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What are the chemical properties of 1h-inn-2-amine, 2,3-dihydro-5-iodo-?
2,3-Dihydro-5-iodine-1H-indene-2-amine, this is an organic compound. It has unique chemical properties, let me tell you in detail.
From the structural point of view, the core of the compound is an indene ring, with an amino group connected at the 2nd position of the indene ring, a saturated bond between the 3rd and 2nd positions, in the state of dihydrogen, and an iodine atom connected at the 5th position.
In terms of physical properties, due to the iodine-containing atom, its molecular mass is relatively large, and the intermolecular force may be strong, so the melting boiling point may be higher. And the iodine atom has a certain electronegativity, which will affect the polarity of the molecule, causing its solubility to be different from that of similar compounds without iodine, and it may have a certain solubility in polar solvents.
Its chemical properties are also quite interesting. Amino groups are nucleophilic and can participate in many nucleophilic reactions, such as reacting with halogenated hydrocarbons to form secondary or tertiary amines; they can also react with acyl halides, acid anhydrides, etc., to obtain amide compounds. As a leaving group, iodine atoms can participate in nucleophilic substitution reactions and be replaced by other nucleophilic reagents, thereby modifying molecular structures and derived many new compounds. Although the indene ring part is not a typical aromatic ring, it has certain aromatic properties and can participate in aromatic electrophilic substitution reactions such as the Fourier-gram reaction. The introduction of other functional groups on the ring expands the chemical uses of the compound and provides various possibilities for the field of organic synthesis.
What are the physical properties of 1h-inn-2-amine, 2,3-dihydro-5-iodo-
2,3-Dihydro-5-iodine-1H-indene-2-amine is an organic compound. Looking at its properties, it is a crystalline powder at room temperature, white or yellowish in color, with a certain crystalline form, fine and uniform.
In terms of its solubility, this compound behaves differently in common organic solvents. In polar organic solvents such as ethanol and methanol, it may have a certain solubility, because the amine group in the molecule can form hydrogen bonds with alcohols to improve solubility; in non-polar solvents such as n-hexane and benzene, the solubility is low, because its molecular structure contains polar groups, and the interaction force with non-polar solvents is weak.
In terms of melting and boiling point, due to the interaction of hydrogen bonds and van der Waals forces between molecules, the melting point may be relatively high. When heating, a specific temperature needs to be reached to overcome the intermolecular forces before it can be melted into a liquid state. Its boiling point is also determined by factors such as intermolecular forces and relative molecular weights.
In terms of density, according to its molecular composition and accumulation mode, there may be a certain value. Compared with water, the density may be greater than that of water, due to the large relative atomic weight of iodine atoms in the molecule, resulting in an increase in the overall density.
In terms of stability, iodine atoms in molecules have a certain activity. Under light, heat or a specific chemical environment, reactions such as substitution and elimination may occur, which affect their stability. Amine groups are also alkaline and can react with acids to participate in various chemical transformations.
What are the common uses of 1h-ink-2-amine, 2,3-dihydro-5-iodo-?
1H-indene-2-amine, 2,3-dihydro-5-iodide, this is a specific compound in the field of organic chemistry. To obtain this compound, common methods are as follows:
In the selection of starting materials, compounds containing corresponding functional groups can be selected. Start with those with indene ring structure and a convertible group in an appropriate position, which may have halogen atoms, hydroxyl groups, etc. at a specific position, which is the basis for subsequent reactions.
The halogenation reaction is quite critical. If there is no iodine atom in the starting material, it needs to be introduced. Often iodine elements or iodine-containing reagents are used to replace the hydrogen atom at the target position under suitable reaction conditions. For example, in the presence of appropriate catalysts, such as some transition metal catalysts, in a specific organic solvent, under heating or lighting conditions, the iodine reagent undergoes an electrophilic substitution reaction with the substrate, so that the iodine atom precisely accesses the 5 positions of the indene ring.
