1h Pyrazole 3 Iodo

1H-pyrazole, 3-iodine - This substance has a wide range of uses. In the field of medicinal chemistry, it is often the key raw material for the creation of new drugs. Gainpyrazole compounds have a variety of biological activities, such as anti-inflammatory, antibacterial, anti-tumor, etc. 3-iodine-1H-pyrazole can be chemically modified and transformed to produce drug molecules with specific pharmacological activities, or lay the foundation for the development of specific drugs for specific diseases.
In the field of materials science, it also has extraordinary performance. It can be used as an important intermediate for the synthesis of functional materials. It can be polymerized or combined with other materials to give the material unique electrical, optical or mechanical properties. For example, the preparation of organic semiconductor materials with excellent photoelectric conversion efficiency may make a name for itself in solar cells and other fields.
In the field of organic synthetic chemistry, 3-iodine-1H-pyrazole has become an important building block for the construction of complex organic molecular structures due to the activity of iodine atoms. With the help of various organic reactions, such as coupling reactions, it can connect with many organic fragments, expand the structural diversity of organic molecules, provide an effective way for the synthesis of novel organic compounds, and promote the development and progress of organic synthetic chemistry.

3-Iodine-1H-pyrazole is an organic compound with unique physical properties. It is mostly solid at room temperature, and its appearance may be white to light yellow crystalline powder. Due to the intermolecular force, the molecules are arranged in an orderly manner.
In terms of melting point, it is about 120-130 ° C. The melting point is determined by the interaction strength between molecules, such as hydrogen bonds, van der Waals forces, etc. Moderate heating, the molecules are energized to break free from the lattice binding, and the crystalline state is converted to a liquid state.
3-Iodine-1H-pyrazole is insoluble in water. Because it is an organic molecule, its polarity is weak, and it is difficult to form effective interactions with water molecules. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, ethanol, etc. In dichloromethane, due to the non-polar and weakly polar molecular structure of dichloromethane, it can interact with 3-iodine-1H-pyrazole molecules through van der Waals force, and then dissolve.
Its density is greater than that of water, about 2.0 g/cm ³, which is determined by the molecular weight and the degree of molecular accumulation. The 3-iodine-1H-pyrazole molecule contains iodine atoms. The relative atomic weight of iodine atoms increases the molecular weight, and the molecules are closely arranged, so the density is higher.
In terms of stability, it is relatively stable under normal conditions. But in case of strong oxidizing agent, strong acid or strong base, reaction may occur. Because the pyrazole ring has a certain electron cloud density and reactivity check point, iodine atoms can also participate in nucleophilic substitution and other reactions, when encountering specific reagents, or cause molecular structure changes.

3-Iodine-1H-pyrazole is a chemical substance with relatively stable chemical properties. Because of its structure, the pyrazole ring has a certain conjugate system, which makes the electron cloud distribution more uniform, thus endowing the substance with certain stability.
From the perspective of the characteristics of the pyrazole ring, the existence of its nitrogen atom changes the electron cloud density in the ring, and the lone pair of electrons on the nitrogen atom participates in the conjugation, which contributes a lot to the stability of the whole molecule. The iodine atom connected to the 3 position, although the iodine atom is relatively large and has a certain steric resistance, is not easy to cause significant changes in the structure under normal conditions after being connected to the pyrazole ring.
However, it should be noted that this substance is not absolutely stable. Under certain harsh conditions, such as high temperature, strong oxidizing agents or strong reducing agents, its stability may be affected. In high temperature environments, the thermal motion of molecules intensifies, which may cause the vibration of chemical bonds to increase, which in turn increases the reactivity and changes the molecular structure. Strong oxidizing agents or strong reducing agents can react with some parts of the molecule for electron transfer, breaking the original electron cloud distribution and causing chemical properties to change. However, under conventional laboratory environments and general storage conditions, 3-iodine-1H-pyrazole can maintain a relatively stable state, which is convenient for research and use.

The synthesis method of 3-iodine-1H-pyrazole has been known for a long time, and after years of precipitation, various paths have been developed. The details are as follows:
First, 3-iodine-1H-pyrazole can be prepared by halogenation with pyrazole as the starting material. The halogenation method is to add a halogenating reagent to a suitable solvent, such as dichloromethane. Commonly used, such as N-iodosuccinimide (NIS), this reagent has high activity and can react with pyrazole under mild conditions. During the reaction, the pyrazole is dissolved in the solvent, stirred at low temperature, and slowly added to NIS to maintain the low temperature of the reaction system to avoid side reactions. In this process, the 3-position hydrogen atom of pyrazole is replaced by the iodine atom, and the target product is obtained. After the reaction is completed, the product can be purified by extraction, washing, drying, column chromatography and other means.
Second, 3-iodine-1H-pyrazole can also be synthesized by functional group conversion with compounds containing pyrazole structure as substrates. For example, first prepare pyrazole derivatives with convertible functional groups at the 3-position, such as 3-hydroxypyrazole. React 3-hydroxypyrazole with a suitable iodizing agent, such as a catalytic system composed of cuprous iodide and ligands, and heat the reaction in the presence of a suitable base. The base can be selected from potassium carbonate or the like to promote the reaction. In the reaction, the hydroxyl group is replaced by an iodine atom to form 3-iodine-1H-pyrazole. Conventional separation and purification steps are also required to obtain a purified product.
Third, it is synthesized by cyclization reaction. Using suitable chain compounds as raw materials, a pyrazole ring is formed by intramolecular cyclization and iodine atoms are introduced. For example, 1,4-dione compounds are reacted with hydrazine and iodizing reagents. In a suitable solvent, the three are mixed and heated to reflux. During the reaction, 1,4-dione and hydrazine are condensed first to form a pyrazole ring, and iodizing reagents are introduced into iodine atoms at the 3-position of the pyrazole ring. In this reaction, attention should be paid to the control of reaction conditions. Temperature, ratio of reactants and other factors have a great influence on the yield of the product. After the reaction is completed, 3-iodine-1H-pyrazole is obtained by conventional separation methods.

What is the price of 1H-pyrazole, 3-iodine-this chemical substance in the market today? I will answer it in the style of "Tiangong Kaiwu".
Among the shops in Guanfu, the price of various goods often varies according to time, place, quality and supply and demand. The price of 1H-pyrazole, 3-iodine-this chemical substance is also difficult to generalize.
If its origin is widely distributed, the output is quite abundant, and the demand for various industries is not strong, the price may be leveled. However, if the origin is rare, it is difficult to make, and it is widely needed in the pharmaceutical, chemical and other industries, its price will be high.
Or in the prosperous city of Dayi, where commerce and trade converge, because of the convenient circulation, there are many things gathered, and the price may be relatively easy. And in remote places, traffic blockages, and difficult transshipment of things, the price should increase.
Moreover, the purity of this thing is also a matter of pricing. Those with high purity have more complex preparation, and the required materials are also refined, and the price must be higher than those with low purity.
Therefore, in order to know the exact price of 1H-pyrazole and 3-iodine, we must consider the market supply and demand at that time, the local interests, and our own quality. It is difficult to rely on a few words, that is, to say the height of its price.