately, such as evacuating personnel, blocking fire sources, and selecting suitable materials for cleaning according to the leakage situation. Once you feel unwell during the operation, be sure to seek medical attention as soon as possible and inform the doctor of the contact situation in detail. In this way, the safety of personnel and the environment can be fully guaranteed.