For the formation of dihydrogen structures, a reduction reaction is often used. If the starting material is an unsaturated indene ring, a suitable reducing agent can be selected. If hydrogen is used as a reducing agent, under the action of metal catalysts (such as palladium-carbon catalysts), under suitable temperature and pressure conditions, the double bonds at the 2,3 positions on the indene ring are hydrogenated and reduced to form a 2,3-dihydrogen structure. The retention and modification of the
amine group also need attention. If the amine group of the starting material may affect the reaction process, it can be protected first, and then de-protected after the reaction is completed. Commonly used amine protecting groups such as benzyloxycarbonyl, etc., the introduction and removal of protecting groups need to follow standard organic synthesis steps to ensure that the amine participates in the reaction at a suitable stage or remains stable.
During the synthesis process, according to the reaction process and the characteristics of each step of the product, it is necessary to separate and purify by means such as column chromatography and recrystallization to obtain high purity 1h-indene-2-amine, 2,3-dihydro-5-iodide. The precise control of the reaction conditions at each step, such as temperature, reactant ratio, reaction time, etc., are all key elements for the successful synthesis of this compound, requiring careful operation and careful regulation.
What is the synthesis method of 1h-inn-2-amine, 2,3-dihydro-5-iodo-?
To prepare 2,3-dihydro-5-iodine-1H-indene-2-amine, the following ancient method can be used.
First, indene is used, and the iodine atom is introduced into the 5-position indene ring by halogenation. When halogenating, select a suitable halogenating agent, such as iodine elemental substance blended with a suitable catalyst, and under appropriate reaction conditions, the iodine atom is precisely attached to the designated place in the indene ring. Among them, the choice of temperature and solvent is the key, and careful regulation is required to make the reaction smooth and obtain a higher yield of 5-iodine indene.
The 5-iodoindene is hydrogenated to add hydrogen atoms at the 2,3 positions to form 2,3-dihydro-5-iodoindene. In this step, a suitable hydrogenation catalyst, such as palladium carbon, is selected to promote the hydrosaturation of the double bond under a certain hydrogen pressure and temperature. Control the reaction conditions to prevent over-hydrogenation from impurities of the product.
At the end, 2,3-dihydro-5-iodoindene is reacted with ammonia or ammonia derivatives to aminate to obtain 2,3-dihydro-5-iodine-1H-indene-2-amine. In the reaction, the proportion of solvent, reactants and reaction time need to be carefully considered. After the reaction, the impurities are removed by separation and purification methods, such as column chromatography, recrystallization, etc., to obtain a pure target product.
Each step of the reaction requires detailed observation of the reaction process. According to the experimental image, the reaction conditions can be adjusted in time to make this synthesis path smooth and obtain the expected 2,3-dihydro-5-iodine-1H-indene-2-amine.
1H-inn-2-amine, 2,3-dihydro-5-iodo- What are the relevant safety precautions?
2-Amino-5-iodine-1,3-dihydroindene This substance is related to safety and requires attention to many matters.
During operation, due to its toxicity and irritation, the operator should be fully armed, wearing protective clothing, protective gloves and goggles to prevent skin contact and eye irritation. The operation should be carried out in a well-ventilated place, preferably in a fume hood, to avoid the accumulation of harmful gases and endanger personal safety.
When storing, it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Be sure to store separately from oxidizing agents, acids, alkalis, etc., and must not be mixed to prevent dangerous chemical reactions. The storage area should be equipped with suitable materials to contain leaks.
During transportation, make sure that the container does not leak, collapse, fall, or damage. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidizing agents, acids, alkalis, edible chemicals, etc. During transportation, it should be protected from exposure to the sun, rain, and high temperature.
In the event of a leak, isolate the leaking contaminated area and restrict access. Emergency responders should wear dust masks and gas suits. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, collect it in a dry, clean, covered container with a clean shovel. In the event of a large leak, collect it for recycling or transport it to a waste treatment site for disposal.
In short, when dealing with 2-amino-5-iodine-1,3-dihydroindene, safety regulations must be strictly followed from operation, storage to transportation, and no negligence should be allowed to avoid safety accidents.
